Wyszukiwarka
Ph. D. Student Kavya Kondaka
Zatrudnienie
- 2021 - present PhD Student w Politechnika Gdańska
Publikacje
Filtry
wszystkich: 8
Katalog Publikacji
Rok 2025
-
Anticancer drugs targeting topoisomerase II for antifungal treatment
PublikacjaFungal topoisomerase II (TopoII) has been identified as essential for viability. Thus, our research aimed to investigate the potential of fungal TopoII as a novel target for antifungal chemotherapy. We conducted studies on eleventh antitumor compounds targeting human topoisomerase II, either approved by the U.S. Food and Drug Administration (FDA) or currently under clinical trials to evaluate their potential for use in other therapeutic...
-
Structural insights into fungal and human topoisomerase II with implications for in silico antifungal drug design
PublikacjaTopoisomerases are essential enzymes regulating DNA supercoiling and disentanglement, critical for genomic integrity. While topoisomerase inhibitors are well-established in anticancer and antibacterial chemotherapy, their potential as antifungal agents remains underexplored or even not proofed. This study investigates structural distinctions between Saccharomyces cerevisiae topoisomerase II (ScTopoII) and human topoisomerase IIα...
Rok 2023
-
Reverse vaccinology-based prediction of a multi-epitope SARS-CoV-2 vaccine and its tailoring to new coronavirus variants
PublikacjaThe genome feature of SARS-CoV-2 leads the virus to mutate and creates new variants of concern. Tackling viral mutations is also an important challenge for the development of a new vaccine. Accordingly, in the present study, we undertook to identify B- and T-cell epitopes with immunogenic potential for eliciting responses to SARS-CoV-2, using computational approaches and its tailoring to coronavirus variants. A total of 47 novel...
Rok 2022
-
Reverse vaccinology-based prediction of a multi-epitope SARS-CoV-2 vaccine and its tailoring to new coronavirus variants
Publikacja -
Targeting DNA Topoisomerase II in Antifungal Chemotherapy.
PublikacjaTopoisomerase inhibitors have been in use clinically for the treatment of several diseases for decades. Although those enzymes are significant molecular targets in antibacterial and anticancer chemotherapy very little is known about the possibilities to target fungal topoisomerase II (topo II). Raising concern for the fungal infections, lack of effective drugs and a phenomenon of multidrug resistance underlie a strong need to expand...
Rok 2020
-
Characterization of Selected Jackfruit Germplasm Accessions for Fruit Shape Through Morphological and Marker Based Assay
Publikacja -
Comparative efficacy of different methods in the generation of 12S particles from 146S particles of FMDV serotype A and their detection using serotype (146S) specific monoclonal antibodies
Publikacja
Rok 2019
wyświetlono 903 razy