Wyniki wyszukiwania dla: SELF-EXPRESSION - MOST Wiedzy

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Wyniki wyszukiwania dla: SELF-EXPRESSION

Wyniki wyszukiwania dla: SELF-EXPRESSION

  • Modelling gene expression of a self-regulating protein

    Publikacja

    - Rok 2014

    We analyze a model of gene transcription and protein synthesis. We take into account the number of sites on the protein’s promoter at which the protein’s dimers can bind blocking transcription of protein mRNA.

  • Justification of quasi-stationary approximation in models of gene expression of a self-regulating protein

    We analyse a model of Hes1 gene transcription and protein synthesis with a negative feedback loop. The effect of multiple binding sites in the Hes1 promoter as well as the dimer formation process are taken into account. We consider three, possibly different, time scales connected with: (i) the process of binding to/dissolving from a binding site, (ii) formation and dissociation of dimers, (iii) production and degradation of Hes1...

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  • The Self-employment of Women in Azerbaijan

    Publikacja

    Azerbaijan has a population of more than 10 million, of which women accounted for 50% in 2020. At the same time, 93% of Azerbaijan’s citizens describe themselves as Muslims. Since the beginning of independence, Azerbaijan has been a secular state by virtue of Article 48 of the Constitution, which guarantees the freedom of worship, choice, or non-practice of religion and the freedom of...

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  • TINKTEP: A fully self-consistent, mutually polarizable QM/MM approach based on the AMOEBA force field

    Publikacja
    • J. Dziedzic
    • Y. Mao
    • Y. Shao
    • J. Ponder
    • T. Head-Gordon
    • M. Head-Gordon
    • C. Skylaris

    - JOURNAL OF CHEMICAL PHYSICS - Rok 2016

    We present a novel quantum mechanical/molecular mechanics (QM/MM) approach in which a quantum subsystem is coupled to a classical subsystem described by the AMOEBA polarizable force field. Our approach permits mutual polarization between the QM and MM subsystems, effected through multipolar electrostatics. Self-consistency is achieved for both the QM and MM subsystems through a total energy minimization scheme. We provide an expression...

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  • Data on solutions of Hes1 system

    Dane Badawcze
    open access

    Hes1 protein (hairy and enhancer of split 1) belongs to the helix-loop-helix (bHLH) family of transcription proteins, i.e. DNA-binding proteins in the promoter region or in another region where regulation of transcription processes occurs.    The database collects data on solutions of the Hes1 systems with multiple binding sites and the dimer formation...

  • Entropy Production Associated with Aggregation into Granules in a Subdiffusive Environment

    Publikacja
    • P. Weber
    • P. Bełdowski
    • M. Bier
    • A. Gadomski

    - ENTROPY - Rok 2018

    We study the entropy production that is associated with the growing or shrinking of a small granule in, for instance, a colloidal suspension or in an aggregating polymer chain. A granule will fluctuate in size when the energy of binding is comparable to k_{B}T, which is the “quantum” of Brownian energy. Especially for polymers, the conformational energy landscape is often rough and has been commonly modeled as being self-similar...

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  • Electron mobility variance in semiconductors: the variance approach

    Publikacja
    • S. Melkonyan
    • H. Asriyan
    • A. Surmalyan
    • J. Smulko

    - Armenian Journal of Physics - Rok 2011

    Praca przedstawia nowe podejście da analizy zjawisk losowych w półprzewodnikach. Uwzględnia kilka mechanizmów zjawisk fluktuacji ruchliwości w półprzewodnikach, prowadzących do powstawamai składowej szumów typu 1/f, dominujących w zakresie małych czetotliwości. Przedstawia analizę sposobu wyznaczenia stałej Hooge'a określającej intensywność szumów typu 1/f.The statistical non-triviality of current carrier mobility fluctuations...

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  • Design Equation for Stirring Fluid by a Stream Pump in a Circulating Tank

    Publikacja

    A circulating tank is a very useful theoretical scheme for many fluid-flow objects in several branches of engineering. The motion of the fluid in such objects can be induced in different ways. A stream pump provides an especially interesting possibility; however, the quantitative description of such devices shows some shortcomings. Such a device is analogous to a jet pump, thus has similar advantages (simplicity of construction,...

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  • Framework for gamification of specialized subjects within engineering studies

    Publikacja

    - Rok 2017

    Gamification is a relatively new term forged along with the occurrence of new information technology, especially easy access to internet and smartphones. Gamification is a use of game mechanics, to modify the behavior of people in non-games situations to increase the involvement of individuals. The method is based on the pleasure that comes from overcoming the obstacles to reach next achievable level, which consists of challenges,...

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  • O07 Filaggrin insufficiency renders keratinocyte-derived small extracellular vesicles capable of affecting CD1a-mediated T-cell responses and promoting allergic inflammation

    Publikacja
    • A. Kobiela
    • W. Hewelt-Belka
    • J. Frackowiak
    • N. Kordulewska
    • L. Hovhannisyan
    • A. Bogucka
    • R. Etherington
    • A. Pirog
    • I. Dapic
    • S. Gabrielsson... i 3 innych

    - BRITISH JOURNAL OF DERMATOLOGY - Rok 2023

    The association between FLG loss-of-function mutations and the development of atopic dermatitis (AD) indicates that filaggrin is critical to skin barrier function; the mutations are also linked to additional allergic manifestations, but it is unknown how the skin may influence inflammation in distant tissues. Here we investigated the impact of filaggrin insufficiency on keratinocyte-derived exosome-enriched small extracellular...

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  • Practical Approach to Large-Scale Electronic Structure Calculations in Electrolyte Solutions via Continuum-Embedded Linear-Scaling Density Functional Theory

    Publikacja
    • J. Dziedzic
    • A. Bhandari
    • L. Anton
    • C. Peng
    • J. Womack
    • M. Famili
    • D. Kramer
    • C. Skylaris

    - Journal of Physical Chemistry C - Rok 2020

    We present the implementation of a hybrid continuum-atomistic model for including the effects of a surrounding electrolyte in large-scale density functional theory (DFT) calculations within the Order-N Electronic Total Energy Package (ONETEP) linear-scaling DFT code, which allows the simulation of large complex systems such as electrochemical interfaces. The model represents the electrolyte ions as a scalar field and the solvent...

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  • Online brand communities’ contribution to digital business models

    Abstract Purpose – There is limited research examining social drivers and mediators of online brand community identification in the context of business models development. This study aims to identify them behind the social mechanisms and present essential factors which should be applied in business models to foster value co-creation. Design/methodology/approach – Data were collected from a convenience sample of 712 cases gathered among...

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