Inhibitors of glucosamine-6-phosphate synthase as potential antimicrobials or antidiabetics – synthesis and properties - Publikacja - MOST Wiedzy

Wyszukiwarka

Inhibitors of glucosamine-6-phosphate synthase as potential antimicrobials or antidiabetics – synthesis and properties

Abstrakt

Glucosamine-6-phosphate synthase (GlcN-6-P synthase) is known as a promising target for antimicrobial agents and antidiabetics. Several compounds of natural or synthetic origin have been identified as inhibitors of this enzyme. This set comprises highly selective L-glutamine, amino sugar phosphate or transition state intermediate cis-enolamine analogues. Relatively low antimicrobial activity of these inhibitors, poorly penetrating microbial cell membranes, has been improved using the pro-drug approach. On the other hand, a number of heterocyclic and polycyclic compounds demonstrating antimicrobial activity have been presented as putative inhibitors of the enzyme, based on the results of molecular docking to GlcN-6-P synthase matrix. The most active compounds of this group could be considered promising leads for development of novel antimicrobial drugs or antidiabetics, provided their selective toxicity is confirmed.

Cytowania

  • 6

    CrossRef

  • 0

    Web of Science

  • 6

    Scopus

Słowa kluczowe

Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY nr 37, strony 1928 - 1956,
ISSN: 1475-6366
Język:
angielski
Rok wydania:
2022
Opis bibliograficzny:
Stefaniak J., Nowak M., Wojciechowski M., Milewski S., Skwarecki A.: Inhibitors of glucosamine-6-phosphate synthase as potential antimicrobials or antidiabetics – synthesis and properties// JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY -Vol. 37,iss. 1 (2022), s.1928-1956
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1080/14756366.2022.2096018
Weryfikacja:
Politechnika Gdańska

wyświetlono 73 razy

Publikacje, które mogą cię zainteresować

Meta Tagi