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Wyniki wyszukiwania dla: IN VITRO BIODEGRADATION
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XV edition 2022-24, International MBA in Strategy, Programme and Project Management
Kursy Online1 2 3
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Application of Mathematics in Technology, ET, sem. 3, winter 2022/2023, (PG_00049767)
Kursy OnlineApplication of Mathematics lectures and exercises
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X edition 2018-20, International MBA in Strategy, Programme and Project Management
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IX edition 2017-19, International MBA in Strategy, Programme and Project Management
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XI edition – 2019-21, International MBA in Strategy, Programme and Project Management
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XIV edition 2021-23, International MBA in Strategy, Programme and Project Management
Kursy Online1 2 3
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Environmental Protection in Energetics (PG_00049751), W, ET, sem.1, winter 2024/2025
Kursy OnlineEnvironmental aspects of energy production and processing.
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XIII edition – 2020-22, International MBA in Strategy, Programme and Project Management
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Actions of a nitric oxide donor on prostaglandin production and angiogenic activity in the equine endometrium
PublikacjaNitric oxide (NO) plays an important role in prostaglandin secretion and angiogenesis in the reproductive system. In the present study, the roles of the NO donor spermine NONOate and tumour necrosis factor-alpha (TNF; as a positive control) in prostaglandin production and angiogenic activity of equine endometria during the oestrous cycle were evaluated. In addition, the correlation between NO production...
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Carbonic anhydrase inhibitors. Synthesis, and molecular structure of novel series N-substituted N'-(2-arylmethylthio-4-chloro-5- methylbenzenesulfonyl)guanidines and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII
PublikacjaA series of novel N-substituted N'-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)guanidines 9 e41 have been synthesized and investigated as inhibitors of four isoforms of zinc enzyme carbonic anhydrase (CA.EC 4.2.1.1), that is the cytosolic CA I and II, and cancer-associated isozymes CA IX and XII. Against the human CA I investigated compounds showed KI in the range of 87e6506 nM, toward hCA II ranging from 7.8 to 4500 nM,...
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NUTRITIONAL AND PHARMACEUTICAL APPLICATIONS OF BIOACTIVE COMPOUNDS IN TROPICAL FRUITS
PublikacjaDuring the past two decades our international scientific group investigated in vitro the physicochemical and nutritional characteristics of some cultivars of durian at various stages of ripening, mangosteen and new cultivars of snake fruit in comparison with widely used avocado, kiwifruit and mango, and in vivo their influence on laboratory animals. The main objective of the present study was to screen and compare the properties...
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A comprehensive evaluation of flexible FDM/FFF 3D printing filament as a potential material in medical application
PublikacjaThe use of FDM/FFF in 3D printing for medical sciences is becoming common. This is due to the high availability and decent price of both 3D printers and filaments useful for FDM/FFF. Currently, researchers' attention is focused mainly on the study of medical filaments based on PLA, PCL or their modifications. This contributes to insufficient diversity of medical-grade filaments on the market. Moreover, due to the lack of specified...
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Ruthenium(II) and Iridium(III) Complexes as Tested Materials for New Anticancer Agents
PublikacjaThe oncological use of cisplatin is hindered by its severe side eects and a very important resistance problem. To overcome these problems, scientists have attempted to design new generation transition-metal anticancer complexes. In this study, we present new complexes, ruthenium(II) [(6-p-cymene)RuCl(py2CO)]PF6 (1), iridium(III) [(5-Cp)IrCl(py2CO)]PF6 (2), and NH4[IrCl4(py2CO)]H2O (3), based on di-2-pyridylketone (py2CO). The prepared...
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Diamond Nanofilm Normalizes Proliferation and Metabolism in Liver Cancer Cells
PublikacjaPurpose: Surgical resection of hepatocellular carcinoma can be associated with recurrence resulting from the degeneration of residual volume of the liver. The objective was to assess the possibility of using a biocompatible nanofilm, made of a colloid of diamond nanoparticles (nfND), to fill the side after tumour resection and optimize its contact with proliferating liver cells, minimizing their cancerous transformation. Methods:...
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Synteza i badania biologiczne nowych analogów kwasu mykofenolowego z pochodnymi adenozyny jako potencjalnych leków immunosupresyjnych
PublikacjaPrzedstawiona praca doktorska pt. „Synteza i badania biologiczne nowych analogów kwasu mykofenolowego z pochodnymi adenozyny jako potencjalnych leków immunosupresyjnych” poświęcona jest związkom immunosupresyjnym opartym o cząsteczkę kwasu mykofenolowego oraz pochodnych adenozyny. Z medycznego punktu widzenia, gdy długotrwała choroba lub nagły przypadek powoduje nieodwracalny uraz tkanek, komórek lub niewydolność organu i żadna...
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Electrochemical simulation of metabolic reduction and conjugation reactions of unsymmetrical bisacridine antitumor agents, C-2028 and C-2053
PublikacjaElectrochemistry (EC) coupled with analysis techniques such as liquid chromatography (LC) and mass spectrometry (MS) has been developed as a powerful tool for drug metabolism simulation. The application of EC in metabolic studies is particularly favourable due to the low matrix contribution compared to in vitro or in vivo biological models. In this paper, the EC(/LC)/MS system was applied to simulate phase I metabolism of the representative...
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The impact of cooking method on the phenolic composition, total antioxidant activity and starch digestibility of rice (Oryza sativa L.)
PublikacjaThis study investigated changes in the phenolic composition, total antioxidant activity (TAA) and starch digestibility in white and brown rice due to three different cooking procedures, and subsequent reheating of cooked rice after storage. Among the analyzed samples, brown rice showed the highest TAA and phenolic content (622.5 mg kg-1 DW). All cooking methods resulted in significant decrease of phenolic content and TAA of rice...
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THE APPLICATION OF PHENOMENOLOGICAL METHODOLOGY FOR DESIGNING PILE FOUNDATION IN PORT STRUCTURES
PublikacjaIt is of utmost importance in the design process that a suitable, safe and concurrently economic solution be chosen. Issues connected with foundations require adopting a special approach. Soil is a composite medium, and it is essential to describe as precisely as possible the interaction taking place between the subgrade and the structure. There are many design methods of pile foundation that are based on in-situ test of soils....
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Juvenalia Gdańskie 2022
WydarzeniaZapraszamy na Juvenalia 2022 – święto studentów w Gdańsku.
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Inter Applied Chemistry Programme 4 Exploiting Color In Analytical Chemistry - Francisco Pena-Pereira
Kursy OnlineInter Applied Chemistry Programme 4
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MSc in Urbanism 21/22: Comprehensive Urban Planning / Introduction to urban development planning
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Ewa Rogala, WETI, Informatics (studies in English), II st, 1 sem, 21/22z
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Measurements in civil engineering, transport, environmental engineering, mining and power engineering 22/23
Kursy OnlineThe course is primarily open to all PhD students at Gdansk University of Technology. This course is compulsory for PhD students assigned to Civil Engineering and Transport as well as Environmental Engineering, Mining and Power Engineering tracks at Doctoral School of GUT. This course allows the PhD students to obtain the knowledge related to the experimental equipment and types of experiments carried out at GUT in the field of...
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Road Safety Audit - Erasmus+ European Digital Education in Road Infrastructure Management INFRO@D.
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Passive Methods in Heat Transport, W/P, DPE, sem.5, zimowy 22/23
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Measurements in civil engineering, transport, environmental engineering, mining and power engineering 23/24
Kursy OnlineThe course is primarily open to all PhD students at Gdansk University of Technology. This course is compulsory for PhD students assigned to Civil Engineering and Transport as well as Environmental Engineering, Mining and Power Engineering tracks at Doctoral School of GUT. This course allows the PhD students to obtain the knowledge related to the experimental equipment and types of experiments carried out at GUT in the field of...
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Joanna Pawlik WETI, Studies in English, II stopień, 2 sem, 2023/24 Z
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Environmental Protection in Energetics, PG_00049751, W, PE-ET, sem.1, winter 2023/24
Kursy OnlineEnvironmental aspects of energy production and processing.
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Roadside safety management - Erasmus+ European Digital Education in Road Infrastructure Management INFRO@D
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Environmental Protection in Energetics (PG_00049751), W, PE-ET, sem.1, winter 2023/24
Kursy OnlineEnvironmental aspects of energy production and processing.
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XVII International MBA in Strategy, Programme and Project Management, edition XVII, 2024-2026
Kursy Online1 2 3
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Road pavement management - Erasmus+ European Digital Education in Road Infrastructure Management INFRO@D
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Measurements in civil engineering, transport, environmental engineering, mining and power engineering 24/25
Kursy OnlineThe course is primarily open to all PhD students at Gdansk University of Technology. This course is compulsory for PhD students assigned to Civil Engineering and Transport as well as Environmental Engineering, Mining and Power Engineering tracks at Doctoral School of GUT. This course allows the PhD students to obtain the knowledge related to the experimental equipment and types of experiments carried out at GUT in the field of...
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Glucosinolates from lepidium peruvianum as potential antiamnestic drugs
PublikacjaLepidium peruvianum (maca) (Brassicaceae) is a naturally occurring plant mainly in the high Andes of Peru. In recent years, it has been intensively researched in terms of its influence on various diseases and towards health improvement. Alzheimer’s disease is an incurable disease that most often affects adults over the age of 60. As since 2003 the US Food and Drug Administration (FDA) did not approve any new drug for Alzheimer’s...
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Covalent DNA modification by products of myrosinase catalysed glucosinolate degradation in cell-free system
PublikacjaThe bioactive phytochemicals found in Brassica vegetables belonging to glucosinolates (GLS) and especially the products of their degradation isothiocyanates (ITC) and indoles are regarded as the most promising cancer chemopreventive compounds. These secondary metabolites constitute defence system repelling or preventing the development of agrophages attacking brassica plants. The antibiological properties of these compounds suggest...
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Mass spectrometry based identification of geometric isomers during metabolic stability study of a new cytotoxic sulfonamide derivatives supported by quantitative structure-retention relationships
PublikacjaA set of 15 new sulphonamide derivatives, presenting antitumor activity have been subjected to a metabolic stability study. The results showed that besides products of biotransformation, some additional peaks occurred in chromatograms. Tandem mass spectrometry revealed the same mass and fragmentation pathway, suggesting that geometric isomerization occurred. Thus, to support this hypothesis, quantitative structure-retention relationships...
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Fusion of Taq DNA polymerase with single-stranded DNA binding-like protein of Nanoarchaeum equitans—Expression and characterization
PublikacjaDNA polymerases are present in all organisms and are important enzymes that synthesise DNA molecules. They are used in various fields of science, predominantly as essential components for in vitro DNA syntheses, known as PCR. Modern diagnostics, molecular biology and genetic engineering need DNA polymerases which demonstrate improved performance. This study was aimed at obtaining a new NeqSSB-TaqS fusion DNA polymerase from the...
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Joanna Pawlik WETI, ACiR Studies in English, II stopień, 1 sem, 2022/23 L
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Safety and risk in transportation systems (PG_00057094), C, TiL, 1 sem., letni 22/23
Kursy OnlineThe aim of the lectures, exercises is to present the current knowledge of Safety and risk in transportation systems in maritime transportation and inland water transportation, land transport.
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Certification program in Road Infrastructure Safety Management - Erasmus + European Road Safety Partnership EuroS@P
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XVII MBA Edition 2024-2026, International MBA in Strategy, Programme and Project Management - XVII
Kursy Online1 2 3
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XVI MBA Edition 2023-2025, International MBA in Strategy, Programme and Project Management - XVI
Kursy Online1 2 3
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LAND ART / CZŁOWIEK W NATURZE / NATURA CZŁOWIEKA / LAND ART / MAN IN NATURE / HUMAN NATURE
Kursy OnlineKomponent modułu przedmiot Kompozycja - koordynator modułu: prof. Krzysztof Wróblewski Prowadzący: dr hab. Janusz Tkaczuk, prof. uczelni mgr Paweł Sasin english version below Kompozycja rzeźbiarska w przestrzeni: zaprojektowanie rzeźbiarskiego układu jednej lub kilku form abstrakcyjnych wynikających z inspiracji sztuką land art’u. Miejscem zbudowania kompozycji jest środowisko naturalne. Punkt wyjścia to określenie wzajemnej...
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Safety and risk in transportation systems (PG_00057094), W, TiL, 1 sem., letni 22/23
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Safety and risk in transportation systems, PG_00057094, C, TiL, sem.1, letni 2023/2024
Kursy OnlinePraktyczna ocena niezawodności, bezpieczeństwa i ryzyka w systemach transportowych Practical assessment of reliability, safety and risk in transportation systems
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Elective design II: PLANNING GENDERED CITY- GENDER CITY WALKING TOURS Women in Architecture series_2023
Kursy OnlineThe course aim is to get familiar with the topic of tangible and intangible cultural heritage created by women in 100 years. The recognition of the past and present achievements as well as problems and challenges female are facing in built environment is curtail for understanding importance of women involvement and need of their support and promotion. This new perception continues to increase the visibility of creative...
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Insulin-like growth factor type 2 is better than insulin-like growth factor type 1 a survival marker in patients after acute decompensation of heart failure
PublikacjaIntroduction:A decreased IGF-1 has been found in heart failure (HF). There are no reports assessing IGF-2 in HF, although in vitro study has shown, that IGF-2 stimulates cardiomyocyte proliferation more than IGF-1. The study aim was to compare the IGF-1 and IGF-2 concentration depending on HF exacerbation and annual survival.Material and methods:Among 75 patients hospitalized...
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The II phase metabolism of endogenous and exogenous compounds, including antitumor chemotherapeutics
PublikacjaThe II phase metabolism, it is a set of metabolism and excretion pathways of endogenous as well as exogenous compounds including xenobiotics. UDP-glucuronyltransferases (UGTs; EC 2.4.1.17) are the most crucial representatives of II phase enzymes, which are responsible for the transformation of bilirubine and bile acids, steroids and thyroid hormones and lipids. Exogenous compounds, including drugs, carcinogens, environmental pollutants...
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Novel Research on Biomedical Polyurethanes
PublikacjaThe variety of mechanical properties characterizes properly designed PURs. They may be biocompatible and reveal compatibility with blood, making them attractive materials for the fabrication of tissue scaffolds; however, like all synthetic materials, PURs don’t reveal sufficient biocompatibility. PURs may undergo certain chemical modifications (e.g., 1,4:3,6-dianhydro-D-sorbitol, ascorbic acid (AA), growth factors, covering with...
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Design, synthesis and high antitumor potential of new unsymmetrical bisacridine derivatives towards human solid tumors, specifically pancreatic cancers and their unique ability to stabilize DNA G-quadruplexes
PublikacjaNew promising unsymmetrical bisacridine derivatives (UAs), have been developed. Three groupsincluding 36 compounds were synthesized by the condensation of 4-nitro or 4-methylacridinone, imi-dazoacridinone and triazoloacridinone derivatives with 1-nitroacridine compounds linked with anaminoalkyl chain. Cytotoxicity screening revealed the high potency of these compounds against severaltumor cell lines. Particularly, imidazoacridinone-1-nitroacridine...