Search results for: DRUG

• Interactions of dissolved dsDNA with intercalating drug by anodic voltammetry and spectroscopy. Influence of pH

  Publication

  • A. Nowicka
  • E. Zabost
  • B. Klim
  • Z. Mazerska
  • Z. Stojek

  - ELECTROANALYSIS - Year 2009

  Oddziaływanie związku przeciwnowotworowego C-1305 z DNA było badane przy pomocy impulsowej voltametrii różnicowej oraz spektroskopii UV/Vis. Triazoloakrydon C-1305 oddziałuje z DNA na dwóch drogach: przez interkalacje pomiedzy pary zasad oraz przez wiązanie sie w małym rowku helisy. W fizjologicznym pH (7,4) stałe wiązania wynoszą: K1=3,36E+5 i K2=0,18E+5 [1/M] a wielkość miejsca wiązania: n1=2,5 i n2=4,0, odpowiednio dla pierwszego...

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• Batracylina (BAT) - potencjalny lek przeciwnowotworowy. Batracylin (BAT) - potential of anticancer drug

  Publication

  • K. Dzierzbicka
  • J. Kawula
  • A. Kołodziejczyk

  - Postępy Biochemii - Year 2002

  Opisano działanie potencjalnego leku przeciwnowotworowego - batracyliny(BAT). Batracylina została wyselekcjonowana przez National Cancer Institute (NCI, Bethesda, USA) w 1978 roku jako efekt programu poszukiwań nowych leków chemioterapii.Związek ten w badaniach in vivo u myszy okazał się bardzo aktywny przeciw nowotworowi okrężnicy 38 (colon 38), trudnemu do wyleczenia przez znane leki przeciwnowotworowe. Okazała się ona skuteczna...

• Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice

  Publication

  • P. Sosnowski
  • P. Sass
  • P. Słonimska
  • R. Płatek
  • J. Kamińska
  • J. Baczyński-Keller
  • P. Mucha
  • G. Peszyńska-Sularz
  • A. Czupryn
  • M. Pikuła... and 5 others

  - Pharmaceuticals - Year 2022

  The ear pinna is a complex tissue consisting of the dermis, cartilage, muscles, vessels, and nerves. Ear pinna healing is a model of regeneration in mammals. In some mammals, including rabbits, punch wounds in the ear pinna close spontaneously; in common-use laboratory mice, they remain for life. Agents inducing ear pinna healing are potential regenerative drugs. We tested the effects of selected bioactive agents on 2 mm ear pinna...

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• International Journal for Parasitology-Drugs and Drug Resistance

  Journals

  ISSN: 2211-3207

• Nanosize effect of clay mineral nanoparticles on the drug diffusion processes in polyurethane nanocomposite hydrogels

  Publication

  • M. Miotke
  • J. Strankowska
  • J. Kwela
  • M. Strankowski
  • Ł. Piszczyk
  • M. Józefowicz
  • M. Gazda

  - European Physical Journal Plus - Year 2017

  Studies of swelling and release of naproxen sodium (NAP) solution by polyurethane nanocomposite hydrogels containing Cloisite® 30B (organically modified montmorillonite (OMMT)) have been performed. Polyurethane nanocomposite hydrogels are hybrid, nontoxic biomaterials with unique swelling and release properties in comparison with unmodified hydrogels. These features enable to use nanocomposite hydrogels as a modern wound dressing....

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• Bovine Serum Albumin – Hydroxyapatite Nanoflowers as Potential Local Drug Delivery System of Ciprofloxacin

  Publication

  • K. Bobrowska
  • K. Sadowska
  • K. Stolarczyk
  • M. Prześniak-Welenc
  • P. Golec
  • R. Bilewicz

  - International Journal of Nanomedicine - Year 2023

  Introduction: Hybrid nanoflowers are structures consisting of organic (enzymes, proteins, nucleic acids) and inorganic components (mostly metal phosphates) with a flower-like hierarchical structure. Novel hybrid nanoflowers based on bovine serum albumin (BSA) and hydroxyapatite (HA) were obtained and characterized. Study on BSA-HA nanoflowers as potential drug delivery system is reported for the first time. Methods: Embedding ciprofloxacin...

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• Elastic-contractile model proteins: Physical chemistry, protein function and drug design and delivery

  Publication

  • D. Urry
  • K. Urry
  • W. Szaflarski
  • M. Nowicki

  - ADVANCED DRUG DELIVERY REVIEWS - Year 2010

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• Drug-Eluting Biopsy Needle as a Novel Strategy for Antimicrobial Prophylaxis in Transrectal Prostate Biopsy

  Publication

  • M. Sieczkowski
  • A. Gibas
  • A. Wasik
  • A. Kot-Wasik
  • L. Piechowicz
  • J. Namieśnik
  • M. Matuszewski

  - TECHNOLOGY IN CANCER RESEARCH & TREATMENT - Year 2017

  OBJECTIVES: To preclinically evaluate drug-eluting biopsy needles (patent pending WO2016118026) as a new potential way of antimicrobial prophylaxis for transrectal prostate biopsy. METHODS: Twenty steel biopsy needles have been coated with polyvinyl alcohol, ciprofloxacin, and amikacin. Modified biopsy needles have been randomly divided into 3 groups (1:2:1 ratio). Needles from group I were immersed for 30 minutes in dedicated...

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• ENCAPSULATION OF ROXITHROMYCIN INTO GELLAN GUM MATRICES AND THE IMPACT OF OTHER NATURAL POLYMERS ON DRUG RELEASE

  Publication

  • P. Gadziński
  • A. Froelich
  • U. Kowalska
  • M. Soból
  • M. Szybowicz
  • T. Osmałek

  - Acta Poloniae Pharmaceutica - Drug Research - Year 2020

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• Drug transporter expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line

  Publication

  • R. Januchowski
  • P. Zawierucha
  • M. Ruciński
  • M. Andrzejewska
  • K. Wojtowicz
  • M. Nowicki
  • M. Zabel

  - BIOMEDICINE & PHARMACOTHERAPY - Year 2014

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• Microneedle‐Based Generation of Microbubbles in Cancer Tumors to Improve Ultrasound‐Assisted Drug Delivery

  Publication

  • A. Zandi
  • M. Khayamian
  • M. Saghafi
  • S. Shalileh
  • P. Katebi
  • S. Assadi
  • A. Gilani
  • M. Salemizadeh
  • S. Vanaei
  • M. Esmailinejad... and 4 others

  - Advanced Healthcare Materials - Year 2019

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• Silver Nanoparticles as Chlorhexidine and Metronidazole Drug Delivery Platforms: Their Potential Use in Treating Periodontitis

  Publication

  • K. Steckiewicz
  • P. Cieciórski
  • E. Barcińska
  • M. Jaśkiewicz
  • M. Narajczyk
  • M. Bauer
  • W. Kamysz
  • E. Megiel
  • I. Inkielewicz-Stepniak

  - International Journal of Nanomedicine - Year 2022

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• The modulatory effect of green tea catechin on drug resistance in human ovarian cancer cells

  Publication

  • D. Przystupski
  • O. Michel
  • J. Rossowska
  • S. Kwiatkowski
  • J. Saczko
  • J. Kulbacka

  - MEDICINAL CHEMISTRY RESEARCH - Year 2019

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• Acinetobacter baumannii isolated from hospital‐acquired infection: biofilm production and drug susceptibility

  Publication

  • P. Krzyściak
  • A. Chmielarczyk
  • M. Pobiega
  • D. Romaniszyn
  • J. Wójkowska‐Mach

  - APMIS - Year 2017

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• Fulminant hepatic failure in woman with iron and non-steroidal anti-inflammatory drug intoxication

  Publication

  • J. Magdalan
  • M. Zawadzki
  • T. Sozański

  - HUMAN & EXPERIMENTAL TOXICOLOGY - Year 2011

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• Bioactive silica-based drug delivery systems containing doxorubicin hydrochloride: In vitro studies

  Publication

  • M. Prokopowicz
  • J. Żegliński
  • A. Gandhi
  • W. Sawicki
  • S. Tofail

  - COLLOIDS AND SURFACES B-BIOINTERFACES - Year 2012

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• Use of Materials Based on Polymeric Silica as Bone-Targeted Drug Delivery Systems for Metronidazole

  Publication

  • K. Czarnobaj
  • M. Prokopowicz
  • K. Greber

  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Year 2019

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• Cisplatin filled multiwalled carbon nanotubes – a novel molecular hybrid of anticancer drug container

  Publication

  • C. Tripisciano
  • S. Costa
  • R. Kalenczuk
  • E. Borowiak-Palen
  • E. Mijowska

  - EUROPEAN PHYSICAL JOURNAL B - Year 2010

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• New Life of an Old Drug: Caffeine as a Modulator of Antibacterial Activity of Commonly Used Antibiotics

  Publication

  • A. Woziwodzka
  • M. Krychowiak-Maśnicka
  • G. Gołuński
  • A. Łosiewska
  • A. Borowik
  • D. Wyrzykowski
  • J. Piosik

  - Pharmaceuticals - Year 2022

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• The Current Use of Mass Spectrometry in Combination with Other Separation Techniques in Drug Discovery Arena

  Publication

  • P. Kawczak
  • T. Baczek

  - Medicinal Chemistry - Year 2016

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• Activity of Phage–Lactoferrin Mixture against Multi Drug Resistant Staphylococcus aureus Biofilms

  Publication

  • K. Kosznik-Kwaśnicka
  • N. Kaźmierczak
  • L. Piechowicz

  - Antibiotics-Basel - Year 2022

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• Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method

  Publication

  • K. AbouAitah
  • M. Bil
  • E. Pietrzykowska
  • U. Szałaj
  • D. Fudala
  • B. Woźniak
  • J. Nasiłowska
  • A. Swiderska-Sroda
  • M. Lojkowski
  • B. Sokołowska... and 3 others

  - Nanomaterials - Year 2021

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• Glucosamine-6-phosphate synthase,a novel target for antifungalagents.Molecular modelling studies in drug design

  Publication

  • M. Wojciechowski
  • S. Milewski
  • J. Mazerski
  • E. Borowski

  - Year 2005

  Praca dotyczy modelowania zarówno samych inhibitorów syntazy glukozamino-6-fosforanu jak i ich oddziaływania z obydwiema domenami tego enzymu. Enzym syntaza glukozamino-6-fosforanu został zaproponowany jako nowy cel molekularny w chemoterapii infekcji grzybowych. Zaprojektowano i zsyntezowano szereg inhibitorów tego enzymu - potencjalnych nowych leków przeciwgrzybowych. Dzięki modelowaniu molekularnemu udało się wyjaśnić mechanizm...

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• Homoisocitrate dehydrogenase from Candida albicans: properties, inhibition, and targeting by an antifungal pro-drug

  Publication

  • I. Gabriel
  • N. D. Vetter
  • D. R. J. Palmer
  • M. J. Milewska
  • M. Wojciechowski
  • S. Milewski

  - FEMS YEAST RESEARCH - Year 2013

  The LYS12 gene from Candida albicans, coding for homoisocitrate dehydrogenase was cloned and expressed as a His-tagged protein in Escherichia coli. The purified gene product catalyzes the Mg2+- and K+-dependent oxidative decarboxylation of homoisocitrate to alpha-ketoadipate. The recombinant enzyme demonstrates strict specificity for homoisocitrate. SDS-PAGE of CaHIcDH revealed its molecular mass of 42.6±1 kDa, while in size-exclusion...

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• DRUG AND CHEMICAL TOXICOLOGY

  Journals

  ISSN: 0148-0545 , eISSN: 1525-6014

• DRUG METABOLISM AND DISPOSITION

  Journals

  ISSN: 0090-9556 , eISSN: 1521-009X

• DRUG DEVELOPMENT RESEARCH

  Journals

  ISSN: 0272-4391 , eISSN: 1098-2299

• DRUG METABOLISM REVIEWS

  Journals

  ISSN: 0360-2532 , eISSN: 1097-9883

• ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

  Journals

  ISSN: 1540-658X , eISSN: 1557-8127

• ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH

  Journals

  ISSN: 0004-4172

• Expert Opinion On Drug Safety

  Journals

  ISSN: 1474-0338 , eISSN: 1744-764X

• American Health and Drug Benefits

  Journals

  ISSN: 1942-2962 , eISSN: 1942-2970

• Drug Delivery and Translational Research

  Journals

  ISSN: 2190-393X , eISSN: 2190-3948

• Expert Opinion on Drug Delivery

  Journals

  ISSN: 1742-5247 , eISSN: 1744-7593

• Journal of Drug Metabolism & Toxicology

  Journals

  ISSN: 2157-7609

• International Journal of Drug Discovery

  Journals

  ISSN: 0975-4423

• Expert Opinion on Drug Discovery

  Journals

  ISSN: 1746-0441 , eISSN: 1746-045X

• FOOD AND DRUG LAW JOURNAL

  Journals

  ISSN: 1064-590X

• Drug Healthcare and Patient Safety

  Journals

  ISSN: 1179-1365

• Clinical Pharmacology in Drug Development

  Journals

  ISSN: 2160-7648

• INTERNATIONAL JOURNAL OF DRUG POLICY

  Journals

  ISSN: 0955-3959 , eISSN: 1873-4758

• Journal of Drug Policy Analysis

  Journals

  ISSN: 1941-2851

• Current drug abuse reviews

  Journals

  ISSN: 1874-4737

• Infectious Disorders - Drug Targets

  Journals

  ISSN: 1871-5265

• Journal of Nanopharmaceutics and Drug Delivery

  Journals

  ISSN: 2167-9312

• Drug Discovery Today: Technologies

  Journals

  ISSN: 1740-6749

• Therapeutic Advances in Drug Safety

  Journals

  ISSN: 2042-0986 , eISSN: 2042-0994

• Adverse Drug Reaction Bulletin

  Journals

  ISSN: 0044-6394

• Current Drug Discovery Technologies

  Journals

  ISSN: 1570-1638

• Drug Safety - Case Reports

  Journals

  ISSN: 2199-1162