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Wyniki wyszukiwania dla: dna mismatch repai
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Knowledge-Based Virtual Modeling and Simulation of Manufacturing Processes for Industry 4.0
PublikacjaABSTRACT Industry 4.0 aims at providing a digital representation of a production landscape, but the challenges in building, maintaining, optimizing, and evolving digital models in inter-organizational production chains have not been identified yet in a systematic manner. In this paper, various Industry 4.0 research and technical challenges are addressed, and their present scenario is discussed. Moreover, in this article, the novel...
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Bartłomiej Ferra dr inż.
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Zespół Systemów Geoinformatycznych
Zespoły BadawczeW katedrze prowadzone są badania naukowe w zakresie szeroko rozumianych Systemów Informacji Geograficznej (GIS). Tematyka badań obejmuje zastosowanie GIS w technologiach bezpieczeństwa, wizualizacje i analizy przestrzenne, systemy numerycznego prognozowania pogody, technologie nawigacji w ramach mobilnych systemów informacji przestrzennej, oraz zaawansowane techniki obrazowania satelitarnego. Katedra kontynuuje również badania...
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Katedra Zarządzania
Zespoły Badawcze* zarządzanie wiedzą i informacją * zarządzanie strategiczne w wyższych uczelniach * wykorzystywanie metod nieparametrycznych do pomiaru efektywności systemów szkolnictwa wyższego * modele biznesowe w zarządzaniu organizacjami * zarządzanie procesem innowacyjnym w MŚP * strategia i modele biznesu współczesnego przedsiębiorstwa * społeczeństwo informacyjne i jego wskaźniki rozwoju * zarządzanie morskimi portami jachtowymi 2 gospodarce...
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A novel cold-active beta-D-galactosidase from the Paracoccus sp. 32d - gene cloning, purification and characterization
PublikacjaBeta-D-galactosidase (EC 3.2.1.23) catalyze the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. Cold-active beta-D-galactosidases have recently become a focus of attention of researchers and dairy product manufactures owing to theirs ability to: (I) eliminate of lactose from refrigerated milk for people afflicted with lactose intolerance, (II) convert lactose to glucose and galactose which...
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Urządzenie samobieżne do badania środowiska wodnego, zwłaszcza do badania dna morskiego
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Experience-Oriented Intelligence for Internet of Things
PublikacjaThe Internet of Things (IoT) has gained significant attention from industry as well as academia during the past decade. The main reason behind this interest is the capabilities of the IoT for seamlessly integrating classical networks and networked objects, and hence allows people to create an intelligent environment based on this powerful integration. However, how to extract useful information from data produced by IoT and facilitate...
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Hazard Control in Industrial Environments: A Knowledge-Vision-Based Approach
PublikacjaThis paper proposes the integration of image processing techniques (such as image segmentation, feature extraction and selection) and a knowledge representation approach in a framework for the development of an automatic system able to identify, in real time, unsafe activities in industrial environments. In this framework, the visual information (feature extraction) acquired from video-camera images and other context based gathered...
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Five-hour diagnosis of dermatophyte nail infections with specific detection of Trichophyton rubrum
PublikacjaW publikacji przedstawiono szybką dwuetapową metodę oczyszczania DNA oraz opartą na technice multiplex PCR metodę wykrywania grzybów z rodzaju dermatofitów oraz gatunku Trichophyton rubrum z hodowli grzybów oraz bezpośrednio ze zmienionych chorobowo paznokci. Testy stu osiemnastu próbek z użyciem zaprojektowanej reakcji multiplex PCR i dwóch kolejnych (jedna wykrywająca grzyby z rodzaju dermatofitów, druga wykrywająca gatunek T....
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EXPERIENCE-ORIENTED SMART EMBEDDED SYSTEM
PublikacjaThe Experience-Oriented Smart Embedded System (EOSES) is proposed as a new technological platform providing a common knowledge management approach that allows mass embedded systems for experiential knowledge capturing, storage, involving, and sharing. Knowledge in the EOSES is represented as SOEKS, and organized as Decisional DNA. The platform is mainly based on conceptual principles from Embedded Systems and Knowledge Management....
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Solid Phase Synthesis and Biological Activity of Tuftsin Conjugates
PublikacjaNew tuftsin/retro-tuftsin conjugates were designed and synthesized using a classical fluorenylmethoxycarbonyl (Fmoc) solid phase procedure. All the peptide conjugates were divided into three series: 1,4-dihydroxyanthraquinone (type A), 1-nitroacridine (type B), and 4-carboxyacridone (type C) derivatives. In type A conjugates, the N-terminal group of the peptide chain is directly connected to the anthraquinone ring at C1 (Scheme...
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Zróżnicowanie bakterioplanktonu w wodach fiordów Spitsbergenu
PublikacjaPodczas rejsu polarnego latem 2013 roku w ramach projektów naukowych GAME i FACE2FACE zebrano materiał badawczy w dwóch fiordach Spitsbergenu: południowym Hornsund i północnym Kongsfjord. Punkty poboru próbek zlokalizowane były wzdłuż osi fiordów oraz w trójkącie o boku około 1,5 km wyznaczonym przez stacje w głębi fiordów. W zależności od punktu pobrano wodę z od 6 do 10 głębokości: od powierzchni do dna fiordu. Za pomocą fluorescencyjnego...
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Motility activity, slime production, biofilm formation and genetic typing by ERIC-PCR for Pseudomonas aeruginosa strains isolated from bovine and other sources (human and environment)
PublikacjaThe molecular-typing strategy, ERIC-PCR was used in an attempt to determine the genomic relationship of 28 P. aeruginosa strains isolated from faeces of healthy bovine, bovine mastitis and from faeces of hospital patients as well as from environment. ERIC-PCR fingerprinting revealed large molecular differentiation within this group of isolates. Twenty two out of 28 strains tested generated unique patterns of DNA bands and only...
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Context-Aware Indexing and Retrieval for Cognitive Systems Using SOEKS and DDNA
PublikacjaVisual content searching, browsing and retrieval tools have been a focus area of interest as they are required by systems from many different domains. Context-based, Content-Based, and Semantic-based are different approaches utilized for indexing/retrieving, but have their drawbacks when applied to systems that aim to mimic the human capabilities. Such systems, also known as Cognitive Systems, are still limited in terms of processing...
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Synthesis of eosin modified TiO2 film with co-exposed {001} and {101} facets for photocatalytic degradation of para-aminobenzoic acid and solar H2 production
PublikacjaOwing to the increasing photosensitivity and DNA damage properties of para-aminobenzoic acid (PABA), concerns have been raised over the exposure of humans to PABA. Solar light-driven photocatalysis (SPC) provides a promising solution for the effective removal of organic pollutants especially when directed towards sulfate radical (SO4−) production. Herein, we have developed a sulfite-enhanced SPC using Eosin-Y sensitized TiO2/Ti...
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Neptunium Enhancing Baltic Region Research Cooperation Badanie oddziaływań aktywnych przeciwnowotworowo pochodnych (bis)akrydyny z DNA: podejście elektrochemiczne vs. enzymatyczne jako wstęp do badań in vivo.
ProjektyProjekt realizowany w Wydział Chemiczny zgodnie z porozumieniem DEC-5/1/2024/IDUB/II.2b/Np z dnia 2024-10-02
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Algorytmy analizy i przetwarzania danych z sonarów wielowiązkowych w rozproszonych systemach GIS
PublikacjaTelemonitoring morski oraz szeroko rozumiane badania morza są ważnym elementem aktywności człowieka w sferze badań, nauki oraz gospodarki. Prowadzenie działań związanych z tworzeniem map dna, inspekcją nadbrzeży, umocnień, badaniem fauny morskiej pozwala zrozumieć procesy zachodzące w środowisku morskim oraz przyczynia się do rozwoju wielu gałęzi gospodarki takich jak transport morski, bezpieczeństwo, ochrona portów i inne. W ramach...
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Genetycznie modyfikowane mikroorganizmy narzędziem służącym do usuwania metali ciężkich ze środowiska
PublikacjaMetale ciężkie są pierwiastkami metalicznymi i półmetalicznymi o gęstości powyżej 4,5 g•cm-3. Powodują zaburzenia w strukturze DNA, mogą być przyczyną chorób nowotworowych, układu nerwowego, pokarmowego, naczyniowego i kostnego. Wykorzystywane są w przemyśle chemicznym, elektromaszynowym, szklarskim, metalurgicznym, farbiarskim, wydobywczym, energetyce jądrowej. Wiele metali, takich jak kobalt, miedź, nikiel, stanowi mikroelementy...
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StryrKom StyrKom „Ocena wpływu polistyrenu pochodzącego z opakowań i materiałów termoizolacyjnych na DNA organizmów żywych z wykorzystaniem testu kometowego”- Radium
ProjektyProjekt realizowany w Katedra Chemii,Technologii i Biotechnologii Żywności zgodnie z porozumieniem DEC-2/RADIUM/2021 z dnia 2021-07-13
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Triazoloacridone C-1305 abrogates the restriction checkpoint in cells lacking functional p53 and promotes their accumulation in the G2/M phase of the cell cycle
PublikacjaTriazoloakrydon C-1305, nowy inhibitor topoizomerazy II, wykazuje wysoką aktywość cytotoksyczną wobec komórek wielu typów nowotworów. Komórki mysie pozbawione genu PARP-1 wykazywały nadwrażliwość na działanie tego związku. W pracy testowaliśmy działanie związku wobec dwóch różnych komóek nowotworowych różniących się statusem p53: komórkami białaczki myelocytarnej HL-60 i raka sutka MCF-7. Wykazaliśmy, że inkubacja ze związkiem...
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Microscopic Imaging to Visualize the Distribution of Dietary Nucleic Acids in Food Products of Various Origins
PublikacjaDietary nucleic acids (dietNAs) are being increasingly recognized as important food components with nutritional value. However, the precise dietary recommendations for dietNAs are limited, because established methods for determining the quantity and nutritional role of dietNAs are still lacking. One of the tools to narrow this gap could be microscopic imaging, as a convenient approach to visualize the abundance and distribution...
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Genetyka człowieka, seminarium
Kursy OnlineTematy referatów: 1. Budowa chromosomu i metody badania (metody cytogenetyczne, FISH, CGH) 2. Badanie DNA w medycynie sądowej 3. Genetyczne podstawy odporności immunologicznej 4. Klonowanie zwierząt i ludzi 5. Genetyka nowotworów 6. Katastrofy elektrowni atomowych w Czarnobylu i w Fukushimie a zachorowalność na nowotwory 7. Dziedziczenie epigenetyczne 8. Mikromacierze hybrydyzacyjne w badaniu ekspresji genów, metylacji...
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LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069382491]
Dane BadawczeThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Squamous cell carcinoma, keratinizing, NOS - Unknown, 62 - Tissue image [3300730069389471]
Dane BadawczeThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069384391]
Dane BadawczeThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069386901]
Dane BadawczeThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3301001549117101]
Dane BadawczeThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Squamous cell carcinoma, keratinizing, NOS - Unknown, 62 - Tissue image [3300730069384751]
Dane BadawczeThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069383701]
Dane BadawczeThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069386181]
Dane BadawczeThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069388751]
Dane BadawczeThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069387581]
Dane BadawczeThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Squamous cell carcinoma, keratinizing, NOS - Unknown, 62 - Tissue image [3300730069381971]
Dane BadawczeThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069388591]
Dane BadawczeThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Squamous cell carcinoma, keratinizing, NOS - Unknown, 62 - Tissue image [3300730069383151]
Dane BadawczeThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069384081]
Dane BadawczeThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069382121]
Dane BadawczeThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069382081]
Dane BadawczeThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069383321]
Dane BadawczeThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [330073006938321]
Dane BadawczeThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069384201]
Dane BadawczeThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069384551]
Dane BadawczeThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Detection of Toxoplasma gondii Infection in Small Ruminants: Old Problems, and Current Solutions
PublikacjaToxoplasmosis is a parasitic zoonosis of veterinary importance, with implications for public health. Toxoplasma gondii infection causes abortion or congenital disease in small ruminants. Moreover, the consumption of infected meat, cured meat products, or unpasteurized milk and dairy products can facilitate zoonotic transmission. Serological studies conducted in various European countries have shown the high seroprevalence of specific...
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Dimeric structure of the N-terminal domain of PriB protein from Thermoanaerobacter tengcongensis solved ab initio
PublikacjaPriB is one of the components of the bacterial primosome, which catalyzes the reactivation of stalled replication forks at sites of DNA damage. The N-terminal domain of the PriB protein from the thermophilic bacterium Thermoanaerobacter tengcongensis (TtePriB) was expressed and its crystal structure was solved at the atomic resolution of 1.09 Å by direct methods. The protein chain, which encompasses the first 104 residues of the...
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Antitumour imidazoacridone C-1311 induces cell death by mitotic catastrophe in human colon carcinoma cells
PublikacjaW przedstawionych badaniach określano mechanizm śmierci komórkowej indukowanej przez imidazoakrydon C-1311 (Symadex) w komórkach HT-29 ludzkiego raka jelita grubego, które wykazywały szczególną wrażliwość na ten związek w eksperymentalnych modelach in vitro i in vivo. Przy stężeniu odpowiadającemu dawce IC99, związek powodował zahamowanie progresji cyklu komórkowej w fazie S po czym następował blok w fazie G2. Po czasach 48-96...
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Morphological and cellular alternations of HepG2 cells overexpressing CYP3A4 after treatment with antitumor imidazoacridinone derivative C-1311
PublikacjaW pracy badano odpowiedź biologiczną komórek nowotworu wątroby HepG2 z nadekspresją izoenzymu CYP3A4 pod wpływem pochodnej imidazoakrydonu C-1311. Wyniki porównywano z odpowiedzią komórek HepG2 z tzw. wektorem zerowym.Izoeznym CYP3A4 jest jednym z izoenzymów cytochromu P450 odpowiedzialnych za przemiany metaboliczne pochodnej C-1311. Wykazano, że pochodna C-1311 indukuje w obu liniach komórkowych blok w fazie G2/M cyklu komórkowego,...
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An MTA-phosphorylase gene discovered in the metagenomic library derived from Antarctic top soil during screening for lipolytic active clones confers strong pink fluorescence in the presence of rhodamine B.
PublikacjaIn this work, we present the construction of a metagenomic library in Escherichiacoli using the pUC19 vector and environmental DNA directly isolated fromAntarctic topsoil and screened for lipolytic enzymes. Unexpectedly, the screeningon agar supplemented with olive oil and rhodamine B revealed one unusual pinkfluorescent clone (PINKuv) out of 85 000 clones. This clone harbored a plasmid,pPINKuv, which has an insert of 8317 bp that...
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A cryptic ribosome binding site, false signals in reporter systems and avoidance of protein translation chaos
PublikacjaThe expression of reporter gene may be induced by activation of cryptic signalling sequences, as we found while constructing the mutS-lacZ fusion gene. We cloned the Escherichia coli lacZ gene encoding beta-galactosidase into a plasmid vector carrying the Thermus thermophilus mutS gene. The clones expected to produce beta-galactosidase as the C-terminal fusion were selected for the complementation of beta-galactosidase activity...
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Identification and molecular modeling of a novel lipase from an Antarctic soil metagenomic library.
PublikacjaIn this work, we present the construction of a metagenomic library in Escherichia coli using pUC19 vector and environmental DNA directly isolated from Antarctic topsoil and screened for lipolytic enzymes. The screening on agar supplemented with olive oil and rhodamine B revealed one clone with lipolytic activity (Lip1) out of 11,000 E. coli clones. This clone harbored a plasmid, pLip1, which has an insert of 4722 bp that has been...
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A Semiautomatic Experience-Based Tool for Solving Product Innovation Problem
PublikacjaIn this paper we present the idea of Smart Innovation Engineering (SIE) System and its implementation methodology. The SIE system is semi-automatic system that helps in carrying the process of product innovation. It collects the experiential knowledge from the formal decisional events. This experiential knowledge is collected from the group of similar products having some common functions and features. The SIE system behaves like...