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Search results for: CIRCULAR DICHROISM
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Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA
PublicationA DNA cross-link adduct of the antitumor agent mitomycin C (MC) to DNA has been isolated and characterized; the results provide direct proof for bifunctional alkylation of DNA by MC. Exposure of MC to Micrococcus luteus DNA under reductive conditions and subsequent nuclease digestion yielded adducts formed between MC and deoxyguanosine residues. In addition to the two known monoadducts, a bisadduct was obtained. Reductive MC activation...
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Influence of Urea and Dimethyl Sulfoxide on K-Peptide Fibrillation
PublicationProtein fibrillation leads to formation of amyloids—linear aggregates that are hallmarks of many serious diseases, including Alzheimer’s and Parkinson’s diseases. In this work, we investigate the fibrillation of a short peptide (K-peptide) from the amyloidogenic core of hen egg white lysozyme in the presence of dimethyl sulfoxide or urea. During the studies, a variety of spectroscopic methods were used: fluorescence spectroscopy...
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Design and optimization of a novel compact broadband linearly/circularly polarized wide-slot antenna for WLAN and Wi-MAX applications
PublicationA novel topologically modified structure of a compact low profile wide-slot antenna for broadband applications is presented. The antenna comprises a modified E-shaped slot with unequal arm lengths in the ground plane, and a parasitic quasi-rectangular loop placed coplanar with the feedline. For exciting orthogonal modes with equal amplitude, a single-point feeding technique with an asymmetrical geometry of the coplanar waveguide...
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Implementation of spatial/polarization diversity for improved-performance circularly polarized multiple-input-multiple-output ultra-wideband antenna
PublicationIn this paper, spatial and polarization diversities are simultaneously implemented in an ultra-wideband (UWB) multiple-input-multiple-output (MIMO) antenna to reduce the correlation between the parallel-placed radiators. The keystone of the antenna is systematically modified coplanar ground planes that enable excitation of circular polarization (CP). To realize one sense of circular polarization as well as ultra-wideband operation,...
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Highly Integrable Planar-structured Printed Circularly Polarized Antenna for Emerging Wideband Internet of Things Applications in the Millimeter-Wave Band
PublicationThis paper proposes a numerically and experimentally validated printed wideband antenna with a planar geometry for Internet of Things (IoT) applications. This design tackles the challenges associated with deploying IoT sensors in remote areas or across extensive geographical regions. The proposed design exploits a coplanar-waveguide-fed modified microstrip line monopole for excitation of circularly polarized waves radiating in...
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Thermodynamics and kinetics of amphotericin B self-association in aqueous solution characterized in molecular detail
PublicationAmphotericin B (AmB) is a potent but toxic drug commonly used to treat systemic mycoses. Its efficiency as a therapeutic agent depends on its ability to discriminate between mammalian and fungal cell membranes. The association of AmB monomers in an aqueous environment plays an important role in drug selectivity, as oligomers formed prior to membrane insertion – presumably dimers – are believed to act differently on fungal (ergosterol-rich)...
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The Interaction of Heptakis (2,6-di-O-Methyl)-β-Cyclodextrin with Mianserin Hydrochloride and Its Influence on the Drug Toxicity
PublicationOne tetracyclic antidepressant, mianserin hydrochloride (MIA), has quite significant side effects on a patients’ health. Cyclodextrins, which are most commonly used to reduce the undesirable features of contained drugs within their hydrophobic interior, also have the potential to alter the toxic behavior of the drug. The present paper contains investigations and the characteristics of interaction mechanisms for MIA and the heptakis...
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EM-Driven Size Reduction and Multi-Criterial Optimization of Broadband Circularly-Polarized Antennas Using Pareto Front Traversing and Design Extrapolation
PublicationMaintaining small size has become an important consideration in the design of contemporary antenna structures. In the case of broadband circularly polarized (CP) antennas, miniaturization is a challenging process due to the necessity of simultaneous handling of electrical and field properties (reflection, axial ratio, gain), as well as ensuring sufficient frequency range of operation, especially at the lower edge of the antenna...
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Novel Coplanar-Strip-Based Excitation Technique for Design of Broadband Circularly Polarization Antennas with Wide 3-dB Axial Ratio Beamwidth
PublicationIn this paper, a novel excitation technique for design of a single-point-fed compact low-profile wide-slot antennas with broadband circular polarization (CP) and wide 3 dB axial ratio (AR) beamwidth is presented. Two inverted L-shape parasitic strips placed coplanar to the microstrip line of an asymmetric CPW, and a horizontal strip that protrudes from the vertical edge of the backside ground plane of the substrate are used for...
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2022-2023 - Strenght of materials towards applications, PG_00053661
e-Learning CoursesThe course is mainly dedicated to the DAPE Students. From the theoretical point of view the course consists of the following problems to be discussed during the lectures and exercises: -fundamentals of strength of materials -basic structures and environment -loads on structures -strength of materials: tension, stress, analysis of stress and strain, bending moments and shearing forces, longitudinal and shearing stress in beams,...
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Strenght of materials towards applications , PG_00053661
e-Learning CoursesThe course is dedicated to the DAPE WIMiO Students. From the theoretical point of view the course consists of the following problems to be discussed during the lectures: -fundamentals of strength of materials -basic structures and environment -loads on structures -strength of materials: tension, stress, analysis of stress and strain, bending moments and shearing forces, longitudinal and shearing stress in beams, bending stress...
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Process engineering in circular economy
e-Learning CoursesDefinition and principles of the circular economy (CE). The transition from a linear model to a circular model. Business models for the CE. Circular design and innovation. CE assessment carbon footprint, life cycle assessment. Case studies of the cities implementing the CE concept. CE policy and legislation (EU and Poland). Wastewater treatment plants as an element of the CE. Energy and nutrient recovery technologies in wastewater...
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PTD4 Peptide Increases Neural Viability in an In Vitro Model of Acute Ischemic Stroke
PublicationIschemic stroke is a disturbance in cerebral blood flow caused by brain tissue ischemia and hypoxia. We optimized a multifactorial in vitro model of acute ischemic stroke using rat primary neural cultures. This model was exploited to investigate the pro-viable activity of cell-penetrating peptides: arginine-rich Tat(49–57)-NH2 (R49KKRRQRRR57-amide) and its less basic analogue, PTD4 (Y47ARAAARQARA57-amide). Our model included glucose...
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Synthesis, structure, DNA binding and anticancer activity of mixed ligand ruthenium(II) complex
PublicationIn order to obtain a potential chemotherapeutic which is not affected on the normal BALB/3T3 cell line, a new arene ruthenium(II) complex {[RuCl(L1)(η6-p-cymene)]PF6}2 · H2O has been synthesized by a direct reaction of precursor, [{(η6-p-cymene)Ru(μ-Cl)}2Cl2], with N,N-chelating ligand (L1 - 2,2′-bis(4,5-dimethylimidazole). The compound has been fully characterized by elemental analysis, X-ray diffraction, IR, UV–Vis and 1H, 13C...
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Circularly Polarized Antenna Array design with the Potential of Gain-Size Trade-off and Omnidirectional Radiation for Millimeter-Wave Small Base Station Applications
PublicationThis paper presents the design and validation of a slot-patch-hybrid circularly polarized antenna array for 28 GHz millimeter (mm) wave (mm-wave) applications. The proposed design has a simple geometry that facilitates the fabrication process, which is otherwise a challenging task due to the sub-mm dimensions of the circuit in the mm-wave band. In the proposed structure, aperture-coupled series slot-fed array is utilized to excite...
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STRENGTH of MATERIALS TOWARDS APPLICATIONS (2024)
e-Learning CoursesThe SMTA DATE Course consists of the following problems to be discussed during the lectures: - Introduction to strength of materials towards applications - Fundamentals of modelling in strength of materials towards applications - Materials and basic structures - Fundamentals of modelling in strength of materials towards applications - Definition of environment and loads - General, energy-based and advanced methods for analysis...
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P4604Insights into left ventricular remodelling and clinical outcomes after Wharton's jelly multipotent stem cells transcoronary administration in a pilot cohort of CIRCULATE-AMI Trial (NCT03404063)
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Tadeusz Połoński prof. dr hab. inż.
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Evolution of left ventricular function after Wharton's jelly mesenchymal stem cells transcoronary administration: 5-year follow up in a pilot cohort of CIRCULATE-AMI Randomized Trial
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Process engineering in circular economy
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Mode vibrations of plates – experimental analysis
PublicationIn this paper results of the square MDF plate and circular saw blades examination with the use of the harmonic method to static identification of resonant frequencies and shapes of mode vibrations are presented. Obtained results reveled that for circular saws with large holes in a saw blade appeared two resonant frequencies for the same nodal number.
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Acute myocardial infarction reparation/regeneration strategy using Wharton’s jelly multipotent stem cells as an ‘unlimited’ therapeutic agent: 3-year outcomes in a pilot cohort of the CIRCULATE-AMI trial
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Ruthenium(II) and Iridium(III) Complexes as Tested Materials for New Anticancer Agents
PublicationThe oncological use of cisplatin is hindered by its severe side eects and a very important resistance problem. To overcome these problems, scientists have attempted to design new generation transition-metal anticancer complexes. In this study, we present new complexes, ruthenium(II) [(6-p-cymene)RuCl(py2CO)]PF6 (1), iridium(III) [(5-Cp)IrCl(py2CO)]PF6 (2), and NH4[IrCl4(py2CO)]H2O (3), based on di-2-pyridylketone (py2CO). The prepared...
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Development and evaluation of RADA-PDGF2 self-assembling peptide hydrogel for enhanced skin wound healing
PublicationBackground: Wound healing complications affect numerous patients each year, creating significant economic and medical challenges. Currently, available methods are not fully effective in the treatment of chronic or complicated wounds; thus, new methods are constantly sought. Our previous studies showed that a peptide designated as PDGF2 derived from PDGF-BB could be a promising drug candidate for wound treatment and that RADA16-I...
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Release systems based on self-assembling RADA16-I hydrogels with a signal sequence which improves wound healing processes
PublicationSelf-assembling peptides can be used for the regeneration of severely damaged skin. They can act as scaffolds for skin cells and as a reservoir of active compounds, to accelerate scarless wound healing. To overcome repeated administration of peptides which accelerate healing, we report development of three new peptide biomaterials based on the RADA16-I hydrogel functionalized with a sequence (AAPV) cleaved by human neutrophil elastase...
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A spice equivalent circuit for modeling the performance of dual frequency echo-sounder
PublicationThe paper presents novel network equivalent circuit of piezoceramic circular disc transducers that takes into account thickness and radial mode of vibrations. The starting point of the analysis is 4-port description of circular disc element representing the solution of wave equation set in radial and thickness directions. The approximate solution for harmonic case is represented in the form of 4x4 matrix, which is synthesised and...
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Multi-modality imaging in the CIRCULATE-AMI pilot study cohort: a framework for an imaging-based randomized controlled trial of Wharton jelly mesenchymal stem cell use to stimulate myocardial repair/regeneration
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Similarities and differences in d6 low-spin ruthenium, rhodium and iridium half-sandwich complexes: synthesis, structure, cytotoxicity and interaction with biological targets
PublicationIn this paper, we discussed the similarities and diferences in d6 low-spin half-sandwich ruthenium, rhodium and iridium complexes containing 2,2′-biimidazole (H2biim). Three new complexes, {[RuCl(H2biim)(η6 -p-cymene)]PF6}2·H2O (1), [(η5 - Cp)RhCl(H2biim)]PF6 (2), and [(η5 -Cp)IrCl(H2biim)]PF6 (3), were fully characterized by CHN, X-ray difraction analysis, UV–Vis, FTIR, and 1 H, 13C and 15N NMR spectroscopies. The complexes exhibit...
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Generation of chirality in 4,4'-azopyridine by co-crystallization with optically active dicarboxylic acids
PublicationOtrzymano kokryształy anti-4,4'-azopirydyny z optycznie czynnymi kwasai: 9,10-dihydro-9,10-etanoantraceno-11,12-dikarboksylowym i trans-1,2-cykloheksnodikarboksylowym. Następnie pomierzono dichroizm kołowy otrzymanych kryształów. Dodatni znak efektu Cottona, odpowiadający niskoenergetycznemu wzbudzeniu elektronowemu n-pi*, został skorelowany z M helikalnością skręconego chromoforu Ar-N=N. Absolutna konfiguracja skręconej cząsteczki...
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Karolina Krośnicka dr hab. inż. arch.
PeopleKarolina A. Krośnicka, Ph.D., D.Sc., Eng. Arch., is associated professor at Department of Urban Design and Regional Planning, Faculty of Architecture, Gdańsk University of Technology (Poland). For many years (1998 – 2016) she was employed at the Department of Transport and Logistics at the Faculty of Navigation at Gdynia Maritime University (Gdynia, Poland), where she was mostly involved in issues connected with seaports and port...
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Pemphigoid - Female, 68 - Tissue image [12040630008877661]
Open Research DataThis is the histopathological image of SKIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Optical activity of benzophenone and thiobenzophenone generated by spontaneous crystallization and inclusion complexation with cholic acid.
PublicationOtrzymano związki inkluzyjne benzofenonu i jego tioanalogu z kwasem cholowym. W zależności od stosowanej metody syntezy kompleksów inkluzyjnych benzofenonu powstawały one w dwóch różnych postaciach polimorficznych. Jedna z nich wykazuje istnienie cząsteczek gościa w czterech konformacjach, przy czym dominuje konformer o helikalności M. Struktura krystalograficzna kompleksu tiobenzofenonu z kwasem cholowym ujawniła obecność tylko...
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Extending transition curve in analytical design method
PublicationThe paper presents the problem of extending the transitional curves, using for this purpose an analytical design method. The basis for the analysis of numerical calculations were carried out for a wide set of parameters characterizing the standard geometric system. We considered an importance of the size of radius of the circular arc and return angle of route on the obtained results after the formulation of appropriate theoretical...
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Managerial Energy in Sustainable Enterprises: Organizational Wisdom Approach
PublicationThe circular economy (CE) as an idea involves applying the concept of sustainable development that has been gaining worldwide support. This shift in perception of energy and resource-use from its linear to circular forms creates a specific business environment, which constitutes the subject of this research. This article aims to analyze the impact of a manager’s energy on organizational wisdom, focusing on its circular business...
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Pemphigoid - Female, 30 - Tissue image [12060630017627221]
Open Research DataThis is the histopathological image of SKIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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STUM CIRCULAR ECONOMY - AN ANSWER TO CONTEMPORARY CLIMATE CHALLENGES
ProjectsProject realized in Department of Environmental Engineering Technology
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Satellite pump and motor
PublicationThe article describe the design and operation of a prototype of satellite pump and a prototype of satellite motor. In both machines, the operating mechanism consists of a non-circular gear with external teeth (rotor), non-circular gear with internal teeth (curvature), and ten gear wheels which cooperate with the rotor and the curvature. The differences between the commutation unit in the pump and the commutation unit in the motor...
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A Note on Fractional Curl Operator
PublicationIn this letter, we demonstrate that the fractional curl operator, widely used in electromagnetics since 1998, is essentially a rotation operation of components of the complex Riemann–Silberstein vector representing the electromagnetic field. It occurs that after the wave decomposition into circular polarisations, the standard duality rotation with the angle depending on the fractional order is applied to the left-handed basis vector...
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Analytical design method of reverse curves
PublicationThe paper deals with a new approach relating to the design of the region of railway track direction alteration adapted to Mobile Satellite Measurements technique. The method may be particularly useful in situations when both the straights of the route directions cannot be connected in an elementary way using a circular arc with transition curves; this also refers to the application of a compound curve. Thus the only solution becomes...
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Sewage sludge pretreatment by low thermal disintegration for better efficacy of sludge digestion process
PublicationThe wastewater water treatment plant (WWTP) sector and it is developing technologies strive to be implement circular economy. The methane production from the sludge digestion process constitute promising source of the renewable energy for WWTP and approaching circular economy assumptions. For this reason, the objective of the study was to examine the modification of sludge characteristics due to the low temperature pretreatment....
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FINITE GROUND CPW-FED UWB ANTENNA OVER THE METALLIC CYLINDRICAL SURFACES
PublicationThe investigation of finite ground coplanar fed ultra-wideband (UWB) antenna and the influence of its curvature and the proximity of circular metallic screen on the reflection coefficients and radiation characteristics is presented. The antenna is composed of two circular coplanar strips which enclose slot aperture of similar shape and is designed on a thin and flexible substrate which allows its bending. The antenna configuration...
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CUTTING POWER FORECASTING WHILE WOOD SAWING: FRACTURE MECHANICS APPROACH AND AXELSSON’S MODEL COMPARISON
PublicationIn the classical approach, energetic effects (cutting forces and cutting power) of wood sawing process are generally calculated on the basis of the specific cutting resistance, which is in the case of wood cutting the function of more or less important factors. On the other hand, cutting forces (power) could be considered from a point of view of modern fracture mechanics. Another way is to forecast cutting power consumption on...
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Prospects in elongation of railway transition curves
PublicationThe paper presents an analysis of the elongation of transition curves in relation to railway track alignment correction and modernisation. The analysis is based on numerical computations for a wide range of parameters describing a typical railway geometrical layout with transition curves. The differences between the horizontal ordinates of the existing layout and the layout with the elongated transition curves are evaluated and...
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Ryszard Katulski prof. dr hab. inż.
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Analityczna metoda projektowania łuków odwrotnych
PublicationW pracy przedstawiono nową metodę projektowania rejonu zmiany kierunku trasy kolejowej, dostosowaną do techniki Mobilnych Pomiarów Satelitarnych. Metoda ta może się okazać szczególnie przydatna wówczas, gdy obydwu prostych kierunków trasy nie można połączyć w sposób elementarny, stosując łuk kołowy z krzywymi przejściowymi; dotyczy to również. zastosowania łuku koszowego. Jedynym rozwiązaniem staje się wówczas wprowadzenie do układu...
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Połączenie G3 dwóch kierunków prostych z użyciem krzywej NURBS
PublicationW artykule przedstawiono nową metodę projektowania układu geometrycznego toru kolejowego opartą na zastosowaniu krzywych NURBS (Non-Uniform Rational B-Spline) do opisu krzywizny. Punkty kontrolne krzywej NURBS wyznaczane są w procesie optymalizacji za pomocą algorytmu genetycznego. Jako kryterium optymalizacji przyjęto minimalizację oddziaływań dynamicznych występujących w układzie tor-pojazd przy spełnieniu warunków geometrycznych...
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Wideband crossover structure with double ring resonators
PublicationThe structure of a four-port microstrip crossover is presented. The device is composed of two ring resonators, one circular and one built from meander lines, connected by four straight lines. The equivalent circuit model of the crossover is derived. The structure is designed on thin and flexible substrate to allow it to bend. The possibility of applying the device on curved surfaces is tested experimentally.
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ON AXIALLY SYMMETRIC SHELL PROBLEMS WITH REINFORCED JUNCTIONS
PublicationWithin the framework of the six-parameter nonlinear resultant shell theory we consider the axially symmetric deformations of a cylindrical shell linked to a circular plate. The reinforcement in the junction of the shell and the plate is taken into account. Within the theory the full kinematics is considered. Here we analyzed the compatibility conditions along the junction and their in uence on the deformations and stressed state.
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Sawing Processes as a Way of Determining Fracture Toughness and Shear Yield Stresses of Wood
PublicationA new computational model, based on fracture mechanics, was used to determine cutting forces. Unlike traditional computing methods, which depend on many coefficients reflecting the machining of solid wood, the new model uses two main parameters: fracture toughness and shear yield stresses. The aim of this study was to apply this new method to determine these parameters for the tooth cutting edge principal positions and longitudinal...
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A prototype information system for managing and pricing e-waste
PublicationThere is no doubt that innovation drives development in all areas of human activity, including electrical and electronic equipment. However, the production of new equipment has a significant impact on the natural environment and a relatively high consumption of natural resources. To address these issues, the circular economy has been implemented in recent years by promoting and introducing numerous measures to facilitate the recycling...