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Search results for: aspergillus fumigatus
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Detection of Polish clinical Aspergillus fumigatus isolates resistant to triazoles
PublicationWe studied the presence of triazole resistance of 121 Aspergillus fumigatus clinical isolates collected in two Polish cities, Warsaw and Wrocław, to determine if resistance is emerging in our country. We identified five itraconazole resistant isolates (4.13%) carrying the TR34/L98H alteration in Cyp51A gene, four of which were cross-resistant to posaconazole and one to voriconazole. One isolate was intermediate susceptible to itraconazole...
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Low frequency of itraconazole resistance found among avian Aspergillus fumigatus isolates
PublicationAspergillus fumigatus is the most frequent etiological factor of invasive aspergillosis in human as well as animals, including birds. Aspergillosis caused by drug-resistant strains poses a significant therapeutic issue, especially if resistance pattern includes insensitivity to triazoles, i.e. drugs recommended for the primary therapy purposes. Majority of resistant isolates hold the TR34/L98H...
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The Effect of Posaconazole, Itraconazole and Voriconazole in the Culture Medium on Aspergillus fumigatus Triazole Resistance
PublicationTriazoles are the only compounds used as antibiotics in both medicine and agriculture. The presence of triazoles in the environment can contribute to the acquisition of azole resistance among isolates of Aspergillus fumigatus. The objective of this study was to investigate the effect of A. fumigatus exposure to triazoles on susceptibility to these compounds. Seventeen triazole-resistant and 21 triazole-sensitive A. fumigatus isolates...
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Activity of isavuconazole and other triazole derivatives against clinical isolates of Aspergillus fumigatus
PublicationAspergillus fumigatus is the most frequent pathogen of the genus Asperillus, which is highly susceptible to triazole derivatives, especially to isavuconazole and voriconazole. Many countries face a growing problem of infections due to A. fumigatus showing acquired resistance to one or several triazoles. In medical centres, monitoring the susceptibility of isolated Aspergillus spp. is recommended. The aim of this study was to collect...
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Production of paclitaxel with anticancer activity by two local fungal endophytes, Aspergillus fumigatus and Alternaria tenuissima
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Agro‐industrial wastes for production of paclitaxel by irradiated Aspergillus fumigatus under solid‐state fermentation
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Strain improvement and immobilization technique for enhanced production of the anticancer drug paclitaxel by Aspergillus fumigatus and Alternaria tenuissima
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Examination of cyp51A and cyp51B expression level of the first Polish azole resistant clinical Aspergillus fumigatus isolate
PublicationAspergillus fumigatus is one of the most prevalent airborne fungal pathogens causing infections worldwide. Most A. fumigatus strains are susceptible to azoles, which are administered as the first line therapeutics. However, during last decade the acquired resistance to triazoles by these species has been described. There is a number of publications concerning the examination of clinical A. fumigatus strains from different countries,...
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Semi-continuous production of the anticancer drug taxol by Aspergillus fumigatus and Alternaria tenuissima immobilized in calcium alginate beads
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Występowanie oraz charakterystyka molekularna oporności na azole wśród klinicznych i środowiskowych izolatów Aspergillus fumigatus
PublicationCelem badań prowadzonych w ramach niniejszej pracy doktorskiej było sprawdzenie występowania oporności na azole grzybów A. fumigatus pochodzących z Polski oraz jej molekularna charakterystyka. W toku badań utworzono kolekcję 200 izolatów A. fumigatus pochodzących z różnych miejsc Polski. W skład kolekcji wchodziły izolaty kliniczne, środowiskowe i weterynaryjne. Przynależność gatunkową badanych grzybów potwierdzono metodami diagnostyki...
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Relation of the polymorphism of cyp51A sequence and the susceptibility of Aspergillus fumigatus isolates to triazoles determined by commercial gradient test (Etest) and by reference methods
PublicationThe aim of this study was to evaluate the accuracy of commercial gradient test (Etest) in the detection of triazole resistant Aspergillus fumigatus isolates using reference microdilution methods and the analysis of sequences of the cyp 51A gene. The study was performed on twenty clinical isolates which were identified as Aspergillus fumigatus based on the DNA sequences of the ITS1-2 fragment of ribosomal DNA and the β-tubulin gene,...
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Bioprocess optimization using response surface methodology for production of the anticancer drug paclitaxel by Aspergillus fumigatus and Alternaria tenuissima: Enhanced production by ultraviolet and gamma irradiation
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Occurrence of fungi and cytotoxicity of the species: Aspergillus ochraceus, Aspergillus niger and Aspergillus flavus isolated from the air of hospital wards
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Characterization of d-xylose reductase, XyrB, from Aspergillus niger
PublicationD-xylose reductase is a member of the aldo-keto reductase family, and is involved in D-xylose and L-arabinose conversion through the Pentose Catabolic Pathway (PCP) in fungi. In this study, we biochemically characterized a newly identified second D-xylose reductase (XyrB) from Aspergillus niger. This NADPH-dependent reductase is able to efficiently convert D-xylose and L-arabinose, and it has the highest affinity for these sugars...
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Initial studies on the influence of Aspergillus niger on the wood components of Populus sp.
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Nested PCR for the detection of Aspergillus species in maxillary sinus samples of patients with chronic sinusitis
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Method-Dependent Epidemiological Cutoff Values for Detection of Triazole Resistance in Candida and Aspergillus Species for the Sensititre YeastOne Colorimetric Broth and Etest Agar Diffusion Methods
PublicationAlthough the Sensititre Yeast-One (SYO) and Etest methods are widely utilized, interpretive criteria are not available for triazole susceptibility testing of Candida or Aspergillus species. We collected fluconazole, itraconazole, posaconazole, and voriconazole SYO and Etest MICs from 39 laboratories representing all continents for (method/agent-dependent) 11,171 Candida albicans, 215 C. dubliniensis, 4,418 C. glabrata species complex,...
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Evaluation of antimicrobial activities of powdered cuttlebone against Klebsiella oxytoca, Staphylococcus aureus, and Aspergillus flavus
PublicationBackground: The presence of medicines in the environment is considered as a serious threat to the human health. The entrance of these substances into the water sources causes soil pollution, which eventually leads to the environmental pollution and it creates some problems for the public health. Also, increasing antibiotic resistant bacteria has attracted the attention of researchers to the use of natural resources such as marine...
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Novel mycosynthesis of Co3O4, CuO, Fe3O4, NiO, and ZnO nanoparticles by the endophytic Aspergillus terreus and evaluation of their antioxidant and antimicrobial activities
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Structural changes of bacterial cellulose due to incubation in conditions simulating human plasma in the presence of selected pathogens
PublicationBacterial nanocellulose (BNC) is a natural biomaterial with a wide range of medical applications. However, it cannot be used as a biological implant of the circulatory system without checking whether it is biodegradable under human plasma conditions. This work aimed to investigate the BNC biodegradation by selected pathogens under conditions simulating human plasma. The BNC was incubated in simulated biological fluids with or...
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Exploiting the exceptional biosynthetic potency of the endophytic Aspergillus terreus in enhancing production of Co3O4, CuO, Fe3O4, NiO, and ZnO nanoparticles using bioprocess optimization and gamma irradiation
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In vitro biodegradation of bacterial nanocellulose under conditions simulating human plasma in the presence of selected pathogenic microorganisms
PublicationThe Biodegradability of bacterial nanocellulose (BNC) was assessed based on a change in its properties under conditions simulating human plasma in the presence or absence of the pathogens Staphylococcus aureus, Candida albicans and Aspergillus fumigatus. It was shown that the dry mass of BNC did not change during 6 months of incubation, except for samples stored in the presence of moulds, where the dry mass reduced by 40 %. The...
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Morphology and degradation of polyurehanes in different environments.
PublicationW pracy przedstawiono wyniki badań degradacji poli(estro-uretanów) (PEsUA i PEsUB) oraz poli(etero-uretano-mocznika)(PEtUU) w roztworach buforowych o zmiennym pH (168 godz., 70 oC), w środowisku trypsyny (37 oC, 1 m-c), Aspergillys niger (12 m-cy), kompoście z osadem czynnym (12 m-cy) i w wodzie morskiej (12 m-cy). Analizowano zmiany w morfologii i właściwościach fizykomechanicznych. Ustalono następujące sekwencje w zmianach zależności...
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Sick building syndrome due to molds
PublicationThe term Sick Building Syndrome (SBS) is a combination of ailments occurring in a specific building. Building occupants complain of symptoms such as headaches and dizziness, fainting, nausea, irritation of the mucosal membranes, skin irritation and other nonspecific hypersensitivity reactions.One of the SBS causes can be molds, which are ubiquitous in the air (over 400 species). It is estimated that 30% of the health problems (related...
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Grzyby środowiskowe jako biologiczne wskaźniki jakości powietrza w budynkach
PublicationAnaliza mikrobiologiczna powietrza ulega ciągłym usprawnieniom począwszy od lat czterdziestych XX wieku. Dzięki temu wykazano, iż grzyby środowiskowe (ich elementy lub substancje przez nie produkowane) mogą wpływać na stan powietrza w budynkach. Wysunięcie tych wniosków zeszło się w czasie z odkryciem Zespołu Chorego Budynku. Podczas gdy w normalnym powietrzu w budynkach dominuje rodzaj Cladosporium, w chorych budynkach znajduje...
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Wytyczne dotyczące diagnostyki inwazyjnych zakażeń grzybiczych u pacjentów hematologicznych i onkologicznych
PublicationInwazyjne zakażenia grzybicze (ang. invasive fungal diseases - IFD) są główną przyczyną zachorowań i śmiertelności, szczególnie u pacjentów z nowotworami hematologicznymi. Grzyby, które są najczęstszymi przyczynami schorzeń u tego typu pacjentów to Aspergillus spp. oraz Candida albicans. Gatunki Candida nie-albicans oraz rosnąca liczba innych grzybów (np. Zygomycetes, Trichosporon, Fusarium spp.) są także coraz częściej wykrywane....
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Phenotypic consequences of the LYS4 gene disruption in Candida albicans
PublicationThe main scientific purpose of our studies was to verify the hypothesis that homoaconitase (HA) from Candida albicans, an enzyme catalyzing a second step of the α-aminoadipate pathway (AAP) of L-Lys biosynthesis may become a new target for antifungal chemotherapy. Previous studies indicated that the A. fumigatus mutant lacking the functional lysF gene, encoding HA, exhibited attenuated virulence in a low-dose mouse infection model...