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Wyniki wyszukiwania dla: human tumor xenografts
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Indole-Acrylonitrile Derivatives as Potential Antitumor and Antimicrobial Agents—Synthesis, In Vitro and In Silico Studies
PublikacjaA series of 2-(1H-indol-2-yl)-3-acrylonitrile derivatives, 2a–x, 3, 4a–b, 5a–d, 6a–b, and 7, were synthesized as potential antitumor and antimicrobial agents. The structures of the prepared compounds were evaluated based on elemental analysis, IR, 1H- and 13NMR, as well as MS spectra. X-ray crystal analysis of the representative 2-(1H-indol-2-yl)-3-acrylonitrile 2l showed that the acrylonitrile double bond was Z-configured. All...
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Selected adipocytokines in patients with an incidentally discovered pheochromocytoma
PublikacjaBACKGROUND: Adipose tissue secretes many adipokines and cytokines, which may be an additional risk factor of cardiovascular and metabolic diseases in patients with an incidentally discovered pheochromocytoma (PHEO). The aim of the study was to investigate levels of selected adipocytokines in these patients. METHODS: This prospective study included 12 patients with an incidentally discovered PHEO and 18 healthy participants. In...
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imPlatelet classifier: image‐converted RNA biomarker profiles enable blood‐based cancer diagnostics
PublikacjaLiquid biopsies offer a minimally invasive sample collection, outperforming traditional biopsies employed for cancer evaluation. The widely used material is blood, which is the source of tumor-educated platelets. Here, we developed the imPlatelet classifier, which converts RNA-sequenced platelet data into images in which each pixel corresponds to the expression level of a certain gene. Biological knowledge from the Kyoto Encyclopedia...
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Novel 2-alkythio-4-chloro-N-[imino(heteroaryl)methyl]benzenesulfonamide Derivatives: Synthesis, Molecular Structure, Anticancer Activity and Metabolic Stability
PublikacjaA series of novel 2-alkythio-4-chloro-N-[imino-(heteroaryl)methyl]benzenesulfonamide derivatives, 8–24, were synthesized in the reaction of the N-(benzenesulfonyl)cyanamide potassium salts 1–7 with the appropriate mercaptoheterocycles. All the synthesized compounds were evaluated for their anticancer activity in HeLa, HCT-116 and MCF-7 cell lines. The most promising compounds, 11–13, molecular hybrids containing benzenesulfonamide...
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CYP3A4-dependent cellular response does not relate to CYP3A4-catalysed metabolites of C-1748 and C-1305 acridine antitumor agents in HepG2 cells
PublikacjaHigh CYP3A4 expression sensitizes tumor cells to certain antitumor agents while for others it can lower their therapeutic ef fi cacy. We have elucidated the in fl uence of CYP3A4 overexpression on the cellular response induced by antitumor acridine derivatives, C-1305 and C-1748, in two hepatocellular carcinoma (HepG2) cell lines, Hep3A4 stably transfected with CYP3A4 isoenzyme, and HepC34 expressing empty vector. The compounds...
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Concurrent DNA Copy-Number Alterations and Mutations in Genes Related to Maintenance of Genome Stability in Uninvolved Mammary Glandular Tissue from Breast Cancer Patients
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P-448 The impact of assisted reproductive technology for second births: a follow-up study
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P-666 Detecting gene variants correlated with MII oocytes developed during ovarian stimulation
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P-653 The impact of clinical factors on the number of MII oocytes
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Obstetric and perinatal outcomes following programmed compared to natural frozen-thawed embryo transfer cycles: a systematic review and meta-analysis
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Dual-task exercise as a therapy for executive motor function in Parkinson’s disease
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When technology use causes stress: Challenges for contemporary research
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Perceived technostress while learning a new mobile technology: Do individual differences and the way technology is presented matter?
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An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in women
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Prediction of skin color, tanning and freckling from DNA in Polish population: linear regression, random forest and neural network approaches
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P-674 Automatizing ovarian follicle counting and measurement with artificial intelligence
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P-544 Biochemical markers as a predictor of clinical pregnancy on day 6 after embryo transfer
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O-256 Evaluation of the fertility potential of semen using Proton NMR
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Body fat, energy balance and estradiol levels: a study based on hormonal profiles from complete menstrual cycles
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Deep convolutional neural network for predicting kidney tumour malignancy
PublikacjaPurpose: According to the statistics, up to 15-20% of removed solid kidney tumors turn out to be benign in postoperative histopathological examination, despite having been identified as malignant by a radiologist. The aim of the research was to limit the number of unnecessary nephrectomies of benign tumors. Methods or Background: We propose a machine-aided diagnostic system for kidney...
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Cytotoxic and Antioxidant Activities of Benzohydroxamic Acid Analogues
Publikacja20 benzohydroxamic acid analogues were synthesized and evaluated for their in vitro cytotoxicities against mouse mammary tumor cells as well as antioxidant activities against DPPH radical and superoxide anion. It was found that benzothiohydroxamic acids exhibit greater cytotoxicities than benzohydroxamic acids and N-isopropyl derivatives are more active than N-methyl ones. On the other hand, benzothiohydroxamic acids show more...
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Phospholipids as potential prevention factor in carcinogenesis
PublikacjaPhospholipids are a group of complex lipids, which can be used in cancer chemoprevention. Glicerophospholipids are composed of fatty acids esterified to a glycerol backbone, a phosphate group and a hydrophilic residue such as: cho- line, ethanoloamine, serine or inositol. In the sn-2 position of glicerophospholipid usually there are unsaturated fatty acids, i.e. linolenic acid, while in the sn-1 position more typi- cal are saturated...
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Novel anticancer strategy aimed at targeting shelterin complexes by the induction of structural changes in telomeric DNA: hitting two birds with one stone.
PublikacjaThe ends of chromosomes in mammals are composed of telomeric DNA containing TTAGGG repeats, which bind specific proteins called shelterins. This telomeric DNA together with shelterins form a cap that protects the ends of chromosomes from being recognized as sites of DNA damage and from chromosomal fusions. Many very successful antitumor drugs used in the treatment of cancer patients bind to DNA, some of them with a prominent sequence...
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Biochemical, Structural Analysis, and Docking Studies of Spiropyrazoline Derivatives
PublikacjaIn this study, we evaluated the antiproliferative potential, DNA damage, crystal struc‐ tures, and docking calculation of two spiropyrazoline derivatives. The main focus of the research was to evaluate the antiproliferative potential of synthesized compounds towards eight cancer cell lines. Compound I demonstrated promising antiproliferative properties, especially toward the HL60 cell line, for which IC50 was equal to 9.4 μM/L....
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Caffeine Inhibits Differentiation Of Lung Cancer Stem Cells By Modulating Their Respiratory Metabolism
PublikacjaIt is ell established that many tumor types contain a fraction of cells, with stem cell-like properties, called cancer stem cells (CSCs), that are resistant to apoptosis induced by therapeutic agents. The presence of CSCs may explain why a standard anticancer treatment, that eliminates only differentiated cancer cells, does not lead to cancer cure.We previously showed the existence of caffeine-sensitive mechanism that controls...
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Analiza Niezawodności Człowieka w Ramach Funkcji związanych z Bezpieczeństwem w Przykładowej Instalacji
PublikacjaW analizie bezpieczeństwa funkcjonalnego systemów sterowania i zabezpieczeń należy określić wymagany poziom nienaruszalności bezpieczeństwa SIL w procesie analizy ryzyka, a następnie zweryfikować ten poziom stosując odpowiednie metody modelowania probabilistycznego. Działania człowieka mogą mieć istotny wpływ na realizację funkcji bezpieczeństwa. Wpływ ten ocenia się na podstawie wyników analizy niezawodności człowieka HRA. W niniejszym...
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Proces tworzenia zespołów zróżnicowanych jako element zarządzania zasobami ludzkimi
PublikacjaArtykuł dotyczy problematyki zarządzania zespołami zróżnicowanymi pod względem płci i wieku w kontekście procesów zarządzania zasobami ludzkimi. Skupiono się głównie na pierwszych etapach tego procesu, czyli na planowaniu zasobów i doborze pracowników i wskazano ich znaczenie dla zarządzania kapitałem ludzkim zespołów pracowniczych. Zaprezentowano wyniki badań przeprowadzonych na pracownikach działów HR, które dotyczyły uwzględniania...
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RAGE as a Novel Biomarker for Prostate Cancer: A Systematic Review and Meta-Analysis
PublikacjaThe receptor for advanced glycation end-products (RAGE) has been implicated in driving prostate cancer (PCa) growth, aggression, and metastasis through the fueling of chronic inflammation in the tumor microenvironment. This systematic review and meta-analysis summarizes and analyzes the current clinical and preclinical data to provide insight into the relationships among RAGE levels and PCa, cancer grade, and molecular effects....
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Blockchain technologies to address smart city and society challenges
PublikacjaNew Information and Communications Technologies (ICT) are changing the way in which the world works. These technologies provide new tools to face the issues of contemporary society (poverty, migrations, sustainable development challenges, governance, etc.). Among them, blockchain emerge as a disruptive technology able to make things in a completely different and innovative way. They can provide solutions where before there were...
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Impact of European vaccination policies on seasonal influenza vaccination coverage rates: An update seven years later
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Multiple group membership and collective actions of opinion-based internet groups: The case of protests against abortion law restriction in Poland
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Technical and Training Related Aspects of Resistance Training Using Blood Flow Restriction in Competitive Sport - A Review
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The Influence of Grip Width on Training Volume During the Bench Press with Different Movement Tempos
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Does Tempo of Resistance Exercise Impact Training Volume?
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Social Inclusion of People with Disabilities: National and International Perspectives by Arie Rimmerman
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Kinematics and Kinetics of Taekwon-do Side Kick
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Fatal intoxication with hydrocarbons in deltamethrin preparation
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The Reduced Folate Carrier (SLC19A1) c.80G>A Polymorphism is Associated with Red Cell Folate Concentrations Among Women
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Influence of selenium and/or magnesium on alleviation alcohol induced oxidative stress in rats, normalization function of liver and changes in serum lipid parameters
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Fulminant hepatic failure in woman with iron and non-steroidal anti-inflammatory drug intoxication
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Kinematic quantification of straight-punch techniques using the preferred and non-preferred fist in taekwon-do
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Seeking Optimal Nutrition for Healthy Body Mass Reduction Among Former Athletes
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Effect of resveratrol analogue, DMU-212, on antioxidant status and apoptosis-related genes in rat model of hepatocarcinogenesis
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The Effects of the Movement Tempo on the One-Repetition Maximum Bench Press Results
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Effects of Acute Caffeine Intake on Power Output and Movement Velocity During a Multiple-Set Bench Press Exercise Among Mild Caffeine Users
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The Effects of Plyometric Conditioning on Post-Activation Bench Press Performance
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The role of background color, interletter spacing, and font size on preferences in the digital presentation of a product
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Examining users’ preferences towards vertical graphical toolbars in simple search and point tasks
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Impact of Movement Tempo Distribution on Bar Velocity During a Multi-Set Bench Press Exercise
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A Comparison of Electromyographic Inter-Limb Asymmetry during a Standard versus a Sling Shot Assisted Bench Press Exercise
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