Search results for: DRUG–DRUG INTERACTIONS

• Journal of Drug Delivery

  Journals

  ISSN: 2090-3014 , eISSN: 2090-3022

• DRUG DISCOVERY TODAY

  Journals

  ISSN: 1359-6446 , eISSN: 1878-5832

• DRUG RESISTANCE UPDATES

  Journals

  ISSN: 1368-7646 , eISSN: 1532-2084

• Current Drug Safety

  Journals

  ISSN: 1574-8863 , eISSN: 2212-3911

• BIOINFO Drug targets

  Journals

  ISSN: 2249-1759

• Drug Metabolism and Pharmacokinetics

  Journals

  ISSN: 1347-4367 , eISSN: 1880-0920

• Current Drug Therapy

  Journals

  ISSN: 1574-8855 , eISSN: 1065-7630

• JOURNAL OF DRUG ASSESSMENT

  Journals

  ISSN: 1369-9474 , eISSN: 2155-6660

• DRUG AND ALCOHOL REVIEW

  Journals

  ISSN: 0959-5236 , eISSN: 1465-3362

• Drug and Therapeutics Bulletin

  Journals

  ISSN: 0012-6543

• Drug Discovery World

  Journals

  ISSN: 1469-4344

• Drug Metabolism Letters

  Journals

  ISSN: 1872-3128

• Drug Delivery Letters

  Journals

  ISSN: 2210-3031

• WHO Drug Information

  Journals

  ISSN: 1010-9609

• Drug Invention Today

  Journals

  ISSN: 0975-7619

• Drug Delivery System

  Journals

  ISSN: 0913-5006

• Contemporary Drug Problems

  Journals

  ISSN: 0091-4509

• Drug Development and Registration

  Journals

  ISSN: 2305-2066 , eISSN: 2658-5049

• JOURNAL OF DRUG TARGETING

  Journals

  ISSN: 1061-186X , eISSN: 1029-2330

• Medicine in Drug Discovery

  Journals

  eISSN: 2590-0986

• PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

  Journals

  ISSN: 1053-8569 , eISSN: 1099-1557

• Drug Evaluation Research

  Journals

  ISSN: 1674-6376

• JOURNAL OF DRUG EDUCATION

  Journals

  ISSN: 0047-2379 , eISSN: 1541-4159

• JOURNAL OF DRUG ISSUES

  Journals

  ISSN: 0022-0426 , eISSN: 1945-1369

• Cancer Drug Resistance

  Journals

  eISSN: 2578-532X

• THERAPEUTIC DRUG MONITORING

  Journals

  ISSN: 0163-4356 , eISSN: 1536-3694

• Natural carbon-based quantum dots and their applications in drug delivery: A review

  Publication

  • A. Nair
  • J. Haponiuk
  • S. Thomas
  • S. Gopi

  - BIOMEDICINE & PHARMACOTHERAPY - Year 2020

  Full text to download in external service

• The significance of lumican expression in ovarian cancer drug-resistant cell lines

  Publication

  • A. Klejewski
  • K. Sterzyńska
  • K. Wojtowicz
  • M. Świerczewska
  • M. Partyka
  • M. Brązert
  • M. Nowicki
  • M. Zabel
  • R. Januchowski

  - Oncotarget - Year 2017

  Full text to download in external service

• Magnetic Silica Nanotubes: Synthesis, Drug Release, and Feasibility for Magnetic Hyperthermia

  Publication

  • X. Chen
  • R. Klingeler
  • M. Kath
  • A. El
  • K. Cendrowski
  • R. Kalenczuk
  • E. Borowiak-Palen
  • E. Mijowska

  - ACS Applied Materials & Interfaces - Year 2012

  Full text to download in external service

• Multi‐wall carbon nanotubes – a vehicle for targeted Irinotecan drug delivery

  Publication

  • C. Tripisciano
  • M. Rümmeli
  • X. Chen
  • E. Borowiak‐Palen
  • E. Mijowska

  - physica status solidi (b) - Year 2010

  Full text to download in external service

• Antimicrobial peptides (AMPs) as drug candidates: a patent review (2003–2015)

  Publication

  • P. Kosikowska
  • A. Lesner

  - EXPERT OPINION ON THERAPEUTIC PATENTS - Year 2016

  Full text to download in external service

• Single-wall carbon nanotubes based anticancer drug delivery system

  Publication

  • C. Tripisciano
  • K. Kraemer
  • A. Taylor
  • E. Borowiak-Palen
  • E. Mijowska

  - Chemical Physics Letters - Year 2009

  Full text to download in external service

• Chemometric Evaluation of THz Spectral Similarity for the Selection of Early Drug Candidates

  Publication

  • L. Sterczewski
  • K. Nowak
  • B. Szlachetko
  • M. Grzelczak
  • B. Szczesniak-Siega
  • S. Plinska
  • W. Malinka
  • E. Plinski

  - Scientific Reports - Year 2017

  Full text to download in external service

• Quantitative proteomic analysis of anticancer drug RH1 resistance in liver carcinoma

  Publication

  • M. Ger
  • A. Kaupinis
  • A. Nemeikaite-Ceniene
  • J. Sarlauskas
  • J. Cicenas
  • N. Cenas
  • M. Valius

  - Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics - Year 2016

  Full text to download in external service

• The impact of lipophilicity on environmental processes, drug delivery and bioavailability of food components

  Publication

  • T. Chmiel
  • A. Mieszkowska
  • D. Kempińska-Kupczyk
  • A. Kot-Wasik
  • J. Namieśnik
  • Z. Mazerska

  - MICROCHEMICAL JOURNAL - Year 2019

  Lipophilic properties of the compound allow to predict its fate in living organisms and to propose the models of chemicals transport and accumulation in the ecosystem. Lipophilicity is also useful as the characteristic of chemicals in respect to their optimal attributes for specific biological and non-biological tasks. The lipophilicity descriptors define the potency of endo- and xenobiotics to metabolic transformations and their...

  Full text to download in external service

• pH-dependent composite coatings for controlled drug delivery system - Review

  Publication

  • Ł. Pawłowski
  • M. Bartmański
  • A. Zieliński

  - Inżynieria Materiałowa - Year 2019

  Nowadays in case of long-term implants, the most common postoperative complications are bacterial infections, which in consequence may provoke loos- ening of the implants in the primary phase of stabilization. Bacterial infections are currently the most frequent cause of revision surgery of the implants such as hip joint endoprosthesis, knee joint endoprosthesis and dental implants. In order to provide the local and long-term antibacterial...

  Full text available to download

• Influence of Escherichia coli on Expression of Selected Human Drug Addiction Genes

  Publication

  • R. Kotlowski

  - Life - Year 2021

  The impact of enteric microflora on the expression of genes associated with cocaine and amphetamine addiction was described. Human genome-wide experiments on RNA transcripts expressed in response to three selected Escherichia coli strains allowed for significant alteration (p > 0.05) of the linear regression model between HT-29 RNA transcripts associated with the KEGG pathway:hsa05030:Cocaine addiction after 3 h stimulation with...

  Full text available to download

• Resistance of human prostate carcinoma cells to a new antitumor compound capridine beta is associated with changed drug metabolism combined with both inherent and drug-induced overexpression of ABC transporters

  Publication

  • M. Hyży
  • K. Lemke
  • A. Składanowski

  - Targeted Oncology - Year 2007

  W pracy charakteryzujemy mechanizm oporności na nową pochodną 1-nitroakrydyny, związku capridine beta (C-1748) o wysokiej aktywności przeciwnowotworowej, znajdującego się w badaniach klinicznych. Nasze dane wskazują, że oporność na ten związek jest wynikiem zmienionego metabolizmu inaktywującego C-1748 oraz wzrostem ekspresji pompy błonowej ABCG2 a także innych białek transportowych typu ABC.

  Full text to download in external service

• Determination of the chemical structure of potencial organic impurities occuring in the drug substance opopramol

  Publication

  • E. Luboch
  • E. Wagner-Wysiecka
  • M. Jamrógiewicz
  • J. Szczygelska-Tao
  • J. Biernat

  - PHARMAZIE - Year 2010

  The tricyclic antipsychotic and antidepressant drug opipramol was examined with regard to the chemical structure of its organic impurities. Impurities were isolated from the technical product by chromatographic methods and their chemical structures were estabilished by HMNR, MS and FTIR.

  Full text available to download

• Synthetic strategies in construction of organic low molecular-weight carrier-drug conjugates

  Publication

  • A. S. Skwarecki
  • M. Nowak
  • M. J. Milewska

  - BIOORGANIC CHEMISTRY - Year 2020

  Inefficient transportation of polar metabolic inhibitors through cell membranes of eukaryotic and prokaryotic cells precludes their direct use as drug candidates in chemotherapy. One of the possible solutions to this problem is application of the ‘Trojan horse’ strategy, i.e. conjugation of an active substance with a molecular carrier of organic or inorganic nature, facilitating membrane penetration. In this work, the synthetic...

  Full text available to download

• The Imidazoacridinone Antitumor Drug, C-1311, Is Metabolized by Flavin Monooxygenases but Not by Cytochrome P450s.

  Publication

  • A. Potęga
  • E. Dąbrowska
  • M. Niemira
  • A. Kot-Wasik
  • S. Ronseaux
  • C. Henderson
  • R. Wolf
  • Z. Mazerska

  - DRUG METABOLISM AND DISPOSITION - Year 2011

  Prezentowane w publikacji wyniki badań mają na celu wyjaśnienie roli enzymów wątrobowych w metabolizmie przeciwnowotworowych pochodnych C-1311 oraz C-1330. Oba związki inkubowane były z frakcją mikrosomalną oraz enzymami rekombinantowymi należącymi do grypy cytochromu P450, FMO oraz UGT. Badania wykazały, że oba związki są metabolizowane przez enzymy frakcji mikrosomalnej, ale nie przez enzymy cytochromu P450. Aktywność enzymatyczna...

• Determination of the chemical structure of potential organic impurities occurring in drug substance opipramol

  Publication

  • M. Jamrógiewicz
  • E. Luboch
  • E. Wagner-Wysiecka
  • J. Szczygelska-Tao
  • S. Magiełka

  - PHARMAZIE - Year 2010

  The tricyclic antipsychotic and antidepressant drug opipramol (opipramole) was examined with regard to the chemical structure of its organic impurities. Impurities were isolated from the technical product by chromatographic methods and their chemical structures were established by 1H NMR, MS and FTIR and further confirmed by comparison with commercially available products or with products obtained by independent synthesis, and...

• The influence of small amount of substances present in tissue on the optical spectrum of immunosuppressive drug

  Publication

  • M. J. Marzejon
  • M. Szczerska

  - Photonics Letters of Poland - Year 2018

  In this paper, we describe how commonly present in tissue substances - sodium chloride and glucose - affect the optical spectrum of an immunosuppressive drug (Cyclaid® by Apotex). Prepared samples were investigated using the spectrophotometer in the spectrum range from 250 nm to 1100 nm. The maximum wavelength shift calculated on the basis of measurement results is not bigger than the measurement wavelength step. So, it can be...

  Full text available to download

• Exposure to non-opioid analgesics during pregnancy and the risk of adverse drug reactions

  Publication

  • K. Karlowicz-Bodalska
  • A. Prochera
  • A. Rogowska
  • A. Muszyńska
  • N. Sauer
  • E. Kuchar
  • K. Głowacka
  • A. Wiela-

  - Acta Poloniae Pharmaceutica - Drug Research - Year 2022

  Full text to download in external service

• Antimicrobials Are a Photodynamic Inactivation Adjuvant for the Eradication of Extensively Drug-Resistant Acinetobacter baumannii

  Publication

  • A. Wozniak
  • A. Rapacka-Zdonczyk
  • N. Mutters
  • M. Grinholc

  - Frontiers in Microbiology - Year 2019

  Full text to download in external service

• Use of magnetic nanoparticles as a drug delivery system to improve chlorhexidine antimicrobial activity

  Publication

  • G. Tokajuk
  • K. Niemirowicz
  • P. Deptuła
  • E. Piktel
  • M. Cieśluk
  • A. Wilczewska
  • J. Dąbrowski
  • R. Bucki

  - International Journal of Nanomedicine - Year 2017

  Full text to download in external service

• Preparation and in vitro characterisation of bioactive mesoporous silica microparticles for drug delivery applications

  Publication

  • M. Prokopowicz
  • K. Czarnobaj
  • A. Szewczyk
  • W. Sawicki

  - Materials Science & Engineering C-Materials for Biological Applications - Year 2016

  Full text to download in external service

• Molecular mechanism of the enzymatic oxidation investigated for imidazoacridinone antitumor drug C-1311.

  Publication

  • J. Konopa
  • P. Sowiński
  • Z. Mazerska

  - BIOCHEMICAL PHARMACOLOGY - Year 2003

  Praca miala na celu określenie molekularnego mechanizmu enzymatycznej utleniającej aktywacji wymienionego związku przeciwnowotworowego w takim układzie modelowym, w którym wcześniej wykazano jego kowalencyjne wiązanie się do DNA. Badania struktur chemicznych produktów enzymatycznej aktywacji wykazały, że dwa z nich powstają w wyniku dealkilacji łańcucha bocznego cząsteczki, natomiast dwa inne w wyniku aktywacji pierścienia imidazoakrydonu....

• Batracylina (BAT) - potencjalny lek przeciwnowotworowy. Batracylin (BAT) - potential of anticancer drug

  Publication

  • K. Dzierzbicka
  • J. Kawula
  • A. Kołodziejczyk

  - Postępy Biochemii - Year 2002

  Opisano działanie potencjalnego leku przeciwnowotworowego - batracyliny(BAT). Batracylina została wyselekcjonowana przez National Cancer Institute (NCI, Bethesda, USA) w 1978 roku jako efekt programu poszukiwań nowych leków chemioterapii.Związek ten w badaniach in vivo u myszy okazał się bardzo aktywny przeciw nowotworowi okrężnicy 38 (colon 38), trudnemu do wyleczenia przez znane leki przeciwnowotworowe. Okazała się ona skuteczna...

• Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice

  Publication

  • P. Sosnowski
  • P. Sass
  • P. Słonimska
  • R. Płatek
  • J. Kamińska
  • J. Baczyński-Keller
  • P. Mucha
  • G. Peszyńska-Sularz
  • A. Czupryn
  • M. Pikuła... and 5 others

  - Pharmaceuticals - Year 2022

  The ear pinna is a complex tissue consisting of the dermis, cartilage, muscles, vessels, and nerves. Ear pinna healing is a model of regeneration in mammals. In some mammals, including rabbits, punch wounds in the ear pinna close spontaneously; in common-use laboratory mice, they remain for life. Agents inducing ear pinna healing are potential regenerative drugs. We tested the effects of selected bioactive agents on 2 mm ear pinna...

  Full text available to download