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Wyniki wyszukiwania dla: OPIPRAMOL BASE
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Improvement of opipramol base solubility by complexation with β-cyclodextrin
PublikacjaOpipramol (OPI), a tricyclic antidepressant and anxiolytic compound, is administered orally in the form of a dihydrochloride. Salt form of the drug has a higher solubility in water and hence bioavailability and stability. A similar effect can be achieved by closing the hydrophobic part of the drug molecule in the cyclodextrin cavity. The paper presents opipramol inclusion complexes with beta-cyclodextrin (β-CD) in 1:1 molar ratio....
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Applied Sciences-Basel
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Determination of the chemical structure of potential organic impurities occurring in drug substance opipramol
PublikacjaThe tricyclic antipsychotic and antidepressant drug opipramol (opipramole) was examined with regard to the chemical structure of its organic impurities. Impurities were isolated from the technical product by chromatographic methods and their chemical structures were established by 1H NMR, MS and FTIR and further confirmed by comparison with commercially available products or with products obtained by independent synthesis, and...
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Agronomy-Basel
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Agriculture-Basel
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Determination of the chemical structure of potencial organic impurities occuring in the drug substance opopramol
PublikacjaThe tricyclic antipsychotic and antidepressant drug opipramol was examined with regard to the chemical structure of its organic impurities. Impurities were isolated from the technical product by chromatographic methods and their chemical structures were estabilished by HMNR, MS and FTIR.
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Plants-Basel
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Antibiotics-Basel
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Symmetry-Basel
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Detoxification of the tricyclic antidepressant opipramol and its analog – IS-noh by UGT enzymes before and after activation by phase I enzymes in rat liver microsomes
PublikacjaThe present studies were carried out to evaluate the simultaneous one-pot metabolism of opipramol (IS-opi) and analog (IS-noh) by phase I and phase II enzymes present in rat liver microsomes (RLM) as an alternative to separate testing with recombinant enzymes. This approach allows for more time-saving and cost-effective screening of the metabolism of newly discovered drugs. We also considered that the lack of results for phase...
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KNOWLEDGE-BASED SYSTEMS
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Contextualizing a Knowledge Base by Approximation – A Case Study
PublikacjaModular knowledge bases give their users opportunity to store and access knowledge at different levels of generality. In this paper we present how to organize a modular knowledge bases organized into contexts in which a user can express their knowledge in much simplified way, yet without losing its precision. The work is centered around the notion of approximation - i.e. reducing the arity of predicates used. The presentation is...
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Oase
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Case Study and Case Report
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Evaluation of Readiness of IT Organizations to Agile Transformation Based on Case-Based Reasoning
PublikacjaNowadays many of IT organization decides to change the way of delivering from classic, waterfall approach to agile. This transition is called “agile transformation” (AT). The problem of this process is that part of companies started AT without any analysis. This causes that many of transitions fails and organizations must return to old methods of delivering. Cost of return is significant and number of projects with violated project...
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Smart Cities System Design Method Based on Case Based Reasoning
PublikacjaThe objective of this paper is to present the results of research carried out to develop a design method for Smart Cities systems. The method is based on the analysis of design cases of Smart Cities systems in cities, the selection of the city appropriate to the requirements for implementation and application. The Case Based Reasoning method was used to develop the proposed design methodology, along with mechanisms of the conversion...
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SKULL BASE-AN INTERDISCIPLINARY APPROACH
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Informatics-Basel
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Batteries-Basel
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Diversity-Basel
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Dietetics-Basel
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Logistics-Basel
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Obesities-Basel
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CASE Journal
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Nutraceuticals-Basel
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DBpedia and YAGO as Knowledge Base for Natural Language Based Question Answering—The Evaluation
PublikacjaThe idea of automatic question answering system has a very long history. Despite constant improvement of the systems asking questions in the natural language requires very complex solutions. In this paper the DBpedia and YAGO are evaluated as a knowledge bases for simple class 1 and 2 question answering system. For this purpose a question answering system was designed and implemented. The proposed solution and the knowledge bases...
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Case Studies in Construction Materials
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Supporting compliance with safety standards by trust case templates
PublikacjaStandard Compliance (SC) Framework presented in this paper encompasses methods and tools which provide support for application of standards. The framework is based on trust case methodology. A trust case is a data structure which represents a justification that an object (a system, an infrastructure, an organization) exhibits certain properties. It contains an argument and related evidence which support claimed properties. A trust...
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Vanadium complexes with salicylaldehyde-based Schiff base ligands—structure, properties and biological activity
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Ensemble Online Classifier Based on the One-Class Base Classifiers for Mining Data Streams
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Case Studies in Thermal Engineering
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DATA BASE FOR ADVANCES IN INFORMATION SYSTEMS
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A model-based approach to analysis of security protocols - a case study
PublikacjaArtykuł przedstawia zintegrowane środowisko analizy protokołów bezpieczeństwa. Środowisko zostało oparte o znaną metodę formalną CSP oraz wspierające ją narzędzia: Casper oraz FDR. Integralną częścią opisywanego środowiska jest pół-formalne zorientowane obiektowo podejście do modelowania protokołów kryptograficznych, ich kontekstu aplikacyjnego oraz wymagań bezpieczeństwa. Modelowanie obiektowe zostało oparte o język UML oraz...
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On application of the Case-Based Reasoning methods in ship automation design
PublikacjaW artykule przedstawiono metodę wnioskowania na podstawie przypadków oraz dwa przykłady jej zastosowania w projektowaniu statków. Pierwszy przykład dotyczy systemu projektowania koncepcyjnego statku. Drugi przykład odnosi się do projektowania układów automatyki okrętowej. Omówiono szczegółowo problemy doboru funkcji podobieństwa w metodzie wnioskowania na podstawie przypadków.
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Equivalence scales based on stochastic indifference criterion : the case of Poland
PublikacjaArtykuł przedstawia koncepcję stochastycznych skał ekwiwalentności (SES), która bazuje na kryterium stochastycznej indyferencji. SES jest dowolną funkcją, która transformuje rozkład wydatków określonej grupy gospodarstw domowych w taki sposób, że wynikowy rozkład jest stochastycznie indyferentny wobec rozkładu wydatków grupy gospodarstw odniesienia. Kryterium stochastycznej indyferencji jest także wykorzystane dla opracowania metody...
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Base Group Sp. z o.o. na PG – spotkanie stacjonarne
Wydarzenia25 maja br. Biuro Karier PG oraz Wydział Inżynierii Mechanicznej i Okrętownictwa zaprasza studentów i absolwentów PG na spotkanie z przedstawicielami firmy produkcyjnej Base Group Sp. z o.o.
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A & A Practice
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Biosensors-Basel
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Children-Basel
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Nase More
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Hospital case management : the monthly update on hospital-based care planning and critical paths
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Copula-based geohazard assessment – case of flood-prone area in Poland
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Experience Based Clinical Decision Support Systems: An Overview and Case Studies
PublikacjaThis chapter briefly overviews the evolution of the application of the Decisional DNA and the Set of Experience Knowledge Structure (SOEKS) in the medical domain and in particular in the specific case of the experience-based decision support systems. Decisional DNA, as a knowledge representation structure, offers great possibilities on gathering explicit knowledge of formal decision events as well as a tool for decision making...
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Smart Virtual Bass Synthesis Algorithm Based on Music Genre Classification
PublikacjaThe aim of this paper is to present a novel approach to the Virtual Bass Synthesis (VBS) algorithms applied to portable computers. The proposed algorithm employed automatic music genre recognition to determine the optimum parameters for the synthesis of additional frequencies. The synthesis was carried out using the non-linear device (NLD) and phase vocoder (PV) methods depending on the music excerpt genre. Classification of musical...
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Bass Enhancement Settings in Portable Devices Based on Music Genre Recognition
PublikacjaThe paper presents a novel approach to the Virtual Bass Synthesis (VBS) applied to mobile devices, called Smart VBS (SVBS). The proposed algorithm uses an intelligent, rule-based setting of bass synthesis parameters adjusted to the particular music genre. Harmonic generation is based on a nonlinear device (NLD) method with the intelligent controlling system adapting to the recognized music genre. To automatically classify music...
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STUDIA BAS
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ACTA HAEMATOL-BASEL
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Case Reports in Ophthalmology
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Case Reports in Dermatology
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Case Reports in Pediatrics
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