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Search results for: REPORTER GENE
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An examination of an Antarctic soil metagenomic-derivate putative methylthioadenosine phosphorylase gene as a novel reporter gene for promoter trapping
PublicationThe rsfp gene was discovered during examination ofan Antarctic soil-derived metagenome library and encodesa bacterial methylthioadenosine phosphorylase (GenBank accession number GQ202582). In a previous study, we found that E. coli colonies expressing the rsfp gene reveal strong pink fluorescence after exposure to UV light when grown on culture medium supplemented with rhodamine B (Cieśliński et al., 2009). In contrast to that,...
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Enterococci from ready-to-eat food - horizontal gene transfer of antibiotic resistance genes and genotypic characterization by PCR melting profile
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Analysis of a gene expression model
PublicationWe study a mathematical model of gene transcription and protein synthesis with negative feedback. We consider a system of equations taking into account the number of active binding sites, the way in which dimers bind to DNA and time delay in translation process. For a simplified model that consist of three ordinary differential equations with time delay we derive conditions for stability of the positive steady state and for the...
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REPORT Verification expertise of Detroit Diesel engines 16V149TI on the vessel ORP GEN. PUŁASKI
PublicationVerification expertise of propulsion engines for generating sets of the ORP GEN. PUŁASKI - type 16V149TI related to a complaint sent by the shipowner to Shiprepair Yard NAUTA S.A.
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Reporter Fluorescent Molecules in Biological Systems: The Current Overview
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Osteoprotegerin gene polymorphism in diabetic Charcot neuroarthropathy
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Genistein modulates gene activity in psoriatic patients
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Modelling gene expression of a self-regulating protein
PublicationWe analyze a model of gene transcription and protein synthesis. We take into account the number of sites on the protein’s promoter at which the protein’s dimers can bind blocking transcription of protein mRNA.
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ANALYSIS OF THE p53 PROTEIN GENE EXPRESSION MODEL
PublicationWe study the asymptotic behaviour of the solutions of the p53-Mdm2 model proposed by Monk (2003). The p53 gene is crucial for cellular inhibition of the angiogenesis process, while Mdm2 is a negative regulator of the p53 tumor-suppressor. We investigate the stability of the positive steady state and perform some numerical experiments.
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Identyfikacja i izolacja genu kodującego zaadaptowaną do zimna β-galaktozydazę Paracoccus sp. = Identification and izolation of the gene encoding cold-active β-galactosidase from paracoccus sp.
PublicationZaprezentowane badania były prowadzone u eehi wyizolowania ze środo¬wiska organizmu psychrofilnego, zdolnego do hydrolizy laktozy w niskiej tempe¬raturze, oraz zidentyfikowania genu kodującego (i-galaktozydazę zaadaptowaną do zimna.Poszukiwan gen został w izolowany z psychrofilnego szczepu autarkicz¬nego Paracoccus sp. 321). Na podstawie sekwencji nukleotydowej genu kodują¬cego fS-galaktozdaze ustalono skład aminokwasów),...
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Expression patterns of candidate genes for the Lr46/Yr29 “slow rust” locus in common wheat (Triticum aestivum L.) and associated miRNAs inform of the gene conferring the Puccinia triticina resistance trait
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Circadian Gene Polymorphisms Associated with Breast Cancer Susceptibility
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Phenotypic consequences of the LYS4 gene disruption in Candida albicans
PublicationThe main scientific purpose of our studies was to verify the hypothesis that homoaconitase (HA) from Candida albicans, an enzyme catalyzing a second step of the α-aminoadipate pathway (AAP) of L-Lys biosynthesis may become a new target for antifungal chemotherapy. Previous studies indicated that the A. fumigatus mutant lacking the functional lysF gene, encoding HA, exhibited attenuated virulence in a low-dose mouse infection model...
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Gene-based identification of bacterial colonies with an electric chip
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Gene copy numbers of HER family in breast cancer
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Estrogen Receptor 2 Gene Polymorphism in Idiopathic Scoliosis
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CHD7 gene polymorphisms in female patients with idiopathic scoliosis
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Cognitive decline in Huntington's disease expansion gene carriers
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Phenotypic consequences of LYS4 gene disruption in Candida albicans
PublicationA BLAST search of the Candida Genome Database with the Saccharomyces cerevisiae LYS4 sequence known to encode homoaconitase (HA) revealed ORFs 19.3846 and 19.11327. Both alleles of the LYS4 gene were sequentially disrupted in Candida albicans BWP17 cells using PCR-based methodology. The null lys4Δ mutant exhibited lysine auxotrophy in minimal medium but was able to grow in the presence of L-Lys and α-aminoadipate, an intermediate...
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Analogue GPS repeater
PublicationThis article concerns the problem of difficulty in correct indoor Global Positioning System (GPS) signals reception due to attenuation. Radio signal repeaters are proposed as means to solve this problem. Firstly, the GPS signal characteristics are described, emphasizing their low power in the point of reception. In the second part, various applications of GPS signal repeater, where indoor GPS signals reception is required, are...
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Cancer Familial Aggregation (CFA) and G446A polymorphism in ARLTS1 gene
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Reproducibility of Finding Enriched Gene Sets in Biological Data Analysis
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Ranking metrics in gene set enrichment analysis: do they matter?
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Newborn screening and gene therapy in SMA: Challenges related to vaccinations
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Vitamin D receptor gene polymorphisms in Alzheimer's disease patients
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Beta-2 adrenoreceptor gene polymorphisms and sympathetic outflow in humans
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Delay induced oscillations in gene expression of Hes1 protein model
PublicationW pracy został omówiony model produkcji białka Hes1. Stężenie Hes1 jest kontrolowane przez ujemne sprzężenie zwrotne wbudowane w białko i jego mRNA. Przeprowadzona analiza potwierdziła znane wyniki numeryczne, że oscylacje wywołane są przez opóźnienie. Pokazaliśmy również, że jeśli współczynnik Hilla jest większy niż 1, to istnieje krytyczna wartość opóźnienia, dla której ma miejsce bifurkacja Hopfa i pojawiają się rozwiązania...
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Hopf bifurcation in time‐delayed gene expression model with dimers
PublicationWe study a mathematical model of gene transcription and protein synthesis with negative feedback. We consider a system of equations taking into account the formation of dimers (i.e., complex formed by two protein monomers), the way in which dimers bind to DNA and time delay in translation process. For the model consisting of three ordinary differential equations with time delay, we derive conditions for stability of the positive...
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Mathematical analysis of a generalised p53-Mdm2 protein gene expression model
PublicationWe propose the generalisation of the p53-Mdm2 protein gene expression model introduced by Monk (2003). We investigate the stability of a unique positive steady state and formulate conditions which guarantee the occurrence of the Hopf bifurcation. We show that oscillatory behaviour can be caused not only by time lag in protein transcription process, but also can be present in the model without time delay. Moreover, we investigate...
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A common nonsense mutation of the BLM gene and prostate cancer risk and survival
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First recurrent large genomic rearrangement in the BRCA1 gene found in Poland
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Robustness of Pathway Enrichment Analysis to Transcriptome-Wide Gene Expression Platform
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Clinical presentation of Y189C mutation of the NOTCH3 gene in the Polish family with CADASIL
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Expression of alternatively spliced variants of the Dclk1 gene is regulated by psychotropic drugs
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Statistical Integration of p-values for Enhancing Discovery of Radiotoxicity Gene Signatures
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Iron overload and HFE gene mutations in Polish patients with liver cirrhosis
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K-ras gene mutation as an early prognostic marker of colon cancer
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HPV16 E6 Gene Transcripts in Primary Type II Endometrial Carcinomas
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Vitamin D Metabolism Gene Polymorphisms and Their Associated Disorders: A Literature Review
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Adverse Childhood Experiences and Methylation of the FKBP5 Gene in Patients with Psychotic Disorders
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Stability of delay induced oscillations in gene expression of Hes1 protein model
PublicationW pracy prezentowana jest matematyczna analiza modelu ekspresji genu białka Hes1. Rozważamy układ równań z dwoma opóźnieniami - w produkcji białka Hes1 oraz jego mRNA. Dowodzimy istnienia i jednoznaczności oraz nieujemności rozwiązań. Pokazujemy istnienie dokładnie jednego dodatniego stanu stacjonarnego. Wykazujemy, że stabilność stanu stacjonarnego zależy od sumy opóźnień. Podajemy warunek dostateczny na wystąpienie bifurkacji...
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Transcriptomic responses to wounding: meta-analysis of gene expression microarray data
PublicationBackground A vast amount of microarray data on transcriptomic response to injury has been collected so far. We designed the analysis in order to identify the genes displaying significant changes in expression after wounding in different organisms and tissues. This meta-analysis is the first study to compare gene expression profiles in response to wounding in as different tissues as heart, liver, skin, bones, and spinal cord, and...
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Justification of quasi-stationary approximation in models of gene expression of a self-regulating protein
PublicationWe analyse a model of Hes1 gene transcription and protein synthesis with a negative feedback loop. The effect of multiple binding sites in the Hes1 promoter as well as the dimer formation process are taken into account. We consider three, possibly different, time scales connected with: (i) the process of binding to/dissolving from a binding site, (ii) formation and dissociation of dimers, (iii) production and degradation of Hes1...
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Prognostic Significance of TOP2A Gene Dosage in HER-2-Negative Breast Cancer
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Germline mutations in theCHEK2 kinase gene are associated with an increased risk of bladder cancer
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Gene set enrichment for reproducible science: comparison of CERNO and eight other algorithms
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Adaptive filtering of microarray gene expression data based on Gaussian mixture decomposition
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Proteins Structure Models in the Evaluation of Novel Variant (C.472_477del) in the MOCS2 Gene
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Optimised expression cassettes of hpt marker gene for biolistic transformation of Miscanthus sacchariflorus
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The role of FNDC5 gene expression in irisin level changes accompanying thyroid pathologies
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