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Search results for: GENOME EDITING
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International Journal of Accounting, Auditing and Performance Evaluation
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Journal of Dong Hua University (English Edition)
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Journal of Sichuan University (Medical Science Edition)
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Review of Clinical Pharmacology and Pharmacokinetics, International Edition
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Journal of Beijing Institute of Technology (English Edition)
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Archives of Disease in Childhood-Education and Practice Edition
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Archives of Disease in Childhood-Fetal and Neonatal Edition
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Establishing the allosteric mechanism in CRISPR‐Cas9
PublicationAllostery is a fundamental property of proteins, which regulates biochemical information transfer between spatially distant sites. Here, we report on the critical role of molecular dynamics (MD) simulations in discovering the mechanism of allosteric communication within CRISPR‐Cas9, a leading genome editing machinery with enormous promises for medicine and biotechnology. MD revealed how allostery intervenes during at least three...
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Improvement of the Water Resistance of a Narrow-Band Red-Emitting SrLiAl3N4:Eu2+Phosphor Synthesized under High Isostatic Pressure through Coating with an Organosilica Layer
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Application of the Heavy-Atom Effect for (Sub)microsecond Thermally Activated Delayed Fluorescence and an All-Organic Light-Emitting Device with Low-Efficiency Roll-off
PublicationThefeatureof abundantandenvironmentallyfriendlyheavyatoms(HAs)like bromineto acceleratespin-forbiddentransitionsin organicmoleculeshas beenknownforyears.In combinationwiththe easinessof incorporation,brominederivativesof organicemittersshowingthermallyactivateddelayedfluorescence(TADF)emergeas a cheapand efficientsolutionforthe slowreverseintersystemcrossing(rISC)problemin suchemittersand strongefficiencyroll-offof all-organiclight-emittingdiodes(OLEDs).Here,we...
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JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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Identification and cloning of C. albicans SC5314 genes encoding L-methionine biosynthetic pathway enzymes.
Open Research DataEnzymes of fungal L-methionine biosynthetic pathway: homoserine O-acetyltransferase (Met2p), O-acetylhomoserine sulfhydrylase (Met15p) and cystathionine-γ-synthase (Str2p) could be exploited as molecular targets for antifungal chemotherapy. The goal of the study was to identify and clone genes encoding mentioned above enzymes. MET2, MET15 and STR2 genes...
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Smart Virtual Bass Synthesis Algorithm Based on Music Genre Classification
PublicationThe aim of this paper is to present a novel approach to the Virtual Bass Synthesis (VBS) algorithms applied to portable computers. The proposed algorithm employed automatic music genre recognition to determine the optimum parameters for the synthesis of additional frequencies. The synthesis was carried out using the non-linear device (NLD) and phase vocoder (PV) methods depending on the music excerpt genre. Classification of musical...
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Intelligent equalizer solution employing music genre and the room characteristics analysis
PublicationThe paper presents an intelligent equalizer solution based on room acoustic conditions and music genre analysis. A series of acoustic characteristic measurements are performed for checking the concept proposed. White noise (reference signal) and audio excerpts belonging to six music genres are utilized as excitation signals in measurements. This results in registration of frequency responses of rooms and reverberation times. Signals...
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Bass Enhancement Settings in Portable Devices Based on Music Genre Recognition
PublicationThe paper presents a novel approach to the Virtual Bass Synthesis (VBS) applied to mobile devices, called Smart VBS (SVBS). The proposed algorithm uses an intelligent, rule-based setting of bass synthesis parameters adjusted to the particular music genre. Harmonic generation is based on a nonlinear device (NLD) method with the intelligent controlling system adapting to the recognized music genre. To automatically classify music...
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An examination of an Antarctic soil metagenomic-derivate putative methylthioadenosine phosphorylase gene as a novel reporter gene for promoter trapping
PublicationThe rsfp gene was discovered during examination ofan Antarctic soil-derived metagenome library and encodesa bacterial methylthioadenosine phosphorylase (GenBank accession number GQ202582). In a previous study, we found that E. coli colonies expressing the rsfp gene reveal strong pink fluorescence after exposure to UV light when grown on culture medium supplemented with rhodamine B (Cieśliński et al., 2009). In contrast to that,...
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Evolving gene regulatory networks controlling foraging strategies of prey and predators in an artificial ecosystem
PublicationCo-evolution of predators and prey is an example of an evolutionary arms race, leading in nature to selective pressures in positive feedback. We introduce here an artificial life ecosystem in which such positive feedback can emerge. This ecosystem consists of a 2-dimensional liquid environment and animats controlled by evolving artificial gene regulatory networks encoded in linear genomes. The genes in the genome encode chemical...
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INFORT EDITIONS
Publishing Houses -
edition lumière
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Malignant neoplasm arising from pre-existing spiradenoma - Male, 64 - Tissue image [912072957516291]
Open Research DataThis is the histopathological image of SKIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Malignant neoplasm arising from pre-existing spiradenoma - Male, 63 - Tissue image [9220729551204161]
Open Research DataThis is the histopathological image of BRONCHUS AND LUNG tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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A concept of Signal Equalization Method Based on Music Genre and the Listener's Room Characteristics
PublicationA research study that investigates the influence of the room acoustics environment on the frequency characteristic of the audio signal playback is presented. First, a novel spectral equalization method of the room acoustic conditions is introduced. On the basis of the frequency response of the room, a system for room acoustics compensation based on eight-band equalizer is proposed. The system settings depend on music genre. In...
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Targeting Spike‐ACE2 Interface of SARS‐CoV‐2 and its Omicron Variant: A Comparative Screening of Potential Inhibitors for Existing and Anticipating Variants Using Molecular Modelling Approach
PublicationThe recent COVID pandemic has shown major impact on public health and economic crisis. Despite the development of many vaccines and drugs against the severe acute respiratory syndrome (SARS) coronavirus 2, the pandemic still persists. The continued spread of the virus is largely driven by the emergence of viral variants such as α, β, γ, delta, epsilon spike, omicron and its subvariants (BA.1,2,3) which can evade the current vaccines...
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Modelling gene expression of a self-regulating protein
PublicationWe analyze a model of gene transcription and protein synthesis. We take into account the number of sites on the protein’s promoter at which the protein’s dimers can bind blocking transcription of protein mRNA.
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Osteoprotegerin gene polymorphism in diabetic Charcot neuroarthropathy
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Genistein modulates gene activity in psoriatic patients
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ANALYSIS OF THE p53 PROTEIN GENE EXPRESSION MODEL
PublicationWe study the asymptotic behaviour of the solutions of the p53-Mdm2 model proposed by Monk (2003). The p53 gene is crucial for cellular inhibition of the angiogenesis process, while Mdm2 is a negative regulator of the p53 tumor-suppressor. We investigate the stability of the positive steady state and perform some numerical experiments.
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A Simple Model of Linkage Disequilibrium and Genetic Drift in Human Genomic SNPs: Importance of Demography and SNP Age
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Genomic and Functional Characterization of the Unusual pLOCK 0919 Plasmid Harboring thespaCBAPili Cluster inLactobacillus caseiLOCK 0919
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Properties of Ginkgo biloba L.: Antioxidant Characterization, Antimicrobial Activities, and Genomic MicroRNA Based Marker Fingerprints
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Wielkoskalowe formy handlu we współczesnym mieście – szansa czy zagrożenie? Studium przypadku wrocławskiej „Renomy”
PublicationArtykuł związany jest z kwestią kształtowania struktur handlu wielkoskalowego we współczesnych miastach. Zagadnienie to zaprezentowano na bazie transformacji historycznego budynku wrocławskiej Renomy.
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Uprzednie uzgodnienia cenowe jako narzędzie w sprawach porozumień w zakresie ustalania cen transakcyjnych
PublicationW dobie nasilonych procesów globalizacji, problem unikania opodatkowania poprzez lokowanie dochodów w krajach o niskim opodatkowaniu staje się coraz bardziej istotnym. Narzędziem ograniczenia sporów z organem podatkowym w zakresie cen stosowanych przez podmioty powiązane są ''uprzednie porozumienie cenowe''. Narzędzie to zostało po raz pierwszy wprowadzone do polskiego prawodastwa podatkowego od 1.01.2006 r.
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When migrant men become more involved in household and childcare duties – the case of Polish migrants in Norway
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Fenomen przemocy w doktrynach prawnych. Tendencje legislacyjne dotyczące sprawcy i osoby doznającej przemocy
PublicationPrzemoc, aczkolwiek różnie postrzegana, stanowi przedmiot zainteresowania wielu dziedzin prawa. Pod różnymi postaciami reguluje je prawo karne, szeroko rozumiane prawo cywilne, ale także prawo pracy. Z uwagi na wieloaspektowość omawianego zjawiska niemożliwe jest przedstawienie wszystkich odsłon, a jedynie zasygnalizowanie tych obszarów, w których ono występuje i w których odgrywa szczególną rolę. Do przeprowadzenia analizy wykorzystano...
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Composition and antimicrobial activity of fatty acids detected in the hygroscopic secretion collected from the secretory setae of larvae of the biting midge Forcipomyia nigra (Diptera: Ceratopogonidae)
PublicationThe hygroscopic secretion produced by the secretory setae of terrestrial larvae of the biting midge Forcipomyia nigra (Winnertz) was analysed using gas chromatography coupled with mass spectrometry (GC-MS). The viscous secretion is stored at the top of each seta and absorbs water from moist air. GC-MS analyses (four independent tests) showed that the secretion contained 12 free fatty acids, the most abundant of which were oleic...
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Changes in Life Situations during the SARS-CoV-2 Virus Pandemic and Their Impact on Eating Behaviors for Residents of Europe, Australia as Well as North and South America
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Principles of target DNA cleavage and the role of Mg2+ in the catalysis of CRISPR–Cas9
PublicationAt the core of the CRISPR–Cas9 genome-editing technology, the endonuclease Cas9 introduces site-specific breaks in DNA. However, precise mechanistic information to ameliorate Cas9 function is still missing. Here, multimicrosecond molecular dynamics, free energy and multiscale simulations are combined with solution NMR and DNA cleavage experiments to resolve the catalytic mechanism of target DNA cleavage. We show that the conformation...
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Bulletin de la Société d'Egyptologie de Genève
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Gene Therapy and Molecular Biology
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Gene Regulation and Systems Biology
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Human Gene Therapy Methods
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Journal of RNAi and Gene Silencing
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HIGH ENERGY PHYSICS AND NUCLEAR PHYSICS-CHINESE EDITION
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Recherche et Applications en Marketing-English Edition
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Journal of Chengdu University of Technology (Science and Technology Edition)
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Southern African Journal of Accountability and Auditing Research-SAJAAR
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Reading & Writing-Journal of the Reading Association of South Africa
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Victoriographies-A Journal of Nineteenth-Century Writing 1790-1914
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Journal of Nanjing Forestry University (Natural Sciences Edition)
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JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
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