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Search results for: ONTOLOGY EDITOR
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EZH2 and SMYD3 expression in papillary thyroid cancer
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Survivin DEx3 as a biomarker of thyroid cancers: A study at the mRNA and protein level
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High efficacy and safety of VTD as an induction protocol in patients with newly diagnosed multiple myeloma eligible for high dose therapy and autologous stem cell transplantation: A report of the Polish Myeloma Study Group
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Physical and psychological impairments of women with upper limb lymphedema following breast cancer treatment
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CDK9 inhibitors in multiple myeloma: a review of progress and perspectives
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Can popular films instil carcinophobia? Images of cancer in popular Polish cinema
PublicationIntroduction: Although cancer is currently considered a serious socio-medical challenge and health education in Poland has been positioned as a public health priority, the impact of popular culture on people’s ideas about cancer has been neglected. This study therefore aims to analyse the way popular Polish films portray cancer and the experience of cancer.Material and Methods: Seven popular Polish films featuring cancer...
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A Translational Model to Improve Early Detection of Epithelial Ovarian Cancers
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FGF7 / FGFR2 – JunB signalling counteracts the effect of progesterone in luminal breast cancer
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Comprehensive analysis of microRNA expression profile in malignant glioma tissues
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P04.06 Temozolomide influence on global DNA methylation in glioblastoma cell lines
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Long-term efficacy of 90Y-DOTATATE in patients with nonresectable pancreatic and small bowel neuroendocrine neoplasms
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Baseline chromogranin A and its dynamics are prognostic markers in gastroenteropancreatic neuroendocrine tumors
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Serum miRNA-based signature indicates radiation exposure and dose in humans: A multicenter diagnostic biomarker study
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Brachytherapy boost improves survival and decreases risk of developing distant metastases compared to external beam radiotherapy alone in intermediate and high risk group prostate cancer patients
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The molecular function of kallikrein‐related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer
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Complete Mesogastric Excisions Involving Anatomically Based Concepts and Embryological-Based Surgeries: Current Knowledge and Future Challenges
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Prognostic factors in postoperative radiotherapy for prostate cancer – tertiary center experience
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MicroRNA profiling in a case-control study of African American women with uterine serous carcinoma
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Correlation between Early Treatment Failure and Ki67 Antigen Expression in Blast Cells of Children with Acute Lymphoblastic Leukaemia before Commencing Treatment
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A link between seasonality and radiation-related toxicity: The big time or time will tell?
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Regarding the “The spiral ladder technique of facial nerve trunk identification during parotidectomy: A convenient roadmap for the beginners”
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Can popular films instil carcinophobia? Images of cancer in popular Polish cinema
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Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: a multicentre, open-label, phase 2 study
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Lenalidomide versus investigator's choice in relapsed or refractory mantle cell lymphoma (MCL-002; SPRINT): a phase 2, randomised, multicentre trial
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Central nervous system involvement in mantle cell lymphoma: clinical features, prognostic factors and outcomes from the European Mantle Cell Lymphoma Network†
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Outcome and prognostic factors in advanced Hodgkin's disease treated with high-dose chemotherapy and autologous stem cell transplantation: a study of 341 patients
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Association between P-glycoprotein and lymphoid antigen expression on myeloblasts versus therapy response and survival in de novo acute myeloid leukemia: long-term follow-up results
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Liposomal cytarabine in the prophylaxis and treatment of CNS lymphoma: toxicity analysis in a retrospective case series study conducted at Polish Lymphoma Research Group Centers
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Idelalisib or placebo in combination with bendamustine and rituximab in patients with relapsed or refractory chronic lymphocytic leukaemia: interim results from a phase 3, randomised, double-blind, placebo-controlled trial
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Phase IIa study of the CD19 antibody MOR208 in patients with relapsed or refractory B-cell non-Hodgkin’s lymphoma
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DNA-reactive anticancer imidazoacridinone C-1311 is a new inhibitor of hypoxia-inducible factor 1 alpha, vascular endothelial growth factor and tumor angiogenesis
PublicationHypoxia-inducible factor 1 (HIF-1) plays a critical role for tumor adaptation to hypoxia and promotes angiogenesis. Antitumor imidazoacridinone C-1311 is a DNA reactive topoisomerase II and FLT3 receptor tyrosine kinase inhibitor selected for phase II clinical trials for breast cancer. Here, we demonstrate the new mechanism of C-1311 action involving HIF-1a, vascular endothelial growth factor (VEGF) and angiogenesis as additional...
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imPlatelet classifier: image‐converted RNA biomarker profiles enable blood‐based cancer diagnostics
PublicationLiquid biopsies offer a minimally invasive sample collection, outperforming traditional biopsies employed for cancer evaluation. The widely used material is blood, which is the source of tumor-educated platelets. Here, we developed the imPlatelet classifier, which converts RNA-sequenced platelet data into images in which each pixel corresponds to the expression level of a certain gene. Biological knowledge from the Kyoto Encyclopedia...
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Improving platelet‐RNA‐based diagnostics: a comparative analysis of machine learning models for cancer detection and multiclass classification
PublicationLiquid biopsy demonstrates excellent potential in patient management by providing a minimally invasive and cost-effective approach to detecting and monitoring cancer, even at its early stages. Due to the complexity of liquid biopsy data, machine-learning techniques are increasingly gaining attention in sample analysis, especially for multidimensional data such as RNA expression profiles. Yet, there is no agreement in the community...
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Recent advances in 3D bioprinted tumor models for personalized medicine
PublicationCancerous tumors are among the most fatal diseases worldwide, claiming nearly 10 million lives in 2020. Due to their complex and dynamic nature, modeling tumors accurately is a challenging task. Current models suffer from inadequate translation between in vitro and in vivo results, primarily due to the isotropic nature of tumors and their microenvironment's relationship. To address these limitations, hydrogel-based 3D bioprinting...
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Differential ability of cytostatics from anthraquinone group to generatefree radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xantine oxidase.
PublicationZbadano szereg cytostatyków z grupy antrachinonu pod względem ich zdolności do pośredniczenia w przeniesieniu jednoelektronowym i generowaniu wolnych rodników tlenowych pod wpływem trzech oksydoreduktaz. Zdefiniowano czynniki strukturalne związków odpowiedzialne za ten proces katalizowany przez poszczególne enzymy.
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Electroabsorption study of metal-to-ligand charge transfer in an organic complex of iridium (III).
PublicationW pracy zmierzono i zinterpretowano widmo elektroabsorpcji (EA) próżniowo naparowanych warstw organicznego kompleksu Ir(ppy)3, powszechnie stosowanego jako emiter fosforescencyjny w organicznych diodach elektroluminescencyjnych. Analiza widma EA potwierdziła fakt,że niskoenergetyczne stany elektronowe tego kompleksu związane są z przeniesieniem ładunku metal-ligand.
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Current situation in Polish nuclear medicine and Polish example of model Nuclear Medicine Centre meeting European Union requirements
PublicationNuclear medicine is currently a well-established part of medicine. It is applied in many fields of clinical medicine and science like endocrinology, oncology, cardiology, molecular medicine and engineering, radiopharmacy, physics and information science. Due to its increasing importance and application, several regulation and supervision bodies have been founded to ensure safe usage of radiation and to improve diagnostic and therapeutic...
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Intralabyrinthine Hemorrhage in A Patient With COVID-19 – A Challenge For An Otologist
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Intelligent system for editing and analysis of examination documents
PublicationOpisano ogólną koncepcję systemu IATE - systemu do edycji i automatycznej analizy testów egzaminacyjnych. Edytor systemu umożliwia generację 4 typów testów o dowolnej liczbie pytań (do 8 stron tekstu), różnej formie udzielania odpowiedzi oraz możliwością tworzenia wariantów testu. Bardziej szczegółowo opisano wybrane fragmenty systemu: analizę nagłówka testu, edycję i organizację segmentu tworzenia wariantów testu oraz organizację...
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Researching Digital Society: Using Data-Mining to Identify Relevant Themes from an Open Access Journal
PublicationOpen Access scholarly literature is scientific output free from economic barriers and copyright restrictions. Using a case study approach, data mining methods and qualitative analysis, the scholarly output and the meta-data of the Open Access eJournal of e-Democracy and Open Government during the time interval 2009–2020 was analysed. Our study was able to identify the most prominent research topics (defined as thematic clusters)...
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Researching Digital Society: Using Data-Mining to Identify Relevant Themes from an Open Access Journal
PublicationOpen Access scholarly literature is scientific output free from economic barriers and copyright restrictions. Using a case study approach, data mining methods and qualitative analysis, the scholarly output and the meta-data of the Open Access eJournal of e-Democracy and Open Government during the time interval 2009–2020 was analysed. Our study was able to identify the most prominent research topics (defined as thematic clusters)...
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Aplikacje i środowiska kontekstowe: Semantyczny model realizacji ludzkich przedsięwzięć
PublicationPrzedstawiono usystematyzowane podejście do opisu przedsięwzięć ludzkich i usług informacyjnych. Zaprezentowano środowisko WIKI jako platformę wspomagającą przetwarzanie zespołowe oraz zasygnalizowano dalsze trendy jej rozwoju. Wykazano potrzebę uwzględnienia kontekstu związanego z zespołem, realizowanym przedsięwzięciem oraz dziedziną, której ono dotyczy. Podano sposób budowy ontologii dla opisu wymaganych kontekstów.
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System przetwarzania testów egzaminacyjnych.
PublicationW pracy zaprezentowano wykonany przez autorów system AATE, służący do automatycznej analizy testów egzaminacyjnych. System daje możliwość przetwarzania trzech rodzajów ankiet i składa się z trzech modułów: edycji arkuszy, analizy dokumentów i prezentacji wyników. W pracy zamieszczono przykładowe formularze egzaminacyjne, schemat blokowy edytora testów oraz wyniki przeprowadzonych eksperymentów.
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Asking Data in a Controlled Way with Ask Data Anything NQL
PublicationWhile to collect data, it is necessary to store it, to understand its structure it is necessary to do data-mining. Business Intelligence (BI) enables us to make intelligent, data-driven decisions by the mean of a set of tools that allows the creation of a potentially unlimited number of machine-generated, data-driven reports, which are calculated by a machine as a response to queries specified by humans. Natural Query Languages...
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Rozwój środowiska szkieletowego do uruchamiania kontekstowej aplikacji przetwarzania wszechobecnego
PublicationPrzedstawiono koncepcje przetwarzania wszechobecnego orazinteraktywnej aplikacji wykorzystuj¡cej kontekst. Przeanalizowano kluczowe składowe tego typu aplikacji. Opisano znaczenie i architekturę szkieletowego środowiska uruchomieniowego dla takich aplikacji. Środowisko to integruje usługi sieciowe, konteksty, scenariusze i ontologie w czasie działania. Na bazieeksperymentów, scharakteryzowano kolejne etapy jego budowy i metodologię...
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Project-Based Learning as a Method for Interdisciplinary Adaptation to Climate Change—Reda Valley Case Study
PublicationThe challenges of the global labour market require university authorities to extend traditional forms of education into more innovative and effective solutions. Project-based learning (PjBL) is one of highly effective methods for acquiring knowledge and teaching “soft” skills to future employees. This article describes an experimental use of PjBL at a university with a long history of teaching based on traditional methods—the Gdansk...
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O semantyce kontekstowych baz wiedzy
PublicationW artykule omawiany jest problem poprawnego projektowania kontekstowych baz wiedzy. Rozszerzamy w nim definicje pojęć wprowadzonych przez metodę OntoClean - jedną z najbardziej znanych metod oceny jakości ontologii niekontekstowych. Pozwala nam to na sformułowanie wymagań jakościowych dla porjektów uwzględniających semantykę kontekstów. Następnie analizujemy pod kątem tych wymagań metodę projektowania kontekstowych baz wiedzy SIM.
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Odwzorowania międzyontologiczne w algebrze konglomeratów
PublicationModularyzacja i integracja ontologii to dziedziny, które w ostatnim okresie są obiektem intensywnego rozwoju. Rozwój nowych idei spowodował konieczność wprowadzenia ich systematyzacji i klasyfikacji. W niniejszym artykule przeanalizowano możliwość wyrażenia odwzorowań i złączeń za pomocą algebry konglomeratów oraz przedyskutowano możliwość wykorzystania roli algebry jako ujednoliconego medium opisu metod integracji i modularyzacji.
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Chimeric Dr fimbriae with a Herpes Simplex virus type 1 epitope as a model for a recombinant vaccine.
PublicationBiałko adhezyny DraE uropatogennych szczepów E. coli Dr+ zostało wykorzystane jako nośnik 11a a determinanty antygenowej glikoproteiny D wirusa HSV ty-pu 1. Sekwencja kodująca epitop HSV została wklonowana do genu draE w obrębie regionu N- terminalnego eksponowanej powierzchniowo domeny 2. Ekspresjachimerycznych białek DraE-HSV została potwierdzona za pomocą mikroskopii immunofluorescencyjnej i elektronowej.
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Modelling and simulation of GPU processing in the MERPSYS environment
PublicationIn this work, we evaluate an analytical GPU performance model based on Little's law, that expresses the kernel execution time in terms of latency bound, throughput bound, and achieved occupancy. We then combine it with the results of several research papers, introduce equations for data transfer time estimation, and finally incorporate it into the MERPSYS framework, which is a general-purpose simulator for parallel and distributed...