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Development of potential candidate reference materials for drugs in bottom sediment, cod and herring tissues
PublikacjaRegular use of a reference material and participation in a proficiency testing program can improve the reliability of analytical data. This paper presents the preparation of candidate reference materials for the drugs metoprolol, propranolol, carbamazepine, naproxen, and acenocoumarol in freshwater bottom sediment and cod and herring tissues. These reference materials are not available commercially. Drugs (between 7 ng/g and 32...
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Chemical Composition and Antimicrobial Activity of New Honey Varietals
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Searching for in vitro biomarkers of susceptibility to prostate and cervical cancers by analysis of chromosomal instability, γ-H2AX foci, polymorphisms in DNA repair genes and apoptosis
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Neurological Prognostic Factors in Hospitalized Patients with COVID-19
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The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part III: Polymorphisms of genes involved in Tregs’ activation and function
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The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part I: Treg properties and functions
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Coalition Shaping the Vaccination Landscape
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Functionalized Peptide Fibrils as a Scaffold for Active Substances in Wound Healing
PublikacjaTechnological developments in the field of biologically active peptide applications in medicine have increased the need for new methods for peptide delivery. The disadvantage of peptides as drugs is their low biological stability. Recently, great attention has been paid to self-assembling peptides that can form fibrils. Such a formulation makes bioactive peptides more resistant to enzymatic degradation and druggable. Peptide fibrils...
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Analysis of Reconstituted Tripartite Complex Supports Avidity-based Recruitment of Hsp70 by Substrate Bound J-domain Protein
PublikacjaHsp70 are ubiquitous, versatile molecular chaperones that cyclically interact with substrate protein(s). The initial step requires synergistic interaction of a substrate and a J-domain protein (JDP) cochaperone, via its J-domain, with Hsp70 to stimulate hydrolysis of its bound ATP. This hydrolysis drives conformational changes in Hsp70 that stabilize substrate binding. However, because of the transient nature of substrate and JDP...
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The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part II: The Treg role in skin diseases pathogenesis
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New Molecular Markers Involved in Regulation of Ovarian Granulosa Cell Morphogenesis, Development and Differentiation during Short-Term Primary In Vitro Culture—Transcriptomic and Histochemical Study Based on Ovaries and Individual Separated Follicles
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Adult pneumococcal vaccination – new opportunities
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Student Perspectives on the 2017 ESA Concurrent Engineering Challenge
PublikacjaIn September 2017, the first ESA Academy’s Concurrent Engineering Challenge (CEC) was held, giving 88 Master’s and PhD-level students from twelve ESA Member and Associate States a powerful platform to experience system engineering in an intense, fast paced, and real-world environment. Within four days, teams of physics and engineering students in Concurrent Design Facilities (CDF) located in Politecnico di Torino, Universidad Polit´ecnica...
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Trends in biomedical analysis of red blood cells – Raman spectroscopy against other spectroscopic, microscopic and classical techniques
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Comparison of Hemodynamic Response between Patients with Systolic Heart Failure Differing in Serum Aldosterone Concentrations during and after a 6-Minute Walk Test
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Effects of renal sympathetic denervation on blood pressure and glycaemic control in patients with true resistant hypertension: results of Polish Renal Denervation Registry (RDN-POL Registry)
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Биополитика согласно Чеславу Милошу
PublikacjaThe paper shows the origins of the transformation of history into biohistory as well as politics into biopolitics in the writings of Miłosz. It takes into account his view of history when he was a child and his social experiences when he was at school. It proves that the fact that Miłosz comprehends the world within the categories of biopolitics results from projecting Darwinism on the historical past, and then projecting on...
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A New Approach for Investigating the Impact of Pesticides and Nutrient Flux from Agricultural Holdings and Land-Use Structures on Baltic Sea Coastal Waters
PublikacjaKnowledge related to land-use management impacts on the Baltic Sea ecosystem is limited. The constant release of pollutants into water bodies has resulted in water quality degradation. Therefore, only the innovative approaches integrated with research will provide accurate solutions and methods for proper environment management and will enable understanding and prediction of the impacts of land-use in the Baltic Sea region. Modelling...
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Genes regulating biochemical pathways of oxygen metabolism in porcine oviductal epithelial cells during long-term IVC
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Integrated information and prediction Web Service WaterPUCK General concept
PublikacjaIn this paper, general concept of a new method as ‘Integrated information and prediction Web Service WaterPUCK’ for investigation influence of agricultural holdings and land-use structures on coastal waters of the southern Baltic Sea is presented. WaterPUCK Service is focused on determination of the current and future environmental status of the surface water and groundwater located in the Puck District (Poland) and its impact...
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Polish Polar Research: Green-and-White Paper under the aegis of the Polish Polar Consortium (PPC)
PublikacjaPolar research is a colloquial term for cross-area, cross-domain and interdisciplinary research in the Arctic and Antarctic. Polar research is mainly the domain of natural sciences, but technical sciences and humanities also grow in importance. Being vulnerable to climate change, polar regions are commonly considered as a kind of litmus paper of changes in geosystems, hence the importance of research done there. It aims at a better...
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Common variants of xeroderma pigmentosum genes and prostate cancer risk
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“Biological Adhesion” is a Significantly Regulated Molecular Process during Long-Term Primary In Vitro Culture of Oviductal Epithelial Cells (Oecs): A Transcriptomic and Proteomic Study
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New markers for regulation of transcription and macromolecule metabolic process in porcine oocytes during in vitro maturation
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Introduction of a multiplex amplicon sequencing assay to quantify DNA methylation in target cytosine markers underlying four selected epigenetic clocks
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Transcriptomic Pattern of Genes Regulating Protein Response and Status of Mitochondrial Activity Are Related to Oocyte Maturational Competence—A Transcriptomic Study
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Analysis of epigenetic clocks links yoga, sleep, education, reduced meat intake, coffee, and a SOCS2 gene variant to slower epigenetic aging
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New Gene Markers Expressed in Porcine Oviductal Epithelial Cells Cultured Primary In Vitro Are Involved in Ontological Groups Representing Physiological Processes of Porcine Oocytes
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The Unique Mechanisms of Cellular Proliferation, Migration and Apoptosis are Regulated through Oocyte Maturational Development—A Complete Transcriptomic and Histochemical Study
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Pediatric Inflammatory Multisystem Syndrome (PIMS) Did Occur in Poland during Months with Low COVID-19 Prevalence, Preliminary Results of a Nationwide Register
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Use of broad-spectrum antibiotics in children diagnosed with multisystem inflammatory syndrome temporarily associated with SARS-CoV-2 infection in Poland: the MOIS-CoR study
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Pathogenesis of psoriasis in the “omic” era. Part II. Genetic, genomic and epigenetic changes in psoriasis
PublikacjaPsoriasis is a multifactorial disease in which genetic, environmental and epigenetic factors regulating gene expression play a key role. In the “genomic era”, genome-wide association studies together with target genotyping platforms performed in different ethnic populations have found more than 50 genetic susceptible markers associated with the risk of psoriasis which have been identified so far. Up till now, the strongest association...
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Pathogenesis of psoriasis in the “omic” era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis
PublikacjaPsoriasis is a systemic disease that is strictly connected with metabolic disorders (insulin resistance, atherogenic dyslipidemia, arterial hypertension, and cardiovascular diseases). It occurs more often in patients with a more severe course of the disease. Obesity is specially an independent risk factor and it is associated with a worse treatment outcome because of the high inflammatory activity of visceral fatty tissue and...
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Pathogenesis of psoriasis in the “omic” era. Part I. Epidemiology, clinical manifestation, immunological and neuroendocrine disturbances
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Distinct characteristics of multisystem inflammatory syndrome in children in Poland
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Neurological symptoms in hospitalised patients with COVID-19 and their association with in-hospital mortality
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Going to extremes – a metagenomic journey into the dark matter of life
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A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants
PublikacjaThe World Health Organization Global Action Plan recommends integrated surveillance programs as crucial strategies for monitoring antibiotic resistance. Although several national surveillance programs are in place for clinical and veterinary settings, no such schemes exist for monitoring antibiotic-resistant bacteria in the environment. In this transnational study, we developed, validated, and tested a low-cost surveillance and...
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Gender Gap in Parental Leave Intentions: Evidence from 37 Countries
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The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis
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Global 30-day outcomes after bariatric surgery during the COVID-19 pandemic (GENEVA): an international cohort study
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Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study
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Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries
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Handling of the Covid-19 Pandemic and Its Effects on Bariatric Surgical Practice: Analysis of GENEVA Study Database
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Global wealth disparities drive adherence to COVID-safe pathways in head and neck cancer surgery
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18th European Symposium on Radiopharmacy and Radiopharmaceuticals
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Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study
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Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe
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Global variation in anastomosis and end colostomy formation following left‐sided colorectal resection
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Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
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