
dr inż. Beata Adamczak
Zatrudnienie
- Bibliotekarz w Sekcja Obsługi Czytelnika
Media społecznościowe
Kontakt
- beata.adamczak@pg.edu.pl
Bibliotekarz
- Miejsce pracy
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Gmach Główny
pokój 77 otwiera się w nowej karcie - Telefon
- +48 58 3471170
- beata.adamczak@pg.edu.pl
Wybrane publikacje
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Are stabilizing osmolytes preferentially excluded from the protein surface? FTIR and MD studies
Interactions between osmolytes and hen egg white lysozyme in aqueous solutions were studied by means of FTIR spectroscopy and molecular dynamics. A combination of difference spectra method and chemometric analysis of spectroscopic data was used to determine the number of osmolyte molecules interacting with the protein, and the preferential interaction coefficient in presented systems. Both osmolytes – L-proline and trimethylamine-N-oxide...
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Hydration of amino acids: FTIR spectra and molecular dynamics studies
The hydration of selected amino acids, alanine, glycine, proline, valine, isoleucine and phenylalanine, has been studied in aqueous solutions by means of FTIR spectra of HDO isotopically diluted in H2O. The difference spectra procedure and the chemometric method have been applied to remove the contribution of bulk water and thus to separate the spectra of solute-affected HDO. To support interpretation of obtained spectral results,...
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Effect of osmolytes on the thermal stability of proteins: replica exchange simulations of Trp-cage in urea and betaine solutions
Although osmolytes are known to modulate the folding equilibrium, the molecular mechanism of their effect on thermal denaturation of proteins is still poorly understood. Here, we simulated the thermal denaturation of a small model protein (Trp-cage) in the presence of denaturing (urea) and stabilizing (betaine) osmolytes, using the all-atom replica exchange molecular dynamics simulations. We found that urea destabilizes Trp-cage...
wyświetlono 1721 razy