Filtry
wszystkich: 506
wybranych: 445
Wyniki wyszukiwania dla: wies
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Investigation of the Membrane Localization and Interaction of Selected Flavonoids by NMR and FTIR Spectroscopy
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Polar localization of new flavonoids from aerial parts of Scleranthus perennis and Hottonia palustris and their modulatory action on lipid membranes properties
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Choline Supplementation Sensitizes Legionella dumoffii to Galleria mellonella Apolipophorin III
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Can Immobilized Artificial Membrane Chromatography Support the Characterization of Antimicrobial Peptide Origin Derivatives?
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Photophysical properties of 3-[2-(N-phenylcarbazolyl)benzoxazol-5-yl]alanine derivatives – experimental and theoretical studies
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Early post-fire bird community in European boreal forest: Comparing salvage-logged with non-intervention areas
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Cadmium inhibitory action leads to changes in structure of ferredoxin:NADP+ oxidoreductase
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The Product of Matrix Metalloproteinase Cleavage of Doxorubicin Conjugate for Anticancer Drug Delivery: Calorimetric, Spectroscopic, and Molecular Dynamics Studies on Peptide–Doxorubicin Binding to DNA
PublikacjaMatrix metalloproteinases (MMPs) are extracellular matrix degradation factors, promoting cancer progression. Hence, they could provide an enzyme-assisted delivery of doxorubicin (DOX) in cancer treatment. In the current study, the intercalation process of DOX and tetrapeptide-DOX, the product of the MMPs' cleavage of carrier-linked DOX, into dsDNA was investigated using stationary and time-resolved fluorescence spectroscopy, UV-Vis...
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Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells
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Ontology groups representing angiogenesis and blood vessels development are highly up-regulated during porcine oviductal epithelial cells long-term real-time proliferation – a primary cell culture approach
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Carcinogenesis in mammalian oral mucosa from the perspective of biomedical research
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Selected molecular and physiological aspects of mammalian ovarian granulosa cells in primary culture
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Genetic diversity of Legionella pcs and pmtA genes and the effect of utilization of choline by Legionella spp. on induction of proinflammatory cytokines
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Up-regulation of ferritin ubiquitination in skeletal muscle of transgenic rats bearing the G93A hmSOD1 gene mutation
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Structure–bioavailability relationship study of genistein derivatives with antiproliferative activity on human cancer cell
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Cyclic Dipeptides as Building Units of Nano- and Microdevices: Synthesis, Properties, and Structural Studies
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Self-Association of Amphotericin B: Spontaneous Formation of Molecular Structures Responsible for the Toxic Side Effects of the Antibiotic
PublikacjaAmphotericin B (AmB) is a lifesaving antibiotic used to treat deep-seated mycotic infections. Both the pharmaceutical activity and highly toxic side effects of the drug rely on its interaction with biomembranes, which is governed by the molecular organization of AmB. In the present work we present detailed analysis of self-assembly of AmB molecules in different environments, interesting from the physiological standpoint, based...
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Self-assembly, stability and conductance of amphotericin B channels: bridging the gap between structure and function
PublikacjaAmphotericin B (AmB), one of the most powerful but also toxic drugs used to treat systemic mycoses, is believed to selectively permeabilize fungal cell membranes to ions in a sterol-dependent manner. Unfortunately, the structure of the biologically active AmB channels has long eluded researchers, obstructing the design of safer alternatives. Here, we investigate the structural and thermodynamic aspects of channel formation, stability,...
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Pharmacological treatment of a depressive episode and recurrent depressive disorder – guidelines of the Polish Psychiatric Association and the National Consultant for Adult Psychiatry
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Expression Profile of Genes Regulating Steroid Biosynthesis and Metabolism in Human Ovarian Granulosa Cells—A Primary Culture Approach
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Identification and characterization of Staphylococcus spp. and their susceptibility to insect apolipophorin III
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Modification of gradient HPLC method for determination of small molecules' affinity to human serum albumin under column safety conditions: Robustness and chemometrics study
PublikacjaIn the early stages of drug discovery, beyond the biological activity screening, determining the physicochemical properties that affect the distribution of molecules in the human body is an essential step. Plasma protein binding (PPB) is one of the most important investigated endpoints. Nevertheless, the methodology for measuring %PPB is significantly less popular and standardized than other physicochemical properties, like lipophilicity....
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Structural and luminescence investigation of GeO2-PbO-Bi2O3-SrF2 glasses doped with Eu3+, Tb3+ and Tm3+ ions
PublikacjaThe GeO2-PbO-Bi2O3-SrF2 (GePbBiSr) glass systems doped with Eu3 +, Tb3 +, Tm3 + and triply-doped with Eu3 +/Tb3 +/Tm3 + ions were successfully synthesized. Their structural and luminescent properties have been investigated with various techniques. Obtained results indicate that these glass systems are suitable materials for the RE3 + ions hosts. RE3 + ions can be excited by single UV light wavelength (355/378/395 nm) and simultaneously...
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New Molecular Markers Involved in Regulation of Ovarian Granulosa Cell Morphogenesis, Development and Differentiation during Short-Term Primary In Vitro Culture—Transcriptomic and Histochemical Study Based on Ovaries and Individual Separated Follicles
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The Teutonic crusade in Prussia: reconstruction of a medieval fortified settlement complex at Unisław
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A review on application of artificial neural network (ANN) for performance and emission characteristics of diesel engine fueled with biodiesel-based fuels
PublikacjaBiodiesel has been emerging as a potential and promising biofuel for the strategy of reducing toxic emissions and improving engine performance. Computational methods aiming to offer numerical solutions were inevitable as a study methodology which was sometimes considered the only practical method. Artificial neural networks (ANN) were data-processing systems, which were used to tackle many issues in engineering and science, especially...
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SCORE model underestimates cardiovascular risk in hypertensive patients: Results of the Polish Hypertension Registry
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Time- and Dose-Dependent Effects of 17 Beta-Estradiol on Short-Term, Real-Time Proliferation and Gene Expression in Porcine Granulosa Cells
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Positive Regulation of Macromolecule Metabolic Process Belongs to the Main Mechanisms Crucial for Porcine Oocytes Maturation
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Does Porcine Oocytes Maturation in Vitro is Regulated by Genes Involved in Transforming Growth Factor Beta Receptor Signaling Pathway?
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Expression of integrins and GDF9 mRNAs is associated with ovarian follicle size and donor puberty status in pigs
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Morphogenesis-related gene-expression profile in porcine oocytes before and after in vitro maturation
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“Cell Migration” Is the Ontology Group Differentially Expressed in Porcine Oocytes Before and After In Vitro Maturation: A Microarray Approach
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Genes of cellular components of morphogenesis in porcine oocytes before and after IVM
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Influence of Estradiol-17beta on Progesterone and Estrogen Receptor mRNA Expression in Porcine Follicular Granulosa Cells during Short-Term, In Vitro Real-Time Cell Proliferation
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‘Heart development and morphogenesis’ is a novel pathway for human ovarian granulosa cell differentiation during long‑term in�vitro cultivation‑a microarray approach
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Multivariate assessment of anticancer oleanane triterpenoids lipophilicity
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Determination of tocopherols and tocotrienols in human breast adipose tissue with the use of high performance liquid chromatography-fluorescence detection
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Effect of Drip Fertigation with Nitrogen on Yield and Nutritive Value of Melon Cultivated on a Very Light Soil
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“Bone Development” Is an Ontology Group Upregulated in Porcine Oocytes Before In Vitro Maturation: A Microarray Approach
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Expression of genes associated with BMP signaling pathway in porcine oocytes before and after IVM – a microarray approach
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Acute hypoxia diminishes the relationship between blood pressure and subarachnoid space width oscillations at the human cardiac frequency
PublikacjaAcute hypoxia exerts strong effects on the cardiovascular system. Heart-generated pulsatile cerebrospinal fluid motion is recognised as a key factor ensuring brain homeostasis. We aimed to assess changes in heart-generated coupling between blood pressure and subarachnoid space width oscillations during hypoxic exposure.
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Light-Modulated Sunscreen Mechanism in the Retina of the Human Eye
PublikacjaThe functioning of the human eye in the extreme range of light intensity requires a combination of the high sensitivity of photoreceptors with their photostability. Here, we identify a regulatory mechanism based on dynamic modulation of light absorption by xanthophylls in the retina, realized by reorientation of pigment molecules induced by trans–cis photoisomerization. We explore this photochemically switchable system using chromatographic...
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The lipid composition of Legionella dumoffii membrane modulates the interaction with Galleria mellonella apolipophorin III
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Multisensor System for the Protection of Critical Infrastructure of Seaport
PublikacjaThere are many separated infrastructural objects within a harbor area that may be considered “critical”, such as gas and oil terminals or anchored naval vessels. Those objects require special protection, including security systems capable of monitoring both surface and underwater areas, because an intrusion into the protected area may be attempted using small surface vehicles (boats, kayaks, rafts, floating devices with weapons...
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Genes Involved in the Processes of Cell Proliferation, Migration, Adhesion, and Tissue Development as New Potential Markers of Porcine Granulosa Cellular Processes In Vitro: A Microarray Approach
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Response of Chosen American Asparagus officinalis L. Cultivars to Drip Irrigation on the Sandy Soil in Central Europe: Growth, Yield, and Water Productivity
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The differentiation and transdifferentiation of epithelial cells in vitro – is it a new strategy in regenerative biomedicine?
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Amino acids metabolism and degradation is regulated during porcine oviductal epithelial cells (OECs) primary culture in vitro – a signaling pathways activation approach
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Potential of Explainable Artificial Intelligence in Advancing Renewable Energy: Challenges and Prospects
PublikacjaModern machine learning (ML) techniques are making inroads in every aspect of renewable energy for optimizationand model prediction. The effective utilization of ML techniques for the development and scaling up of renewable energy systemsneeds a high degree of accountability. However, most of the ML approaches currently in use are termed black box since their work isdifficult to comprehend. Explainable artificial intelligence (XAI)...