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Search results for: ENTREPRENEURS MOTIVATION
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Layer of protection analysis in industrial hazardous installations =n Analiza warstw zabezpieczeń w przemysłowych instalacjach podwyższonego ryzyka
PublicationIn the paper The Layer of Protection Analysis (LOPA) as a technique for the risk evaluation relating to the hazardous industriall installations performance is presented. The results of the analyses are important in the terms of the safety management process in such installations. Based on obtained estimations deccisions might be made which solutions to be applied in order to mitigate the risk of the hazardous installations performance...
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Electrochemistry meets enzymes: Investigation of the biotransformation pathway of C-1311 based on electrochemical simulation in comparison to in vitro methods.
PublicationThe knowledge of the metabolic pathways and the biotransformation of new drugs is one of the major challenges in pharmaceutical research. It is crucial for elucidation of degradation routes of the new biologically active compounds, especially in the area of possible toxicity. Conventional in vitro drug metabolism studies are based on incubating drug candidate with e.g. hepatocytes or, most importantly, liver cell microsomes and...
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Denitrification Process Enhancement and Diversity of the Denitrifying Community in the Full Scale Activated Sludge System after Adaptation to Fusel Oil
PublicationImplementation of anaerobic digestion of primary sludge in modern wastewater treatment plants (WWTPs) limits the availability of organic carbon for denitrification in conventional nitrification-denitrification (N/DN) systems. In order to ensure efficient denitrification, dosage of the external carbon source is commonly undertaken. However, application of commercial products, such us ethanol or acetate, greatly increases operational...
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Биополитика согласно Чеславу Милошу
PublicationThe paper shows the origins of the transformation of history into biohistory as well as politics into biopolitics in the writings of Miłosz. It takes into account his view of history when he was a child and his social experiences when he was at school. It proves that the fact that Miłosz comprehends the world within the categories of biopolitics results from projecting Darwinism on the historical past, and then projecting on...
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Zrównoważony rozwój lokalny. Podstawy teoretyczne i działania praktyczne
PublicationRozwój zrównoważony to jedna z koncepcji rozwoju lokalnego. Celem monografii jest prezentacja podstaw tego rozwoju na poziomie lokalnym oraz ukazanie jego przejawów i działań praktycznych w sferach gospodarczej, społecznej i ekologicznej, ze szczególnym uwzględnieniem dwóch wewnętrznych czynników rozwojowych – turystyki i oświaty. W pierwszym rozdziale przedstawiono teoretyczne podstawy rozwoju lokalnego. Omówiono najpowszechniej...
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Antitumor DNA-Damaging C-1748 is a New Inhibitor of Autophagy that Triggers Apoptosis in Human Pancreatic Cancer Cell Lines
PublicationDespite the enormous progress that has been made over the past decades in diagnosis, treatment and prevention of many types of tumors, survival rates in pancreatic cancer still remain poor. Pancreatic cancer is one of the most malignant and chemoresistant tumors and the profound mechanism supporting these phenomena is the constitutively activated prosurvival autophagy. The antitumor 1-nitroacridine derivative C-1748 belongs to...
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Elemental composition, environment of deposition of the Lower Carboniferous Emma Fiord Formation oil shale in Arctic Canada
PublicationThe sedimentary succession of 51-m consisting of a thin coal seam (1 m) and oil shale with a marlstone and carbonate-mudstone matrix of the Lower Carboniferous (Viséan) Emma Fiord Formation located on the Grinnell Peninsula, Devon Island, Arctic Canada was examined. The techniques used include reflected light microscopy, and instrumental neutron activation analysis (INAA) for elemental concentration, and inductively coupled plasma...
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DNA-reactive anticancer imidazoacridinone C-1311 is a new inhibitor of hypoxia-inducible factor 1 alpha, vascular endothelial growth factor and tumor angiogenesis
PublicationHypoxia-inducible factor 1 (HIF-1) plays a critical role for tumor adaptation to hypoxia and promotes angiogenesis. Antitumor imidazoacridinone C-1311 is a DNA reactive topoisomerase II and FLT3 receptor tyrosine kinase inhibitor selected for phase II clinical trials for breast cancer. Here, we demonstrate the new mechanism of C-1311 action involving HIF-1a, vascular endothelial growth factor (VEGF) and angiogenesis as additional...
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Antitumor 1-nitroacridine derivative C-1748 induces significant apoptosis in pancreatic cancer cells.
PublicationPancreatic cancer is the fifth leading cause of cancer death and has the lowest survival rate of any solid cancer in the industrial countries. The poor prognosis of pancreatic cancer results from its tendency for late presentation, aggressive invasion, early metastasis, and resistance to chemotherapy. Gemcitabine still remains the best chemotherapeutic agent available for the treatment of advanced pancreatic cancer. However, gemcitabine...
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Increasing the conductivity of V2O5 -TeO2 glass by crystallization: structure and charge transfer studies
PublicationIn the present paper, V2O5-TeO2 glass...
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Getting to know the potential of social media in forest education
PublicationThe development of social network sites not only facilitates the acquisition and deepening of knowledge but also provides the possibility of easily contacting foresters, specialists in natural sciences and nature enthusiasts. In addition, for some years...
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Doskonalenie strumienia wartości
PublicationKsiążka ta ma na celu praktyczne ujęcie problemu optymalizacji przedsiębiorstwa opartej na koncepcji Lean (z ang. Lean – szczupły) i jej narzędziu Mapowania Strumienia Wartości. ---- Tu pobierzesz jej pełną treść w wersji elektronicznej: https://drive.google.com/file/d/1xNrdiuOHKpyjzG5dY3ocFG8fp2hY1b9C/view?usp=sharing ---- Prezentowane...