Wyszukiwarka
Thermodynamic Characteristics of Phenacetin in Solid State and Saturated Solutions in Several Neat and Binary Solvents
Abstrakt
The thermodynamic properties of phenacetin in solid state and in saturated conditions in neat and binary solvents were characterized based on differential scanning calorimetry and spectroscopic solubility measurements. The temperature-related heat capacity values measured for both the solid and melt states were provided and used for precise determination of the values for ideal solubility, fusion thermodynamic functions, and activity coefficients in the studied solutions. Factors affecting the accuracy of these values were discussed in terms of various models of specific heat capacity difference for phenacetin in crystal and super-cooled liquid states. It was concluded that different properties have varying sensitivity in relation to the accuracy of heat capacity values. The values of temperature-related excess solubility in aqueous binary mixtures were interpreted using the Jouyban–Acree solubility equation for aqueous binary mixtures of methanol, DMSO, DMF, 1,4-dioxane, and acetonitrile. All binary solvent systems studied exhibited strong positive non-ideal deviations from an algebraic rule of mixing. Additionally, an interesting co-solvency phenomenon was observed with phenacetin solubility in aqueous mixtures with acetonitrile or 1,4-dioxane. The remaining three solvents acted as strong co-solvents.
Cytowania
-
1 3
CrossRef
-
0
Web of Science
-
1 3
Scopus
Autorzy (5)
-
Anna Kowalska
-
Natalia Tymorek
-
-
Cytuj jako
Pełna treść
- Wersja publikacji
- Submitted Version
- Licencja
-
otwiera się w nowej karcie
Słowa kluczowe
Informacje szczegółowe
- Kategoria:
- Publikacja w czasopiśmie
- Typ:
- Publikacja w czasopiśmie
- Opublikowano w:
-
MOLECULES
nr 26,
wydanie 13,
ISSN: 1420-3049 - Rok wydania:
- 2021
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.3390/molecules26134078
- Weryfikacja:
- Brak weryfikacji
wyświetlono 122 razy
Publikacje, które mogą cię zainteresować
Experimental and Theoretical Screening for Green Solvents Improving Sulfamethizole Solubility
- P. Cysewski,
- M. Przybyłek,
- R. Rozalski
New Screening Protocol for Effective Green Solvents Selection of Benzamide, Salicylamide and Ethenzamide
- M. Przybyłek,
- A. Miernicka,
- M. Nowak
- + 1 autorów