Cyanogenic Compounds and Estrogen Disruptors
Balanced diet consists largely of plants containing cyanogenic compounds in the form of the more common cyanogenic glycosides and sometimes lipids. Maize, wheat, rye, apples, barley, oats, sugar cane and yet many other plants consumed by humans contain cyanogenic compounds. However the risk of poisoning is negligible as it is very easy to remove the toxic HCN by grinding and drying in air or soaking in water and an additional thermal treatment contributes to the denaturation of proteins (enzymes) that initiate process of cyanogenesis. Furthermore, man is provided with a quite effective cyanide detoxifying mechanisms, functioning effectively with adequate protein diet. In 1990, scientists suggested that the role of cyanogenic compounds can only come down to defense against fungi because their harmfulness is negligible. Since little evidences exist on possibility of cyanogenic compounds as direct EDC, studies are needed to confirm possibility of their impact on hormonal action of higher animals due to binding with hormones, their degradation or metabolic shifts after HCN release into circulation system.
Błażej Kudłak, Monika Wieczerzak, Jacek Namieśnik. (2017). Cyanogenic Compounds and Estrogen Disruptors, 243-251.
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