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Search results for: reverse transcriptase
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Molecular basis and potential activity of HIV-1 reverse transcriptase toward trimethylamine-based compounds
PublicationReverse transcriptase (RT) inhibitors are currently used to treat human immunodeficiency virus (HIV)-1 infections. In this work, novel triethylamine derivatives were designed and studied by rigid and flexible docking and molecular dynamics (MD) approaches. An apo form of HIV-1 RT was also studied by MD simulation to analyze comparative response of protein in ligand-bound and ligand-unbound forms. Among newly designed HIV-1 RT inhibitors,...
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Inhibiting Activity of HIV-1: Protease, Reverse Transcriptase and Integrase All Together by Novel Compounds Using Computational Approaches
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Inhibiting activity of HIV-1: protease, reverse transcriptase and integrase all together by novel compounds using computational approaches (flexible and rigid docking)
PublicationAcquired immunodeficiency syndrome (AIDS), caused by human immunodeficiency virus type 1 (HIV-1) infection, is one of the most challenging diseases in recent decades. Nevertheless the shortcomings of chemical drugs such as toxicity, lack of curative effects, the search for more potent anti-HIV agents have been focused in our study. In current study, novel scaffold was designed having a benzyl and imidazole in it which are very...
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Rivers Try Harder. Reversed “Differential Erosion” as Geological Control of Flood in the Large Fluvial Systems in Poland
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A contribution to the moss and liverwort flora of the Reberce Nature Reserve at the Przemyśl Foothills (Western Carpathians, Poland)
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Surface shape reverse engineering with nurbs
PublicationW artykule zaprezentowano algorytm, który interpoluje prostokątną tablice punktów w przestrzeni trójwymiarowej przy pomocy powierzchni NURBS. Algorytm oblicza parametry powierzchni NURBS tak, aby jak najwierniej oddać kształt opisany przez punkty. Do interpolacji punktów wybrano powierzchnię NURBS, jako najbardziej uniwersalny i najczęściej używany w programach CAD rodzaj powierzchni. Interpolowane punkty mogą pochodzić zarówno...
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Analytical design method of reverse curves
PublicationThe paper deals with a new approach relating to the design of the region of railway track direction alteration adapted to Mobile Satellite Measurements technique. The method may be particularly useful in situations when both the straights of the route directions cannot be connected in an elementary way using a circular arc with transition curves; this also refers to the application of a compound curve. Thus the only solution becomes...
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The methylome and transcriptome of fetal skin: implications for scarless healing
PublicationAim: Fetal skin is known to heal without scarring. In mice, the phenomenon is observed until the 16–17 day of gestation – the day of transition from scarless to normal healing. The study aims to identify key methylome and transcriptome changes following the transition. Materials & methods: Methylome and transcriptome profiles were analyzed in murine dorsal skin using microarray approach. Results & conclusion: The genes associated...
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RSN reverse converter based on core function
Publicationzaprezentowano nową architekturę konwertera z systemu resztowego do systemu binarnego opartego na funkcji jądra dla modułów 5-bitowego. Zastosowano niekrytyczną funkcję jądra.Obliczanie funkcji jądra jest realizowane przy użyciu chińskiego twierdzenia dla funkcji jądra (CRTCF). Założono także, że jeden z modułów jest potegą 2. Architektura ta umożliwia zmniejszenie złożoności sprzętowej o ok. 12.5% w porównaniu z innymi architekturami...
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Hybrid Obfuscation Technique for Reverse Engineering Problems
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Design of reverse curves adapted to the satellite measurements
PublicationThe paper presents a new method for designing railway route in the direction change area adapted to the Mobile Satellite Measurements technique. The method may be particularly useful in the situations when both tangents cannot be connected in an elementary way using a circular arc with transition curves. Thus, the only solution would be the application of two circular arcs of opposite curvature signs, that is, the use of an inverse...
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INVERSE PROBLEMS
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Computing algebraic transfer entropy and coupling directions via transcripts
PublicationMost random processes studied in nonlinear time series analysis take values on sets endowed with a group structure, e.g., the real and rational numbers, and the integers. This fact allows to associate with each pair of group elements a third element, called their transcript, which is defined as the product of the second element in the pair times the first one. The transfer entropy of two such processes is called algebraic transfer...
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Robustness of Pathway Enrichment Analysis to Transcriptome-Wide Gene Expression Platform
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Transcriptome profiling and environmental linkage to salinity across Salicornia europaea vegetation
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HPV16 E6 Gene Transcripts in Primary Type II Endometrial Carcinomas
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Hybrid Algorithm to Protect Java’s Code from Reverse Engineering
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Formulating a defensive technique to prevent the threat of prohibited reverse engineering
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RNS reverse converter based on the new chinese remainder theorem.
PublicationPrzeanalizowano złożoność układu cyfrowego opartego na nowej odmianie chińskiego twierdzenia o resztach.
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Bound on Bell inequalities by fraction of determinism and reverse triangle inequality
PublicationIt is an established fact that entanglement is a resource. Sharing an entangled state leads to nonlocal correlations and to violations of Bell inequalities. Such nonlocal correlations illustrate the advantage of quantum resources over classical resources. In this paper, we quantitatively study Bell inequalities with 2 × n inputs. As found in Gisin et al. [Int. J. Quantum. Inform. 05, 525 (2007)], quantum mechanical correlations...
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Application of Reverse Engineering Technology in Part Design for Shipbuilding Industry
PublicationIn the shipbuilding industry, it is difficult to create CAD models of existing or prototype parts, especially with many freeform surfaces. The paper presents the creation of the CAD 3D model of a shipbuilding component with the application of the reverse engineering technology. Based on the data obtained from the digitization process, the component is reconstructed in point cloud processing programs and the CAD model is created....
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pH Gradient Reversed-Phase HPLC
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Non-steroidal anti-inflammatory drugs are safe with respect to the transcriptome of human dermal fibroblasts
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Transcriptome sequencing of Brassica napus highlights the complex issues with soil supplementation with sewage sludge
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Coordinated reprogramming of renal cancer transcriptome, metabolome and secretome associates with immune tumor infiltration
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Pilot plant studies on the removal of trihalomethanes by composite reverse osmosis membranes
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Reverse flow routing problem solved by the Space-Time Conservation Method
PublicationW artykule rozpatruje się zagadnienie odwrotnej transformacji przepływów dla przypadku przepływu nieustalonego wolno zmiennego w kanałach otwartych, opisanego układem równań de Saint Venanta. Przedstawiono specyficzne dla rozpatrywanego przypadku problemy powstające na etapie jego rozwiązywania oraz zaproponowano efektywny algorytm obliczeniowy, wykorzystujący nową, atrakcyjną metodę czasoprzestrzennych objętości skończonych. Do...
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Investigation of RTS Noise in Reverse Polarized Silicon Carbide Schottky Diodes
PublicationOne of the method of electronic device quality and reliability evaluation is observation of its inherent noise. The RTS phenomena usually indicates the presence of large defects in the structure of the material of the device, therefore it can be treated as an indicator of technology quality. In the paper authors present results of RTS investigations in reverse polarized Silicon Carbide Schottky diodes. Devices being studied are...
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Revenue-cycle strategist
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Inverse Problems and Imaging
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Transcriptome profiling reveals distinctive traits of retinol metabolism and neonatal parallels in the MRL/MpJ mouse
PublicationBackground: The MRL/MpJ mouse is a laboratory inbred strain known for regenerative abilities which are manifested by scarless closure of ear pinna punch holes. Enhanced healing responses have been reported in other organs. A remarkable feature of the strain is that the adult MRL/MpJ mouse retains several embryonic biochemical characteristics, including increased expression of stem cell markers. Results: We explored the transcriptome...
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Low Frequency Noise Measurement of Reverse Polarized Silicon Carbide Schottky Diodes
PublicationW artykule przedstawiono wyniki pomiaró szumów cz. wstecznie spolaryzowanych diod Schottky'ego.
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Reverse splits in international stock markets: Reconciling the evidence on long-term returns
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Preparation of silver nanoparticles in reverse micelles and antibacterial activity of silver modified-paints
PublicationW publikacji została opisana metoda otrzymywania nanocząstek srebra oraz farb modyfikowanych srebrem i ich wpływ na zahamowanie rozwoju wybranych bakterii i grzybów. Podjęto również próbę porównania wpływu rodzaju prekursora srebra oraz substancji powierzchniowo czynnej na stabilność otrzymanych nanocząstek srebra. Przygotowane mikroemulsje zawierały od 500 do 2000 ppm srebra
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Comparison of Language Models Trained on Written Texts and Speech Transcripts in the Context of Automatic Speech Recognition
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Transcriptome Changes in Three Brain Regions during Chronic Lithium Administration in the Rat Models of Mania and Depression
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Transcriptome Dynamics Underlying Planticine®-Induced Defense Responses of Tomato (Solanum lycopersicum L.) to Biotic Stresses
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Determination of pKa by pH Gradient Reversed-Phase HPLC
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Enantiopure C1-Cyclotriveratrylene with a Reversed Spatial Arrangement of the Substituents
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Boundary value problems with advanced arguments involving upper and lower solutions in reverse order
PublicationPraca dotyczy problemów brzegowych dla równań różniczkowo-całkowych pierwszego rzędu z argumentami wyprzedzonymi. Podano wystarczające warunki, dla których problemy dotyczące takich równań mają rozwiązania minimalne i maksymalne w odpowiadającym obszarze ograniczonym przez rozwiązania górne i dolne. W celu uzyskania wyników zastosowano nową metodę opartą na twierdzeniu Heikkila-Lakshmikantham'a. Wyniki zilustrowano na przykładzie.
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The Application of Cellulose Acetate Membranes for Separation of Fermentation Broths by the Reverse Osmosis: A Feasibility Study
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Hybrid Obfuscation Technique to Protect Source Code From Prohibited Software Reverse Engineering
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Trimethylamine N-oxide and the reverse cholesterol transport in cardiovascular disease: a cross-sectional study
PublicationThe early atherosclerotic lesions develop by the accumulation of arterial foam cells derived mainly from cholesterol-loaded macrophages. Therefore, cholesterol and cholesteryl ester transfer protein (CETP) have been considered as causative in atherosclerosis. Moreover, recent studies indicate the role of trimethylamine N-oxide (TMAO) in development of cardiovascular disease (CVD). The current study aimed to investigate the association...
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Inverse shadowing and related measures
PublicationWe study various weaker forms of the inverse shadowing property for discrete dynamical systems on a smooth compact manifold. First, we introduce the so-called ergodic inverse shadowing property (Birkhoff averages of continuous functions along an exact trajectory and the approximating one are close). We demonstrate that this property implies the continuity of the set of invariant measures in the Hausdorff metric. We show that the...
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Bystander Effects Induced by Medium From Irradiated Cells: Similar Transcriptome Responses in Irradiated and Bystander K562 Cells
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Gradient reversed-phase high-performance chromatography of ionogenic analytes
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pH/Organic Solvent Double-Gradient Reversed-Phase HPLC
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Flow Boiling in Minigap in the Reversed Two-Phase Thermosiphon Loop
PublicationThe paper presents the results of experimental investigations of a model of a heat exchanger featuring a minigap, which is perceived as an evaporator for an inverted thermosiphon. The system works with a single component test fluid. The tested evaporator generates pumping power in the test loop in a way similar to the mammoth pump. The tests regarded a module of the heat exchanger, consisting of a hot leg and a cold leg with the...
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Small-lot Production with Additive Production Using Reverse Logistics and IT Solutions in COVID-19 Era
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RNS reverse high-speed converter with quasi-regular structure based on the Chinese Remainder Theorem
PublicationPrzedstawiono dwie nowe architektury szybkiego konwertera z systemuresztowego do systemu binarnego oparte o chińskie tw. o resztach. Zastosowano nowe struktury 4-operandowych sumatorów modulo 2M. Pierwsza ze struktur oparta jest o wstępne sumowanie najstarszych bitów wektorów sumy i przeniesienia na wyjściu sumatora CSA, natomiast druga o bezpośrednie wykrywanie przekroczenia 2M. Konwerter wykorzystujący drugą ze struktur charakteryzuje...