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Search results for: receptor tyrosine kinase flt3
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Molecular dynamics simulation of human neurohypophyseal hormone receptors complexed with oxytocin—modeling of an activated state
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Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management
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Expression and cellular distribution of estrogen and progesterone receptors and the real-time proliferation of porcine cumulus cells
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Amberlyst-15 catalysed synthesis of novel indole derivatives under ultrasound irradiation: Their evaluation as serotonin 5‑HT2C receptor agonists
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Amberlyst-15 catalysed synthesis of novel indole derivatives under ultrasound irradiation: Their evaluation as serotonin 5‑HT2C receptor agonists
PublicationA series of indole based novel Schiff bases was designed as potential agonists of 5‑HT2C receptor that was supported by docking studies in silico. These compounds were synthesized via Amberlyst-15 catalysed condensation of an appropriate pyrazole based primary amine with the corresponding indole-3-aldehyde under ultrasound irradiation at ambient temperature. A number of target Schiff bases were obtained...
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Anna Brillowska-Dąbrowska dr hab. inż.
PeopleAnna Brillowska-Dąbrowska, born in 1971 in Gdańsk, Poland, graduated in 1996 in Biotechnology from the Faculty of Chemistry, Gdańsk University of Technology (GUT). In 2001 she got her PhD, in 2013 became a DSc (habilitation). She was employed in 2004 as a researcher in Statens Serum Institut in Denmark. Currently she is an Associate Professor (adiunkt) in the Department of Molecular Biotechnology and Microbiology and Vice-dean...
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Electrokinetic properties of n-tetradecane/ethanol emulsions with DPPC and enzyme lipase or phospholipase A2
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Zjawiska sufozyjne w kanale odpływowym Elektrowni Wodnej Straszyn na rzece Raduni.
PublicationArtykuł zawiera prezentację warunków hydrogeologicznych w rejonie elektrowniwodnej Straszyn wraz z opisem istniejących procesów sufozyjnych.
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Badania eksperymentalne wpływu obecności ścianki na ruch pęcherzyków w kanale pionowym.
PublicationW referacie zaprezentowano matematyczny model siły odpychającej działającej na kulę (model pęcherzyka) przepływającą wzdłuż ścianki pionowej. Stwierdzono, że siła ta ma charakter okresowy i zależy od liczby Reynoldsa oraz początkowej odległości pomiędzy kulą i ścianką. Dokonano porównania zarejestrowanej i obliczonej modelem trajektorii ruchu kuli uzyskując zadowalającą zgodność.
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DNA-damaging imidazoacridinone C-1311 induces autophagy followed by irreversible growth arrest and senescence in human lung cancer cells
PublicationImidazoacridinone 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) is an antitumor inhibitor of topoisomerase II and FMS-like tyrosine kinase 3 receptor. In this study, we describe the unique sequence of cellular responses to C-1311 in human non-small cell lung cancer (NSCLC) cell lines, A549 and H460. In A549 cells, C-1311 (IC80 = 0.08 µM) induced G1 and G2/M arrests, whereas H460 cells (IC80 = 0.051 µM) accumulated...
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Effects of acceptor doping on a metalorganic switch: DFT vs. model analysis
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A Potential Relationship Between Estrogen Receptors Polymorphisms, Sperm Function and in vitro Fertilization Success: A Preliminary Study*
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Pharmacological characterization and binding modes of novel racemic and optically active phenylalanine-based antagonists of AMPA receptors
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The expression of Platelet-derived Growth factor receptors (PDGFRs) and their correlation with overall survival of patients with ovarian cancer
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Novel anion receptors: hybrid materials based on quaternary ammonium salts for selective extraction of dichromate ions
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Clinical and Biological Significance of ESR1 Gene Alteration and Estrogen Receptors Isoforms Expression in Breast Cancer Patients
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Stromal Derived Factor-1 (SDF-1) and Its Receptors CXCR4 and CXCR7 in Endometrial Cancer Patients
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Estrogen Receptor Type 1 and Type 2 Presence in Paravertebral Skeletal Muscles: Expression Level and Relation to Phenotype in Children with Idiopathic Scoliosis
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Expression of Estrogen Receptor Coactivator Proline-, Glutamic Acid- and Leucine-Rich Protein 1 within Paraspinal Muscles in Adolescents with Idiopathic Scoliosis
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Efficacy of high-dose corticosteroid-based treatment for chronic lymphocytic leukemia patients with p53 abnormalities in the era of B-cell receptor inhibitors
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A New Phenylalanine Derivative Acts as an Antagonist at the AMPA Receptor GluA2 and Introduces Partial Domain Closure: Synthesis, Resolution, Pharmacology, and Crystal Structure
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Agrimoniin up-regulates collagen biosynthesis through increase in expression of β1-integrin receptor and prolidase activity in cultured human skin fibroblasts
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Texture or Linker? Competitive Patterning of Receptor Assembly toward Ultra-Sensitive Impedimetric Detection of Viral Species at Gold-Nanotextured Titanium Surfaces
PublicationIn this work, we study the electrodes with a periodic matrix of gold particles pattered by titanium dimples and modified by 3-mercaptopropionic acid (MPA) followed by CD147 receptor grafting for specific impedimetric detection of SARS-CoV-2 viral spike proteins. The synergistic DFT and MM/MD modeling revealed that MPA adsorption geometries on the Au–Ti surface have preferential and stronger binding patterns through the carboxyl...
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The effect of sunscreen 4‐methylbenzylidene camphor in different and reproductive models, its bioaccumulation and molecular effects on ligand‐receptor interaction, and protein expression
Publication4-Methylbenzylidene camphor (4-MBC) is a photo-absorbing UV filter prevalently used in cosmetics, which can be absorbed into circulation and cause systemic effects. 4-MBC is continued to be released in the environment despite the growing knowledge about its bioaccumulation and endocrine disrupting effects. Previous reviews have mentioned UV-filter together but this review considers 4-MBC alone, due to its prevalence and concerning...
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New imidazoline/alpha2-adrenoceptors affecting compounds - 4(5)-(2-aminoethyl)imidazoline (dihydrohistamine) derivatives. synthesis and receptor affinity studies
Publicationpołączenie struktury agmatyny i imidazoliny pozwoliło na otrzymanie nowej grupy ligandów receptorów imidazolinowych i alfa2-adrenergicznych, pochodnych 4(5)-(2-aminoetylo)imidazoliny. otrzymano oraz zbadano oddziaływanie nowych pochodnycch jak i analogów znanych ligandów - klonidyny, rilmenidyny, idazoksanu i antazoliny w stosunku do receptorów imidazolinowych oraz alfa2-adrenergicznych.
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Molecularly targeted nanoparticles: an emerging tool for evaluation of expression of the receptor for advanced glycation end products in a murine model of peripheral artery disease
PublicationAbstract Background: Molecular imaging with molecularly targeted probes is a powerful tool for studying the spatio-temporal interactions between complex biological processes. The pivotal role of the receptor for advanced glycation end products (RAGE) in numerous pathological processes, aroused the demand for RAGE targeted imaging in various diseases. In the study, we evaluated the use of a diagnostic imaging agent for RAGE quantification...
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The Web Based System for Recording and Analysing Different Kinds o Negotiations
PublicationNegocjacje są podstawą wielu ludzkich przedsięwzięć. Artykuł opisuje internetowy system rejestracji i analizy wybranych elementów negocjacji. Przedstawiono też wybrane eksperymenty negocjacyjne i ich wyniki zebrane przy pomocy omawianego systemu.
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Visualization of events using various kinds of synchronized data for the Border Guard
PublicationSTRADAR project is dedicated to streaming real-time data in a distributed dispatcher and teleinfor-mation system of the Border Guard. The Events Visualization Post is a software designed for simultaneous visualization of data of different types in BG headquarters. The software allows the operator to visualize files, images, SMS, SDS, video, audio, and current or archival data on naval situation on digital maps. All the visualized...
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DAF - and collagen-binding properties of chimeric Dr fimbriae
PublicationEkspozycja białek heterologicznych na powierzchni mikroorganizmów jest jedną z nowych strategii stosowanych w mikrobiologii, biotechnologii oraz projektowaniu nowoczesnych szczepionek. W niniejszej pracy zbadano możliwość wykorzystania białka podjednostkowego DraE fimbrii Dr uropatogennych szczepów Escherichia coli jako nośnika heterologicznych sekwencji. W rejon odpowiadający N-terminalnej domenie 2 białka DraE wprowadzono epitopową...
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Effect of Temperature on n-Tetradecane Emulsion in the Presence of Phospholipid DPPC and Enzyme Lipase or Phospholipase A2
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Odbiór zbiorczy z filtracją adaptacyjną RLS w transmisji danych w kanale hydroakustycznym
PublicationTransmisja danych w kanale hydroakustycznych realizowana jest w trudnych warunkach propagacyjnych. Jednym z problemów podczas takiej transmisji są zakłócenia międzysymbolowe (ISI – intersymbol interference) spowodowane głównie przez efekt wielodrogowości. To zjawisko utrudnia, bądź uniemożliwia transmisję danych w takim kanale. Stąd podjęto analizę wpływu zastosowania odbioru zbiorczego oraz filtracji adaptacyjnej RLS (Recursive...
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The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses ood intake and food-reinforced behavior but does not induce signs of nausea in rats
PublicationPrzeprowadzone badania biochemiczne wykazują, że związek AM4113 wiąże się z receptorem kanabinoidowym CB1, ale nie wykazuje właściwości odwrotnego agonisty (między innymi nie wpływa na powstawanie cyklicznego AMP). W testach na swobodne przemieszczanie się szczurów i znieczulenie związek AM4113 osłabia wpływ agonisty AM411 na receptor CB1. AM4113 wpływa na zachowanie szczurów związane z karmieniem oraz powoduje spadek łaknienia...
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Prenatal stress affects insulin-like growth factor-1 (IGF-1) level and IGF-1 receptor phosphorylation in the brain of adult rats
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Safety and efficacy of P2X3 receptor antagonist for the treatment of refractory or unexplained chronic cough: A systematic review and meta-analysis of 11 randomized controlled trials
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An Influence of the Aromatic Side Chains Conformations in Positions 2 and 3 of Vasopressin Analogs on Interactions with Vasopressin and Oxytocin Receptors
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O-substituted tetrahydroxamate derivatives of p-tert-butylcalix[4]arene as receptors for transition and heavy metal cations
PublicationTetrasubstituted O-hydroxamate derivatives of p-tert-butylcalix[4]arene were applied as active materials in ion-selective membrane electrodes and were tested towards Pb-selectivity. The electrodes gave near-Nernstian characteristics for Pb2+ cations. The selectivity coefficients were determined. The influence of plasticizer on the electrode behaviour was studied. The dependence of the chemical structure on selectivity coefficients...
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Interactions of vasopressin and oxytocin receptors with vasopressin analogues substituted in position 2 with 3,3′-diphenylalanine - a molecular docking study
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Nonradiative long range energy transfer in donor-acceptor systems with excluded volume
PublicationW pracy analizowano bezpromienisty długozasięgowy transfer energii w układach donor-akceptor z uwzględnieniem objętości wyłączonej. Stwierdzono, że zanik fluorescencji pierwotnie wzbudzonych donorów jest wolniejszy, jeżeli uwzględnia się objętość wyłączoną. Ten efekt jest znacznie wzmocniony, gdy akceptory znajdują się w pewnej objętości niedostępnej dla donorów. Analizę numeryczną przeprowadzono stosując metodę symulacji Monte...
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The reception of Adam Smith´s works in Poland from the eighteenth to the twentieth centuries
PublicationOmówiono recepcję twórczości Adama Smitha w Polsce od końca XVIII w. do cza-sów najnowszych. Oprócz krótkiego wprowadzenia historycznego przedstawiono recepcję dwóch dzieł A. Smitha: ''Bogactwa narodów'' oraz ''Teorii uczuć moral-nych''. Praca zawiera liczne przypisy i odsyłacze do źródeł, a także Appendix: Early editions of the Adam Smithłs Works in Warsaw and Gdańsk [Wczesne edycje dzieł Adama Smitha w bibliotekach polskich...
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Reception of Terrestrial DAB+ and FM Radio with a Mobile Device: A Subjective Quality Evaluation
PublicationNowadays, terrestrial broadcasting enables to receive content anytime and everywhere. People can obtain information both with a portable or desktop receiver, which include pocket-sized devices as well as high-end Hi-Fi equipment, not to mention car audio systems. Numerous manufacturers include FM-compatible chipsets in a variety of user equipment (UE), including mobile phones. However, digital radio signal processing modules, such...
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Naphthyl-vs. anthrylpyridine-2,6-dicarboxamides in cation binding studies. Synthesis and spectroscopic properties
PublicationPyridine-2,6-carboxamides bearing - or -naphthyl- and - or -anthryl- residues were prepared using simple method from pyridine-2,6-carboxylic acid dichloride and the respective aromatic amines. For the obtained receptors selective binding of lead(II), and copper(II) was found. Ion-receptor interactions were studied using UV-vis spectroscopy, spectrofluorimetry, 1H NMR, and FTIR spectroscopy. The reversible lead(II) and copper(II)...
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Ewa Wagner-Wysiecka dr hab. inż.
PeopleEwa Wagner-Wysiecka is a graduate of the Faculty of Chemistry at Gdańsk University of Technology (specializing in Chemical Technology, with a focus on Inorganic Technology and a sub-specialty in Technical and Industrial Analytics). She completed her master's thesis, entitled "Identification of Contaminants in Pharmacopoeial Sulfaquinoxaline," under the supervision of Professor Jan F. Biernat. After completing her master's degree...
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Evidence for electric field dependent dissociation of exciplexes in electron donor-acceptor organic solid films
PublicationBadano wpływ zewnętrznego pola elektrycznego na zanik luminescencji w układzie dendrymer aminowy m-MTDATA:fenantrolina BPT:poliwęglan PC oraz domieszkowanym organicznym kompleksem platyny. Zaobserwowano silne wygaszenie luminescencji na skutek dysocjacji ekscypleksów singletowych i trypletowych. Pole elektryczne obniżało zarówno amplitudę, jak i czas życia luminescencji.
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The Effects of Two Kinds of Dietary Interventions on Serum Metabolic Profiles in Haemodialysis Patients
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Magnetoacoustic Heating in Nonisentropic Plasma Caused by Different Kinds of Heating-Cooling Function
PublicationThe nonlinear phenomena which associate with magnetoacoustic waves in a plasma are analytically studied. A plasma is an open system with external inflow of energy and radiation losses. A plasma’s flow may be isentropically stable or unstable. The nonlinear phenomena occur differently in dependence on stability or instability of a plasma’s flow. The nonlinear instantaneous equation which describes dynamics of nonwave entropy mode...
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Two kinds of oxygen vacancies in lithium titaniate doped with copper as detected by EPR
PublicationLithium titanate (Li1+xTi2-xO4) doped with Cu2+ ions was synthesized by sol-gel processing method. The structure and morphology are characterized by X-ray Diffraction (XRD), X-ray Photoemission Spectroscopy (XPS), Scanning Electron Microscopy (SEM) and Electron Paramagnetic Resonance (EPR). Spin Hamiltonian parameters describing Zeeman and hyperfine interaction for 63Cu2+ ions were obtained from EPR spectra simulations. The spectra...
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The PolarScreen™ Estrogen Receptor Competitor Assays for determination of estradiol equivalent concentrations (EEQs) in sewage and drinking water samples.
Open Research DataMunicipal waste waters are one of the main sources of estrogenic compounds in aquatic environments. Feminization of fish downstream of Waste Water Treatment Plants (WWTPs) discharges has been observed worldwide. Some estrogenic chemicals, particularly steroid estrogens, are known to cause disruption of the endocrine system of fishes and abnormalities...
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The relationship between 8-oxo-7,8-dihydro-2′-deoxyguanosine level and extent of cytosine methylation in leukocytes DNA of healthy subjects and in patients with colon adenomas and carcinomas
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Photoprotection and Antiaging Activity of Extracts from Honeybush (Cyclopia sp.)—In Vitro Wound Healing and Inhibition of the Skin Extracellular Matrix Enzymes: Tyrosinase, Collagenase, Elastase and Hyaluronidase
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Jacek Namieśnik prof. dr hab. inż.
PeopleScientific discipline: chemistryRector in 2016-2019 He was born on 10 December, 1949 in Mogilno. He graduated in 1972 at the Faculty of Chemistry at Gdańsk University of Technology, obtaining a master's degree in chemical engineering. In 1972 he started working at Gdańsk University of Technology, where in 1978 he defended his doctoral thesis and in 1985 he completed his habilitation. He was appointed an associate professor in 1991...