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total: 179
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Search results for: pathology
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On the Role of Melatonin in Skin Physiology and Pathology
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Vitamin D in the skin physiology and pathology.
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Metal accumulation in the human uterus varies by pathology and smoking status
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Lipids and Lipid Mediators Associated with the Risk and Pathology of Ischemic Stroke
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Characteristics of olfactory function in a healthy geriatric population. Differences between physiological aging and pathology
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Increased risk of thyroid pathology in patients with thyroid hemiagenesis: results of a large cohort case–control study
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Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
PublicationThe proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...
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Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
PublicationThe proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...
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Transcriptomics‐Based and AOP‐Informed Structure–Activity Relationships to Predict Pulmonary Pathology Induced by Multiwalled Carbon Nanotubes
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Analysis of 21 appendices from children with multisystem inflammatory syndrome compared to specimens of acute appendicitis – a new insight into MIS-C pathology
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Can We Go beyond Pathology? The Prognostic Role of Risk Scoring Tools for Cancer-Specific Survival of Patients with Bladder Cancer Undergoing Radical Cystectomy
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Pre-clinical toxicology and pathology of 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine (C-1748), a novel anti-cancer agent in male Beagle dogs
PublicationPraca zawiera wyniki badań przedklinicznych i morfologicznych pochodnej akrydyny o symbolu C-1748 przeprowadzonych na psach. Wyznaczono maksymalną dawkę tolerowaną oraz przeprowadzono analizy zmiany składu krwi i morfologii jej komórek, pracy aminotransferaz, fosfokinaz, fosfataz i innych enzymów funkcjonalnych. Obserwowano też zachowanie się zwierząt. Stwierdzono, że związek ten wykazuje stosunkowo niską toksyczność, co przy obserwowanej...
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Allelic length of a CA dinucleotide repeat in theegfr gene correlates with the frequency of amplifications of this sequence—first results of an inter-ethnic breast cancer study
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Morphological Alterations in the Tympanic Membrane Affected by Tympanosclerosis: Ultrastructural Study
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Molecular Heterogeneity of Papillary Thyroid Cancer: Comparison of Primary Tumors and Synchronous Metastases in Regional Lymph Nodes by Mass Spectrometry Imaging
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Waveguide model of the hearing aid earmold system
PublicationBackground The earmold system of the Behind-The-Ear hearing aid is an acoustic system that modifies the spectrum of the propagated sound waves. Improper selection of the earmold system may result in deterioration of sound quality and speech intelligibility. Computer modeling methods may be useful in the process of hearing aid fitting, allowing physician to examine various earmold system configurations and choose the optimum one...
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Automatic assessment of the motor state of the Parkinson's disease patient --a case study
PublicationThis paper presents a novel methodology in which the Unified Parkinson's Disease Rating Scale (UPDRS) data processed with a rule-based decision algorithm is used to predict the state of the Parkinson's Disease patients. The research was carried out to investigate whether the advancement of the Parkinson's Disease can be automatically assessed. For this purpose, past and current UPDRS data from 47 subjects were examined. The results...
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A new method for measuring the psychoacoustical properties of tinnitus
Publicationinformation, select the tinnitus treatment and quantitatively substantiate its effects, the measurement of the Tinnitus psychoacoustic parameters should be made an inherent part of the Tinnitus therapy. Methods For this purpose the multimedia-based sound synthesizer has been proposed for testing tinnitus and the results obtained this way are compared with the outcome of the audiometer-based Wilcoxon test. The method has been verified...
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Methods of Improving Speech Intelligibility for Listeners with Hearing Resolution Deficit
PublicationMethods developed for real-time time scale modification (TSM) of speech signal are presented. They are based onthe non-uniform, speech rate depended SOLA algorithm (Synchronous Overlap and Add). Influence of theproposed method on the intelligibility of speech was investigated for two separate groups of listeners, i.e. hearingimpaired children and elderly listeners. It was shown that for the speech with average rate equal to or...
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Ultrastructural analysis of the submandibular sialoliths: Raman spectroscopy and electron back-scatter studies
PublicationThe aim of work was the epidemiological analysis of the occurrence of sialolithiasis of the submandibular gland in adults and the evaluation of the ultrastructure of salivary stones. The study sample consisted of 44 sialoliths. Analysis of the structure and chemical composition of sialoliths was performed using a Scanning Electron Microscope and Raman Spectroscopy. Comparing our results with the literature we can say that the epidemiology...
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Reduced expression of ELAVL4 in male meningioma patients
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Molecular Classification of Low-Grade Diffuse Gliomas
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High- and low-Molecular Weight oat Beta-Glucan Reveals Antitumor Activity in Human Epithelial Lung Cancer
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Ultrastructural alterations of the tympanic membrane in retraction pockets from patients with chronic otitis media
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The influence of road transport on the activities of glutathione reductase, glutathione peroxidase, and glutathione-S-transferase in equine erythrocytes
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Serum biochemical reference intervals for the Polish Konik horse (Equus cabalus gmeliniAnt.)
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Effects of melatonin on lipid peroxidation and antioxidative enzyme activities in the liver, kidneys and brain of rats administered with benzo(a)pyrene
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Ezrin--a useful factor in the prognosis of nephrotic syndrome in children: an immunohistochemical approach
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Prognostic value of stage IV neuroblastoma metastatic immunophenotype in the bone marrow: preliminary report
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The significance of substance P in physiological and malignant haematopoiesis
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The predicting role of substance P in the neoplastic transformation of the hypoplastic bone marrow
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Comparison of pathological staging and grading of urothelial bladder carcinoma in post-transurethral resection and post-radical cystectomy specimens
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Docking is not enough: 17-trifluoromethylphenyl trinor PGF2α is only a very weak ligand of neurokinin-1 receptor
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CD99 correlates with low cyclin D1, high topoisomerase 2 status and triple negative molecular phenotype but is prognostically irrelevant in breast carcinoma
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Prognostic Value of TOP2A Gene Amplification and Chromosome 17 Polysomy in Early Breast Cancer
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Keratin 7 expression in lymph node metastases but not in the primary tumour correlates with distant metastases and poor prognosis in colon carcinoma
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Pathomorphology of the Liver in Dogs with Clinical Signs of Portosystemic Shunts
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Effects of stressful physico-chemical factors on the fitness of the plant pathogenic bacterium Dickeya solani
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Nonfatal and fatal intoxications with pure caffeine – report of three different cases
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Myeloid-derived suppressor cells: a double-edged sword?
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Effects of seed treatment with mustard meal in control of Fusarium culmorum Sacc. and the growth of common wheat (Triticum aestivum ssp. vulgare)
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Cinnamon powder: an in vitro and in vivo evaluation of antifungal and plant growth promoting activity
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Study the impact of design method preference on the usefulness of concrete and on CO2 emissions
PublicationPurpose – The research investigates the impact of concrete design methods on performance, emphasizing environmental sustainability. The study compares the modified Bolomey method and Abrams’ law in designing concretes. Significant differences in cement consumption and subsequent CO2 emissions are revealed. The research advocates for a comprehensive life cycle assessment, considering factors like compressive strength, carbonation...
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Assessment of the Relationship between the Shape of the Lateral Meniscus and the Risk of Extrusion Based on MRI Examination of the Knee Joint
PublicationBackground Meniscus extrusion is a serious and relatively frequent clinical problem. For this reason the role of different risk factors for this pathology is still the subject of debate. The goal of this study was to verify the results of previous theoretical work, based on the mathematical models, regarding a relationship between the cross-section shape of the meniscus and the risk of its extrusion. Materials and Methods Knee...
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Impact of Visual Image Quality on Lymphocyte Detection Using YOLOv5 and RetinaNet Algorithms
PublicationLymphocytes, a type of leukocytes, play a vital role in the immune system. The precise quantification, spatial arrangement and phenotypic characterization of lymphocytes within haematological or histopathological images can serve as a diagnostic indicator of a particular lesion. Artificial neural networks, employed for the detection of lymphocytes, not only can provide support to the work of histopathologists but also enable better...
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Molecular Imaging and Nanotechnology—Emerging Tools in Diagnostics and Therapy
PublicationPersonalized medicine is emerging as a new goal in the diagnosis and treatment of diseases. This approach aims to establish differences between patients suffering from the same disease, which allows to choose the most effective treatment. Molecular imaging (MI) enables advanced insight into molecule interactions and disease pathology, improving the process of diagnosis and therapy and, for that reason, plays a crucial role in personalized...
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Kobieta ciężarna i alkohol-toksyczny związek. Smółka noworodków jako materiał w diagnostyce spożywania alkoholu w czasie ciąży
PublicationKażda ilość alkoholu spożyta przez ciężarną kobietę może spowodować poronienie, przedwczesny poród, patologię łożyska, zahamowanie wzrostu wewnątrzmacicznego płodu i wystąpienie licznych wad wrodzonych wywołanych alkoholem, określanych wspólnie mianem spektrum płodowych zaburzeń alkoholowych - FASD. Mogą one objawiać się zaburzeniami psychicznymi i/lub fizycznymi. Współczesna diagnostyka u noworodków zespołu FASD opiera się najczęściej...
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Proximal fibular osteotomy as a treatment for degenerative meniscal extrusion
PublicationMeniscal extrusion treatment is a key focus area for research and clinical study of degenerative knee pathology. The contact forces between the meniscus and the bones cause external displacements of the meniscus that are resisted by the circumferential fibres. The main risk factors for the excessive deformation of the meniscus are meniscal root tears, disruption of the circumferential fibres, knee malalignment and high body mass...
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Neurochemical changes underlying cognitive impairment in olfactory bulbectomized rats and the impact of the mGlu5-positive allosteric modulator CDPPB
PublicationThe olfactory bulbectomized (OBX) rat model is a well-established model of depression in which antidepressant drugs reverse deficits in the passive avoidance test 14 days after administration. Recently, the olfactory bulbectomized rat model has been proposed to be a model of Alzheimer’s disease (AD), and the available data indicate similarities between the changes that typically occur in AD and those observed in OBX animals. In...
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Bortezomib induces methylation changes in neuroblastoma cells that appear to play a significant role in resistance development to this compound
PublicationThe anticancer activity of bortezomib (BTZ) has been increasingly studied in a number of indications and promising results for the use of this treatment have been shown in neuroblastoma. As BTZ treatment is usually administered in cycles, the development of resistance and side effects in patients undergoing therapy with BTZ remains a major challenge for the clinical usage of this compound. Common resistance development also means...