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Search results for: peptide profile
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JOURNAL OF PEPTIDE SCIENCE
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Synthesis and conformational analysis of salivary proline-rich peptide P-B
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Antimicrobial Activity of Chimera Peptides Composed of Human Neutrophil Peptide 1 (HNP-1) Truncated Analogues and Bovine Lactoferrampin
PublicationThree chimera peptides composed of bovine lactoferrampin and the analogue of truncated human neutrophil peptide 1 were synthesized by the solid-phase method. In two compounds peptide chains were connected via isopeptide bond, whereas in the third one disulfide bridge served as a linker. All three chimeras displayed significantly higher antimicrobial activity than the constituent peptides as well as their equimolar mixtures. The...
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Peptide splicing in a double‐sequence analogue of trypsin inhibitor SFTI‐1 substituted in the P1 positions by peptoid monomers
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JOURNAL OF PEPTIDE RESEARCH
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Structure–activity relationships study on biological activity of peptides as dipeptidyl peptidase IV inhibitors by chemometric modeling
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PEPTIDES
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PROFILE GLEBOKICH OTWORÓW WIERTNICZYCH
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Dipeptidyl Peptidase IV Inhibitory Peptides Generated in Dry-Cured Pork Loin during Aging and Gastrointestinal Digestion
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Peptide Permeases in Candida albicans
PublicationAims: The aim of this work was to characterize oligopeptide uptake in Candida albicans mutants in which the genes encoding putative peptide permeases were selectively disrupted. Initial velocities of transport of model oligopeptides, (Ala)2, (Ala)3, (Ala)4, and sensitivity of mutants to antifungal oligopeptides containing N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP) were determined and compared to those of the wild-type...
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Peptide modification with thiomalonoamide moiety
PublicationAbstract: Meldrum acid derivatives under the thermal decomposition are well known source of ketenes. Recently we investigated chemical properties of thiocarbamolyl meldrum acids. We found that 5-(α-alkylamino- α'-sulfhydryl)methylene Meldrum's acids hated in the presence of amines produce thiomalonamides. We used this reaction to the one pot synthesis of series of short peptides containing thiomalonoamide motif.
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Investigation of peptide splicing using two‐peptide‐chain analogs of trypsin inhibitor SFTI‐1
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REGULATORY PEPTIDES
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Sibutramine and its cardiovascular profile
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Profile-Issues in Teachers Professional Development
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Functionalized Peptide Fibrils as a Scaffold for Active Substances in Wound Healing
PublicationTechnological developments in the field of biologically active peptide applications in medicine have increased the need for new methods for peptide delivery. The disadvantage of peptides as drugs is their low biological stability. Recently, great attention has been paid to self-assembling peptides that can form fibrils. Such a formulation makes bioactive peptides more resistant to enzymatic degradation and druggable. Peptide fibrils...
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Meat Proteins as Dipeptidyl Peptidase IV Inhibitors and Glucose Uptake Stimulating Peptides for the Management of a Type 2 Diabetes Mellitus In Silico Study
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PROTEIN AND PEPTIDE LETTERS
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Amino Acid and Peptide‐Based Antiviral Agents
PublicationA significant number of antiviral agents used in clinical practice are amino acids, short peptides, or peptidomimetics. Among them, several HIV protease inhibitors (e. g. lopinavir, atazanavir), HCV protease inhibitors (e. g. grazoprevir, glecaprevir), and HCV NS5A protein inhibitors have contributed to a significant decrease in mortality from AIDS and hepatitis. However, there is an ongoing need for the discovery of new antiviral...
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CURRENT PROTEIN & PEPTIDE SCIENCE
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Profile of the growing sme's in pomerania region
PublicationRozdział opisuje profil firmy wzrostowej na Pomorzu. Opis został poprzedzony analizą teorii wzrostowych małych przedsiębiorstw. Materiał badawczy ujęty w rozdziale pochodzi z badań przeprowadzonych w ramach Pomorskiego Obserwatorium Gospodarczego.
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Standard Bluetooth i jego profile.
PublicationPrzedstawiono historie rozwoju oraz zasady dostępu do medium transmisyjnego standardu Bluetooth 1.1 (oraz 1.2). Scharaktyzowano architekturę protokolarną tego standardu oraz przedstawiono jego profile, które umożliwiają realizacje konkretnych modeli zastosowań (tzw. modeli użytkowych) technologii Bluetooth.
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International Journal of Peptide Research and Therapeutics
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International Journal of Peptides
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Influence of Urea and Dimethyl Sulfoxide on K-Peptide Fibrillation
PublicationProtein fibrillation leads to formation of amyloids—linear aggregates that are hallmarks of many serious diseases, including Alzheimer’s and Parkinson’s diseases. In this work, we investigate the fibrillation of a short peptide (K-peptide) from the amyloidogenic core of hen egg white lysozyme in the presence of dimethyl sulfoxide or urea. During the studies, a variety of spectroscopic methods were used: fluorescence spectroscopy...
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Alanine Scanning Studies of the Antimicrobial Peptide Aurein 1.2
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Antitumor activity of opiorphin, sialorphin and their conjugates with a peptide klaklakklaklak
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Gαi-derived peptide binds the µ-opioid receptor
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Optymalizacja profilu pompoturbinowego.
PublicationW wyniku rozwiązania zadania odwrotnego (konstrukcyjnego), dla obydwu trybów prac maszyny rewersyjnej: pompowego i turbinowego, uzyskuje się dwa różne kształty łopatek z parametrami nominalnymi pracy. Mając te łopatki, konieczne jest w dalszej kolejności poszukiwanie jednego profilu wypadkowego dla wirnika pompoturbiny, który byłby kompromisem dla obydwu reżimów przepływowych. Niezbędne jest w takim przypadku wykorzystanie...
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Potentilla—A review of its phytochemical and pharmacological profile
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A Method for Optimising the Blade Profile in Kaplan Turbine
PublicationThis paper introduces a method of blade profile optimisation for Kaplan-type turbines, based on modelling the interaction between rotor and stator blades. Rotor and stator blade geometry is described mathematically by means of a midline curve and thickness distribution. Genetic algorithms are then used to find a global optimum that minimises the loss coefficient. This allows for variety of possible blade shapes and configurations....
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Storing Matter’technique in SIMS depth profile analysis
PublicationSecondary ion mass spectrometry (SIMS) is a very useful technique for the analysis of layered systems. It is based on the primary ion beam sputtering of solids and mass analysis of the emitted secondary ions. A main limitation of this technique results from the direct quantitative analysis, since the ionization efficiency of a given atom is highly influenced by the neighbouring atoms at the surface. This phenomenon is known as...
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Is the Fatty Acids Profile in Blood a Good Predictor of Liver Changes? Correlation of Fatty Acids Profile with Fatty Acids Content in the Liver
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New Peptide Based Fluconazole Conjugates with Expanded Molecular Targets
PublicationInfections of Candida spp. etiology are frequently treated with azole drugs. Among azoles, the most widely used in the clinical scenario remains fluconazole (FLC). Promising results in treatment of dangerous, systemic Candida infections demonstrate the advantages of combined therapies carried out with combinations of at least two different antifungal agents. Here, we report five conjugates composed of covalently linked FLC and...
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Dynamics of Antimicrobial Peptide Encapsulation in Carbon Nanotubes: The Role of Hydroxylation
PublicationIntroduction: Carbon nanotubes (CNTs) have been widely employed as biomolecule carriers, but there is a need for further functionalization to broaden their therapeutic application in aqueous environments. A few reports have unraveled biomolecule–CNT interactions as a measure of response of the nanocarrier to drug-encapsulation dynamics. Methods: Herein, the dynamics of encapsulation of the antimicrobial peptide HA-FD-13 (accession...
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DMSO and TMAO—Differences in Interactions in Aqueous Solutions of the K-Peptide
PublicationInteractions between a solvent and their co-solute molecules in solutions of peptides are crucial for their stability and structure. The K-peptide is a synthetic fragment of a larger hen egg white lysozyme protein that is believed to be able to aggregate into amyloid structures. In this study, a complex experimental and theoretical approach is applied to study systems comprising the peptide, water, and two co-solutes: trimethylamide...
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Gemcitabine Peptide-Based Conjugates and Their Application in Targeted Tumor Therapy
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Bladder cancer detection using a peptide substrate of the 20S proteasome
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Structural Analysis of a Peptide Fragment of Transmembrane Transporter Protein Bilitranslocase
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Membrane structure and interactions of peptide hormones with model lipid bilayers
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Synthesis and structure-activity studies of peptide-acridine/acridone conjugates
PublicationW artykule opisano strukturę, syntezę i biologiczną aktywność peptydowych koniugatów akrydyny i akrydonu jako potencjalnych leków o aktywności przeciwnowotworowej i przeciwwirusowej.
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Elusive π-helical peptide foldamers spotted by chiroptical studies
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Coulomb-Assisted Dissociative Electron Attachment: Application to a Model Peptide
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Simulating Electron Transfer Attachment to a Positively Charged Model Peptide
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Nutritional value, protein and peptide composition of edible cricket powders
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The influence of substrate peptide length on human β‐tryptase specificity
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Anticancer Properties of Amino Acid and Peptide Derivatives of Mycophenolic Acid
PublicationBackground: Although Mycophenolic Acid (MPA) is applied as prodrugs in clinic as an immunosuppressant, it also possesses anticancer activity. MPA acts as Inosine-5’-Monophosphate Dehydrogenase (IMPDH) inhibitor, where the carboxylic group at the end of the side chain interacts with Ser 276 of the enzyme via hydrogen bonds. Therefore, MPA derivatives with other polar groups indicated high inhibition too. On the other hand, potent...
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Immunosuppressive properties of amino acid and peptide derivatives of mycophenolic acid
PublicationMycophenolic acid (MPA) was coupled with amino acids and biologically active peptides including derivatives of tuftsin to modify its immunosuppressive properties. Both amino acid unit in the case of simple MPA amides and modifications within peptide moiety of MPA - tuftsin conjugates influenced the observed activity. Antiproliferative potential of the obtained conjugates was investigated in vitro and MPA amides with threonine methyl...
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The role of antimicrobial peptides in selected dermatoses
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Rapid Screening of Antimicrobial Synthetic Peptides
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