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Search results for: Williams syndrome
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Induction of unique structural changes in guanine-rich DNA regions by the triazoloacridone C-1305, a topoisomerase II inhibitor with antitumor activities.
PublicationCelem pracy było scharakteryzowanie odziaływania związku C-1305 z DNA w porównaniu do innych inhibitorów topoizomerazy II. Badania pokazują, że C-1305 odziaływuje preferencyjnie z parami CG, interkaluje do DNA i zaburza sąsiednie otoczenie w bardzo charakterystyczny sposób, który nie został zaobserwowany u pozostałych 22 badanych związków.
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Renal artery denervation for treatment of patients with self-reported obstructive sleep apnea and resistant hypertension
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Structure-based design and evaluation of novel N-phenyl-1H-indol-2-amine derivatives for fat mass and obesity-associated (FTO) protein inhibition
PublicationFat mass and obesity-associated (FTO) protein contributes to non-syndromic human obesity which refers to excessive fat accumulation in human body and results in health risk. FTO protein has become a promising target for anti-obesity medicines as there is an immense need for the rational design of potent inhibitors to treat obesity. In our study, a new scaffold N-phenyl-1H-indol-2-amine was selected as a base for FTO protein inhibitors...
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Novel Nystatin A1 derivatives exhibiting low host cell toxicity and antifungal activity in an in vitro model of oral candidosis
PublicationOpportunistic oral infections caused by Candida albicans are frequent problems in immunocompromised patients. Management of such infections is limited due to the low number of antifungal drugs available, their relatively high toxicity and the emergence of antifungal resistance. Given these issues, our investigations have focused on novel derivatives of the antifungal antibiotic Nystatin A1, generated by modifications at the amino...
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Leptin interacts with heart rate but not sympathetic nerve traffic in healthy male subjects
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Detecting harmful gases using fluctuation-enhanced sensing with Taguchi sensors
PublicationTechniki sensorowe powinny być nie tylko wszechstronne ale także poprawiać dostarczaną informację.Artykuł przedstawia nowe podejście do analizy sygnałów obserwowanych podczas wykrywania gazów. Wykorzystuje się całe pasmo częstotliwości obserwowanych fluktuacji rezystancji sensora, w przecwieństwie do klasycznego podejścia wykorzystującego tylko obserwacje zmian rezystancji stałoprądowej. Nowe podej[cie pozwala zredukować liczbę...
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Computed tomography indicators of cerebral microperfusion improve long term after carotid stenting in symptomatic patients
PublicationOBJECTIVES: We tested the hypothesis that computed tomography (CT) perfusion markers of cerebral microcirculation would improve 36 months after internal carotid artery stenting for symptomatic carotid stenosis while results obtained 6-8 weeks after the stenting procedure would yield a predictive value. METHODS: We recruited consecutive eligible patients with >70% symptomatic carotid stenosis with a complete circle of Willis and...
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Cancer-selective, single agent chemoradiosensitising gold nanoparticles
PublicationTwo nanometre gold nanoparticles (AuNPs), bearing sugar moieties and/or thiol-polyethylene glycol-amine (PEG-amine), were synthesised and evaluated for their in vitro toxicity and ability to radiosensitise cells with 220 kV and 6 MV X-rays, using four cell lines representing normal and cancerous skin and breast tissues. Acute 3 h exposure of cells to AuNPs, bearing PEG-amine only or a 50:50 ratio of alpha-galactose derivative and...
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Development of Physics-Based Energy Functions that Predict Medium-Resolution Structures for Proteins of the α, β, and α/β Structural Classes
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A Database Schema for the Analysis of Global Dynamics
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Expertise: No Longer a Sine Qua Non for Guideline Authors?
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Coordination polymers based on octacyanometalates(iv,v) (M = Mo, W) and aliphatic polyamine copper(ii) tectons with [N3] donor atom sets
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Growth and Isolation of Large Area Boron‐Doped Nanocrystalline Diamond Sheets: A Route toward Diamond‐on‐Graphene Heterojunction
PublicationMany material device applications would benefit from thin diamond coatings, but current growth techniques, such as chemical vapor deposition (CVD) or atomic layer deposition require high substrate and gas‐phase temperatures that would destroy the device being coated. The development of freestanding, thin boron‐doped diamond nanosheets grown on tantalum foil substrates via microwave plasma‐assisted CVD is reported. These diamond...
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First Report of the Global SYMPLICITY Registry on the Effect of Renal Artery Denervation in Patients With Uncontrolled Hypertension
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Reply
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Expertise
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Outcomes Following Radiofrequency Renal Denervation According to Antihypertensive Medications: Subgroup Analysis of the Global SYMPLICITY Registry DEFINE
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Heritability of plasma leptin levels
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Generation of biodiesel and glycerol from waste of rice industries in Brazil
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Renal denervation reduces office and ambulatory heart rate in patients with uncontrolled hypertension
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A rapid-response ultrasensitive biosensor for influenza virus detection using antibody modified boron-doped diamond
PublicationAccording to the World Health Organization (WHO), almost 2 billion people each year are infected worldwide with flu-like pathogens including influenza. This is a contagious disease caused by viruses belonging to the family Orthomyxoviridae. Employee absenteeism caused by flu infection costs hundreds of millions of dollars every year. To successfully treat influenza virus infections, detection of the virus during the initial development...
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Triple Combination of Ascorbate, Menadione and the Inhibition of Peroxiredoxin-1 Produces Synergistic Cytotoxic Effects in Triple-Negative Breast Cancer Cells
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Pharmacokinetics and Antibody Responses to the CD3 Antibody Otelixizumab Used in the Treatment of Type 1 Diabetes
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Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases
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Rationale and design of a large registry on renal denervation: the Global SYMPLICITY registry
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Activation Energy and Inclination Magnetic Dipole Influences on Carreau Nanofluid Flowing via Cylindrical Channel with an Infinite Shearing Rate
PublicationThe infinite shear viscosity model of Carreau fluid characterizes the attitude of fluid flow at a very high/very low shear rate. This model has the capacity for interpretation of fluid at both extreme levels, and an inclined magnetic dipole in fluid mechanics has its valuable applications such as magnetic drug engineering, cold treatments to destroy tumors, drug targeting, bio preservation, cryosurgery, astrophysics, reaction kinetics,...
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Student Perspectives on the 2017 ESA Concurrent Engineering Challenge
PublicationIn September 2017, the first ESA Academy’s Concurrent Engineering Challenge (CEC) was held, giving 88 Master’s and PhD-level students from twelve ESA Member and Associate States a powerful platform to experience system engineering in an intense, fast paced, and real-world environment. Within four days, teams of physics and engineering students in Concurrent Design Facilities (CDF) located in Politecnico di Torino, Universidad Polit´ecnica...
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The molecular function of kallikrein‐related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer
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Ionosphere variability I: Advances in observational, monitoring and detection capabilities
PublicationThe paper aims to review recent advances regarding the observational and monitoring capabilities of the ionization conditions in the Earth's upper atmosphere. The analysis spans both ground and space-based experiments, seeking for new installations and/or missions, new or upgraded instrumentation and/or observational network establishments as means for advancing current understanding and prediction ability of the ionosphere variability....
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Central nervous system involvement in mantle cell lymphoma: clinical features, prognostic factors and outcomes from the European Mantle Cell Lymphoma Network†
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Pharmacokinetics and bioequivalence of a liquid formulation of hydroxyurea in children with sickle cell anemia
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Converting beach wrack into a resource as a challenge for the Baltic Sea (an overview)
PublicationThe paper distinguishes beach wrack, the marine generated organic part of beach cast, as a separate management object and discusses research questions related to its management and economically viable use. Based on experiences from the Baltic Sea and existing practices from countries with different management systems clear distinction between the management of natural and anthropogenic components of cast material is seen as an...
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What makes a group worth dying for? Identity fusion fosters perception of familial ties, promoting self-sacrifice.
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Inhibitor kinazy Brutona u chorych z nawrotowym lub opornym na leczenie chłoniakiem z komórek płaszcza – wyniki międzynarodowego, wieloośrodkowego, badania II fazy z ibrutynibem (PCI-32765) – EHA Encore
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Independent Mechanisms Lead to Genomic Instability in Hodgkin Lymphoma: Microsatellite or Chromosomal Instability
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Erratum: Cuceu, C., et al. Independent Mechanisms Lead to Genomic Instability in Hodgkin Lymphoma: Microsatellite or Chromosomal Instability. Cancers 2018, 10, 233
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Long-term follow-up of MCL patients treated with single-agent ibrutinib: updated safety and efficacy results
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The Global Boundary Stratotype Section and Point (GSSP) for the base of the Coniacian Stage (Salzgitter-Salder, Germany) and its auxiliary sections (Słupia Nadbrzeżna, central Poland; Střeleč, Czech Republic; and El Rosario, NE Mexico)
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COVID-19 Vaccine Boosters: The Good, the Bad, and the Ugly
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Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: a multicentre, open-label, phase 2 study
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2018 Practice Guidelines for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension
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2018 Practice guidelines for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension
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2018 ESC/ESH Guidelines for the management of arterial hypertension
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2018 ESC/ESH Guidelines for the management of arterial hypertension
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International Expert Consensus Statement
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Postibrutinib outcomes in patients with mantle cell lymphoma
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Targeting BTK with Ibrutinib in Relapsed or Refractory Mantle-Cell Lymphoma
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Venetoclax for Patients With Chronic Lymphocytic Leukemia With 17p Deletion: Results From the Full Population of a Phase II Pivotal Trial
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Evaluation of the BNT162b2 Covid-19 Vaccine in Children 5 to 11 Years of Age
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Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe — recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency
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