Rok 2024

• Meldrum’s acid assisted formation of tetrahydroquinolin‑2‑one derivatives a short synthetic pathway to the biologically useful scaffold

  Publikacja

  • M. Ryczkowska
  • A. Trocka
  • A. Hromova
  • S. Makowiec

  - Scientific Reports - Rok 2024

  A new method for the preparation of tetrahydroquinolin-2-one derivatives is presented. This approach involves a two-step reaction between enaminones and acylating agents, immediately followed by electrophilic cyclization, all within a single synthesis procedure, eliminating the need to isolate intermediates. The entire process is facilitated by the use of acyl Meldrum’s acids which not only shortens the preparation time of the...

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Rok 2022

• Application of the 2-deoxyglucose scaffold as a new chiral probe for elucidation of the absolute configuration of secondary alcohols

  Publikacja

  • A. Trocka
  • S. Makowiec
  • K. Szwarc-Karabyka
  • T. Laskowski

  - Scientific Reports - Rok 2022

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• Application of the 2-deoxyglucose scaffold as a new chiral probe for elucidation of the absolute configuration of secondary alcohols

  Publikacja

  • A. Trocka
  • K. Szwarc-Karabyka
  • S. Makowiec
  • T. Laskowski

  - Scientific Reports - Rok 2022

  Herein, we present the application of 2-deoxy-D-glucose derivatives as chiral probes for elucidation of the absolute configuration of chiral secondary alcohols. The probes are attached to the studied molecules via glycosylation reaction and the resulting products are examined by a set of standard 2D NMR experiments. The absolute configuration of an oxymethine carbon atom binding the probe is established on a basis of a set of diagnostic...

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