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Search results for: BETAINA
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Conformers and hydrogen bond transformations in N-methylpiperidine betaine 2,4-dinitrophenolate crystals
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Effect of urea and glycine betaine on the hydration sphere of model molecules for the surface features of proteins
PublicationWater properties may significantly affect protein stability. Osmolytes are compounds that intrinsically affect water in many different ways and thus can influence proteins with this type of indirect mechanism. In this study, we characterize water properties in ternary solutions: model–water–osmolyte, with two model molecules: N-methylacetamide (NMA) and dimethyl sulfoxide (DMSO) and two osmolytes: glycine betaine (TMG)and urea....
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Anab initiostudy of the betaine anion–dipole-bound anionic state of a model zwitterion system
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Sopot - is it possible to retain the unique image of the city?
PublicationSopot is the best-known seaside resort in Poland. The city is unique with regard not only to its location and natural values, but also its interesting architecture, which dates back to the end of the 19th and the beginning of the 20th century. The relic of that era is the largest in the country number of buildings characteristic for the Northern European seaside resorts. The architecture of historic Sopot is dominated by eclectic...
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Betaine and L-carnitine ester bromides: Synthesis and comparative study of their thermal behaviour and surface activity
PublicationSix esters of both betaine and L-carnitine bromides, featuring alkyl groups ranging from C8 to C18 in length, have been synthesized. The thermal behaviour of these twelve bio-based salts has been analyzed and compared by thermal gravimetric analysis and differential scanning calorimetry. The L-carnitine alkyl ester bromides melted below 100 C and can hence be considered ionic liquids (ILs) with full rights. Conversely, the betaine...
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Retina Today
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Retina-Vitreus
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Ophthalmology Retina
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Effect of osmolytes on the thermal stability of proteins: replica exchange simulations of Trp-cage in urea and betaine solutions
PublicationAlthough osmolytes are known to modulate the folding equilibrium, the molecular mechanism of their effect on thermal denaturation of proteins is still poorly understood. Here, we simulated the thermal denaturation of a small model protein (Trp-cage) in the presence of denaturing (urea) and stabilizing (betaine) osmolytes, using the all-atom replica exchange molecular dynamics simulations. We found that urea destabilizes Trp-cage...
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Light-Modulated Sunscreen Mechanism in the Retina of the Human Eye
PublicationThe functioning of the human eye in the extreme range of light intensity requires a combination of the high sensitivity of photoreceptors with their photostability. Here, we identify a regulatory mechanism based on dynamic modulation of light absorption by xanthophylls in the retina, realized by reorientation of pigment molecules induced by trans–cis photoisomerization. We explore this photochemically switchable system using chromatographic...
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An Attempt to Create Speech Synthesis Model That Retains Lombard Effect Characteristics
PublicationThe speech with the Lombard effect has been extensively studied in the context of speech recognition or speech enhancement. However, few studies have investigated the Lombard effect in the context of speech synthesis. The aim of this paper is to create a mathematical model that allows for retaining the Lombard effect. These models could be used as a basis of a formant speech synthesizer. The proposed models are based on dividing...
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The sensitiveness of the speed of pile displacement to speed variations of hammer in beating down process
PublicationIn this paper there is presented dynamical system described speed of pile displacement during beating down process. Its response is determined by using Heaviside operator. There is introduced the convergence with regulator in partially ordered space. There is given an answer to the question, whetdisplacement is sensitive to hammer's speed variations.
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Rewitalizacja Berlina i Lipska jako źródło inspiracji dla polskich praktyk rewitalizacyjnych
PublicationArtykuł odnosi się do możliwości wykorzystania niemieckich doświadczeń rewitalizacyjnych z okresu 1995-2015 w aktualnych uwarunkowaniach polskich. Wykorzystano fragment syntezy badań własnych prowadzonych na terenie Berlina i Lipska (partnerzy DASL, DAAD). Wnioski z analizy polskiej praktyki (współpraca z Miastem Łódź) posłużyły wyborowi przykładów dobrej praktyki z Berlina i Lipska zastosowanych w odmiennych uwarunkowaniach społeczno-gospodarczych....
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Invasive Assessment of the Myocardial Microcirculation during Beating Heart Coronary Artery Bypass Grafting
PublicationCoronary artery bypass grafting may be associated with several cardiac complications, including ischemia, acute myocardial infarction, arrhythmias, or hemodynamic instability. Accumulating evidence suggests that well-developed coronary collateral circulation may protect against adverse effects, including myocardial ischemia. Assessment of myocardial microvascular perfusion is, therefore, of great clinical interest in beating heart...
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Działanie preparatu antyseptycznego Betadine (EGIS Pharmaceutical L.t.d.) na wielooporne szpitalne szczepy bakterii
PublicationStwierdzono silne działanie bakteriobójcze preparatu Betadine na wszystkie badane izolaty. Uzyskano redukcję liczby żywych bakterii w zawiesinie o 99,99% co jest zgodne z wymaganiami dla preparatów przeznaczonych do dezynfekcji higienicznej i chirurgicznej.
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Współczesne miejskie krajobrazy pamięci o II wojnie światowej na przykładzie Warszawy i Berlina
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International Journal of Retina and Vitreous
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Introduction of Pro and Its Analogues in the Conserved P1 Position of Trypsin Inhibitor SFTI-1 Retains Its Inhibitory Activity
PublicationA number of monocyclic SFTI-1 analogues modified in the conserved inhibitor P1 position by Pro, its L-hydroxyproline (Hyp) derivative as well as mimetics with different ring size were synthesized by the solid-phase method. Replacement of Ser6 by Pro, Hyp, and a four-member ring, L-azetidine-2-carboxylic acid (Aze), retained trypsin or chymotrypsin inhibitory activity. The determined association equilibrium constants of these analogues...
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Ophthalmic Surgery Lasers & Imaging Retina
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RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
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Program URBAN II w Europie jako jedno z narzędzi polityki Unii Europejskiej w planowaniu przestrzennym miast - przypadek Berlina
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Analogues of trypsin inhibitor SFTI-1 modified in the conserved P1′ position by synthetic or non-proteinogenic amino acids retain their inhibitory activity
PublicationA series of linear and monocyclic (with a disulfide bridge only) analogues of trypsin inhibitor SFTI-1 modified in the P-1 and/or P-1' positions were synthesized by the solid-phase method. In the substrate specificity P-1 position, Phe or N-benzylglycine (Nphe) were introduced, whereas the conserved Ser6 in Bownam-Birk (BBI) inhibitors was replaced by Hse (L-homoserine), Nhse [N-(2-hydroxyethyl)glycine], Sar, and Ala. Kinetic studies...
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Wpływ osmolitów na stabilność białek w oparciu o metodę dynamiki molekularnej
PublicationCelem niniejszej pracy było zbadanie molekularnego mechanizmu wpływu biologicznie znaczących związków, tzw. osmolitów na stabilność białek. Aby zweryfikować istniejące hipotezy i dostarczyć spójnego obrazu działania osmolitów na poziomie molekularnym, wykorzystano metodę dynamiki molekularnej do zasymulowania mechanicznej denaturacji modelowych białek – lizozymu i ubikwityny. W tym podejściu odtworzony został efekt stabilizujący...
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Molecular basis of the osmolyte effect on protein stability: a lesson from the mechanical unfolding of lysozyme
PublicationOsmolytes are a class of small organic molecules that shift the protein folding equilibrium. For this reason, they are accumulated by organisms under environmental stress, and find applications in biotechnology where proteins need to be stabilized or dissolved. However, despite years of research, debate continues over the exact mechanisms underpinning the stabilizing and denaturing effect of osmolytes. Here, we simulated the mechanical...
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Małgorzata Gawrycka dr hab.
PeopleMałgorzata Gawrycka, a graduate of the Faculty of Management at the University of Gdańsk, PhD in economics. From 2012-2020, deputy dean for teaching at the Faculty of Management and Economics of the Gdańsk University of Technology. Currently Dean of the Faculty. Scientific interests focus on issues related to the macroeconomic policy of the state. In particular, the problems of the situation on the labour market, demographic changes,...
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Synthesis and transport studies of model dipeptides with modified n-terminal amino groups into e. coli k12 mutant strains
Publicationotrzymano na drodze syntezy chemicznej kilka modelowych dipeptydów zawierających n-terminalna guanidynę oraz betainę. zbadano transport tych peptydów do komorek e. coli k12, posiadających zróżnicowane systemy transportowe. wyniki badań potwierdziły brak transportu do komórek bakteryjnych z wykorzystaniem permeaz peptydowych. dodatnio naładowana i silnie polarna grupa aminowa uniemożliwia efektywny transport tych związków do komórek...
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CURRENT SITUATION ON THE POLAND REAL ESTATE MARKET
PublicationIn recent years the polish real estate market has been characterised by a significant increase in supply and demand. This was facilitated by a number of macroeconomic factors. In recent years, housing has been commissioned as 30 years ago. Therefore, the depth analysis issue of the causes and consequences for the Polish economy of these trends is now relevant. Among the reasons are significant economic growth, low interest rates...
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PAYMENT TRANSACTIONS’ ENERGY EFFICIENCY
PublicationThe payment system and infrastructure is a sector that is not given enough attention today in the context of energy efficiency. This sector plays a big role in organizing and ensuring money circulation and funds. It has its value consisting on the one hand of the cost of payment equipment, infrastructure, payment instruments. On other hand, its value consists of the cost of energy for their manufacture and maintenance. The European...
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ENERGIEEFFIZIENZ DER ZAHLUNGSOPERATIONEN
PublicationHeute kannman nach verschiedenen Schätzungen mehr als zehn Möglichkeiten nutzen, um Einzelhandelswaren, Dienstleistungen oder geleistete Arbeit zu bezahlen. Die beliebtesten, bedeutendsten und sensibelsten sind Bargeld-und bargeldlose Zahlungen. Als die modernste kann man Kryptowährungzahlungen schätzen. Jede Zahlungsart ist mit Zeit-und Energiekosten für ihre Wartung und dementsprechend mit finanziellen Kosten verbunden....
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Deep CNN based decision support system for detection and assessing the stage of diabetic retinopathy
PublicationThe diabetic retinopathy is a disease caused by long-standing diabetes. Lack of effective treatment can lead to vision impairment and even irreversible blindness. The disease can be diagnosed by examining digital color fundus photographs of retina. In this paper we propose deep learning approach to automated diabetic retinopathy screening. Deep convolutional neural networks (CNN) - the most popular kind of deep learning algorithms...
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The Dynamics of Trade Relations between Ukraine and Romania: Modelling and Forecasting
PublicationThe article examines the monthly dynamics of exports, imports and balance of trade between Ukraine and Romania in the period from 2005 to 2021. Time series from 2015 to 2021 were used for modelling and forecasting (since the date the European Union–Ukraine Association Agreement took effect). Adequate models of the dynamics series of the Box-Jenkins methodology were built: additive models with seasonal component ARIMA (Autoregressive...
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Chemometric Method of Spectra Analysis Leading to Isolation of Lysozyme and CtDNA Spectra Affected by Osmolytes
PublicationW niniejszej pracy zaprezentowana została chemometryczna metoda analizy danych widmowych, prowadząca do wyizolowania widm FTIR biomakrocząsteczek (lizozymu z białka jaja kurzego i ctDNA) zaburzonych przez wybrane osmolity (TMAO, betainę) w roztworach wodnych. Została ona oparta na metodzie widm różnicowych, wykorzystywanej pierwotnie do określania struktury rozpuszczalnika wokół cząsteczek substancji rozpuszczonej. Cykliczne wykorzystanie...
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In vivo imaging of the human eye using a two-photon excited fluorescence scanning laser ophthalmoscope
PublicationBACKGROUND. Noninvasive assessment of metabolic processes that sustain regeneration of human retinal visual pigments (visual cycle) is essential to improve ophthalmic diagnostics and to accelerate development of new treatments to counter retinal diseases. Fluorescent vitamin A derivatives, which are the chemical intermediates of these processes, are highly sensitive to UV light; thus, safe analyses of these processes in humans...
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The hydration of the protein stabilizing agents: trimethylamine-N-oxide, glycine and its N-methylderivatives - the volumetric and compressibility studies
PublicationThe densities at T = (288.15, 293.15, 298.15, 303.15, and 308.15) K and sound velocities at T = 298.15 K have been measured for aqueous solutions of trimethylamine-N-oxide, glycine, N-methylglycine (sarcosine), N,N-dimethylglycine, N,N,N-trimethylglycine (betaine). From these data the apparent molar volumes, VΦ, the apparent molar isentropic compressions, KS,Φ, and the solvation numbers of solutes have been determined. The concentration...
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Review of non- welded piping technologies on offshore equipment projects
PublicationThe aim of this article are considerations on welded and non-welded tube connection technologies, with advantages and disadvantages of both. After choosing non-welded solutions as the assembly method of choice, the thesis progresses to describing the most widely-used tube connection technologies (JIC, Ermeto, retain ring flanges, flared tube flanges and other, minor, solutions) and their properties.
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Fuel price, income and road safety as determinants of the level of the population’s economic well-being in Poland
PublicationThe opportunity to travel is one of the most favorite human activities, given that on a trip a person gets new knowledge, impressions and positive emotions. Recreational trips occupy a prominent place in the concept of the economics of happiness, and the study of factors that influence decision-making regarding travel is important for forecasting the number of tourists, infrastructure development, income and expenses of businesses...
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Team Roles and Team Performance in Small Virtual Software Teams
PublicationThe article presents the results of research on the composition of team roles conducted in 24 student software teams. An adaptation of M. Belbin’s model by B. Kożusznik was used. The model of team balance according to Belbin and Haaf is presented and correlations between team balance and team performance are analysed. Team performance is measured at three levels: result, satisfaction and team climate. The selected constellation...
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Simulation of fluid structure interaction in a novel design of high pressure axial piston hydraulic pump
PublicationA novel type of an axial, piston-driven high pressure hydraulic pump with variable capacity marks a significant improvement in the area of the hydraulic machinery design. Total discharge from hydrostatic forces eliminates a need for a servomechanism, thus simplifying operation, reducing weight and introducing the possibility of the pump displacement control by computer. PWK-type pumps, invented in the Gdansk University of Technology,...
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Simulation of fluid structure interaction in a novel design of high pressure axial piston pump
PublicationA novel type of an axial, piston-driven high pressure hydraulic pump with variable capacity marks a significant improvement in the area of the hydraulic machinery design. Total discharge from hydrostatic forces eliminates a need for a servomechanism, thus simplifying operation, reducing weight and introducing the possibility of the pump displacement control by computer. PWK-type pumps, invented in the Gdansk University of Technology,...
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Compensation of pressure peaks in pwk-type hydraulic pumps
Publicationhydraulic axial pumps equipped with cam-driven commutation unit (pwk pumps) proved their high efficiency up to 55 mpa and ability to work self-sucking, even at high speed. displacement of pwk pump may easily be changed by moving its control cam. full discharge from hydrostatic forces makes such control possible by direct action of a low-energy actuator like proportional electromagnet or stepping motor. that eliminates heavy and...
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Dependence of Housing Real Estate Prices on Inflation as One of the Most Important Factors: Poland’s Case
PublicationThe study aimed to examine the impact of inflation on the real estate market using Polish panel data for the last 13 years. It is based on a panel model, where price changes of one square meter of housing are determined as a function in changes of inflation, the central bank's base rate, dwellings built, as well as new mortgage loans. The quarterly dynamics of the average price of 1 square meter of housing in...
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Consequences of russia’s military invasion of Ukraine for Polish-Ukrainian trade relations
PublicationAn accurate forecast of interstate trade volume allows for short-term and long-term planning, particularly deciding on state budget revenues, foreign exchange earnings, border arrangement, other infrastructure, migration and social policies. Hostilities are destructive so the russian military aggression against Ukraine in 2022 needs to be assessed in terms of its effects on key economic aspects of Polish-Ukrainian relations, as...
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Forecasting of the Employment Rate in the EU ICT Field
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Struktura i role zespołowe w realizacji projektu badawczego
PublicationRozdział prezentuje specyfikę zarządzania projektem badawczym w kontekście realizowanych celów, podziału zadań i struktury grupy, która sprzyja ich wykonaniu. Główny nacisk położono na charakterystykę ról zespołowych wg koncepcji M. Belbina, odniesiono je do zadań realizowanych przez członków zespołów badawczych wskazując na konieczność ich optymalnego dopasowania. Szczególne znaczenie przypisano roli lidera zespołu, wzorując się...
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Ocena wrażliwości na fluorochinolony drobnoustrojów izolowanych od pacjentów z zakażeniami układu moczowego leczonych w warunkach ambulatoryjnych
PublicationWykazano, że drobnoustroje powodujące zakażenia układu moczowego u pacjentów ambulatoryjnych są nadal wrażliwe na fluorochinolony; dotyczy to jednak drobnoustrojów z rodziny Enterobacteriacae. Natomiast w przypadku zakażeń drobnoustrojami Gram-dodatnimi leki te mogą okazać się nieskuteczne. Stwierdzono silne działanie bakteriobójcze preparatu Betadine na wszystkie badane izolaty. Uzyskano redukcję liczby żywych bakterii w zawiesinie...
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Interactions in Ternary Aqueous Solutions of NMA and Osmolytes—PARAFAC Decomposition of FTIR Spectra Series
PublicationIntermolecular interactions in aqueous solutions are crucial for virtually all processes in living cells. ATR-FTIR spectroscopy is a technique that allows changes caused by many types of such interactions to be registered; however, binary solutions are sometimes difficult to solve in these terms, while ternary solutions are even more difficult. Here, we present a method of data pretreatment that facilitates the use of the Parallel...
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Experimental and Machine-Learning-Assisted Design of Pharmaceutically Acceptable Deep Eutectic Solvents for the Solubility Improvement of Non-Selective COX Inhibitors Ibuprofen and Ketoprofen
PublicationDeep eutectic solvents (DESs) are commonly used in pharmaceutical applications as excellent solubilizers of active substances. This study investigated the tuning of ibuprofen and ketoprofen solubility utilizing DESs containing choline chloride or betaine as hydrogen bond acceptors and various polyols (ethylene glycol, diethylene glycol, triethylene glycol, glycerol, 1,2-propanediol, 1,3-butanediol) as hydrogen bond donors. Experimental...
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Experimental and Machine-Learning-Assisted Design of Pharmaceutically Acceptable Deep Eutectic Solvents for the Solubility Improvement of Non-Selective COX Inhibitors Ibuprofen and Ketoprofen
PublicationDeep eutectic solvents (DESs) are commonly used in pharmaceutical applications as excellent solubilizers of active substances. This study investigated the tuning of ibuprofen and ketoprofen solubility utilizing DESs containing choline chloride or betaine as hydrogen bond acceptors and various polyols (ethylene glycol, diethylene glycol, triethylene glycol, glycerol, 1,2-propanediol, 1,3-butanediol) as hydrogen bond donors. Experimental...
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Nietypowa podziemna konstrukcja oporowa w technologii DSM jako zabezpieczenie głębokiej wymiany gruntu
PublicationW artykule przedstawiono nietypowe rozwiązanie podparcia i zabezpieczenia głębokiej wymiany gruntu z zastosowaniem przestrzennej konstrukcji oporowej w technologii DSM, ze względu na ograniczenie miejsca oraz zapewnienie stateczności nasypu drogowego. Opisano również realizację rozwiązania oraz prowadzony monitoring geotechniczny.
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Nietypowa podziemna konstrukcja oporowa w technologii DSM jako zabezpieczenie głębokiej wymiany gruntu
PublicationW artykule przedstawiono nietypowe rozwiązanie podparcia i zabezpieczenia głębokiej wymiany gruntu z zastosowaniem przestrzennej konstrukcji oporowej w technologii DSM, ze względu na ograniczenie miejsca oraz zapewnienie stateczności nasypu drogowego. Opisano również realizację rozwiązania oraz prowadzony monitoring geotechniczny.