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Characterization of recombinant homocitrate synthase from Candida albicans
PublikacjaLYS21 and LYS22 genes from Candida albicans encoding isoforms of homocitrate synthase (HCS), an enzyme catalyzing the first committed step in the L-lysine biosynthetic pathway, were cloned and expressed as NoligoHistagged fusion proteins in Escherichia coli. The purified gene products revealed HCS activity, i.e. catalyzed the condensation of α-ketoglutarate with acetyl-coenzyme A to yield homocitrate. The recombinant enzymes were purified...
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Activity of isavuconazole and other triazole derivatives against clinical isolates of Aspergillus fumigatus
PublikacjaAspergillus fumigatus is the most frequent pathogen of the genus Asperillus, which is highly susceptible to triazole derivatives, especially to isavuconazole and voriconazole. Many countries face a growing problem of infections due to A. fumigatus showing acquired resistance to one or several triazoles. In medical centres, monitoring the susceptibility of isolated Aspergillus spp. is recommended. The aim of this study was to collect...
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Antibiotic-Based Conjugates Containing Antimicrobial HLopt2 Peptide: Design, Synthesis, Antimicrobial and Cytotoxic Activities
PublikacjaRecent studies have shown that modified human lactoferrin 20−31 fragment, named HLopt2, possesses antibacterial and antifungal activity. Thus, we decided to synthesize and evaluate the biological activity of a series of conjugates based on this peptide and one of the antimicrobials with proven antibacterial (ciprofloxacin, CIP, and levofloxacin, LVX) or antifungal (fluconazole, FLC) activity. The drugs were covalently connected...
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Type III Responses to Transient Inputs in Hybrid Nonlinear Neuron Models
PublikacjaExperimental characterization of neuronal dynamics involves recording both of spontaneous activity patterns and of responses to transient and sustained inputs. While much theoretical attention has been devoted to the spontaneous activity of neurons, less is known about the dynamic mechanisms shaping their responses to transient inputs, although these bear significant physiological relevance. Here, we study responses to transient...
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Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site
PublikacjaAn important stage in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) life cycle is the binding of the spike (S) protein to the angiotensin converting enzyme-2 (ACE2) host cell receptor. Therefore, to explore conserved features in spike protein dynamics and to identify potentially novel regions for drugging, we measured spike protein variability derived from 791 viral genomes and studied its properties by molecular...
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Molecular basis for the DNA damage induction and anticancer activity of asymmetrically substituted anthrapyridazone PDZ-7
Publikacjanthrapyridazones, imino analogues of anthraquinone, constitute a family of compounds with remarkable anti-cancer activity. To date, over 20 derivatives were studied, of which most displayed nanomolar cytotoxicity towards broad spectrum of cancer cells, including breast, prostate and leukemic ones. BS-154, the most potent derivative, had IC50 values close to 1 nM, however, it was toxic in animal studies. Here, we characterize another...
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Imidazoacridinone antitumor agent C-1311 as a selective mechanism- based inactivator of human cytochrome P450 1A2 and 3A4 isoenzymes.
Publikacja5-Diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311), a promising antitumor agent that is also active against autoimmune diseases, was determined to be a selective inhibitor of the cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1311 might modulate the effectiveness of other drugs used in multidrug therapy. The present work aimed to identify the mechanism of the observed C-1311-mediated inactivation of CYP1A2...
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Between therapy effect and false-positive result in animal experimentation
PublikacjaDespite the animal models’ complexity, researchers tend to reduce the number of animals in experiments for expenses and ethical concerns. This tendency makes the risk of false-positive results, as statistical significance, the primary criterion to validate findings, often fails if testing small samples. This study aims to highlight such risks using an example from experimental regenerative therapy and propose a machine-learning...
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Anticancer Properties of Amino Acid and Peptide Derivatives of Mycophenolic Acid
PublikacjaBackground: Although Mycophenolic Acid (MPA) is applied as prodrugs in clinic as an immunosuppressant, it also possesses anticancer activity. MPA acts as Inosine-5’-Monophosphate Dehydrogenase (IMPDH) inhibitor, where the carboxylic group at the end of the side chain interacts with Ser 276 of the enzyme via hydrogen bonds. Therefore, MPA derivatives with other polar groups indicated high inhibition too. On the other hand, potent...
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Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione: characteristics of non-enzymatic and glutathione S-transferase-mediated reactions
PublikacjaUnsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. A significant route of phase II drug metabolism is conjugation with glutathione (GSH), which can be non-enzymatic and/or catalyzed by GSH-dependent enzymes. The aim of this work was to investigate the GSH-mediated metabolic pathway of a representative UA, C 2028. GSH supplemented incubations of C-2028 with rat, but not with human, liver...
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2022-2023 - Assessment of performance of unmanned maritime vehicles (USV, UUV, AUV) by CFD and MES investigation, PG_00053662
Kursy OnlineThe course entitled "APofUMV Assessment of Performance of Unmanned Maritime Vehicles (W-lecture) is mainly conducted for the DAPE Course Students. The lectures (W) are closely connected with the project exercises (P) where some examples for the data designs are conducted. All the AP of UMV lectures are connected with presentation following problems: - major areas of application of UMV unmanned maritime vehicles, - sea environment...
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New trifunctional acrylic water-based paint with self-cleaning, biocidal and magnetic properties
PublikacjaIn the present study, we report the synthesis and application of ZnFe2O4/SiO2-TiO2 nanocomposites with nonstoichiometric content of Fe to Zn used for the first time for the preparation of new generation trifunctional paints with self-cleaning, biocidal and magnetic properties. Currently, there are no compositions on the market for obtaining protective coatings in the form of paint, which simultaneously exhibit biocidal, magnetic...
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Application of Mathematics in Technology 2 [2022/23]
Kursy Online{mlang en}Numerical methods in electrical engineering.{mlang} {mlang pl}Metody numeryczne w elektrotechnice{mlang}
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[IMa] Electrical methods of materials and structures characterization
Kursy Online{mlang pl} Dyscyplina: inżynieria materiałowa Zajęcia fakultatywne dla doktorantów I i II roku Prowadzący: prof. dr hab. inż. Piotr Jasiński Liczba godzin: 15 Forma zajęć: wykład/seminarium {mlang} {mlang en} Discipline: materials engineering Facultative course for 1st and 2nd year PhD students Academic teachers: prof. dr hab. inż. Piotr Jasiński Total hours of training: 15 teaching hours Course type: lecture/seminar {mlang}
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METHODS OF QUANTITATIVE ANALYSIS (TEAM PROJECT) (2022/2023)
Kursy OnlineMETHODS OF QUANTITATIVE ANALYSIS (TEAM PROJECT) - Economic Analytics, Lecture and Lab, Winter Semester 2022/2022. Teacher: dr Piotr Paradowski
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Fundamentals of Electrotechnics and Electronics 1 [2022/23]
Kursy OnlineBasic concepts in electrical engineering, analysis of electric circuits, phenomena occurring in electrical systems.
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Computer modeling and design of materials 2022/2023
Kursy OnlineComputer modeling and design of materials, kierunek: Nanotechnologia, specjalność: Mathematics for new materials design, II stopień, semestr 3
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Theory of Organisation and Management and System's Theory
Kursy OnlineWe will have our lectures and classes in Theory of Organisation and Management and System's Theory on Wednesday Since 9:15 till 12:00. We will meet on MsTeams and here is the link: https://teams.microsoft.com/dl/launcher/launcher.html?url=%2F_%23%2Fl%2Fmeetup-join%2F19%3Ameeting_MTBjMTg4ZWYtY2Q2NS00YjlkLWFmZTItMWUzYTcwM2ZmNzU0%40thread.v2%2F0%3Fcontext%3D%257b%2522Tid%2522%253a%2522b2b950ec-1ee3-4d9d-ac5e-4dd9db5e0b73%2522%252c%2522Oid%2522%253a%252233f97504-8676-4b87-96ad-a9394d16b3b2%2522%257d%26anon%3Dtrue&type=meetup-join&deeplinkId=ce188d79-726a-418e-ab34-eb9f59172f62&directDl=true&msLaunch=true&enableMobilePage=true&suppressPrompt=true
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Catalysis, process design and industrial production of polymers
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2022-2023 - Strenght of materials towards applications, PG_00053661
Kursy OnlineThe course is mainly dedicated to the DAPE Students. From the theoretical point of view the course consists of the following problems to be discussed during the lectures and exercises: -fundamentals of strength of materials -basic structures and environment -loads on structures -strength of materials: tension, stress, analysis of stress and strain, bending moments and shearing forces, longitudinal and shearing stress in beams,...
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Advanced Mechanics of Marine Structures II W2021/22
Kursy OnlineLecture and Laboratory classes Advanced Mechanics of Marine Structures II W2021/22
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Composite materials - fabrication, properties and prospects of application
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INFRO@D Safety management of unprotected road users
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Conservation and Protection of Architectural Heritage 2020/21
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[ITiT] Technologies of Spatial Data Analysis and Processing
Kursy Online{mlang pl} Dyscyplina: Informatyka Techniczna i Telekomunikacja Zajęcia obowiązkowe dla doktorantów II roku Prowadzący: dr hab. inż. Marcin Kulawiak Liczba godzin: 30 h Forma zajęć: wykład/seminarium {mlang} {mlang en} Discipline: Technical Informatics and Telecommunications Obligatory course for 2nd year PhD students Academic teacher: dr hab. inż. Marcin Kulawiak Total hours of training: 30 teaching hours Course...
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Application of Mathematics in Technology 2 [2020/21]
Kursy OnlineKurs dla studentów sem. 4 na kierunku Energy Technologies studiów stacjonarnych I stopnia w języku angielskim. Metody numeryczne. Zastosowania w elektrotechnice. Wykład+ćwiczenia.
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Physical and chemical basis of energy generation - 2023
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Heat and mass transfer in lack of gravity
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Application of Mathematics in Technology 2 [2021/22]
Kursy Online{mlang en}Numerical methods in electrical engineering.{mlang} {mlang pl}Metody numeryczne w elektrotechnice{mlang}
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WASTEWATER TREATMENT AND DISPOSAL OF SEWAGE SLUDGE 2021
Kursy OnlineThe aim of the course is to learn the characteristics of different types of wastewater depending on their origin (industrial sector) as well as introduce the commonly used technologies for removing pollutants from wastewater and get to know an alternative methods. Another goal is to understand the problems of management of sewage sludge generated in municipal wastewater treatment plants and industrial plants.
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Heat and mass transfer in lack of gravity
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Reliability of Structures - 3rd semester, Civil Engineering - Nowy
Kursy OnlineReliability of Structures, 2nd grade studies, Civil Engineering
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Fundamentals of Power Electronics [Energy Technologies][2020/21]
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Fundamentals of Optical Fibers and Photonics - 2021/2022
Kursy OnlineTechnika światłowodowa i fotonika: 2 st. 2 sem., kierunek elektronika i telekomunikacja
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[ZiJ, EiF] Philosophy, research methodology, elements of logic
Kursy Online{mlang pl} Dyscyplina: nauki o zarządzaniu i jakości; ekonomia i finanse Zajęcia obowiązkowe dla doktorantów I roku Prowadzący: dr Mateusz Bonecki Liczba godzin: 30 Forma zajęć: wykład {mlang} {mlang en} Discipline: management and quality; economics and finance Obligatory course for 1st-year PhD students Academic teacher: dr Mateusz Bonecki Total hours of training: 30 teaching hours Course type: lecture {mlang}
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2022 Wastewater Treatment and Disposal of Sewage Sludge
Kursy OnlineThe aim of the course is to learn the characteristics of different types of wastewater depending on their origin (e.g. industrial sector) as well as to introduce the commonly used technologies for removing pollutants from wastewater and get familiar with alternative methods. Another goal is to understand the problems of management of sewage sludge generated in municipal wastewater treatment plants and industrial plants.
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Essentials of micro and macroeconomics - Summer 2021/22
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Essentials of micro and macroeconomics - Summer 2022/23
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Computer design of materials and nanomaterials 2024-25
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Fundamentals of Interpersonal Communication Group Work 24/25
Kursy OnlineThe main objective of this coure is to search information on a given topic. On this course students have to present their opinions on a specific topic in the form of a multimedia presentation. Classes are designed to improve the skills of public speaking and to acquire basic knowledge about verbal and nonverbal communication, speeches principles (rhetoric), statement ethics, the rules of disscusion, the basics of good manners....
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[IMe] Selected problems of heat and mass transfer
Kursy Online{mlang pl} Dyscyplina: Inżynieria mechaniczna (PG + IMP PAN) Zajęcia obowiązkowe Prowadzący: prof. dr. hab. inż. Dariusz Mikielewicz Liczba godzin: 20 h Forma zajęć: wykład {mlang} {mlang en} Discipline: mechanical engineering (GUT + IFFM PAS) Obligatory course Academic teacher: prof. dr. hab. inż. Dariusz Mikielewicz Total hours of training: 20 teaching hours Course type: lecture {mlang}
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Application of Mathematics in Technology, ET, 24/25
Kursy OnlineApplication of Mathematics MOODLE ENV localdevtestprod
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Fundamentals of sociology, Ist., DaPE, zima 23/24
Kursy OnlineThe lecture presents basic issues in the field of sociology.
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Essentials of Accounting Winter 2024 ID sem 3
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Theory of Urban Design sem I MGR ARCH
Kursy OnlineW ramach kursu zamieszcozne zostaną treści programowe dla grupy angielskiej na kierunku magisterkim Architektura
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Theory of Organisation and Management and Systems Theory
Kursy OnlineDear Students, Our classes on Theory of Orgnisation and Management (15 h lecture, 15 hours excercises) and Systems Theory (15 hours lecture) will take place in MSTeams each Wednesday since 21st of February 2024 at 9:15-12:00 am at link https://teams.microsoft.com/l/meetup-join/19%3ameeting_YzY1NTRiOGEtYTQ3Yi00ZmFlLWI3YTYtYjhiNjBhZjZjOGI5%40thread.v2/0?context=%7b%22Tid%22%3a%22b2b950ec-1ee3-4d9d-ac5e-4dd9db5e0b73%22%2c%22Oid%22%3a%2233f97504-8676-4b87-96ad-a9394d16b3b2%22%7d Join...
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Fundamentals of Optical Fibers and Photonics - 2024/2025
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GTM Method of Structural Studies Lecture and Laboratory
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Physical and chemical basis of energy generation - 2024
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History of Contemporary Architecture & Urbanism (2023/24)
Kursy Online