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total: 753
Search results for: PERSONALIZED ONCOLOGY
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p53 Gene status in relation to ex vivo chemosensitivity of non-small cell lung cancer
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Novel therapeutic compound acridine–retrotuftsin action on biological forms of melanoma and neuroblastoma
PublicationPURPOSE: As a continuation of our search for anticancer agents, we have synthesized a new acridine-retrotuftsin analog HClx9-[Arg(NO2)-Pro-Lys-Thr-OCH3]-1-nitroacridine (named ART) and have evaluated its activity against melanoma and neuroblastoma lines. Both tumors develop from cells (melanocytes, neurons) of neuroectodermal origin, and both are tumors with high heterogeneity and unsatisfactory susceptibility to chemotherapies....
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Cancer immune escape: the role of antigen presentation machinery
PublicationThe mechanisms of antigen processing and presentation play a crucial role in the recognition and targeting of cancer cells by the immune system. Cancer cells can evade the immune system by downregulating or losing the expression of the proteins recognized by the immune cells as antigens, creating an immunosuppressive microenvironment, and altering their ability to process and present antigens. This review focuses on the mechanisms...
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New method for personalization of avatar animation
PublicationThe paper presents a method for creating a personalized animation of avatar utilizing fuzzy inference. First the user designs a prototype version of animation, with keyframes only for important poses, roughly describing the action. Then animation is enriched with new motion phases calculated by the fuzzy inference system using descriptors given by the user. Various degrees of motion fluency and naturalness are possible to achieve....
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SKYSCRAPER'S PUBLIC AREAS: THE IMPACT ON SPACE AND SOCIAL LIFE
PublicationIn recent years, more careful consideration is taken into social issues of designing skyscrapers by humanizing adherent internal and external public areas. Case studies of The Shard (London: 2012), 122 Leadenhall Street (London: 2014), 20 Fenchurch Street (London: 2014), Heron Tower (London: 2011), Tower 25 (Nicosia: 2013), Zoofenster (Berlin: 2012), DNB House (Oslo: 2012), Centrum Biurowe Neptun (Gdansk, 2014), Skytower (Wroclaw:...
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Airstrip Ground Improvement Works by Blasting Charge Technique and Dredged-Ash Material Mixture
PublicationSoil improvement by blasting charge technique is known in geotechnics as one of the efficient and inexpensive method. It can be used in preparing of underground to found road construction and buildings as well. The technique proves usefulness especially when dynamic load is applied. It is because of non-stiff or rather resilient type soil after improvement. In noncohesive or organic soil, blasting charge...
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Study on population dynamics for triple-linked food chain using a simulation-based approach
PublicationThe procedures based on simulation have become a feasible testing method that does not require investing valuable resources to create a concrete prototype, especially with the increasing computational power of computers. Thus, design changes can be adopted and design errors can be fixed before it is too late. Simulation turns to be a cheap, safe and often more acceptable from an ethical perspective. In our work we summarize the...
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Recent total cross section measurements in electron scattering from molecules
PublicationThe grand-total cross sections (TCSs) for electron scattering from a range of molecules, measured over the period 2009-2019 in various laboratories, with the use of different electron transmission systems, are reviewed. Where necessary, the presented TCS data are also compared to earlier results. Collection of investigated molecular targets (biomolecules, biofuels, molecules of technological application,hydrocarbons) reflects their...
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Model of an Integration Bus of Data and Ontologies of Smart Cities Processes
PublicationThis paper presents a model of an integration bus used in the design of Smart Cities system architectures. The model of such a bus becomes necessary when designing high-level architectures, within which the silo processes of the organization should be seen from the perspective of its ontology. For such a bus to be used by any city, a generic solution was proposed which can be implemented as a whole or in part depending on the requirements...
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Anticancer Imidazoacridinone C-1311 is Effective in Androgen-Dependent and Androgen-Independent Prostate Cancer Cells
PublicationAndrogen receptor (AR) plays a crutial role in prostate cancer (PCa) development and metastasis. Here, we reported potent anti-PCa activity of a small molecule imidazoacridinone C-1311. In AR-positive PCa cells, C-1311 was found to inhibit the transcriptional activity of AR uncovering a novel mechanism that may be relevant for its anticancer effect. Mechanistically, C-1311 decreased AR binding to prostate-specific antigen (PSA)...
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Aleksandra Karpus dr inż.
PeopleAleksandra Karpus jest absolwentką Matematyki Stosowanej na Wydziale Fizyki Technicznej i Matematyki Stosowanej oraz Informatyki na Wydziale Elektroniki, Telekomunikacji i Informatyki Politechniki Gdańskiej. W latach 2011-2014 pracowała z danymi w przemyśle, wykorzystując bazy danych Oracle. Od 2014 roku jest zawodowo związana z Politechniką Gdańską, obecnie jest zatrudniona na stanowisku adiunkta naukowo-dydaktycznego w Katedrze...
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Using Container Structures in Architecture and Urban Design
PublicationAbstract. The paper presents the use of shipping containers in architecture and urban design. Even today, houses and apartments are still too expensive. Since 1923 architects have been improving the living conditions of citizens by building very simple, repeatable forms. With prefabrication technology it became possible to build quicker, causing house prices to decrease. Apartments in block of flats became affordable to more and...
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Context-aware User Modelling and Generation of Recommendations in Recommender Systems
PublicationRecommender systems are software tools and techniques which aim at suggesting new items that may be of interest to a user. This dissertation is focused on four problems in recommender systems domain. The first one is context-awareness, i.e. how to obtain relevant contextual information, how to model user preferences in a context and use them to make predictions. The second one is multi-domain recommendation, which aim at suggesting...
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Fenomenologi Husserla a tradycja filozofii transcendentalnej
PublicationCelem tekstu jest opisanie miejsca transcendentalnej fenomenologii Husserla w obrębie pokantowskiej filozofii transcendentalnej.
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Seashore sediment and water chemistry at the Admiralty Bay (King George Island, Maritime Antarctica) – geochemical analysis and correlations between the concentrations of chemical species
PublicationThis study covers water and sediment chemical characteristics by the western shore of Admiralty Bay (King George Island, Antarctica) in 2016. Chemical processes between sediment and water have been described based on the determination of ions, metals, non-metals, and TOC concentrations. Rock weathering is an important source of Fe, Ni, Co, Al in the seashore area. The PCA shows the impact of acidification in the release metals...
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Serum MicroRNAs as Xerostomia Biomarkers in Patients With Oropharyngeal Cancer Undergoing Radiation Therapy
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Circulating microRNAs as Biomarkers of Radiation Exposure: A Systematic Review and Meta-Analysis
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Radiation Therapy–Related Changes in Serum Proteome and Lipidome Are Primarily Associated With a Type of Acute Toxicity: Comparison of Radiation-Induced Effects in Patients Treated Because of Head and Neck Cancer or Prostate Cancer
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Radiation Therapy-Related Changes in Serum Proteome Patterns Are Affected by Medium Doses of Radiation Delivered to Large Volumes of Normal Tissue
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Radiation Therapy-Induced Changes in Serum Lipidome of Head and Neck Cancer Patients
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Bystander Effects Induced by Medium From Irradiated Cells: Similar Transcriptome Responses in Irradiated and Bystander K562 Cells
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Serum Proteome Signature of Radiation Response: Upregulation of Inflammation-Related Factors and Downregulation of Apolipoproteins and Coagulation Factors in Cancer Patients Treated With Radiation Therapy—A Pilot Study
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Potential of Serum Proteome Patterns Analysis by MALDI-TOF Mass Spectrometry for Prediction of Acute Radiation Injury Response in Head and Neck Cancers Patients
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Radiation-related Changes in Serum Proteome Profiles Detected by Mass Spectrometry in Blood of Patients Treated with Radiotherapy Due to Larynx Cancer
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Three-dimensional visualization and measurement of conformal dose distributions using magnetic resonance imaging of bang polymer gel dosimeters
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Image registration of BANG® gel dose maps for quantitative dosimetry verification
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City and Urbanity in the Social Discourse
PublicationThe aim of our article is an attempt to present the concept of urbanity that has been shaped throughout centuries along with the development of European civilisation and now entered a new phase of social production of space based on cultural dimensions. The future of the majority of World’s population is connected currently with the urban life with the assumption that qualitative characteristics of life in the 21st century define...
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Filozofować z głębi człowieczeństwa. O fenomenologii Andrzeja Półtawskiego.
PublicationDokonując krytyki tradycji nowożytnego empiryzmu i kartezjańskiego dualizmu Półtawski tworzy realistyczną i dynamiczną interpretację bytu ludzkiego. Przeżywanie, odczuwanie zmysłowe nie jest poślednią odmianą poznania jak i operacją dostarczania jedynie elementów, budulca poznaniu, ale odrębnym sposobem bycia w świecie, jest symbiotycznym kontaktem z otoczeniem, formą życia. Zrywa on radykalnie z tradycją brentanowsko-husserlowską...
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Jakub Kruszyński mgr. inż
PeopleMotivated and focused to steady discovering amazing chemistry of polymer and cooperating with fascinating people. Currently PhD student in cooperation between SABIC B.V and Gdansk University of Technology. I have 3 year industrial experience. Mainly as a R&D Junior Specialist in Synthos S.A and intern in SABIC Technology&Innovation Center, Geleen. Graduate of Gdansk University of Technology in Polymer Specialization on...
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Diversity of microorganisms from forest soils differently polluted with heavy metals
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Secondary metabolites of Rubus caesius (Rosaceae)
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An accurate assignment test for extremely low‐coverage whole‐genome sequence data
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Ancient and modern mitochondrial haplotypes of common bream (Abramis brama L.) in Poland
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Secondary metabolites from Potentilla argentea
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Secondary metabolites from Potentilla recta L. and Drymocallis rupestris (L.) Soják (syn. Potentilla rupestris L.) (Rosaceae)
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Cats kill millions of vertebrates in Polish farmland annually
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Distribution of invasive Cylindrospermopsis raciborskii in the East-Central Europe is driven by climatic and local environmental variables
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Military Training Areas and Vegetation – the Effect of Explosion Craters on Species Diversity along a Moisture Gradient
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Reliability assessment of null allele detection: inconsistencies between and within different methods
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Reduced biodiversity in modernized villages: A conflict between sustainable development goals
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Linking habitat composition, local population densities and traffic characteristics to spatial patterns of ungulate‐train collisions
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Active farmsteads are year-round strongholds for farmland birds
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Sensitivity of binomial N‐mixture models to overdispersion: The importance of assessing model fit
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Impacts of salvage logging on biodiversity: A meta-analysis
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Villages and their old farmsteads are hot spots of bird diversity in agricultural landscapes
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Effects of water level and grassland management on alpha and beta diversity of birds in restored wetlands
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Early post-fire bird community in European boreal forest: Comparing salvage-logged with non-intervention areas
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Absorbciâ vodoroda i povedenie vodoroda v slaâh titanovyh silavov s modificirovannoj poverhnost''û = Hydrogen absorption and hydrogen effects in the modified surface layers of Ti alloys
PublicationW pracy przedstawiono rezultaty badań absorpcji wodoru w stopach tytanu ze zmodyfikowaną za pomocą metod multipleksowych powierzchnią. W wyniku badań stwierdzono, iż po nadtapianiu laserowym w warunkach kriogenicznych, stopy tytanu wykazuja najwyższą zdolność absorpcji wodoru w wytworzonej warstwie wierzchniej.
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Protective Zone of an Industrial Plant as a Tool for Environmental Protection
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Bacteriophage-mediated reduction of Salmonella Enteritidis in swine slurry
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