Binary Mixtures of Selected Bisphenols in the Environment: Their Toxicity in Relationship to Individual Constituents - Publikacja - MOST Wiedzy


Binary Mixtures of Selected Bisphenols in the Environment: Their Toxicity in Relationship to Individual Constituents


Bisphenol A (BPA) is one of the most popular and commonly used plasticizer in the industry. Over the past decade, new chemicals that belong to the bisphenol group have increasingly been used in industrial applications as alternatives to BPA. Nevertheless, information on the combined effects of bisphenol (BP) analogues is insufficient. Therefore, our current study aimed to find the biological response modulations induced by the binary mixtures of BP compounds. We determined the toxicity levels in Microtox and XenoScreen YES/YAS assays for several BP analogs alone, and for their binary mixtures. The results obtained constituted the database for chemometric intelligent data analysis to evaluate the possible interactions occurring in the mixtures. Several chemometric/biophysical models have been used (concentration addition—CA, independent action—IA and polynomial regression calculations) to realize this aim. The best fitting was found for the IA model and even in this description strong evidence for synergistic behaviors (modes of action) of some bisphenol analogue mixtures was demonstrated. Bisphenols A, S, F and FL were proven to be of significant endocrine threat (with respect to XenoScreen YES/YAS assay); thus, their presence in mixtures (including presence in tissues of living organisms) should be most strictly monitored and reported.


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Publikacja w czasopiśmie
artykuł w czasopiśmie wyróżnionym w JCR
Opublikowano w:
MOLECULES nr 23, strony 3226 - 3241,
ISSN: 1420-3049
Rok wydania:
Opis bibliograficzny:
Owczarek K., Kudłak B., Simeonov, V., Mazerska Z., Namieśnik J.: Binary Mixtures of Selected Bisphenols in the Environment: Their Toxicity in Relationship to Individual Constituents// MOLECULES. -Vol. 23, nr. 12 (2018), s.3226-3241
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.3390/molecules23123226
Bibliografia: test
  1. Vogel, S. The Politics of Plastics: The Making and Unmaking of Bisphenol A "Safety". Am. J. Publ. Health 2009, 99, 559-566. otwiera się w nowej karcie
  2. Kundakovic, M.; Gudsnuk, K.; Franks, B.; Madrid, J.; Miller, R.L.; Perera, F.; Champagne, F. Sex-specific epigenetic disruption and behavioral changes following low-dose in utero bisphenol A exposure. PNAS 2013, 110, 9956-9961. otwiera się w nowej karcie
  3. Arbuckle, T.; Davis, K.; Boylan, K.; Fisher, M.; Fu, J. Bisphenol A, phthalates and lead and learning and behavioral problems in Canadian children 6-11 years of age: CHMS 2007-2009. Neurotoxicology 2016, 54, 89-98. otwiera się w nowej karcie
  4. Ahmed, R.G. Maternal bisphenol A alters fetal endocrine system: Thyroid adipokine dysfunction. Food Chem. Toxicol. 2016, 95, 168-174. otwiera się w nowej karcie
  5. Stojanoska, M.M.; Milosevic, N.; Milic, N.; Abenavoli L. The influence of phthalates and bisphenol A on the obesity development and glucose metabolism disorders. Endocrine 2016, 55, 666-681. otwiera się w nowej karcie
  6. Huang, B.; Jiang, C.; Luo, J.; Cui, Y.; Qin, L.; Liu, J. Maternal exposure to bisphenol A may increase the risks of Parkinson's disease through down-regulation of fetal IGF-1 expression. Med. Hypotheses 2014, 82, 245- 249. otwiera się w nowej karcie
  7. Chen, D.; Kannan, K.; Tan, H.; Zheng, Z.; Feng, Y.L.; Wu, Y.; Widelka, M. Bisphenol analogues other than BPA: Environmental occurrence, human exposure and toxicity-A review. Environ. Sci. Technol. 2016, 50, 5438-5453. otwiera się w nowej karcie
  8. Niederst, J.; Evans, R.H.; O'Brien, R.M.; Romagnoli, K.; Killilea, H.T.; Von Maier, M.S.; Deng, L. Developer for Thermally Responsive Record Materials. U.S. Patent 14,418,014, 15 March 2013.
  9. Hsieh, B.Y.; Hsu, J.P. Photosensitive Resin Composition, Color Filter and Method for Manufacturing the Same, and Liquid Crystal Display Apparatus. U.S. Patent 14,554,067, 26 November 2014. 10. Bisphenol A; CASRN 80-05-7. Available online: (accessed on 5 July 2017) otwiera się w nowej karcie
  10. Rochester, J. Bisphenol A and human health: A review on the literature. Reprod. Toxicol. 2013, 42, 132-155. otwiera się w nowej karcie
  11. Rosenmai, A.K; Dybdahl, M.; Pedersen, M.; van Vught-Lussenburg, B.; Wedebye E., Taxvig C., Vinggaard A. Are Structural Analogues to Bisphenol A Safe Alternatives? Toxicol. Sci. 2014, 139, 35-47. otwiera się w nowej karcie
  12. Eladak, S.; Grisin, T.; Moison, D.; Guerquin, M.J.; N'Tumba-Byn, T.; Pozzi-Gaudin, S.; Benachi, A.; Livera, G.; Rouiller-Fabre, V.; Habert, R. A new chapter in the bisphenol A story: Bisphenol S and bisphenol F are not safe alternatives to this compound. Fertil. Steril. 2015, 103, 11-21. otwiera się w nowej karcie
  13. Xue, J.; Kannan, P.; Kumosani, T.; Al-Malki A.; Kannan, K. Resin-based dental sealants as a source of human exposure to bisphenol analogues, bisphenol A diglycidyl ether, and its derivatives, Environ. Res. 2018, 162, 35-40. otwiera się w nowej karcie
  14. Niu, Y.; Wang, B.; Zhao, Y.; Zhang, J.; Shao, B. Highly Sensitive and High-Throughput Method for the Analysis of Bisphenol Analogues and Their Halogenated Derivatives in Breast Milk. J. Agric. Food Chem. 2017, 65, 10452-10463. otwiera się w nowej karcie
  15. Owczarek, K., Kubica, P.; Kudłak, B.; Rutkowska, A.; Rachoń, D.; Namieśnik, J.; Wasik, A. Determination of trace levels of eleven bisphenol A analogues in human blood serum by high performance liquid chromatography-tandem mass spectrometry. Sci. Total Environ. 2018, 628-629, 1362-1368. otwiera się w nowej karcie
  16. Yamazaki, E.; Yamashita, N.; Taniyasu, S.; Lam, J.; Lam, P.; Moon, H.B.; Jeong, Y.; Kannan, P.; Achyuthan, H.; Manuswamy, N.; et al. Bisphenol A and other bisphenol analogues including BPS and BPF in surface water samples from Japan, China, Korea and India. Ecotoxicol. Environ. Saf. 2015, 122, 565-572. otwiera się w nowej karcie
  17. Yang, Y.; Lu, L.; Zhang, J.; Yang, Y.; Wu, Y.; Shao, B. Simultaneous determination of seven bisphenols in environmental water and solid samples by liquid chromatography-electrospray tandem mass spectrometry. J. Chromatogr. A 2014, 1328, 26-34. otwiera się w nowej karcie
  18. Lee, S.; Liao, C.; Song, G.J.; Ra, K.; Kannan, K.; Moon, H.B. Emission of bisphenol analogues including bisphenol A and bisphenol F from wastewater treatment plants in Korea. Chemosphere 2015, 119, 1000-1006. otwiera się w nowej karcie
  19. Song, S.; Song, M.; Zeng, L.; Wang, T.; Liu, R.; Ruan, T.; Jiang, G. Occurrence and profiles of bisphenol analogues in municipal sewage sludge in China. Environ. Pollution 2014, 186, 14-19. otwiera się w nowej karcie
  20. Caballero-Casero, N.; Lunar, L.; Rubio, S. Analytical methods for the determination of mixtures of bisphenols and derivatives in human and environmental exposure sources and biological fluids: A review. Anal. Chim. Acta 2016, 908, 22-53. otwiera się w nowej karcie
  21. Liao, C.; Kannan, K. Concentrations and Profiles of Bisphenol A and Other Bisphenol Analogues in Foodstuffs from the United States and Their Implications for Human Exposure. J. Agric. Food Chem. 2013, 61, 4655-4662. otwiera się w nowej karcie
  22. Rivas A.; Lacroix M.; Olea-Serrano F.; Laios I.; Leclercq G.; Olea N. Estrogenic effect of a series of bisphenol analogues on gene and protein expression in MCF-7 breast cancer cells. J. Steroid Biochem. Mol. Biol. 2002, 82, 45-53. otwiera się w nowej karcie
  23. Fic, A.; Mlakar, S.; Juvan, P.; Mlakar, V.; Marc, J.; Dolnec, M.; Broberg, K.; Masic, L. Genome wide gene expression profiling of low-dose, long-term exposure of human osteosarcoma cells to Bisphenol A and its analogs. Toxicol. In Vitro 2015, 29, 1060-1069. otwiera się w nowej karcie
  24. Wieczerzak, M.; Namieśnik, J.; Kudłak, B. Bioassays as one of the Green Chemistry tools for assessing environmental quality: A review. Environ. Int. 2016, 94, 341-361. 26. Water Framework Directive. Available online: (accessed on 5 October 2017). otwiera się w nowej karcie
  25. Faust, M.; Altenburger, R.; Backhaus, T.; Bodeker, W.; Scholze, M.; Grimme, L.H. Predictive assessment of the aquatic toxicity of multiple chemical mixtures. J. Environ. Qual. 2000, 29, 1063-1068. otwiera się w nowej karcie
  26. Szczepańska, N.; Kudłak, B.; Namieśnik, J. Assessing ecotoxicity and the endocrine potential of selected phthalates, BADGE and BFDGE derivatives in relation to environmentally detectable levels. Sci. Tot. Env. 2018, 610-611, 854-866. otwiera się w nowej karcie
  27. Wieczerzak, M.; Kudłak, B.; Yotova, G.; Nedyalkova, M.; Tsakovski, S.; Simeonov, V.; Namieśnik J. Modeling of pharmaceuticals mixtures toxicity with deviation ratio and best-fit functions models. Sci. Total Environ. 2016, 571, 259-268. otwiera się w nowej karcie
  28. Altenburger, R.; Nendza, M.; Schuurmann, G. Mixture toxicity and its modeling by quantitative structure- activity relationships. Environ. Toxicol. Chem. 2003, 22, 1900-1915. otwiera się w nowej karcie
  29. Belden, J.B.; Gilliom, R.J.; Lydy, M.J. How well can we predict the toxicity of pesticide mixtures to aquatic life? Integr. Environ. Assess. Manag. 2007, 3, 364-372. otwiera się w nowej karcie
  30. Liao, C.; Liu, F.; Guo, Y.; Moon, H-B.; Nakata, H.; Wu, Q.; Kannan, K. Occurrence of Eight Bisphenol Analogues in Indoor Dust from the United States and Several Asian Countries: Implications for Human Exposure. Environ. Sci. Technol. Lett. 2012, 46, 9138-9145. otwiera się w nowej karcie
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