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Targeting yeast topoisomerase II by imidazo and triazoloacridinone derivatives resulting in their antifungal activity
PublikacjaFungal pathogens are considered as serious factors for deadly diseases and are a case of medical concern. Invasive fungal infections also complicate the clinical course of COVID-19, leading to a significant increase in mortality. Furthermore, fungal strains' multidrug resistance has increased the demand for antifungals with a different mechanism of action. The present study aimed to identify antifungal compounds targeting yeast...
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Solvent influence on the crystal structures of new cadmium tri-tert -butoxysilanethiolate complexes with 1,4-bis(3-aminopropyl)piperazine: luminescence and antifungal activity
PublikacjaMonocrystals of dinuclear 1,4-bis(3-aminopropyl)piperazine-�4N1,N10:N4,N40-bis[bis(tri-tert-butoxysilanethiolato-�S)cadmium(II)], [Cd2(C12H27O3SSi)4(C10-H24N4)] or [Cd2{SSi(OtBu)3}4(�-BAPP)], 1, and polynuclear catena-poly[[bis- (tri-tert-butoxysilanethiolato-�S)cadmium(II)]-�-1,4-bis(3-aminopropyl)piperazine-�2N10:N40], [Cd(C12H27O3SSi)2(C10H24N4)]n or [Cd{SSi(OtBu)3}2(�-BAPP)]n, 2, with 1,4-bis(3-aminopropyl)piperazine (BAPP)...
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Anticancer Study on IrIII and RhIII Half-Sandwich Complexes with the Bipyridylsulfonamide Ligand
PublikacjaTwo non-platinum compounds, organometallic half-sandwich complexes [(η 5 -Cp)IrCl(L)]PF 6 (1) and [(η 5 -Cp)RhCl(L)]PF 6 (2) were prepared by treating pentamethylcyclopentadienyl chloride dimers of iridium(III) or rhodium(III) with the obtained 4-amino-N-(2,2'-bipyridin-5- yl)benzenesulfonamide ligand (L) and ammonium hexafluorophosphate. The crystal structures of ligand (L) and complexes 1 and 2 were obtained and then analyzed. Coordination...
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Solvent influence on the crystal structures of new cadmium tri-tert -butoxysilanethiolate complexes with 1,4-bis(3-aminopropyl)piperazine: luminescence and antifungal activity
PublikacjaMonocrystals of dinuclear -1,4-bis(3-aminopropyl)piperazine-4N1,N10:N4,N40-bis[bis(tri-tert-butoxysilanethiolato-S)cadmium(II)], [Cd2(C12H27O3SSi)4(C10-H24N4)] or [Cd2{SSi(OtBu)3}4(-BAPP)], 1, and polynuclear catena-poly[[bis-(tri-tert-butoxysilanethiolato-S)cadmium(II)]--1,4-bis(3-aminopropyl)piperazine-2N10:N40], [Cd(C12H27O3SSi)2(C10H24N4)]n or [Cd{SSi(OtBu)3}2(-BAPP)]n,2, with 1,4-bis(3-aminopropyl)piperazine (BAPP)...
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Possibilities of Using Medicinal Plant Extracts and Salt-Containing Raw Materials from the Aral Region for Cosmetic Purposes
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Biochemical Characterization and Validation of a Catalytic Site of a Highly Thermostable Ts2631 Endolysin from the Thermus scotoductus Phage vB_Tsc2631
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The New 3D Printed Left Atrial Appendage Closure with a Novel Holdfast Device: A Pre-Clinical Feasibility Animal Study
PublikacjaMany patients undergoing cardiac surgery have risk factors for both atrial fibrillation and stroke. The left atrial appendage (LAA) is the primary site for thrombi formation. Therefore LAA occlusion devices should be tested for their ability to reduce future cerebral ischemic events in patients with high-risk of haemorrhage. The aim of this study was to evaluate the safety and feasibility of a novel left atrial appendage exclusion...
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Atypical application of the parametric method for track infrastructure inventory
PublikacjaFor many years, satellite systems have seen widespread use in a variety of technical applications, as well as in operations related to setting-out and the exploitation of track infrastructure. Their main applications include an inventory of the trackage course and detecting changes in its position. In both of these tasks, the most important element that determines the quality of an analyses is the high accuracy of the determinations...
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Palindromic carbazole derivatives: unveiling their antiproliferative effect via topoisomerase II catalytic inhibition and apoptosis induction
PublikacjaHuman DNA topoisomerases are essential for crucial cellular processes, including DNA replication, transcription, chromatin condensation, and maintenance of its structure. One of the significant strategies employed in cancer treatment involves the inhibition of a specific type of topoisomerase, known as topoisomerase II (Topo II). Carbazole derivatives, recognised for their varied biological activities, have recently become a significant...
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Writing in Richardson variant of progressive supranuclear palsy in comparison to progressive non-fluent aphasia
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Relation of the polymorphism of cyp51A sequence and the susceptibility of Aspergillus fumigatus isolates to triazoles determined by commercial gradient test (Etest) and by reference methods
PublikacjaThe aim of this study was to evaluate the accuracy of commercial gradient test (Etest) in the detection of triazole resistant Aspergillus fumigatus isolates using reference microdilution methods and the analysis of sequences of the cyp 51A gene. The study was performed on twenty clinical isolates which were identified as Aspergillus fumigatus based on the DNA sequences of the ITS1-2 fragment of ribosomal DNA and the β-tubulin gene,...
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Multi-Technique Investigation of Grave Robes from 17th and 18th Century Crypts Using Combined Spectroscopic, Spectrometric Techniques, and New-Generation Sequencing
PublikacjaThe textile fragments of the funeral clothes found in the 17th and 18th century crypts were subjected to spectroscopic, spectrometric, and microbial investigation. The next-generation sequencing enabled DNA identification of microorganisms at the genus and in five cases to the species level. The soft hydrofluoric acid extraction method was optimized to isolate different classes of dyes from samples that had direct contact with...
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Methods of Experiment Design, W, E, sem.01, letni 22/23 (PG_00057505)
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Planowanie Eksperymentu i Analiza Błędów, C, MiBM, sem.01, letni 22/23 (PG_00057365)
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Planowanie eksperymentu i analiza błędów, W, MiBM, sem.01, letni 21/22 (PG_00057365)
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Wpływ energetyki na klimat, P, E, sem.02, zimowy 22/23 (PG_00057270)
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Planowanie eksperymentu i analiza błędów, W, MiBM, sem.01, letni 21/22 (PG_00057435)
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KOMPUTEROWE PROJEKTOWANIE MASZYN Z WYKORZYSTANIEM MODELOWANIA 3D, W, MiBM, sem. 5, zimowy 22/23 PG_00005421,
Kursy OnlineMetody opisu kształtu w programach MES. Metody automatycznego podziału modelu geometrycznego konstrukcji na elementy skończone powłokowe i objętościowe. Możliwości i korzyści parametrycznego opisu modelu geometrycznego, podparcia i obciążenia w modelu MES. Przebieg analizy stanu naprężenia i oceny sztywności konstrukcji w zakresie liniowym; różnice w zastosowaniu elementów liniowych, powierzchniowych i objętościowych. Modele...
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Planowanie Eksperymentu i Analiza Błędów, C, MiBM, sem.01, letni 22/23 (PG_00059367)
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WETI - IBM sem. 1 grupy 1, 2, 3 - Matematyka 2022/2023 (W.Dąbrowski)
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Planning of experiments and error analysis, C, IDE, sem.01, letni 22/23 (PG_00057374)
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Methods of Experiment Design, W, E, sem.01, letni 21/22 (PG_00057505)
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Planowanie Eksperymentu i Analiza Błędów, W, MiBM, sem.01, letni 22/23 (PG_00057365)
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Planning of experiments and error analysis, W, MiBM, letni 21/22 (PG_00057374)
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WIMiO - Mechatronika gr. 3, 4, sem. 2 - Matematyka II 2022/2023 (W.Dąbrowski)
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Wybrane zagadnienia transportu ciepła i masy, P, E, sem.02, zimowy 22/23 (PG_00059161)
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Planowanie eksperymentu i analiza błędów, C, MiBM, sem.01, letni 21/22 (PG_00057365)
Kursy Online -
Planowanie eksperymentu i analiza błędów, C, MiBM, sem.01, letni 21/22 (PG_00057435)
Kursy Online -
Wybrane zagadnienia transportu ciepła i masy, P, E, sem.02, zimowy 22/23 (PG_00059161)
Kursy Online -
Planowanie Eksperymentu i Analiza Błędów, W, MiBM, sem.01, letni 22/23 (PG_00059367)
Kursy Online -
Planning of experiments and error analysis, W, IDE, sem.01, letni 22/23 (PG_00057374)
Kursy Online -
Methods of Experiment Design, S, E, sem.01, letni 21/22 (PG_00057505)
Kursy Online -
Methods of Experiment Design, S, E, sem.01, letni 22/23 (PG_00057505)
Kursy Online -
Wpływ energetyki na klimat, C, E, sem.02, zimowy 22/23 (PG_00057270)
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Planning of experiments and error analysis, C, MiBM, letni 21/22 (PG_00057374)
Kursy Online -
Marketing Research ID - summer 2022/2023
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WETI - Informatyka sem. 1 gr. 2 - Analiza Matematyczna 2023/2024 (W.Dąbrowski)
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WIMiO - Mechatronika Matlab 1, 2, 5, 6 2022/2023 (W.Dąbrowski)
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WETI - IBM ACiR, sem. 2 - Analiza Matematyczna II 2023/2024 (W.Dąbrowski)
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WETI - Informatyka sem. 1 gr. 2 - Algebra Liniowa 2023/2024 (W.Dąbrowski)
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WETI - IBM sem. 1 gr. 1, 2, 3, 4 - Podstawy Matematyki 2023/2024 (W.Dąbrowski)
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Modelowanie matematyczne i numeryczne, P, MiBM, sem.01, letni 22/23 (PG_00059366)
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WETI - Informatyka sem. 1 gr. 2 - Matematyka Elementarna 2023/2024 (W.Dąbrowski)
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WETI - IBM sem. 1 gr. 1, 2, 3, 4 - Algebra Liniowa 2023/2024 (W.Dąbrowski)
Kursy Online -
Modelowanie matematyczne i numeryczne, W, MiBM, sem.01, letni 22/23 (PG_00059366)
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WETI - IBM sem. 1 gr. 1, 2, 3, 4 - Analiza Matematyczna 2023/2024 (W.Dąbrowski)
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Crystal structure and initial characterization of a novel archaeal-like Holliday junction-resolving enzyme from Thermus thermophilus phage Tth15-6
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KOMPUTEROWE PROJEKTOWANIE MANIPULATORÓW I ROBOTÓW [2023/24]
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Atypical application of the parametric method for track infrastructure inventory
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Determination of amino acids in urine of patients with prostate cancer and benign prostate growth
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