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Search results for: drug%20discovery
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Electrochemical and biological characterization of lyotropic liquid crystalline phases – retardation of drug release from hexagonal mesophases
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Strain improvement and immobilization technique for enhanced production of the anticancer drug paclitaxel by Aspergillus fumigatus and Alternaria tenuissima
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Molecular characterization of drug-resistant Mycobacterium tuberculosis strains from Poland by use of multiple genetic markers
PublicationW pracy przedstawiono wyniki genotypowania wielolekoopornych szczepów Mycobacterium tuberculosis, izolowanych od pacjentów z Polski.
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Poor sensitization of 50-kHz vocalization response to amphetamine predicts rat susceptibility to self-administration of the drug
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Targeted Nano-Drug Delivery of Colchicine against Colon Cancer Cells by Means of Mesoporous Silica Nanoparticles
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<p>Nanoparticles And Human Saliva: A Step Towards Drug Delivery Systems For Dental And Craniofacial Biomaterials</p>
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Analysis of MDR genes expression and cross-resistance in eight drug resistant ovarian cancer cell lines
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Thromboelastometric Analysis of Anticancer Cerrena unicolor Subfractions Reveal Their Potential as Fibrin Glue Drug Carrier Enhancers
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Controlled Drug Release and Cytotoxicity Studies of Beta-Lapachone and Doxorubicin Loaded into Cyclodextrins Attached to a Polyethyleneimine Matrix
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The Influence of the Co-Dopant Dexamethasone Phosphate on the Electrodeposition Process and Drug-Release Properties of Polypyrrole-Salicylate on Iron
PublicationIn this work, the influence of incorporation of two anti-inflammatory drugs dexamethasone phosphate and sodium salicylate on the electrodeposition process of polypyrrole (PPy) film on iron has been studied. The incorporation of the agents into PPy has been carried out in a one-step electropolymerization process on oxidizable iron. The role of each drug agent during the deposition process has been discussed. The morphological and...
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Electrochemical simulation of metabolism for antitumor-active imidazoacridinone C-1311 and in silico prediction of drug metabolic reactions
PublicationThe metabolism of antitumor-active 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) has been investigated widely over the last decade but some aspects of molecular mechanisms of its metabolic transformation are still not explained. In the current work, we have reported a direct and rapid analytical tool for better prediction of C-1311 metabolism which is based on electrochemistry (EC) coupled on-line with electrospray...
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Accidents, victims and risk levels on regional roads in pomorskie voivodeship, 2017-2019 - Alcohol and drug accidents
Open Research DataData contain risk classification on regional roads (voivodeship roads) in pomorskie voivodeship in 2017-2019, risk group: Offenders under influence of alcohol or drug - driver or pedestrian. Measures used to assess the level of risk are (5 classes low, low to medium, medium, medium to high, high):
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DATA MINING AND KNOWLEDGE DISCOVERY
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Journal of Biomedical Discovery and Collaboration
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Data Analysis and Knowledge Discovery
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Enzymatic Polymerization of Cyclic Monomers in Ionic Liquids as a Prospective Synthesis Method for Polyesters Used in Drug Delivery Systems
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Impact of orthostatic hypotension and antihypertensive drug treatment on total and cardiovascular mortality in a very elderly community-dwelling population
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High mortality explained by mildly elevated blood pressure in Scandinavian adolescent conscripts – A plea for early drug treatment?
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The antitumor derivative, C-1748, affects CYP3A4: crosstalk between drug metabolism, CYP3A4 expression and enzymatic activity
PublicationJedną z głównych przeszkód w przewidywaniu wyników terapii u pacjentów z nowotworem jest indywidualny przebieg metabolizmu stosowanych leków wynikający z polimorfizmu genów enzymów metabolizujących, jak również duża zmienność farmakokinetyki leków obserwowana u różnych pacjentów podczas trwania chemioterapii. Z powodu tzw. ''wąskiego okna terapeutycznego'' występującego w przypadku terapii lekami przeciwnowotworowymi, małe zmiany...
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Semi-continuous production of the anticancer drug taxol by Aspergillus fumigatus and Alternaria tenuissima immobilized in calcium alginate beads
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Electroporation and lipid nanoparticles with cyanine IR-780 and flavonoids as efficient vectors to enhanced drug delivery in colon cancer
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New diamidequat-type surfactants in fabrication of long-sustained theranostic nanocapsules: Colloidal stability, drug delivery and bioimaging
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Inhibition of ALDH1A1 activity decreases expression of drug transporters and reduces chemotherapy resistance in ovarian cancer cell lines
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Microarray-based detection and expression analysis of new genes associated with drug resistance in ovarian cancer cell lines
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Novel 2019 coronavirus structure, mechanism of action, antiviral drug promises and rule out against its treatment
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DNA structure and integrity checkpoints in the cell cycle and their role in drug targeting and resistance of tumor cells to anticancer treatment
PublicationW artykule dokonaliśmy przeglądu literatury dotyczącej różnych typów uszkodzeń DNA indukowanych przez różne czynniki terapeutyczne w komórkach nowotworowych. Omówiliśmy także w jaki sposób aktywują różne typy punktów kontrolnych w cyklu komórkowym i w jaki sposób punkty te są regulowane przez inne szlaki sygnalizacji wewnątrzkomórkowej takie jak szlaki naprawy uszkodzeń DNA, stresu komórkowego i śmierci-przeżycia. W szczególności...
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Longitudinal drug synergy assessment using convolutional neural network image-decoding of glioblastoma single-spheroid cultures
PublicationAbstract Background In recent years, drug combinations have become increasingly popular to improve therapeutic outcomes in various diseases, including difficult to cure cancers such as the brain cancer glioblastoma. Assessing the interaction between drugs over time is critical for predicting drug combination effectiveness and minimizing the risk of therapy resistance. However, as viability readouts of drug combination experiments...
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The Interaction of Heptakis (2,6-di-O-Methyl)-β-Cyclodextrin with Mianserin Hydrochloride and Its Influence on the Drug Toxicity
PublicationOne tetracyclic antidepressant, mianserin hydrochloride (MIA), has quite significant side effects on a patients’ health. Cyclodextrins, which are most commonly used to reduce the undesirable features of contained drugs within their hydrophobic interior, also have the potential to alter the toxic behavior of the drug. The present paper contains investigations and the characteristics of interaction mechanisms for MIA and the heptakis...
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Degradation of cefadroxil drug by newly designed solar light responsive alcoholic template-based lanthanum ferrite nanoparticles
PublicationIn this work, lanthanum ferrite nanoparticles were synthesized via a simple co-precipitation method. Two different templates, namely sorbitol and mannitol, were used in this synthesis to tune the optical, structural, morphological, and photocatalytic properties of lanthanum ferrite. The synthesized lanthanum ferrite-sorbitol (LFOCo-So) and lanthanum ferrite-mannitol (LFOCo-Mo) were investigated through Ultraviolet–Visible (UV–Vis),...
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Wykorzystanie Śródlądowych Dróg Wodnych dla Rozwoju Regionalnego
PublicationMateriał przedstawia działania podjęte przez uczestników projektu InWater - ''Wykorzystanie Śródlądowych Dróg Wodnych dla Rozwoju Regionalnego'' w celu wskazania nowych możliwości rozwoju regionu związanych z drogami wodnymi, przygotowania planów inwestycyjnych terenów przyległych do szlaków wodnych oraz międzynarodowej promocji szlaków wodnych.
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Machine learning applied to bi-heterocyclic drugs recognition
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Dwa projekty dróg wodnych w II Rzeczypospolitej.
PublicationOmówiono dwa projekty kanałów zaprojektowanych w Polsce w latach międzywojennych.
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Ocena ryzyka na sieci dróg w Europie.
PublicationProgram oceny ryzyka na drogach w Europie. Metody oceny ryzyka. Ocena ryzyka na drogach krajowych w Polsce.
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Ultimate biodegradability and ecotoxicity of orally administered antidiabetic drugs
PublicationHypoglycaemic pharmaceuticals are recently more and more frequently detected in the environment. In our previous study, we have shown that even though many of them undergo significant primary degradation some are transformed to stable products or undergo such transformation that a large part of the structure is still preserved. One of the main routes of elimination from wastewaters or surface waters is biodegradation and a lack...
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Metody identyfikacji miejsc niebezpiecznych na sieci dróg
PublicationW artykule przedstawiono metodę identyfikacji miejsc niebezpiecznych na sieci dróg bazującej na ryzyku, jako elemencie systemu zarządzania bezpieczeństwem infrastruktury drogowej na przykładzie sieci dróg krajowych. Przedstawiono doświadczenia zagraniczne identyfikacji miejsc niebezpiecznych i uwarunkowania prawne w Polsce wdrażające konieczność identyfikacji miejsc niebezpiecznych na sieci TEN-T. W ostatniej części zaprezentowano...
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Glucosinolates from lepidium peruvianum as potential antiamnestic drugs
PublicationLepidium peruvianum (maca) (Brassicaceae) is a naturally occurring plant mainly in the high Andes of Peru. In recent years, it has been intensively researched in terms of its influence on various diseases and towards health improvement. Alzheimer’s disease is an incurable disease that most often affects adults over the age of 60. As since 2003 the US Food and Drug Administration (FDA) did not approve any new drug for Alzheimer’s...
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Adaptacyjny system oświetlania dróg oraz inteligentnych miast
PublicationPrzedmiotem rozprawy jest zbadanie praktycznej możliwości wykrywania w czasie rzeczywistym anomalii w systemie oświetlenia drogowego w oparciu o analizę danych ze inteligentnych liczników energii. Zastosowanie inteligentnych liczników energii elektrycznej (Smart Meter) w systemach oświetlenia drogowego stwarza nowe możliwości w zakresie automatycznej diagnostyki takich niepożądanych zjawisk jak awarie lamp, odstępstwa od harmonogramu...
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CURRENT CANCER DRUG TARGETS
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Current Computer-Aided Drug Design
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CNS & Neurological Disorders-Drug Targets
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Acta Poloniae Pharmaceutica - Drug Research
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EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
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ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT
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Expert Opinion on Drug Metabolism & Toxicology
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International Journal of Alcohol and Drug Research
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Journal of Global Drug Policy and Practice
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African Journal of Drug and Alcohol Studies
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Indian Journal of Novel Drug Delivery
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Recent Patents on Drug Delivery and Formulation
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Cardiovascular and Hematological Disorders - Drug Targets
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