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wszystkich: 16
Wyniki wyszukiwania dla: F2-ISOPROSTANES
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Volumetric incorporation of NV diamond emitters in nanostructured F2 glass magneto-optical fiber probes
PublikacjaIntegration of optically-active diamond particles with glass fibers is a powerful method of scaling diamond's magnetic sensing functionality. We propose a novel approach for the integration of diamond particles containing nitrogen-vacancy centers directly into the fiber core. The core is fabricated by stacking the preform from 790 soft glass canes, drawn from a single rod dip-coated with submicron diamond particles suspended in...
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Isoprostanes-Biomarkers of Lipid Peroxidation: Their Utility in Evaluating Oxidative Stress and Analysis
PublikacjaIsoprostanes (IsoPs) are key biomarkers for investigating the role of free radical generation in the pathogenesis of human disorders. To solve IsoPs-related problems with regard to isoprostanes, analytical tools are required. This paper reviews the problems and trends in this field focusing on the methodology for assaying biomarkers in exhaled breath condensate (EBC) samples. A large amount of work has been done in the qualitative...
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Determination of isoprostanes in exhaled breath condensate samples by liquid chromatography coupled with tandem mass spectrometry
PublikacjaOxidative stress (OS) is a state of imbalance between continuously generating reactive oxygen species (ROS) during normal cell metabolism and mechanism of detoxifying oxygen radicals through a network of antioxidative enzymes. Isoprostanes are prostaglandin -like substances that are produced in vivo primarily by free radical-induced peroxidation of arachidonic acid. The measurement of isoprostanes in biological fluids and/or tissue...
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Sensitive determination of isoprostanes in exhaled breath condensate samples with use of liquid chromatography–tandem mass spectrometry
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Sensitive determination of isoprostanes in exhaled breath condensate samples with use of liquid chromatography-tandem mass spectrometry
PublikacjaOxidative stress is the hallmark of various inflammatory lung diseases. Increased concentrations of reactive oxygen species in the lungs are reflected by elevated concentrations of oxidative stress markers in the breath, airways, lung tissue and blood. The aim of this work was to develop a method for the fast measurement of F2 isoprostanes in exhaled breath condensate (EBC) samples using equipment which is nowadays available and...
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LC-MS/MS dtermination of isoprostanes in plasma samples collected from mice exposed to doxorubicin or tert-butyl hydroperoxide
PublikacjaIsoprostanes are stable products of arachidonic acid peroxidation and are regarded as the most reliable markers of oxidative stress in vivo. Here we describe the LC-MS/MS procedure enabling simultaneous determination of four regioisomers (8-iso prostaglandin F2α, 8-iso-15(R)-prostaglandin F2α, 11β-prostaglandin F2α, 15(R)-prostaglandin F2α) in plasma samples collected from mice. The four plasma isoprostanes are determined by LC–ESI-MS/MS...
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Influence of Diosmin Treatment on the Level of Oxidative Stress Markers in Patients with Chronic Venous Insufficiency
PublikacjaOxidative stress plays an important role in the pathophysiology of many human disorders, while antioxidants prevent the development of various adverse symptoms. Diosmin is a natural flavonoid applied in vascular system disorders, especially in chronic venous insufficiency (CVI), and it plays a significant part in the alleviation of CVI symptoms. Due to antioxidant activity, it also has the ability to scavenge the oxygen free radicals...
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Novel liquid chromatography method based on linear weighted regression for the fast determination of isoprostane isomers in plasma samples using sensitive tandem mass spectrometry detection
PublikacjaA simple, fast, sensitive and accurate methodology based on a LLE followed by liquid chromatography–tandem mass spectrometry for simultaneous determination of four regioisomers (8-iso prostaglandin F2α, 8-iso-15(R)-prostaglandin F2α, 11β-prostaglandin F2α, 15(R)-prostaglandin F2α) in routine analysis of human plasma samples was developed. Isoprostanes are stable products of arachidonic acid peroxidation and are regarded as the...
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Transport deficiency is the molecular basis of Candida albicans resistance to antifungal oligopeptides
Publikacja(FMDP), an inhibitor of glucosamine-6-phosphate synthase, exhibited growth inhibitory activity against Candida albicans, with minimal inhibitory concentration values in the 0.05–50 mg/L range. Uptake by the peptide permeases was found to be the main factor limiting an anticandidal activity of these compounds. Di- and tripeptide containing FMDP (F2 and F3) were transported by Ptr2p/Ptr22p peptide transporters (PTR) and FMDP-containing...
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High-performance analog circuits : bipolar noise
PublikacjaOmówiono typowe źródła szumów występujące w tranzystorach bipolarnych, a mianowicie: cieplne, śrutowe, generacyjno-rekombinacyjne, 1/f, 1/f2, wybuchowe (RTS),lawinowe. Przedstawiono szumowy schemat zastępczy tranzystora bipolarnego oraz opisano wydajności poszczególnych źródeł szumów. Przytoczono informacje o zastępczej rezystancji tranzystora szumów oraz współczynniku szumów.
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Noise in semiconductor devices
PublikacjaOmówiono typowe źródła szumów występujące w przyrządach pólprzewodnikowych, a mianowicie: cieplne, śrutowe, generacyjno-rekombinacyjne, 1/f, 1/f2, wybuchowe (RTS), lawinowe. Przedstawiono szumowe schematy zastępcze tranzystora bipolarnego, JFET i MOSFET oraz opisano wydajności poszczególnych źródeł szumów. Zasugerowano jak dobierać przyrządy półprzewodnikowe do małoszumowych układów w zakresie małych częstotliwości.
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Multi-instrument analysis of L-band amplitude scintillation observed over the Eastern Arabian Peninsula
PublikacjaThe study of scintillation-causing ionospheric irregularities is important to mitigate their effects on satellite communications. It is also important due to the spatial and temporal variability of these irregularities, given that their characteristics differ from one region to another. This study investigates the spatial and temporal characteristics of L1 amplitude scintillation-causing ionospheric irregularities over the Eastern...
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Rainwater chemistry composition in Bellsund: Sources of elements and deposition discrepancies in the coastal area (SW Spitsbergen, Svalbard)
PublikacjaDiscrepancies in rainfall chemistry in Bellsund were found to be influenced by the orographic barrier and related to the variability in the inflow of air masses as well as to the distance of sampling sites from the sea and thus the extent of sea spray impact. This study covers measurements of rainfall (P) and air temperature (T), physicochemical parameters (pH, specific electrolytic conductivity (SEC), major ions (Cl , NO3 , SO4...
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Improving the quality of speech in the conditions of noise and interference
PublikacjaThe aim of the work is to present a method of intelligent modification of the speech signal with speech features expressed in noise, based on the Lombard effect. The recordings utilized sets of words and sentences as well as disturbing signals, i.e., pink noise and the so-called babble speech. Noise signal, calibrated to various levels at the speaker's ears, was played over two loudspeakers located 2 m away from the speaker. In...
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The possibility of estimating the height of the ionospheric inhomogeneities based on TEC variations maps obtained from dense GPS network
PublikacjaA state of the ionosphere can be effectively studied using electromagnetic signals received from global navigation satellite systems (GNSS). Utilization of the dual frequency observations allows estimating values of the total electron content (TEC). They can be used for a number of scientific studies such as detection and monitoring of traveling ionospheric disturbances or plasma bubbles. Moreover, maps of TEC variations allow...
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Dietary intervention with beetroot juice during doxorubicin cancer chemotherapy in vivo reduces markers of oxidative stress
PublikacjaCancer chemotherapy with doxorubicin, despite high antitumor activity and broad spectrum of this drug, is on decline due to toxic side effects. The clinical efficacy of anthracyclines have continuously prompted the search for new adjuvants to alleviate undesirable side toxicity incurred by this group of cytostatics. The recent approaches involve the application of synthetic or purified natural antioxidants in combination with doxorubicin...