Preparation of bicyclic β-lactam and bicyclic 1,3- oxazinone scaffolds using combined cycloaddition and metathesis processes - Publikacja - MOST Wiedzy

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Preparation of bicyclic β-lactam and bicyclic 1,3- oxazinone scaffolds using combined cycloaddition and metathesis processes

Abstrakt

A simple, efficient two-step method for the preparation of heterobicyclic compounds was developed. Starting from 5-acyl or 5-carbamoyl-2,2- dimethyl-1,3-dioxa-4,5-dione bicyclic scaffolds of 1-azabicyclo[5.2.0]non- 3-en-9-one, 6,9,10,10a-tetrahydro-4H-[1,3]oxazino[3,2-a]azepin-4-one, and 6,9,10,10a-tetrahydro-2H-[1,3]oxazino[3,2-a]azepine-2,4(3H)-dione were prepared using cycloaddition of thermally generated ketenes to aldimines with unsaturated side chains, followed by metathesis. The method was applied to ring closing metathesis (RCM) of different heterocyclic substrates to demonstrate its versatility..

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Kategoria:
Publikacja w czasopiśmie
Typ:
artykuł w czasopiśmie wyróżnionym w JCR
Opublikowano w:
SYNTHETIC COMMUNICATIONS nr 48, strony 1793 - 1804,
ISSN: 0039-7911
Język:
angielski
Rok wydania:
2018
Opis bibliograficzny:
Zakaszewska A., Najda-Mocarska E., Makowiec S.: Preparation of bicyclic β-lactam and bicyclic 1,3- oxazinone scaffolds using combined cycloaddition and metathesis processes// SYNTHETIC COMMUNICATIONS. -Vol. 48, nr. 14 (2018), s.1793-1804
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1080/00397911.2018.1465980
Bibliografia: test
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