Filters
total: 1568
-
Catalog
- Publications 1144 available results
- Journals 119 available results
- Publishing Houses 2 available results
- People 39 available results
- Projects 9 available results
- Research Teams 2 available results
- e-Learning Courses 60 available results
- Events 7 available results
- Open Research Data 186 available results
displaying 1000 best results Help
Search results for: rovs drag
-
pH-Responsive Drug Delivery Nanoplatforms as Smart Carriers of Unsymmetrical Bisacridines for Targeted Cancer Therapy
PublicationSelective therapy and controlled drug release at an intracellular level remain key challenges for effective cancer treatment. Here, we employed folic acid (FA) as a self-navigating molecule in nanoconjugates containing quantum dots (QDs) and β-cyclodextrin (β-CD) for the delivery of antitumor unsymmetrical bisacridine compound (C-2028) to lung and prostate cancers as well as normal cells. The bisacridine derivative can form the...
-
The bioactivity studies of drug-loaded mesoporous silica-polydimethylsiloxane xerogels using FTIR and SEM/XEDS
Publication -
Correlation between physicochemical properties of doxorubicin-loaded silica/polydimethylsiloxane xerogel and in vitro release of drug
Publication -
The Correlation between Physical Crosslinking and Water-Soluble Drug Release from Chitosan-Based Microparticles
Publication -
Double layer adhesive silicone dressing as a potential dermal drug delivery film in scar treatment
PublicationThe present studies focused on the evaluation of design of an adhesive silicone film intended for scar treatment. Developed silicone double layer film was examined in terms of its future relevance to therapy and applicability on the human skin considering properties which included in vitro permeability of water vapor and oxygen. In order to adapt the patches for medical use in the future there were tested such properties as...
-
Tricyclic xanthine derivatives containing a basic substituent: adenosine receptor affinity and drug-related properties
Publication -
Double layer adhesive silicone dressing as a potential dermal drug delivery film in scar treatment
Publication -
Silver Nanoparticles as Chlorhexidine and Metronidazole Drug Delivery Platforms: Their Potential Use in Treating Periodontitis [Corrigendum]
Publication -
Molecular modeling and evaluation of novel dibenzopyrrole derivatives as telomerase inhibitors and potential drug for cancer therapy
PublicationDuring previous years, many studies on synthesis, as well as on anti-tumor, anti-inflammatory and anti-bacterial activities of the pyrazole derivatives have been described. Certain pyrazole derivatives exhibit important pharmacological activities and have proved to be useful template in drug research. Considering importance of pyrazole template, in current work the series of novel inhibitors were designed by replacing central...
-
Analiza zachowań użytkowników dróg na przejściach dla pieszych na podstawie badań terenowych
PublicationJak wynika z analiz statystyk wypadki z udziałem pieszych stanowią około trzydziestu procent wszystkich wypadków w Polsce. Przyczyny wypadków są bardzo złożone i bardzo trudne do jednoznacznego określenia. Niejednokrotnie przyczyny występują po stronie użytkowników dróg, ale mogą być wynikiem błędów projektowych lub złego stanu pojazdów. W tym celu, bardzo ważne jest przeanalizowanie każdej płaszczyzny z systemu człowiek – pojazd...
-
Biological effects in photodynamic treatment combined with electropermeabilization in wild and drug resistant breast cancer cells
Publication -
Increased Expression of Several Collagen Genes is Associated with Drug Resistance in Ovarian Cancer Cell Lines
Publication -
Wpływ ruchu pojazdów ciężarowych na zniszczenia domów zlokalizowanych w pobliżu dróg przejazdowych
PublicationW niniejszym artykule przestawiono problem występowania drgań w budynkach, spowodowanych poruszającymi się pojazdami oraz ideę rozwiązania problemu pracochłonnych i kosztownych pomiarów takiego zjawiska. Autorzy starają się ukazać czynniki mające wpływ na wielkość drgań w świetle obowiązujących przepisów i norm. Główny wysiłek skupiają na ich pomiarze i interpretacji otrzymanych wyników w świetle propozycji budowy aplikacji wykorzystującej...
-
Novel and effective synthesis protocol of AgNPs functionalized using L-cysteine as a potential drug carrier
Publication -
A randomized and controlled study of noninvasive hemodynamic monitoring as a guide to drug treatment of uncontrolled hypertensive patients
Publication -
Essentials and Perspectives of Computational Modelling Assistance for CNS-oriented Nanoparticle-based Drug Delivery Systems
Publication -
Ocena dróg wojewódzkich położonych w obszarze województwa pod względem bezpieczeństwa ruchu drogowego
PublicationOcena dróg wojewódzkich na obszarze woj. kujawsko - pomorskiego pod kątem brd: liczba wypadków i ich ofiar, wskaźniki brd
-
Ocena dróg krajowych położonych w obszarze województwa pod względem bezpieczeństwa ruchu drogowego
PublicationOcena poziomu brd na drogach krajowych, liczba wypadków, ich ofiary i wskaźniki brd.
-
Niezawodność systemu transportowego dla dróg krajowych w Polsce w aspekcie wpływu kierowców
PublicationCzynniki powodujące zmęczenie kierowców. Analiza wypadków związanych ze zmęczeniem kierowców. Wpływ pory dnia na ryzyko wypadków drogowych spowodowanych przez zmęczonych kierowców.
-
Virulence and Drug-Resistance of Staphylococcus aureus Strains Isolated from Venous Ulcers in Polish Patients
Publication -
Combinatory Treatment with miR-7-5p and Drug-Loaded Cubosomes Effectively Impairs Cancer Cells
Publication -
New amino acid propyl ester ibuprofenates from synthesis to use in drug delivery systems
Publication -
Czynniki wpływające na gęstość ofiar wypadków na odcinkach dróg krajowych w Polsce
PublicationW referacie przedstawiono wstepne wyniki badań wpływu wybranych czynników na gęstość wypadków drogowych oraz ich ofiar (rannych i śmiertelnych) na drogach krajowych w Polsce w latach 2006-2008. Efektem tych badań sa wybrane modele prognozowania wypadków.
-
The noncanonical disulfide bond as the important stabilizing element of the immunoglobulin fold of the Dr fimbrial DraE subunit
PublicationAdhezyny fimbrialne bakterii patogennych stanowią liniowe asocjaty białkowe odpowiedzialne za wiązanie do specyficznych receptorów na powierzchni komórek gospodarza. Biogeneza tych struktur odbywa się przez system sekrecji typu chaperone/usher zakonserwowany pośród bakterii Gram-ujemnych. Powyższe struktury adhezyjne charakteryzują się wysoką odpornością na denaturację i deasocjację, powodowane przez temperaturę lub chemiczne czynniki...
-
Low-Barrier Hydrogen Bond Determines Target-Binding Affinity and Specificity of the Antitubercular Drug Bedaquiline
PublicationThe role of short strong hydrogen bonds (SSHB) in ligand-target binding remains largely unexplored, thereby hin- dering a potentially important avenue in the rational drug de- sign. Here, we investigate the interaction between bedaquiline (Bq), a potent anti-tuberculosis drug, and the mycobacterial ATP synthase, to unravel the role of a specific hydrogen bond to a conserved acidic residue in the target affinity and specificity....
-
Role of the disulfide bond in stabilizing and folding of the fimbrial protein DraE from uropathogenic Escherichia coli
PublicationDr fimbriae are homopolymeric adhesive organelles of uropathogenic Escherichia coli composed of DraE subunits, responsible for the attachment to host cells. These structures are characterized by enormously high stability resulting from the structural properties of an Ig-like fold of DraE. One feature of DraE and other fimbrial subunits that makes them peculiar among Ig-like domain-containing proteins is a conserved disulfide bond...
-
Evaluation of multiple genetic markers for typing drug-resistant Mycobacterium tuberculosis strains from Poland
PublicationW publikacji przedstawiono wyniki genotypowania wielolekoopornych szczepów Mycobacterium tuberculosis izolowanych od pacjentów z Polski.
-
Importance of biofilm formation by uropathogenic E. coli Dr+ strains in urinary tract infections
PublicationImportance of biofilm formation by uropathogenic E. coli Dr+ strains in urinary tract infections
-
Wave energy attenuation in fields of colliding ice floes – Part 1: Discrete-element modelling of dissipation due to ice–water drag
Publication -
Cu(II) complexes with peptides from FomA protein containing -His-Xaa-Yaa-Zaa-His and -His-His-motifs. ROS generation and DNA degradation
Publication -
CFD and FEM model of an underwater vehicle propeller
PublicationDuring the project execution of design and optimization the Remotely Operated Vehicle (ROV) research on its propulsion has been carried out. The entire project was supported by CFD and FEM calculations, which taking into account the characteristics of underwater vehicle. One of the tasks was to optimize the semi-open duct for horizontal propellers, which provided propulsion and controllability in horizontal plane. In order to...
-
Glutathione-mediated conjugation of anticancer drugs: an overview of reaction mechanisms and biological significance for drug detoxification and bioactivation.
PublicationThe effectiveness of many anticancer drugs depends on the creation of specific metabolites that may alter their therapeutic or toxic properties. One significant route of biotransformation is a conjugation of electrophilic compounds with reduced glutathione, which can be non-enzymatic and/or catalyzed by glutathione-dependent enzymes. Glutathione usually combines with anticancer drugs and/or their metabolites to form more polar...
-
Applications of Cannabis Sativa L. in Food and Its Therapeutic Potential: From a Prohibited Drug to a Nutritional Supplement
Publication -
Thromboelastometric Analysis of Anticancer Cerrena unicolor Subfractions Reveal Their Potential as Fibrin Glue Drug Carrier Enhancers
Publication -
Molecular characterization of drug-resistant Mycobacterium tuberculosis strains from Poland by use of multiple genetic markers
PublicationW pracy przedstawiono wyniki genotypowania wielolekoopornych szczepów Mycobacterium tuberculosis, izolowanych od pacjentów z Polski.
-
Poor sensitization of 50-kHz vocalization response to amphetamine predicts rat susceptibility to self-administration of the drug
Publication -
Targeted Nano-Drug Delivery of Colchicine against Colon Cancer Cells by Means of Mesoporous Silica Nanoparticles
Publication -
<p>Nanoparticles And Human Saliva: A Step Towards Drug Delivery Systems For Dental And Craniofacial Biomaterials</p>
Publication -
Analysis of MDR genes expression and cross-resistance in eight drug resistant ovarian cancer cell lines
Publication -
Wpływ efektu komina termicznego na układ różnicowania ciśnień w przestrzeni pionowych dróg ewakuacyjnych.
PublicationPoprawne działanie systemów oddymiania oraz ochrony przed zadymieniem pionowych dróg ewakuacji nabiera szczególnego znaczenia w przypadku budynków wysokich, w których podjęcie akcji ratunkowej z zewnątrz budynku jest utrudnione, bądź niemożliwe. W tego typu budynkach proces projektowania wentylacji pożarowej spełniającej znormalizowane wymagania w przestrzeniach chronionych ulega komplikacji.
-
Controlled Drug Release and Cytotoxicity Studies of Beta-Lapachone and Doxorubicin Loaded into Cyclodextrins Attached to a Polyethyleneimine Matrix
Publication -
Ocena bezpieczeństwa ruchu drogowego na odcinkach dróg wojewódzkich położonych w obszarze poszczególnych gmin
PublicationOcena brd na odcinkach dróg wojewódzkich w poszczególnych gminach woj. kujawsko - pomorskiego. liczba wypadków i ich ofiar, wskaźniki brd.
-
Sandwich-like mesoporous silica flakes for anticancer drug transport—Synthesis, characterization and kinetics release study
Publication -
In vitro and in vivo evaluation of sandwich-like mesoporous silica nanoflakes as promising anticancer drug delivery system
Publication -
Discovery of the anticancer drug vinblastine from the endophytic Alternaria alternata and yield improvement by gamma irradiation mutagenesis
Publication -
Electrochemical and biological characterization of lyotropic liquid crystalline phases – retardation of drug release from hexagonal mesophases
Publication -
Strain improvement and immobilization technique for enhanced production of the anticancer drug paclitaxel by Aspergillus fumigatus and Alternaria tenuissima
Publication -
Structure–Activity Relationships and Therapeutic Applications of Retinoids in View of Potential Benefits from Drug Repurposing Process
Publication -
Optical properties of the chemotherapy drugs used in the central nervous system lymphoma therapy: monitoring drug delivery
PublicationOur aim is to optically monitor the delivery of the chemotherapy drugs for brain tumours, particularly used in the central nervous system (CNS) lymphoma therapy. In vivo monitoring would help to optimize the treatment and avoiding unnecessary medications. Moreover, it would be beneficial to be able to measure which of the multi-regimen drugs actually do penetrate and how well into the brain tissue. There exist several potential...
-
Electrochemical simulation of metabolism for antitumor-active imidazoacridinone C-1311 and in silico prediction of drug metabolic reactions
PublicationThe metabolism of antitumor-active 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) has been investigated widely over the last decade but some aspects of molecular mechanisms of its metabolic transformation are still not explained. In the current work, we have reported a direct and rapid analytical tool for better prediction of C-1311 metabolism which is based on electrochemistry (EC) coupled on-line with electrospray...