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Trimethylamine N-oxide and the reverse cholesterol transport in cardiovascular disease: a cross-sectional study
Abstrakt
The early atherosclerotic lesions develop by the accumulation of arterial foam cells derived mainly from cholesterol-loaded macrophages. Therefore, cholesterol and cholesteryl ester transfer protein (CETP) have been considered as causative in atherosclerosis. Moreover, recent studies indicate the role of trimethylamine N-oxide (TMAO) in development of cardiovascular disease (CVD). The current study aimed to investigate the association between TMAO and CETP polymorphisms (rs12720922 and rs247616), previously identified as a genetic determinant of circulating CETP, in a population of coronary artery disease (CAD) patients (n = 394) and control subjects (n = 153). We also considered age, sex, trimethylamine (TMA) levels and glomerular filtration rate (GFR) as other factors that can potentially play a role in this complex picture. We found no association of TMAO with genetically determined CETP in a population of CAD patients and control subjects. Moreover, we noticed no differences between CAD patients and control subjects in plasma TMAO levels. On the contrary, lower levels of TMA in CAD patients respect to controls were observed. Our results indicated a significant correlation between GFR and TMAO, but not TMA. The debate whether TMAO can be a harmful, diagnostic or protective marker in CVD needs to be continued.
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Autorzy (9)
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Laura Bordoni
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Joanna J. Samulak
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Angelika K. Sawicka
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Iwona Pelikant-Malecka
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Adrianna Radulska
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Lukasz Lewicki
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Rosita Gabbianelli
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Robert Olek dr hab.
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Pełna treść
- Wersja publikacji
- Accepted albo Published Version
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1038/s41598-020-75633-1
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Informacje szczegółowe
- Kategoria:
- Publikacja w czasopiśmie
- Typ:
- artykuły w czasopismach
- Opublikowano w:
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Scientific Reports
nr 10,
ISSN: 2045-2322 - Język:
- angielski
- Rok wydania:
- 2020
- Opis bibliograficzny:
- Bordoni L., Samulak J. J., Sawicka A. K., Pelikant-Malecka I., Radulska A., Lewicki L., Kalinowski L., Gabbianelli R., Olek R.: Trimethylamine N-oxide and the reverse cholesterol transport in cardiovascular disease: a cross-sectional study// Scientific Reports -Vol. 10,iss. 1 (2020), s.18675-
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1038/s41598-020-75633-1
- Weryfikacja:
- Politechnika Gdańska
wyświetlono 71 razy
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