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Search results for: RATIONAL DRUG DESIGN
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International Journal of Design
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Journal of Interior Design
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Bio-Design and Manufacturing
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Advances in Computational Design
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Environment Design Guide
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IEEE Design & Test
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Journal of Learning Design
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Archives of Design Research
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Technology Architecture and Design
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RESEARCH IN ENGINEERING DESIGN
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New Design Ideas
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Policy Design and Practice
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Journal of Organization Design
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Theatre and Performance Design
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Review of Economic Design
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JOURNAL OF ENGINEERING DESIGN
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NUCLEAR ENGINEERING AND DESIGN
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Design of novel microstrip directional coupler for differential signal decoupling
PublicationThis study describes a concept of a novel microstrip directional coupler for differential signal decoupling, which can be used to digital signal overhearing on printed-circuit-boards. The complete design method is proposed with rules given analytically. Considered methodology is suitable for synthesis of couplers with low coupling factors, which have negligible influence on the transmission in main line. Theoretical considerations...
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Hybrid Expert System for Computer-Aided Design of Ship Thruster Subsystems
PublicationThe article presents an expert system supporting the design of ship's power subsystems, in particular the thruster subsystem. The proposed hybrid expert system uses the results of simulation tests as the additional source of knowledge. The results of system operation are collated in a report which can be used as part of ship design description. The work oriented on developing the expert system is the continuation of the research...
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Design of M2M Communications Interfaces in Transport Systems
PublicationIn the paper the principle of M2M communications in transport systems is presented. The concept of M2M system architecture is considered. Characteristics of M2M communications for example data transmission, monitoring and other services for transport applications are presented. The problem of communications interfaces design for M2M applications is analysed. Next, the proposal of M2M communication interface for transport applications...
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COMPUTER-AIDED DESIGN OF ORGANOPHOSPHORUS INHIBITORS OF UREASE
PublicationBased on the structure of the most potential inhibitor diamidophosphate, various novel groups of inhibitors were developed by knowledge-based design approach with covalent carbon-phosphorus or carbon-phosphorus-carbon bond to improve hydrolytic stability to inhibit the microbial ureases. Designed compounds were evaluated with 10 (LigScore1, LigScore2, PLP1, PLP2, JAIN, PMF, PMF04, LUDI_1, LUDI_2 and LUDI_3) different scoring functions...
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Resistance of human prostate carcinoma cells to a new antitumor compound capridine beta is associated with changed drug metabolism combined with both inherent and drug-induced overexpression of ABC transporters
PublicationW pracy charakteryzujemy mechanizm oporności na nową pochodną 1-nitroakrydyny, związku capridine beta (C-1748) o wysokiej aktywności przeciwnowotworowej, znajdującego się w badaniach klinicznych. Nasze dane wskazują, że oporność na ten związek jest wynikiem zmienionego metabolizmu inaktywującego C-1748 oraz wzrostem ekspresji pompy błonowej ABCG2 a także innych białek transportowych typu ABC.
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Interior Design, Erasmus
e-Learning CoursesCelem kursu jest przybliżenie zagadnień związanych z projektowaniem wnętrz.Studenci pracować będą na własnych projektach domów jednorodzinnych, opracowanych w poprzednim semestrze.Zajęcia odbywają się w trybie konsultacji i krótkich wykładów.prowadzący: Kacper Ludwiczak / kacper.ludwiczak@pg.edu.pl
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Machine Design PG_00059691
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Rural Design Lectures
e-Learning CoursesThe lectures are aiming to provide the students with the general understanding of the vernacular architecture, landscape, future, resilience and history.
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Systems Software Design
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System Software Design
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CONCRETE MIX DESIGN USING SIMPLE EQUATIONS
PublicationThe behaviour of concrete, whether fresh or har dened, depends basically on the beha viour of its components and the r elationship between them, ther efore, obtaining a concr ete with cer tain pr operties depends fundamentally on the concr ete mix design. Concr ete mix design gener ally includes two main steps: 1-Selection of the main components suitable for the concr...
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Report of Eurocode 7 application for pile foundation design in Poland
PublicationThe EC7 rules of geotechnical design are in use in Poland for several years, even though there is no National annex. With regard to pile foundations, there are valid EC7 recommendations concerning design approaches, load partial coefficients, correlation coefficients and capacity partial coefficients. Polish designers can be quite flexible when it comes to choose a method for static, bearing capacity and settlement calculations....
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What defines excellent lighting design for humans and animals?
PublicationWhat defines excellent lighting design for humans and animals? The answer to the above question is more than complex. It is not enough nowadays to design a project to make it aesthetically pleasing. Nor is it sufficient to create nicely lit environments, or simply to achieve the light levels required by the lighting norms or standards. With the new scientific research of the last few decades that relates directly or indirectly...
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Progress in module design for membrane distillation
PublicationThere have been tremendous advances in membrane distillation (MD) since the concept was introduced in 1961: new membrane designs and process configurations have emerged, and its commercial viability has been evaluated in several pilot-scale studies. However, its high energy consumption has hindered its commercialization. One of the most promising ways to overcome this obstacle is to develop more energy-efficient membrane modules....
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Relationship between album cover design and music genres.
PublicationThe aim of the study is to find out whether there exists a relationship between typographic, compositional and coloristic elements of the music album cover design and music contained in the album. The research study involves basic statistical analysis of the manually extracted data coming from the worldwide album covers. The samples represent 34 different music genres, coming from nine countries from around the world. There are...
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Design of septic tanks placed on cohesive soils
PublicationThe paper presents a short review of literature with regard to design and erection of the reinforced concrete and concrete tanks. The authors investigated the underground septic tank with of 10 m3 capacity placed on cohesive soils. The authors compared the values of internal forces for soils in drained and undrained conditions with different geotechnical parameters: loamy sand of liquidity index IL = 0.1 and IL = 0.7 and clay with...
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Use of the AHP Method for Preference Determination in Yacht Design
PublicationA sailing yacht is a human-centred product, the design of which revolves primarily around the wants and desires of the future owner. In most cases, these preferences are not measurable, such as a personal aesthetic feeling, or a need for comfort, speed, safety etc. The aims of this paper are to demonstrate that these preferences can be classified and represented numerically, and to show that they are correlated with the type...
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Use of the AHP Method for Preference Determination in Yacht Design
PublicationA sailing yacht is a human-centred product, the design of which revolves primarily around the wants and desires of the future owner. In most cases, these preferences are not measurable, such as a personal aesthetic feeling, or a need for comfort, speed, safety etc. The aims of this paper are to demonstrate that these preferences can be classified and represented numerically, and to show that they are correlated with the type of...
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Degradation of cefadroxil drug by newly designed solar light responsive alcoholic template-based lanthanum ferrite nanoparticles
PublicationIn this work, lanthanum ferrite nanoparticles were synthesized via a simple co-precipitation method. Two different templates, namely sorbitol and mannitol, were used in this synthesis to tune the optical, structural, morphological, and photocatalytic properties of lanthanum ferrite. The synthesized lanthanum ferrite-sorbitol (LFOCo-So) and lanthanum ferrite-mannitol (LFOCo-Mo) were investigated through Ultraviolet–Visible (UV–Vis),...
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Towards Experience-Based Smart Product Design for Industry 4.0
PublicationThis paper presents the concept of smart virtual product development (SVPD) system capable of supporting industrial product development process. It enhances the decision making process during different stages and activities involved in product development i.e. product design, manufacturing, and its inspection planning. The enhancement is achieved by using the explicit knowledge of formal past decision events, which are captured,...
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On geometry parameterization for simulation-driven design closure of antenna structures
PublicationFull-wave electromagnetic (EM) simulation tools have become ubiquitous in antenna design, especially final tuning of geometry parameters. From the reliability standpoint, the recommended realization of EM-driven design is through rigorous numerical optimization. It is a challenging endeavor with the major issues related to the high computational cost of the process, but also the necessity of handling several objectives and constraints...
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Design of horizontal axis wind and water turbines
PublicationThe basic hydrodynamic principles of horizontal axis turbines are presented. Computational methods based on vortex theory for design of such turbines and for calculation of their hydro or aerodynamic characteristics are described in detail. These methods are applicable both to wind and water turbines. The influence of detailed turbine geometry on its characteristics is presented. Several practical computational examples of different...
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Extending transition curve in analytical design method
PublicationThe paper presents the problem of extending the transitional curves, using for this purpose an analytical design method. The basis for the analysis of numerical calculations were carried out for a wide set of parameters characterizing the standard geometric system. We considered an importance of the size of radius of the circular arc and return angle of route on the obtained results after the formulation of appropriate theoretical...
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The value of less Light – Sustainable architectural lighting design
PublicationSince its beginning, the art of external illumination has substantially influ-enced the creation and the perception of architecture and the night-time urban environment. In her lecture, the author examines and defines the significant interdisciplinary conditions related to architectural lighting design that have evolved over the years, starting from the first simple exterior lighting projects to the more modern, complex concepts...
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A structure and simulation-driven design of compact CPW-fed UWB antenna
PublicationIn this letter, a structure of a miniaturized ultra-wideband CPW-fed antenna and its design proce-dure are presented. The antenna is a modified version of the design previously proposed in the literature, with additional degrees of freedom introduced in order to improve the structure flexibility. The small size is achieved by executing a rigorous optimization procedure that consists of two stages: (i) smart random search carried...
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Fast Design Optimization of Waveguide Filters Applying Shape Deformation Techniques
PublicationThis paper presents an efficient design of microwave filters by means of geometry optimization using shape deformation techniques. This design procedure allows for modelling complex 3D geometries which can be fabricated by additive manufacturing (AM). Shape deforming operations are based on radial basis function (RBF) interpolation and are integrated into an electromagnetic field simulator based on the 3D finiteelement method (FEM)....
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Centralized and Distributed Structures of Intelligent Systems for Aided Design of Ship Automation
PublicationA design process and accepted solutions made during this process, often base on non-formalized knowledge, obtained from designer (expert) intuition and practice. There are no formalized rules assuring the correctness of design solutions. The analysis of design process of ship automation, including ship power system, shows that this process can be supported by application of the artificial intelligence elements. The article presents...
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Novel structure and design of compact UWB slot antenna
PublicationIn this paper, a novel structure of a compact UWB slot antenna is presented along with a simulation-driven design optimization algorithm for adjusting geometry parameters of the device. Our primary objective is to obtain small footprint of the structure while maintaining its acceptable electrical performance. It is achieved by introducing sufficiently large number of geometry degrees of freedom, including increased number of parameterized...
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FIR Filter Design Using Distributed Maximal Flatness Method
PublicationIn the paper a novel method for filter design based on the distributed maximal flatness method is presented. The proposed approach is based on the method used to design the most common FIR fractional delay filter - the maximally flat filter. The MF filter demonstrates excellent performance but only in a relatively narrow frequency range around zero frequency but its magnitude response is no greater than one. This ,,passiveness”...
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Accurate simulation-driven modeling and design optimization of compact microwave structures
PublicationCost efficient design optimization of microwave structures requires availability of fast yet reliable replacement models so that multiple evaluations of the structure at hand can be executed in reasonable timeframe. Direct utilization of full-wave electromagnetic (EM) simulations is often prohibitive. On the other hand, accurate data-driven modeling normally requires a very large number of training points and it is virtually infeasible...
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Design of radio communication systems for unmanned transport applications
PublicationIn the paper the principle of OFDMA-based radio communication systems design for unmanned transport applications is presented. The concept of system radio interface is analysed and its basic parameters proposal are considered. In the last part of the paper some air interface characteristics useful for optimization of throughput and system capacity are considered.