The influence of amorphous macrodiol, diisocyanate type and l-ascorbic acid modifier on chemical structure, morphology and degradation behavior of polyurethanes for tissue scaffolds fabrication - Publikacja - MOST Wiedzy

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The influence of amorphous macrodiol, diisocyanate type and l-ascorbic acid modifier on chemical structure, morphology and degradation behavior of polyurethanes for tissue scaffolds fabrication

Abstrakt

Studies described in this work were related to the bulk synthesis and characterization of polyurethanes (PURs) obtained with the use of cyclic 4,4′-methylene bis(cyclohexyl isocyanate) (HMDI) or linear 1,6-hexamethylene diisocyanate (HDI), amorphous α,ω-dihydroxy(ethylene-butylene adipate) macrodiol (PEBA), 1,4-butandiol (BDO) chain extender and dibutyltin dilaurate (DBTDL) catalyst. Obtained PURs were modified with l-ascorbic acid (AA). Raw materials and modifier improving biocompatybility were carefully selected due to the planned use of obtained PURs as a tissue scaffold fabrication material. Performed chemical structure studies (FTIR, ATR-IR, 2D NMR), morphology observations (SEM, TEM and AFM) and characterization of degradation profile revealed that PURs obtained by using HDI were representing a significantly better characteristic than those obtained by using HMDI. Thus, the HDI-based PURs were suggested for further development as a materials useful for tissue scaffolds fabrication in the field of tissue engineering.

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Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuł w czasopiśmie wyróżnionym w JCR
Opublikowano w:
POLYMER DEGRADATION AND STABILITY nr 163, strony 52 - 67,
ISSN: 0141-3910
Język:
angielski
Rok wydania:
2019
Opis bibliograficzny:
Gubańska I., Kucińska-Lipka J., Janik H.: The influence of amorphous macrodiol, diisocyanate type and l-ascorbic acid modifier on chemical structure, morphology and degradation behavior of polyurethanes for tissue scaffolds fabrication// POLYMER DEGRADATION AND STABILITY. -Vol. 163, (2019), s.52-67
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.polymdegradstab.2019.02.025

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