Wyniki wyszukiwania dla: diminished%20toxicity
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Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
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Diminshed toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
PublikacjaThe narrow "therapeutic window" of anti-tumour therapy may be the result of drug metabolism leading to the activation or detoxification of antitumour agents. The aim of this work is to examine (i) whether the diminished toxicity of a potent antitumour drug, C-1748, 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine, compared with its 4-demethyl analogue, C-857, results from the differences between the metabolic pathways for the...
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Prolonged Quercetin Administration Diminishes the Etoposide-Induced DNA Damage in Bone Marrow Cells of Rats
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Acute hypoxia diminishes the relationship between blood pressure and subarachnoid space width oscillations at the human cardiac frequency
PublikacjaAcute hypoxia exerts strong effects on the cardiovascular system. Heart-generated pulsatile cerebrospinal fluid motion is recognised as a key factor ensuring brain homeostasis. We aimed to assess changes in heart-generated coupling between blood pressure and subarachnoid space width oscillations during hypoxic exposure.
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Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia
PublikacjaInduction of proteins involved in drug metabolism and in drug delivery has a significant impact on drug-drug interactions and on the final therapeutic effects. Two antitumor acridine derivatives selected for present studies, C-1748 (9-(2’-hydroxyethylamino)-4-methyl-1-nitroacridine) and C-1305 (5-dimethylaminopropylamino-8-hydroxy-triazoloacridinone), expressed high and low susceptibility to metabolic transformations with liver...
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α-Lipoic Acid Reduces Ceramide Synthesis and Neuroinflammation in the Hypothalamus of Insulin-Resistant Rats, While in the Cerebral Cortex Diminishes the β-Amyloid Accumulation
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Tea and Liver Antioxidant Capabilities in Ethanol Toxicity
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Cadmium and lead toxicity and bioaccumulation in Microcystis aeruginosa
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Rapid test for ionic liquids toxicity evaluation
PublikacjaW literaturze przedmiotu dostępne są dane na temat toksyczności cieczy jonowych, szczególności tych mających zastosowanie przemysłowe, gdzie toksyczność wyrażana jest jako EC50 mierzone względem konkretnego organizmu np. Vibrio fischeri, Daphnia magna itp. Z uwagi na taksonomiczne zróżnicowanie osadu czynnego nie jest możliwe bezpośrednie wnioskowanie na temat toksyczności cieczy jonowych w stosunku do osadu czynnego na podstawie...
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Environmental risk, toxicity, and biodegradation of polyethylene: a review
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In vitro toxicity studies of biodegradable, polyelectrolyte nanocapsules
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Chemoinformatic Approach to Assess Toxicity of Ionic Liquids
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Multi-Objective Genetic Algorithm (MOGA) As a Feature Selecting Strategy in the Development of Ionic Liquids’ Quantitative Toxicity–Toxicity Relationship Models
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Problems in toxicity analysis - application of fuzzy neural networks
PublikacjaPraca dotyczy zastosowania sztucznych sieci neuronowych do przygotowywania danych do szacowania toksyczności (wody powierzchniowe). Przygotowanie to polega na sztucznym zagęszczaniu zbioru danych, które następnie mogą być wykorzystane do szacowania/modelowania wartości toksyczności na ich podstawie.
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Toxicity and chemical analyses of airport runoff waters in Poland
PublikacjaThe aim of this study was to assess the ecotoxicological effects of various compounds in complex airport effluents using a chemical and ecotoxicological integrated strategy. The present work deals with the determination of sum of PCBs, PAHs, pesticides, cations, anions, phenols, anionic, cationic, non-ionic detergents, formaldehyde and metals – as well as TOC and conductivity – in runoff water samples collected from 2009 to 2011...
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Influence of ozonation and biodegradation on toxicity of industrial textile wastewater
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Application of Fenton oxidation to reduce the toxicity of mixed parabens
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Biosurfactants - Biodegradability, toxicity, efficiency in comparison with synthetic surfactants
PublikacjaBiosurfactants are natural surface active agents produced by variety of bacteria yeast and fungi. A review of their biodegradability, toxicity and efficiency is presented in order to compare their properties with synthetic surfactants. Due to their high efficiency in many applications and environmentally friendly character we tried to apply them in oil refining process. The efficiency of biosurfactants in this application was very...
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Daphnia magna model in the toxicity assessment of pharmaceuticals: A review
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Urban city lights. Light pollution as one of the effects of incorrectly designed external illumination. How can a successful lighting masterplan diminish its impact?
PublikacjaIn the modern world, artificial lighting brings many tangible benefits such as the ability to extend working hours and so increase production, recreational use of the city after dark, or the possibility to travel regardless of the time of day. However, this flexibility comes at a price and negatively impacts on the environment. One such negative phenomenon is Light Pollution ‐ a term used to describe excessive nighttime artificial...