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Search results for: blood-brain barrier
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New ESH/ESC Guidelines Signal Progress in Hypertension Management
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RAAS inhibition – a practice of medical progress
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Combination treatment in hypertension – the latest 2013 European Guidelines
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Heightened acute circulatory responses to smoking in women
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Elevated ambulatory systolic-diastolic pressure regression index is genetically determined in hypertensive patients with coronary heart disease
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Need for multiple risk reduction strategies in clinical trials enrolling high risk patients - FOURIER investigating PCSK-9 inhibitor to lower cholesterol revisited
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Masked arterial hypertension in a 64-year-old man with primary aldosteronism
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Prevalence and distribution of left ventricular diastolic dysfunction in treated patients with long-lasting hypertension
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2018 Practice guidelines for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension
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Women’s health, cardiovascular risk and hypertension: the perspective still needs to improve
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The PARAGON Heart Failure trial – ongoing investigation of the angiotensin receptor antagonist/neprilysin inhibitor sacubitril/valsartan in heart failure patients with hypertension and preserved ejection fraction
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New data on antihypertensive drugs and risk of cancer: should we worry?
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Treatment strategies for comorbid conditions lower residual risk in patients with treated hypertension: FOURIER and other randomized outcome trials
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2013 ESH/ESC Practice Guidelines for the Management of Arterial Hypertension
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2018 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension
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Novel approaches: targeting sympathetic outflow in the carotid sinus
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Peter Meredith
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The INTERSTROKE Study: hypertension is by far the most important modifiable risk factor for stroke
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Hypertension Management by Practice Guidelines
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Hypertension and cochlear hearing loss
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The Health Outcomes Prevention and Evaluation 4 (HOPE 4) project: A successful community-based intervention to lower cardiovascular risk in people with hypertension
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The PARAGON-Heart failure trial – another disappointment for heart failure patients with hypertension and preserved ejection fraction
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Insufficiency of the zona glomerulosa of the adrenal cortex and progressive kidney insufficiency following unilateral adrenalectomy – case report and discussion
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HOPE-3, SPRINT, VALUE and a meta-analysis of trials in patients with diabetes support treatment of hypertension to a target below 140 mmHg
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How to measure retinal microperfusion in patients with arterial hypertension
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TIME to face the reality about evening dosing of antihypertensive drugs in hypertension
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Renal denervation in hypertension: is it the end or the beginning of a SPYRAL?
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Single-pill combinations, hypertension control and clinical outcomes: potential, pitfalls and solutions
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Age-dependent sympathetic neural responses to ß1 selective beta-blockade in untreated hypertension-related tachycardia
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Changes of augmentation index early after ischaemic stroke predict functional outcome
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Prevention of heart failure mortality and hospitalizations in SPRINT, EMPA-REG, ALLHAT and HYVET: are diuretics the clue?
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Renal denervation in treatment-resistant hypertension – Oslo RDN, Symplicity HTN-3 and INSPiRED randomized trials
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The polypill: an emerging treatment alternative for secondary prevention of cardiovascular disease
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New 2017 American Heart Association and American College of Cardiology guideline for hypertension in the adults: major paradigm shifts, but will they help to fight against the hypertension disease burden?
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Will we ever use angiotensin receptor neprilysin inhibition (ARNi) for the treatment of hypertension?
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Chemical variability of Rhododendron tomentosum (Ledum palustre) essential oils and their pro-apoptotic effect on lymphocytes and rheumatoid arthritis synoviocytes
PublicationRhododendron tomentosum (Ledum palustre) is an aromatic plant traditionally used for alleviating rheumatic complaints which makes it a potential candidate for a natural drug in rheumatoid arthritis (RA) treatment. However, the effects of plants’ volatiles on apoptosis of synovial fibroblasts and infiltrating leucocytes of RA synovia, have not been reported. Volatile fraction of R. tomentosum is chemically variable and chemotypes...
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Recent advances in reinforced bioplastics for food packaging – A critical review
PublicationRecently, diversifying the material, method, and application in food packaging has been massively developed to find more environment-friendly materials. However, the mechanical and barrier properties of the bioplastics are major hurdles to expansion in commercial realization. The compositional variation with the inclusion of different fillers could resolve the lacking performance of the bioplastic. This review summarizes the various...
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Preparation and Characterization of Films Based on Disintegrated Bacterial Cellulose and Montmorillonite
PublicationThe food packaging materials from natural polymers including polysaccharides offer an ecologically important alternative to commonly used synthetic, non-biodegradable counterparts. The purpose of this work was to modify of bacterial cellulose (BC) leading to the improvement of its functional properties in terms of use as a food packaging material. Effects of disintegration of BC and addition of montmorillonite (MMT) on its water...
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An automated, low-latency environment for studying the neural basis of behavior in freely moving rats
PublicationBackground Behavior consists of the interaction between an organism and its environment, and is controlled by the brain. Brain activity varies at sub-second time scales, but behavioral measures are usually coarse (often consisting of only binary trial outcomes). Results To overcome this mismatch, we developed the Rat Interactive Foraging Facility (RIFF): a programmable interactive arena for freely moving rats with multiple feeding...
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Independent dynamics of low, intermediate, and high frequency spectral intracranial EEG activities during human memory formation
PublicationA wide spectrum of brain rhythms are engaged throughout the human cortex in cognitive functions. How the rhythms of various frequency ranges are coordinated across the space of the human cortex and time of memory processing is inconclusive. They can either be coordinated together across the frequency spectrum at the same cortical site and time or induced independently in particular bands. We used a large dataset of human intracranial...
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Hemocompatibility of nanocrystalline diamond layers
Open Research DataThe biocompatibility of the diamond films were investigated with whole human blood samples. Blood used in this study was drawn from 10 healthy human patients of different age, sex, and blood group. A 2 ml samples were collected into standard tubes with EDTA anticoagulation agent. Blood was used within 6 hours from the collection time. A reference blood...
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Unfolding new values in the landscape of conflict
PublicationThe main objective of the paper is to investigate how the conflict quality of landscape can be used as its asset and potential for creating new values. Like mediation between different overlapping archaeologies offers a basis for the perception of place in the chronology of time, the mediation between conflicted areas creates a capacious zone for enhancing the unique quality of landscape in its architectural, social, cultural and...
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Multi-layered tissue head phantoms for noninvasive optical diagnostics
PublicationExtensive research in the area of optical sensing for medical diagnostics requires development of tissue phantoms with optical properties similar to those of living human tissues. Development and improvement of in vivo optical measurement systems requires the use of stable tissue phantoms with known characteristics, which are mainly used for calibration of such systems and testing their performance over time. Optical and mechanical...
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Detection of Alzheimer's disease using Otsu thresholding with tunicate swarm algorithm and deep belief network
PublicationIntroduction: Alzheimer’s Disease (AD) is a degenerative brain disorder characterized by cognitive and memory dysfunctions. The early detection of AD is necessary to reduce the mortality rate through slowing down its progression. The prevention and detection of AD is the emerging research topic for many researchers. The structural Magnetic Resonance Imaging (sMRI) is an extensively used imaging technique in detection of AD, because...
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Smart Approach for Glioma Segmentation in Magnetic Resonance Imaging using Modified Convolutional Network Architecture (U-NET)
PublicationSegmentation of a brain tumor from magnetic resonance multimodal images is a challenging task in the field of medical imaging. The vast diversity in potential target regions, appearance and multifarious intensity threshold levels of various tumor types are few of the major factors that affect segmentation results. An accurate diagnosis and its treatment demand strict delineation of the tumor affected tissues. Herein, we focus on...
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Dysfunctional prefrontal cortical network activity and interactions following cannabinoid receptor activation.
PublicationCoordinated activity spanning anatomically distributed neuronal networks underpins cognition and mediates limbic-cortical interactions during learning, memory, and decision-making. We used CP55940, a potent agonist of brain cannabinoid receptors known to disrupt coordinated activity in hippocampus, to investigate the roles of network oscillations during hippocampal and medial prefrontal cortical (mPFC) interactions in rats. During...
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Visual Dimensions of Modeling Languages in Interdisciplinary Perspective
PublicationUżyteczność języków modelowania wizualnego zależy od notacji. Notacja może być postrzegana jako zestaw wizualnych komponentów, które w określony sposób oddziałują na ludzkie oko i ludzki mózg. Referat przedstawia analizę interdyscyplinarną wykonaną w celu lepszego zrozumienia wizualnych wymiarów języków modelowania. Wizualne wymiary pochodzą z teorii opisujących percepcję wzrokową, wizualizację danych oraz reprezentacje poznawcze....
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Wyzwania i problemy aktywizacji peryferyjnych niskorozwiniętych obszarów Unii Europejskiej
PublicationSą duże dysproporcje w poziomie rozwoju między obszarami metropolitalnymi a pozostałymi, zwanymi tu peryferyjnymi. Dysproporcje dotyczą też badań – wiele z nich dotyczy obszarów metropolitalnych. Dlatego autor podjął w 2009 r. badania dotyczące problemów aktywizacji obszarów peryferyjnych. Głównym problemem jest w nich niedostatek endogenicznych czynników stanowiący barierę samodzielnego zainicjowania wzrostu. Potrzeba rozwoju...
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Multi-DBD actuator with floating interelectrode for aerodynamic control
PublicationIn this paper the use of a floating inter-electrode in a multi-DBD (dielectric barrier discharge) plasma actuator is described. The multi-DBD plasma actuators with floating inter-electrodes were investigated to get a longer DBD on a dielectric surface and to maximise generated net airflow. Our actuator was used to control the boundary layer flow separation around NACA0012 airfoil model. The results of our investigations suggests...
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TRAVELLING WAVES FOR LOW–GRADE GLIOMA GROWTH AND RESPONSE TO A CHEMOTHERAPY MODEL
PublicationLow-grade gliomas (LGGs) are primary brain tumours which evolve very slowly in time, but inevitably cause patient death. In this paper, we consider a PDE version of the previously proposed ODE model that describes the changes in the densities of functionally alive LGGs cells and cells that are irreversibly damaged by chemotherapy treatment. Besides the basic mathematical properties of the model, we study the possibility of the...