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Search results for: therapeutic landscapes
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Navigating the treatment landscape in gastroenteropancreatic neuroendocrine neoplasms
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Transcriptomic landscape of blood platelets in healthy donors
PublicationBlood platelet RNA-sequencing is increasingly used among the scientific community. Aberrant platelet transcriptome is common in cancer or cardiovascular disease, but reference data on platelet RNA content in healthy individuals are scarce and merit complex investigation. We sought to explore the dynamics of platelet transcriptome. Datasets from 204 healthy donors were used for the analysis of splice variants, particularly with...
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The idea of sustainable development in the landscape contemporary cities
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Polish Suburban Landscape made of Enterpereneurial Tissue
PublicationDwa ostatnie dekady w Polsce to okres ekspansywny rozwój małych przedsiębiorstw i równolegle dynamiczne przekształcenia przestrzeni wokół miasta . Rozwój tych dwóch zjawisk nastąpiło w okresie transformacji gospodarczej po 1989 roku . Głównym celem pracy jest zbadanie poziomu interakcji między procesem suburbanizacji i rozwojem sektora MSP w wybranych podmiejskich obszary, na przykładzie Metropolii Trójmiejskiej.
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Local Development Strategies in Shaping Rural Landscape
PublicationDlaczego krajobraz kulturowy wsi jako zintegrowana całość wymyka się procedurom planistycznym i zarządzaniu? Dlaczego praktyka życia społecznego w dziedzinie gospodarowania przestrzenią na terenach wiejskich przeciwstawia się i zaprzecza równie powszechnie deklarowanej intencji kształtowania harmonijnego krajobrazu?Profesjonalne diagnozy kryzysu krajobrazu kulturowego wsi koncentrują się zwyczajowo na nieskuteczności, często rzeczywiście...
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The Housing Pattern and Entrepreneurship in Polish Suburban Landscape
PublicationAbstract. Housing stimulates the development of SMEs (small and medium enterprises) in the suburbs. The multidisciplinary research in fields of urban planning and economics, carried out by the Authors, confirms this trend. The purpose of this paper is to present the multidisciplinary results of the research on the determinants of SME localization in the suburban areas of Gdansk, Gdynia and Sopot (the Metropolitan Area Gdansk–Gdynia-Sopot...
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Threats to Rural Landscape and Its Protection in Poland
PublicationThe article describes the premises and conditions for the implementation of a pro-landscape spatial policy in rural areas in Poland. It presents the erosion of spatial order in a large part of the country’s territory. Firstly, the state of protection of the rural landscape and the legal aspects of shaping the space of rural areas are described. Secondly, the location is depicted, and the main physiognomic and environmental threats...
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Transcriptomic landscape of blood platelets in healthy donors
PublicationBACKGROUND Blood platelet RNA-sequencing is increasingly used among the scientific community. Aberrant platelet transcriptome is common in cancer or cardiovascular disease, but reference data on platelet RNA content in healthy individuals are scarce and merit complex investigation. METHODS We sought to explore the dynamics of platelet transcriptome. Datasets from 204 healthy donors were used for the analysis of splice variants,...
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The new generation of urban parks and health-promoting landscapes in eco-neighborhoods
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Villages and their old farmsteads are hot spots of bird diversity in agricultural landscapes
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Therapeutic Qualities and Sustainable Approach to Heritage of the City. The Coastal Strip in Gdańsk, Poland
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Purinergic implication in amyotrophic lateral sclerosis—from pathological mechanisms to therapeutic perspectives
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Neuroprotective Effects of Cannabidiol in Hypoxic Ischemic Insult. The Therapeutic Window in Newborn Mice
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Mapping Mechanostable Pulling Geometries of a Therapeutic Anticalin/CTLA-4 Protein Complex
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Myeloid-derived suppressor cells (MDSCs) in brain cancer: challenges and therapeutic strategies
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Isolation and Characterization of NP-POL Nonapeptide for Possible Therapeutic Use in Parkinson’s Disease
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Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets
PublicationNitric oxide (NO) is one of the most important molecules released by endothelial cells, and its antiatherogenic properties support cardiovascular homeostasis. Diminished NO bioavailability is a common hallmark of endothelial dysfunction underlying the patho‑ genesis of the cardiovascular disease. Vascular NO is synthesized by endothelial nitric oxide synthase (eNOS) from the substrate L‑arginine (L‑Arg), with tetrahydrobiopterin...
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Novel therapeutic compound acridine–retrotuftsin action on biological forms of melanoma and neuroblastoma
PublicationPURPOSE: As a continuation of our search for anticancer agents, we have synthesized a new acridine-retrotuftsin analog HClx9-[Arg(NO2)-Pro-Lys-Thr-OCH3]-1-nitroacridine (named ART) and have evaluated its activity against melanoma and neuroblastoma lines. Both tumors develop from cells (melanocytes, neurons) of neuroectodermal origin, and both are tumors with high heterogeneity and unsatisfactory susceptibility to chemotherapies....
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Nonsense-Mediated mRNA Decay: Pathologies and the Potential for Novel Therapeutics
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Blood pressure variability: Emerging role in risk assessment and therapeutics
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Developing a Framework for the Implementation of Landscape and Greenspace Indicators in Sustainable Urban Planning. Waterfront Landscape Management: Case Studies in Gdańsk, Poznań and Bristol
PublicationUrban landscape (UL) management and urban greenspace (UG) delivery require effective planning tools. The aim of the study is to develop a conceptual framework for the implementation of ecological, structural and visual landscape and greenspace indicators (LGI) in spatial development of urban areas. The UL and UG management provisions in Poland are identified at various levels of urban planning (local, municipal and regional). Furthermore,...
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Regulation of Plant Microprocessor Function in Shaping microRNA Landscape
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Landscape of the Vistula Estuary - searching for traces of ingenium embodied
PublicationArtykuł podaje skrótowe informacje o dawnym i współczesnym znaczeniu obiektów inżynieryjnych w krajobrazie delty Wisły, które znalazły się na trasie objazdu konserwatorskiego w dniu 5 maja w ramach realizacji programu konferencji HOT-GO 4 wraz z kalendarium ich dziejów: Most Lisewski przez Wisłę w Tczewie, wielki przekop Wisły w Świbnie, śluzy w Przegalinie, Gdańskiej Głowie i Białej Górze, relikty kanału w Piekle.
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Rural Landscape Planning for Sustainable Development. The Case of Poland
PublicationThis text results from theoretical study on the possibilities of rural landscape renovation in Poland. The introduction marks new spatial phenomena and the scope of their influence. It indicates social and cultural reasons of the changes, and states the need of their renewed interpretation. The second part of the article contains a description of the degrading cultural landscape of the country and presents its features. It then...
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The dynamic Polish suburban landscape created by SME sector
PublicationWspółcześnie zaobserwować można dynamiczne przeobrażenia przestrzeni wokół miast polegające na przemieszczaniu się ludności i podmiotów gospodarczych z miasta centralnego do strefy podmiejskiej. Wydaje się, że charakterystycznym elementem krajobrazu polskich obszarów podmiejskich jest duża ilość działających w nich przedsiębiorstw sektora MSP.
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Landscape as the tool of coherence in the land management of rural communes
PublicationEconomic and social transformation of rural areas in Poland after 1990 reveals itself through disintegration of previous spatial order. Building a new pattern requires a vision, which would counteract complex causes of disintegration. The latter belong to institutional domain of planning strategies and the area of common practices. Therefore, agreement on aims and means between spatial policy strategies and tactics of space users...
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CEACAM6 as a Novel Therapeutic Target to Boost HO-1—mediated Antioxidant Defense in COPD
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Targeting mTORs by omega-3 fatty acids: A possible novel therapeutic strategy for neurodegeneration?
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Current state of a dual behaviour of antimicrobial peptides-Therapeutic agents and promising delivery vectors
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Role of Myeloid-derived suppressor cell (MDSC) in autoimmunity and its potential as a therapeutic target
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Aptamer based tools for environmental and therapeutic monitoring: A review of developments, applications, future perspectives
PublicationNucleic acids in the form of aptamers play a growing and significant role in the targeted and rapid analysis of environmental sample composition and medical analyses. In this paper, the review of both aptamers synthesis methods as well as application of these short chain oligonucleotides (with critical comments on their strong and weak features) are given. The first ones include: systematic evolution of ligands by exponential enrichment...
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HEALTH-AFFIRMING EVERYDAY LANDSCAPES IN SUSTAINABLE CITY. ECO-NEIGHBORHOODS IN FRANCE CASE
PublicationThis paper discusses the close relationship between the concept of health-affirming everyday landscapesand the idea of sustainable city design.The French National program of eco-neighborhood certification ÉcoQuartier is described and the correlation between the concepts of health-affirming landscapes,sustainable cities, and eco-neighborhoods is explained using the example of a selected eco-neighborhood in France.
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Place attachment, place identity and aesthetic appraisal of urban landscape
PublicationAs the aesthetic of the Polish cities became a topic of wider discussions, it is important to detect the potentialrole of human-place relations. Two studies (N = 185 & N = 196) were conducted to explore the relationship betweenplace attachment, place identity and appraisal of urban landscape. Satisfaction with urban aesthetic was predicted by twodimensions of place attachment (place inherited and place...
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Effect of Newly Created Water Reservoirs on Agricultural Landscape Stability
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Impact of water reservoirs in Nienawiszcz on improve of the visual values of landscape
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Quality Structure of the Noctuidae Family in Selected Habitats of the Agricultural Landscape
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The landscape transformations of post-industrial areas based on selected examples
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Actual problems of the polish coastal landscape, architecture and culturalheritage protection
PublicationPraca zawiera ogólną charakterystykę krajobrazu polskiego wybrzeża, przedstawia podstawowe zagrożenia jako wartości wynikające z nieprzemyślanych decyzji planistycznych oraz żywiołowego rozwoju strefy nadmorskiej, prezentuje także walory środowiska kulturowego wsi położonych nad Bałtykiem, ich architekturę oraz aktualne problemy ich ochrony.
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The role of isolated farmsteads in the open landscape protection on the example of Kashubia
PublicationAs a result of the social and economic transformation of rural areas, open landscapes are disappearing. Former farmsteads are being devastated or beginning to lose their landscape context due to the spread of residential building development. At the same time, in many places, the farmstead form is clearly legible and remains an element with which the view is structured and enriched. The article was aimed at drawing attention to...
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Building culture written into the landscape – how to read spatial tradition
PublicationThe article presents a discussion on the experimenting with material leading to practical so-lutions in building structure in the context of the tradition of the place. It sketches out the practical aspects of creation of space while working with different local materials during the intensive workshops within the Structures in Building Culture IP programme. This kind of unique possibility to practice raw materials gives also the...
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Classification of Landscape Physiognomies in Rural Poland: The Case of the Municipality of Cekcyn
PublicationThis article presents a methodology and the results of the classification of the rural landscapes physiognomies conducted on the study area located in the municipality of Cekcyn, Poland. The study aimed to develop a landscape identification method that would combine natural, cultural, and visual criteria with which to implement the provisions of the European Landscape Convention. The realization of the European Landscape Convention...
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Positive results of serological tests for syphilis in pregnancy – diagnostic and therapeutic problems, report of two cases
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Angiotensin receptor - neprilysin inhibiton (ARNI) – A novel therapeutic concept for management of hypertension and heart failure
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Assessment of Therapeutic Progress After Acquired Brain Injury Employing Electroencephalography and Autoencoder Neural Networks
PublicationA method developed for parametrization of EEG signals gathered from participants with acquired brain injuries is shown. Signals were recorded during therapeutic session consisting of a series of computer assisted exercises. Data acquisition was performed in a neurorehabilitation center located in Poland. The presented method may be used for comparing the performance of subjects with acquired brain injuries (ABI) who are involved...
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Applications of Cannabis Sativa L. in Food and Its Therapeutic Potential: From a Prohibited Drug to a Nutritional Supplement
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Structure–Activity Relationships and Therapeutic Applications of Retinoids in View of Potential Benefits from Drug Repurposing Process
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Hepatitis D, B and C virus (HDV/HBV/HCV) coinfection as a diagnostic problem and therapeutic challenge
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Abdominoplasty Skin-Based Dressing for Deep Wound Treatment—Evaluation of Different Methods of Preparation on Therapeutic Potential
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Assessing therapeutic relevance of biologically interesting, ampholytic substances based on their physicochemical and spectral characteristics with chemometric tools
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Novel chalcone-derived pyrazoles as potential therapeutic agents for the treatment of non-small cell lung cancer
PublicationLung cancer is considered to account for approximately one-fifth of all malignant tumor-related deaths worldwide and is therefore one of the most lethal malignancies. Pyrazole scaffold possesses a wide range of biological and pharmacological activities, which play important roles in medicinal chemistry. The present study reports the synthesis and in vitro biological characterization of nine pyrazoles derived from chalcones as potential...