Wyszukiwarka
Filtry
wszystkich: 3965
wybranych: 922
Wyniki wyszukiwania dla: ALZHEIMER’S DISEASE
-
An Overview of Several Inhibitors for Alzheimer’s Disease: Characterization and Failure
Publikacja -
Are advanced glycation end-products specific biomarkers for Alzheimer's disease?
Publikacja -
Vitamin D receptor gene polymorphisms in Alzheimer's disease patients
Publikacja -
Analysis of Serum of Patients With Alzheimer’s Disease for the Level of Advanced Glycation End Products
Publikacja -
SYNTHESIS OF PHOSPHORUS TACRINE ANALOGUES AS A NEW POTENTIAL ANTI-ALZHEIMER’S DISEASE AGENTS
PublikacjaA series of novel phosphorus tacrine derivatives was obtained in three steps, including synthesis of 9-chlorotacrine, connection of 9-chlorotacrine with hexamethylenediamine, 1,8-diaminooctane and 1,12-diaminododecane linkers and reaction of obtained tacrine diamine analogues with corresponding acid ester to give nine tacrine organophosphorus compounds. All of the obtained final structures were characterized by 1H NMR, 13C NMR,...
-
Investigating the disease‐modifying properties of sclerotiorin in Alzheimer's therapy using acetylcholinesterase inhibition
Publikacja -
Investigating the disease- modifying properties of sclerotiorin in Alzheimer's therapy using acetylcholinesterase inhibition
PublikacjaAlzheimer's disease (AD) is a progressive neurodegenerative disorder caused due to the damage and loss of neurons in specific brain regions. It is the most common form of dementia observed in older people. The symptoms start with memory loss and gradually cause the inability to speak and do day-to-day activities. The cost of caring for those affected individuals is huge and is probably beyond most developing countries capability....
-
Ovocystatin Induced Changes in Expression of Alzheimer’s Disease Relevant Proteins in APP/PS1 Transgenic Mice
Publikacja -
Errorless Learning as a method of neuropsychological rehabilitation of individuals suffering from dementia in the course of Alzheimer’s disease
Publikacja -
Tackling Alzheimer's disease: Hypothetical synergism between anti-inflammatory and anti-diabetic agents
Publikacja -
Cognitive Abilities of Alzheimers Disease Transgenic Mice are Modulated by Social Context and Circadian Rhythm
Publikacja -
Selected mice models based on APP, MAPT and presenilin gene mutations in research on the pathogenesis of Alzheimer’s disease
Publikacja -
Design of new cholinesterase inhibitors based on phosphorus analogs of tacrine as potential anti-Alzheimer’s disease agents
PublikacjaBased on the analysis of the determined free binding energy (using the AutoDock Vina 1.1.2 docking program), the most potent cholinesterase inhibitors were selected. Moreover, studies of 3D visualization of the results of molecular modeling led to the identification of potential sites for the interaction of new potential inhibitors with amino acid residues building active sites of investigated cholinesterases.
-
Detection of Alzheimer's disease using Otsu thresholding with tunicate swarm algorithm and deep belief network
PublikacjaIntroduction: Alzheimer’s Disease (AD) is a degenerative brain disorder characterized by cognitive and memory dysfunctions. The early detection of AD is necessary to reduce the mortality rate through slowing down its progression. The prevention and detection of AD is the emerging research topic for many researchers. The structural Magnetic Resonance Imaging (sMRI) is an extensively used imaging technique in detection of AD, because...
-
Oxidative stress and oxidative DNA damage is characteristic for mixed Alzheimer disease/vascular dementia
Publikacja -
Design, synthesis and biological evaluation of novel N-phosphorylated and O-phosphorylated tacrine derivatives as potential drugs against Alzheimer’s disease
PublikacjaIn this work, we designed, synthesised and biologically investigated a novel series of 14N- and O-phosphorylated tacrine derivatives as potential anti-Alzheimer’s disease agents. In the reaction of 9-chlorotacrine and corresponding diamines/aminoalkylalcohol we obtained diamino and aminoalkylhydroxy tacrine derivatives. Next, the compounds were acid to give final products 6–13 and 16–21 that were characterised by 1H, 13 C, 31P...
-
Therapeutic Potential of Multifunctional Tacrine Analogues
PublikacjaTacrine is a potent inhibitor of cholinesterases (acetylcholinesterase and butyrylcholinesterase) that shows limiting clinical application by liver toxicity. In spite of this, analogues of tacrine are considered as a model inhibitor of cholinesterases in the therapy of Alzheimer’s disease. The interest in these compounds is mainly related to a high variety of their structure and biological properties. In the present review, we...
-
Gastroesophageal Reflux Disease in Children with Interstitial Lung Disease
Publikacja -
cGMP level in idiopathic Parkinson’s disease patients with and without cardiovascular disease – A pilot study
Publikacja -
Diverse Expression of Selected SMN Complex Proteins in Humans with Sporadic Amyotrophic Lateral Sclerosis and in a Transgenic Rat Model of Familial Form of the Disease
Publikacja -
Sleep disorders in Parkinson's disease
Publikacja -
Depression and anxiety in cardiovascular disease
Publikacja -
Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
PublikacjaThe proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...
-
Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
PublikacjaThe proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...
-
Oxylipins in Plant Protection/Disease Management
Publikacja -
Kikuchi-Fujimoto disease: State of the art
Publikacja -
Genetic predisposition to inflammatory bowel disease
PublikacjaInflammatory bowel disease (IBD) is a chronic, incurable inflammatory disease of the digestive system. The two main disease entities included in the IBD are ulcerative colitis and Crohn's disease. According to epidemiological studies there are more and more new cases every year. In especially among the youngest patients with symptoms of malnutrition and growth inhibition to land up in hospitalwith cancer suspected. The purpose...
-
Markov Model of Disease Development and Recovery
PublikacjaMarkov models are commonly used to simulate diseases and allow modeling of multiple health states and outcomes. Starting with the well known Le Bras multistate model (cascading failure model) with time-independent transitions we will see how simple Markov mortality models may be pressed into the service of survival and event history analysis. We will focus on more complex models which will be able to take into account remission,...
-
Three episodes of Kawasaki disease including one after the Pneumo 23 vaccine in a child with a family history of Kawasaki disease
Publikacja -
Treatment of Autoinflammatory Diseases
Publikacja -
Vaccinations in rheumatic diseases
Publikacja -
Metabolomics in cardiovascular diseases
Publikacja -
Arsenic causing gallbladder cancer disease in Bihar
Publikacja -
Behçet’s Disease in a Polish Patient: A Case Report
Publikacja -
Diagnosis of preeclampsia in women with diabetic kidney disease
Publikacja -
Gastroesophageal Reflux Disease in Children with Cystic Fibrosis
Publikacja -
Different effect of smoking on genders in Crohn’s disease
Publikacja -
Pertussis: History of the Disease and Current Prevention Failure
Publikacja -
Editorial(Hot Topic: Proteolysis in Health and Disease)
Publikacja -
Antibody Cross-Reactivity in Serodiagnosis of Lyme Disease
PublikacjaLyme disease is a tick-borne disease caused by spirochetes belonging to the Borrelia burgdorferi sensu lato complex. The disease is characterized by a varied course; therefore, the basis for diagnosis is laboratory methods. Currently, a two-tiered serological test is recommended, using an ELISA as a screening test and a Western blot as a confirmatory test. This approach was introduced due to the relatively high number of false-positive...
-
Recent developmentsinthesynthesisand biological activityofacridine/acridoneanalogues
PublikacjaMany people in the world struggle with cancer or bacterial, parasitic, viral, Alzheimer's and other diseases. Therefore, many scientists seek new, more effective, more selective and less toxic drugs. Acridine/acridone derivatives constitute a class of compounds with a broad spectrum of biological activity and are of great interest to scientists. Todate, many acridine/acridone analogues have been obtained,which, inter alia, exhibit...
-
Microbial acetylcholinesterase inhibitors for Alzheimer’s therapy: recent trends on extraction, detection, irradiation-assisted production improvement and nano-structured drug delivery
Publikacja -
Female Fabry disease patients and X-chromosome inactivation
Publikacja -
Elite athletes with COVID-19 — Predictors of the course of disease
Publikacja -
Acceptance of the disease and sexual functions of patients with heart failure
Publikacja -
Managing comorbid cardiovascular disease and sleep apnea with pharmacotherapy
Publikacja -
EDITORIALHypertension and cardiovascular disease: Is arterial stiffness the heart of the matter?
Publikacja -
Plasma Lipid Composition and Risk of Developing Cardiovascular Disease
Publikacja -
Cognitive decline in Huntington's disease expansion gene carriers
Publikacja -
The Impact of Huntington Disease on Family Carers: a Literature Overview
Publikacja