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Modified polycarbonate urethane: synthesis, properties and biological investigation in vitro
PublikacjaNowy poliweglano uretan (PCU-I) otrzymano z alifatycznych monomerów: poliwęglanu heksanodiolu, 4,4'diizocyjanianu dicykloheksanometanu, mieszaniny małocząsteczkowych dioli i oleju rycynowego (zawierającego głównie trigliceryd kwasu 12-hydroksyoleinowego). PCU-II otrzymano analogicznie ale bez udziału oleju rycynowego. Obydwa PCU charakteryzowały się dobrą wytrzymałością na rozciąganie. PCU-I miał niższą temperaturę zeszklenia a...
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Folate/homocysteine metabolism and lung cancer risk among smokers
PublikacjaBackground: Folate and homocysteine are involved in DNA synthesis and methylation processes, which are deregulated during carcinogenesis. Objectives: The aim of this study was to assess the relationship between folate/homocysteine concentrations, the functional polymorphisms of folate/homocysteine genes and lung cancer risk among cigarette smokers. Study design: The study included 132 lung cancer patients and 396 controls from...
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Peroxidative metabolism of fatty acids in the course of tick-borne encephalitis
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Updates on Metabolism in Lactic Acid Bacteria in Light of “Omic” Technologies
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The association between irisin and muscle metabolism in different thyroid disorders
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Lipophagy and Lipolysis Status in Lipid Storage and Lipid Metabolism Diseases
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Integrative genomics reveal a role for MCPIP1 in adipogenesis and adipocyte metabolism
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Diamond Nanofilm Normalizes Proliferation and Metabolism in Liver Cancer Cells
PublikacjaPurpose: Surgical resection of hepatocellular carcinoma can be associated with recurrence resulting from the degeneration of residual volume of the liver. The objective was to assess the possibility of using a biocompatible nanofilm, made of a colloid of diamond nanoparticles (nfND), to fill the side after tumour resection and optimize its contact with proliferating liver cells, minimizing their cancerous transformation. Methods:...
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Health economy of the metabolic syndrome pandemic
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Detoxification of the tricyclic antidepressant opipramol and its analog – IS-noh by UGT enzymes before and after activation by phase I enzymes in rat liver microsomes
PublikacjaThe present studies were carried out to evaluate the simultaneous one-pot metabolism of opipramol (IS-opi) and analog (IS-noh) by phase I and phase II enzymes present in rat liver microsomes (RLM) as an alternative to separate testing with recombinant enzymes. This approach allows for more time-saving and cost-effective screening of the metabolism of newly discovered drugs. We also considered that the lack of results for phase...
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METABOLIC BRAIN DISEASE
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INFOGEST static in vitro simulation of gastrointestinal food digestion
PublikacjaDeveloping a mechanistic understanding of the impact of food structure and composition on human health has increasingly involved simulating digestion in the upper gastrointestinal tract. These simulations have used a wide range of different conditions that often have very little physiological relevance, and this impedes the meaningful comparison of results. The standardized protocol presented here is based on an international consensus...
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In Vitro Measurement of Conformational Stability of Fibrinogen Adsorbed on Siloxane
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In-vitro controlled release of doxorubicin from silica xerogels
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The effectiveness of chemotherapy and electrochemotherapy on ovarian cell lines in vitro
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Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations
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Potential applications of plant in vitro cultures in phytoremediation studies
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In Vitro Biological Evaluation of Aprepitant Based 177Lu-Radioconjugates
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In vitro anticariogenic effects of polyphenolics from Potentilla recta
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In vitro evaluation of novel lipopeptides with potential therapeutic application
PublikacjaThe synthesis of derivatives of Gly-His-Lys was elaborated followed by their antimicrobial activity investigation.
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Application of human bile salts for in vitro digestion models
PublikacjaIn this study, experimental in vitro models simulating the environment of the human gastrointestinal tract were used to assess the impact of physiological surfactants, such as bile salts, on the kinetics of digestion. Bile salts are biosurfactants synthesised in the liver and secreted together with bile into the small intestine. There are many reports on the role of bile salts in lipolysis, but the knowledge of their influence...
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Nanocrystallization as a tool for controlling in vitro dissolution of borophosphate glass
PublikacjaThe controlled nanocrystallization of sodium-calcium-borophosphate glass (Na16.6Ca5.1B10.5Al0.8P10.5 O56.5 in at %) was conducted to investigate its influence on in vitro dissolution. Three temperatures (570 ◦C, 590 ◦C, and 610 ◦C) were selected based on thermal analysis and investigation of the morphology, structure, and in vitro dissolution of glass and glass-ceramics was conducted. The results of X-ray diffraction confirmed...
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Bile conjugation and its effect on in vitro lipolysis of emulsions
PublikacjaBile Salts (BS) are responsible for stimulating lipid digestion in our organism. Gut microbiota are responsible for the deconjugation process of primary conjugated to secondary unconjugated BS. We use two structurally distinct BS and characterize the rate of lipolysis as a compound parameter. A static in-vitro digestion model as well as meta-analysis of literature data has been performed to determine the most influential factors...
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Metabolic Profiles of New Unsymmetrical Bisacridine Antitumor Agents in Electrochemical and Enzymatic Noncellular Systems and in Tumor Cells
PublikacjaNew unsymmetrical bisacridines (UAs) demonstrated high activity not only against a set of tumor cell lines but also against human tumor xenografts in nude mice. Representative UA compounds, named C-2028, C-2045 and C-2053, were characterized in respect to their physicochemical properties and the following studies aimed to elucidate the role of metabolic transformations in UAs action. We demonstrated with phase I and phase II enzymes...
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Antibacterial activity of the secondary metabolites from in vitro cultures of Drosera aliciae
PublikacjaRośliny owadożerne (D. aliciae) metabolity wtórne farmakologicznie czynne substancje. Na wzrost akumulacji tychże substancji w tkankach roślin owadożernych ma wpływ dodatek elicytora. Końcowego oznaczenia zawartości metabolitów w ekstraktach roślinnych dokonano techniką chromatografii cieczowej.
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Lactose and β-Glucosides Metabolism and Its Regulation in Lactococcus lactis: A Review
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Evaluation of bioconcentration and metabolism of diclofenac in mussels Mytilus trossulus - laboratory study
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Vitamin D Metabolism Gene Polymorphisms and Their Associated Disorders: A Literature Review
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Activities of genes controlling sphingolipid metabolism in human fibroblasts treated with flavonoids
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Modulation of expression of genes involved in glycosaminoglycan metabolism and lysosome biogenesis by flavonoids
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Ascorbate and glutathione metabolism in embryo axes and cotyledons of germinating lupine seeds
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Central carbon metabolism influences fidelity of DNA replication in Escherichia coli
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Renal Regulation of Calcium-Phosphate Metabolism in Single- and Twin Pregnant Goats
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The II phase metabolism of endogenous and exogenous compounds, including antitumor chemotherapeutics
PublikacjaThe II phase metabolism, it is a set of metabolism and excretion pathways of endogenous as well as exogenous compounds including xenobiotics. UDP-glucuronyltransferases (UGTs; EC 2.4.1.17) are the most crucial representatives of II phase enzymes, which are responsible for the transformation of bilirubine and bile acids, steroids and thyroid hormones and lipids. Exogenous compounds, including drugs, carcinogens, environmental pollutants...
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DIABETES OBESITY & METABOLISM
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Journal of Endocrinology and Metabolism
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Nutritional Therapy & Metabolism
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Journal of Nutrition and Metabolism
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Archives of Endocrinology Metabolism
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Cardiovascular Endocrinology & Metabolism
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Diabetes & Metabolism Journal
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Drug Metabolism and Pharmacokinetics
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DIABETES NUTRITION & METABOLISM
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Journal of Diabetes & Metabolism
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Drug Metabolism Letters
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Human Nutrition and Metabolism
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MOLECULAR GENETICS AND METABOLISM
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METABOLISM-CLINICAL AND EXPERIMENTAL
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Obesity and Metabolism-Milan
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Endocrinology, Diabetes and Metabolism
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