Filters
total: 1362
-
Catalog
displaying 1000 best results Help
Search results for: CYTOSTATIC DRUGS
-
Is sequential batch reactor an efficient technology to protect recipient against non-steroidal anti-inflammatory drugs and paracetamol in treated wastewater?
PublicationThe tested facility was a wastewater treatment plant (WWTP) in Swarzewo, where the wastewater treatment takes place in aeration chambers with activated sludge using sequential batch reactors (SBRs). The concentration of the following pharmaceuticals: ibuprofen, paracetamol, flurbiprofen, naproxen, diclofenac, and its metabolites 5OH-diclofenac and 4OH-diclofenac was tested in influents and effluents. Simultaneously, the conventional...
-
Design, synthesis and biological evaluation of novel N-phosphorylated and O-phosphorylated tacrine derivatives as potential drugs against Alzheimer’s disease
PublicationIn this work, we designed, synthesised and biologically investigated a novel series of 14N- and O-phosphorylated tacrine derivatives as potential anti-Alzheimer’s disease agents. In the reaction of 9-chlorotacrine and corresponding diamines/aminoalkylalcohol we obtained diamino and aminoalkylhydroxy tacrine derivatives. Next, the compounds were acid to give final products 6–13 and 16–21 that were characterised by 1H, 13 C, 31P...
-
Ti/TiO2 nanotubes sensitized PbS quantum dots as photoelectrodes applied for decomposition of anticancer drugs under simulated solar energy
PublicationOne of the challenges in research into photoelectrocatalytic (PEC) degradation of pollutants is finding the appropriate photoanode material, which has a significant impact on the process efficiency. Among all others, photoelectrodes based on an ordered TiO2 nanotube arrays are a promising material due to well-developed surface area and efficient charge separation. To increase the PEC activity of this material, the SILAR method was...
-
Iso-Partricin, an Aromatic Analogue of Amphotericin B: How Shining Light on Old Drugs Might Help Create New Ones
PublicationPartricin is a heptaene macrolide antibiotic complex that exhibits exceptional antifungal activity, yet poor selective toxicity, in the pathogen/host system. It consists of two compounds, namely partricin A and B, and both of these molecules incorporate two cis-type bonds within their heptaenic chromophores: 28Z and 30Z. In this contribution, we have proven that partricins are susceptible to a chromophore-straightening photoisomerization...
-
Results of modeling of pharmaceuticals mixtures toxicity with deviation ratio and best-fit functions models using Aliivibrio fischeri bacterium as model organism
Open Research DataThe research was concerned with verifying the impact of mixtures of nine pharmaceuticals against a selected organism, i.e., the bacterium Aliivibrio fischeri. A. fisheri is used as a model organism in the monitoring of acute toxicity in environmental and reference samples in Microtox® systems. Tested pharmaceuticals, namely: diclofenac (sodium salt),...
-
BIOPHARMACEUTICS & DRUG DISPOSITION
Journals -
CLINICAL DRUG INVESTIGATION
Journals -
DRUG NEWS & PERSPECTIVES
Journals -
DRUG INFORMATION JOURNAL
Journals -
Drug Target Insights
Journals -
Drug Discoveries and Therapeutics
Journals -
Drug Testing and Analysis
Journals -
CNS DRUG REVIEWS
Journals -
Journal of Drug Delivery
Journals -
DRUG DISCOVERY TODAY
Journals -
DRUG RESISTANCE UPDATES
Journals -
Current Drug Safety
Journals -
BIOINFO Drug targets
Journals -
Drug Metabolism and Pharmacokinetics
Journals -
Current Drug Therapy
Journals -
JOURNAL OF DRUG ASSESSMENT
Journals -
DRUG AND ALCOHOL REVIEW
Journals -
Drug and Therapeutics Bulletin
Journals -
Drug Discovery World
Journals -
Drug Metabolism Letters
Journals -
Drug Delivery Letters
Journals -
WHO Drug Information
Journals -
Drug Invention Today
Journals -
Drug Delivery System
Journals -
Contemporary Drug Problems
Journals -
Drug Development and Registration
Journals -
JOURNAL OF DRUG TARGETING
Journals -
Medicine in Drug Discovery
Journals -
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
Journals -
Drug Evaluation Research
Journals -
JOURNAL OF DRUG EDUCATION
Journals -
JOURNAL OF DRUG ISSUES
Journals -
Cancer Drug Resistance
Journals -
THERAPEUTIC DRUG MONITORING
Journals -
Magnetic Silica Nanotubes: Synthesis, Drug Release, and Feasibility for Magnetic Hyperthermia
Publication -
Multi‐wall carbon nanotubes – a vehicle for targeted Irinotecan drug delivery
Publication -
Antimicrobial peptides (AMPs) as drug candidates: a patent review (2003–2015)
Publication -
Single-wall carbon nanotubes based anticancer drug delivery system
Publication -
Natural carbon-based quantum dots and their applications in drug delivery: A review
Publication -
The significance of lumican expression in ovarian cancer drug-resistant cell lines
Publication -
Quantitative proteomic analysis of anticancer drug RH1 resistance in liver carcinoma
Publication -
Progress in targeting tumor cells by using drug-magnetic nanoparticles conjugate.
PublicationTo limit the cytotoxicity of anticancer drugs against healthy cells, an appropriate carrier should be synthesized to deliver the drug to the tumor tissue only. A good solution is to anchor a magnetic nanoparticle to the molecule of the drug and to use a properly directed external magnetic field. We have shown that the improved by us synthesis of the conjugate of doxorubicin with iron-oxide magnetic nanoparticles allows a substantial...
-
Chemometric Evaluation of THz Spectral Similarity for the Selection of Early Drug Candidates
Publication -
The impact of lipophilicity on environmental processes, drug delivery and bioavailability of food components
PublicationLipophilic properties of the compound allow to predict its fate in living organisms and to propose the models of chemicals transport and accumulation in the ecosystem. Lipophilicity is also useful as the characteristic of chemicals in respect to their optimal attributes for specific biological and non-biological tasks. The lipophilicity descriptors define the potency of endo- and xenobiotics to metabolic transformations and their...
-
pH-dependent composite coatings for controlled drug delivery system - Review
PublicationNowadays in case of long-term implants, the most common postoperative complications are bacterial infections, which in consequence may provoke loos- ening of the implants in the primary phase of stabilization. Bacterial infections are currently the most frequent cause of revision surgery of the implants such as hip joint endoprosthesis, knee joint endoprosthesis and dental implants. In order to provide the local and long-term antibacterial...