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Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use.
PublicationThe acridinone derivates C-1305 and C-1311 are promising antitumor agents with high activity against several experimental cellular and tumor models and which are under evaluation in pre-clinical and early phase clinical trials. Recent evidence from our laboratories has indicated that both compounds were conjugated by several UGT isoforms with the most active being extrahepatic UGT1A10. The present studies were designed to test...
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Typology of the Black Tents Architecture between Iranian nomad tribes
PublicationEvidence of the past shows variation in human settlements. Nomadic house the” Black Tent” shows relationship between humans and the natural environment surrounding them. Black Tents are made of natural materials consistant with environmental conditions. This paper discusses nomadic living space of some Iranian tribes located in different regions to show their unique architecture and culture. Rediscovering different architecture...
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Preeclampsia Risk Prediction Using Machine Learning Methods Trained on Synthetic Data
PublicationThis paper describes a research study that investigates the use of machine learning algorithms on synthetic data to classify the risk of developing preeclampsia by pregnant women. Synthetic datasets were generated based on parameter distributions from three real patient studies. Four models were compared: XGBoost, Support Vector Machine (SVM), Random Forest, and Explainable Boosting Machines (EBM). The study found that the XGBoost...
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The values of Block Entropy for patients with Congestive Heart Failure
Open Research DataThe dataset consists of calculated values of entropy of 75 000 intervals between consecutive heartbeats (RR intervals) for 29 patients with congestive heart failure (CHF). The original data were taken from PhysioNet Congestive Heart Failure RR Interval Database (cf. Goldberger A., Amaral L., Glass L., Hausdorff J., Ivanov P.C., Mark R., Mietus J.E.,...
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The values of Permutation Entropy for patients with Congestive Heart Failure
Open Research DataThe dataset consists of calculated values of entropy of 75 000 intervals between consecutive heartbeats (RR intervals) for 29 patients with congestive heart failure (CHF). The original data were taken from PhysioNet Congestive Heart Failure RR Interval Database (cf. Goldberger A., Amaral L., Glass L., Hausdorff J., Ivanov P.C., Mark R., Mietus J.E.,...
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Javed Ather Siddiqui DR.
PeopleI AM PSYCHATRIST,WANTS TO BRING SMILE ON THE FACES OF MENTALLY ILL PATIENTS. I LOVE MY PROFESSION AND WANT TO FACE CHALLENGES FOR SAKE OF THE PATIENTS. I EARNED POST GRADUATE DEGREE FROM MUMBAI UNIVERSITY AT G S SRTH MEDICAL COLLEGE AND KEM HOSPITAL, MUMBAI, INDIA. I HAVE OVER 20 YEARS OF MENTAL HEALTH EXPERIENCE. I HAVE WORKED IN VARIETY OF CLINICAL SETTINGS THAT HAVE INCLUDED DRUG DEADDICTION, CHILD, ADOLESCENT, GERIATRIC AND...
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Ultrasound and Clinical Preoperative Characteristics for Discrimination Between Ovarian Metastatic Colorectal Cancer and Primary Ovarian Cancer: A Case-Control Study
PublicationThe aim of this study was to describe the clinical and sonographic features of ovarian metastases originating from colorectal cancer (mCRC), and to discriminate mCRC from primary ovarian cancer (OC). We conducted a multi-institutional, retrospective study of consecutive patients with ovarian mCRC who had undergone ultrasound examination using the International Ovarian Tumor Analysis (IOTA) terminology, with the addition of evaluating...
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Orthodontic characteristics of maxillary arch deficiency in 5-year-old patients undergoing unilateral cleft lip and palate repair with and without early gingivoplasty
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Non-dipping and arterial hypertension depend on clinical factors rather than on genetic variability of ACE and RGS2 genes in patients with type 1 diabetes
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Potential of Serum Proteome Patterns Analysis by MALDI-TOF Mass Spectrometry for Prediction of Acute Radiation Injury Response in Head and Neck Cancers Patients
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Comparison of oral-health-related quality of life in patients in the short- and long-term period following lower-facial injury and fractures – preliminary report
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Comparison of Hemodynamic Response between Patients with Systolic Heart Failure Differing in Serum Aldosterone Concentrations during and after a 6-Minute Walk Test
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Staphylococcus aureus Co-Infection in COVID-19 Patients: Virulence Genes and Their Influence on Respiratory Epithelial Cells in Light of Risk of Severe Secondary Infection
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Psychological burden and disease-related quality of life in dialysis patients during the first wave of the COVID-19 pandemic — a cross-sectional observational study
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Hypertension types defined by clinic and ambulatory blood pressure in 14 143 patients referred to hypertension clinics worldwide. Data from the ARTEMIS study
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A label-free graphene-based impedimetric biosensor for real-time tracing of the cytokine storm in blood serum; suitable for screening COVID-19 patients
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Detection ofHelicobacterspecies in liver and stomach tissues of patients with chronic liver diseases using polymerase chain reaction-denaturing gradient gel electrophoresis and immunohistochemistry
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Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial
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In vivo evidence of ascorbate involvement in the generation of epigenetic DNA modifications in leukocytes from patients with colorectal carcinoma, benign adenoma and inflammatory bowel disease
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Recidivism Rate among patients discharged from long care unit in forensic psychiatry program at Mental Health Hospital, Taif, Saudi Arabia
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Dermal microvessel density and maturity is closely associated with atherogenic dyslipidemia and accumulation of advanced glycation end products in adult patients with type 1 diabetes
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30-Day Morbidity and Mortality of Bariatric Surgery During the COVID-19 Pandemic: a Multinational Cohort Study of 7704 Patients from 42 Countries
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The Preoperative Maximum Standardized Uptake Value Measured by 18F-FDG PET/CT as an Independent Prognostic Factor of Overall Survival in Endometrial Cancer Patients
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Isolation of xanthone and benzophenone derivatives from Cyclopia genistoides (L.) Vent. (honeybush) and their pro-apoptotic activity on synoviocytes from patients with rheumatoid arthritis
PublicationA fast and efficient method for the isolation of the C-glucosidated xanthones mangiferin and isomangiferin from the South-African plant Cyclopia genistoides was developed for the first time. Two benzophenone derivatives: 3-C-β-glucosides of maclurin and iriflophenone, were isolated from C. genistoides extracts using semi-preparative. The structures of the compounds were determined by 1D and 2D NMR experiments and/or LC-DAD-ESI–MS.
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Differentiating patients with obstructive sleep apnea from healthy controls based on heart rate-blood pressure coupling quantified by entropy-based indices
PublicationWe introduce an entropy-based classification method for pairs of sequences (ECPS) for quantifying mutual dependencies in heart rate and beat-to-beat blood pressure recordings. The purpose of the method is to build a classifier for data in which each item consists of two intertwined data series taken for each subject. The method is based on ordinal patterns and uses entropy-like indices. Machine learning is used to select a subset...
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Bee Products and Essential Oils as Alternative Agents for Treatment of Infections Caused by S. aureus
PublicationBacteria of the genus Staphylococcus are important human and veterinary pathogens. A crucial characteristic for this group of bacteria is that they can easily acquire mechanisms of antibiotic resistance for a plethora of antibiotics currently in use for human and animal therapies. Therefore, there is a great need to find novel, non-antibiotic chemotherapeutics with marked antistaphylococcal activity. Promising but still underestimated...
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Effect of glycols used as glycolysis agents on chemical structure and thermal stability of produced glycolysates
PublicationZaprezentowano warunki glikolizy poliuretanowych odpadów piankowych, przy użyciu różnych glikoli oraz wyniki badań budowy chemicznej glikolizatów oraz ich właściwości termicznych.
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New Class of Antimicrobial Agents: SBA-15 Silica Containing Anchored Copper Ions
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Current state of a dual behaviour of antimicrobial peptides-Therapeutic agents and promising delivery vectors
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The use of eLearning strategies among travel agents in the United Kingdom, India and New Zealand
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Tackling Alzheimer's disease: Hypothetical synergism between anti-inflammatory and anti-diabetic agents
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Synthesis of phosphono and phosphate derivatives of hydroxyimino-D-alditols as new potential antifungal agents
PublicationIn search for new effective we antyfungals we focus on two enzymes involved in biosynthesis of the fungal cell wall. The first enzyme is glucosamine-6-phosphate (GlmS), which catalyzes transformation of D-fructose-6-phosphate (Fru-6P) to D-glucosamine-6-phodphate (GlcN-6P) in the chitin biosynthesis pathway. The second enzyme is phosphomannose isomerase (PMI) repored to play a crucial role in biosynthesis of many mannosylated structures,...
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Genre-Based Music Language Modeling with Latent Hierarchical Pitman-Yor Process Allocation
PublicationIn this work we present a new Bayesian topic model: latent hierarchical Pitman-Yor process allocation (LHPYA), which uses hierarchical Pitman-Yor pr ocess priors for both word and topic distributions, and generalizes a few of the existing topic models, including the latent Dirichlet allocation (LDA), the bi- gram topic model and the hierarchical Pitman-Yor topic model. Using such priors allows for integration of -grams with a topic...
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Structural Characterization and in Vivo Evaluation of β-Hairpin Peptidomimetics as Specific CXCR4 Imaging Agents
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CD105 and placental growth factor – Potent prognostic factors in childhood acute lymphoblastic leukaemia
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Fermented juices as reducing and capping agents for the biosynthesis of size-defined spherical gold nanoparticles
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High resolution model for assessment of contamination by chemical warfare agents dumped in the Baltic Sea
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The role of cytochrome P450 reductase (CPR) in metabolism of potent nitroacridine antitumor, C-1748
PublicationCelem pracy było poznanie molekularnego mechanizmu działania pochodnych 9-amino-1-nitroakrydyny. Zbadano przemiany enzymatyczne tych związków w różnych układach enzymatycznych: I. Szczurza frakcja mikrosomalna z reduktazą cytochromu P450. II. Rekombinantowe izoenzymy cytochromu P450 z wysokim i niskim poziomem reduktazy cytochromu P450. III. Frakcje mikrosomalne dzikiego typu oraz pozbawione genu kodującego reduktazę cytochromu...
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Genre-Based Music Language Modeling with Latent Hierarchical Pitman-Yor Process Allocation
PublicationIn this work we present a new Bayesian topic model: latent hierarchical Pitman-Yor process allocation (LHPYA), which uses hierarchical Pitman-Yor pr ocess priors for both word and topic distributions, and generalizes a few of the existing topic models, including the latent Dirichlet allocation (LDA), the bi- gram topic model and the hierarchical Pitman-Yor topic model. Using such priors allows for integration of -grams with a topic model,...
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Indole-Acrylonitrile Derivatives as Potential Antitumor and Antimicrobial Agents—Synthesis, In Vitro and In Silico Studies
PublicationA series of 2-(1H-indol-2-yl)-3-acrylonitrile derivatives, 2a–x, 3, 4a–b, 5a–d, 6a–b, and 7, were synthesized as potential antitumor and antimicrobial agents. The structures of the prepared compounds were evaluated based on elemental analysis, IR, 1H- and 13NMR, as well as MS spectra. X-ray crystal analysis of the representative 2-(1H-indol-2-yl)-3-acrylonitrile 2l showed that the acrylonitrile double bond was Z-configured. All...
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Travel agents and destination management organizations: eLearning as a strategy to train tourism trade partners.
PublicationThis article offers an overview of the existing online courses run by national destination management organizations (DMOs) in order to better equip travel agents and tour operators in the sales activities of the tourism destinations. These online courses represent one of the B2B offers by DMOs and an interesting opportunity for travel agents, who are trying to find their identity and competitive advantage within the context of...
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Selected anionic and cationic surface active agents determined in river sediments – the Klodnica catchment
PublicationSurface active agents (SAAs) are specific compounds that contain hydrophilic/ hydrophobic group in their molecules named as amphiphilic structures. According to charge on the hydrophilic part of surfactants they can be classified into three main groups: anionic, cationic and non-ionic compounds. Due to the amphiphilic structure of SAAs they have specific properties (e.g. ability to adsorption at different surfaces, reduction of...
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Scalable Maintenance of Address Mapping and Autodetecion in Environments Where Agents are Uncapable of Self-Registration
PublicationWhen working with multi-agent systems it is often desirable to manage the agent set. The existing methods of central monitoring stems from two different fields of application. The first has its roots in in computer network monitoring, the other in mutli-agent simulation environments. Both approaches are not general enough to cater for loosely controlled environments, where the total agent population is not known and often fluctuating,...
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Effect of tube bundle arrangement on performance of shell-and-tube latent heat storage system
PublicationThis work presents the results of experimental investigation on charging and discharging of latent heat storage systems (LHSS) in the form of shell-and-tube heat exchangers with a variable arrays of the tube bundles. The tests included two tube arrangements – in-line and triangular (staggered), a variable number of tubes in a bundle, two pitch ratios, and different tube positions in a bundle. Three commercial products (LTP56, RT54HC,...
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The effect of new non-cross resistant antitumor agents on the energy state of human erythrocytes
PublicationPrzebadano pochodne benzoperimidynowe i antrapirydonowe odnośnie ich wpływu na stan energetyczny ludzkich erytrocytów. Stwierdzono, że poziom nukleotydów jak i wartość AEC erytrocytów nie zmienił się w ciągu 24 h inkubacji z powyższymi związkami. Jest to wynik obiecujący w odniesieniu do ich zastosowania jako związków aktywnych w pokonywaniu oporności wielolekowej.
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Aneta Łuczkiewicz prof. dr hab. inż.
PeopleI conduct research on the adaptive abilities of microorganisms and their potential use in supporting technological processes. I combine environmental engineering with elements of biomedical and materials engineering. I am interested in innovative methods for detecting clinically significant microorganisms in aquatic environments (so-called wastewater-based epidemiology) and advanced and practical solutions in the water management...
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INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
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Identification and management of the hypertensive patient with elevated heart rate: statement of a European Society of Hypertension Consensus Meeting
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Opioid Growth Factor and its Derivatives as Potential Non-toxic Multifunctional Anticancer and Analgesic Compounds
PublicationIn this paper, we review the structure-activity relationship of OGF and its analogues. We highlight also OGF derivatives with analgesic, immunomodulatory activity and the ability to penetrate the blood-brain barrier and may be used as safe agents enhancing chemotherapy efficacy and improving quality of life in cancer patients. The reviewed papers indicate that Met-enkephalin and its analogues are interesting candidates for the...
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Respiratory system modelling and simulation basing on the forced oscilation technique
PublicationConventional methods of testing lung functioning demand a specific respiratory action of the patient. In contrast, the forced oscillation technique (fot) provides measurements obtained with a minimal cooperation of the subject. The aim of this study is to verify the usefulness of the forced oscillation technique modelling in respiratory system diagnosing. in order to do it two models of fot measurements have been considered: the...