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Search results for: human powered vehicles
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Effect of oxidation and in vitro intestinal hydrolysis on phospholipid toxicity towards HT29 cell line serving as a model of human intestinal epithelium
PublicationOxidation of food-derived phospholipids (PLs) can influence nutrient digestion and induce oxidative stress in gastrointestinal epithelium. In this study, hen egg yolk PL fraction was used to evaluate the effect of lipoxygenase (LOX)-induced PL oxidation on the rate of PL hydrolysis catalyzed by pancreatic phospholipase A2 (PLA2) in the presence of bile salts (BSs). Then, PL/BS solutions containing native or oxidized PLs were used...
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The effective elastic properties of human trabecular bone may be approximated using micro-finite element analyses of embedded volume elements.
PublicationBoundary conditions (BCs) and sample size affect the measured elastic properties of cancellous bone. Samples too small to be representative appear stiffer under kinematic uniform BCs (KUBCs) than under periodicity-compatible mixed uniform BCs (PMUBCs). To avoid those effects, we propose to determine the effective properties of trabecular bone using an embedded configuration. Cubic samples of various sizes (2.63, 5.29, 7.96, 10.58...
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The influence of 4-substituted and unsubstituted derivatives of 1-nitroacridine on the cell cycle and induction of apoptosis in human cancer HT29 and HeLa S3.
PublicationZbadano wpływ pochodnych 1-nitroakrydyny C-1748 i C-857, w stężeniach biologicznie istotnych, na cykl życiowy oraz indukcję apoptozy komórek raka jelita grubego HT29 oraz raka szyjki macicy HeLa S3. Metodą cytometrii przepływowej wykazano, że 4-metylo-1-nitroakrydyna C-1748 powoduje akumulację komórek HT29 w fazie S i komórek HeLa S3 w fazie G2 cyklu komórkowego zaś związek C-857 indukuje akumulację komórek HT29 i HeLa S3 w fazie...
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Novel 2-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)-1-(1,3,5-triazin-2-ylamino)guanidine derivatives: Inhibition of human carbonic anhydrase cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII, anticancer activity, and molecular modeling studies
PublicationA series of novel 2-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)-1-(6-substituted-4-chloro-1,3,5-triazin-2-ylamino)guanidine derivatives 9–20 have been synthesized by substitution of chlorine atom at the 1,3,5-triazine ring in compounds 5–8 with 3- or 4-aminobenzenesulfonamide and 4-(aminomethyl)benzenesulfonamide hydrochloride. All the synthesized compounds were evaluated for their inhibitory activity toward hCA I, II,...
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Biotransformation of Modified Benzylisoquinoline Alkaloids: Boldine and Berberine and In Silico Molecular Docking Studies of Metabolites on Telomerase and Human Protein Tyrosine Phosphatase 1B
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High Quality Independent From a Donor: Human Amniotic Fluid Derived Stem Cells—A Practical Analysis Based on 165 Clinical Cases
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Agrimoniin up-regulates collagen biosynthesis through increase in expression of β1-integrin receptor and prolidase activity in cultured human skin fibroblasts
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Analysis of interactions responsible for vasopressin binding to human neurohypophyseal hormone receptors—molecular dynamics study of the activated receptor–vasopressin–Gα systems
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Combination of ABT-737 and resveratrol enhances DNA damage and apoptosis in human T-cell acute lymphoblastic leukemia MOLT-4 cells
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Pollution characteristics and human health risks of potentially (eco)toxic elements (PTEs) in road dust from metropolitan area of Hefei, China
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Reconstructing human impact on peatland development during the past 200 years in CE Europe through biotic proxies and X-ray tomography
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Human red blood cells targeted metabolome analysis of glycolysis cycle metabolites by capillary electrophoresis using an indirect photometric detection method
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A rapid spectrofluorimetric method for the determination of malondialdehyde in human plasma after its derivatization with thiobarbituric acid and vortex assisted liquid–liquid microextraction
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Phenylalanine derivatives with modulating effects on human α1-glycine receptors and anticonvulsant activity in strychnine-induced seizure model in male adult rats
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A population of human brain cells expressing phenotypic markers of more than one lineage can be induced in vitro to differentiate into mesenchymal cells
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One- and two-photon induced fluorescence of Pacific Blue-labeled human serum albumine deposited on different core size silver colloids
PublicationPublikacja opisuje jedno i dwufotonowo indukowaną Fluorescencje znakowanej barwnikiem ''Pacific Blue'' ludzkiej albuminy osadzonej na srebrnych koloidach różnych rozmiarów
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Human Umbilical Vein Endothelial Cells (HUVECs) Co-Culture with Osteogenic Cells: From Molecular Communication to Engineering Prevascularised Bone Grafts
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‘Heart development and morphogenesis’ is a novel pathway for human ovarian granulosa cell differentiation during long‑term in�vitro cultivation‑a microarray approach
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Modulation of CYP19 expression by cabbage juices and their active components: indole-3-carbinol and 3,30-diindolylmethene in human breast epithelial cell lines
PublicationThe aim of this study was to evaluate the effect of white cabbage and sauerkraut juices of different origin and indole-3-carbinol (I3C) and diindolylmethane (DIM) on expression of CYP19 gene encoding aromatase, the key enzyme of estrogen synthesis.Remarkable differences in the effect on CYP19 transcript and protein level were found between the cab- bage juices (in 2.5-25 mL/L concentrations) and indoles (in 2.5-50 lM doses) in...
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The induction of autophagy in human colon wt p53 and p53-null HCT116 cells by 4-methyl-1-nitroacridine derivative C-1748
PublicationPrzeprowadzone badania miały na celu określenie zdolności pochodnej 4-metylo-1-nitroakrydyny C-1748 do uruchomienia autofagii komórek ludzkiego raka okrężnicy HCT116 posiadających dziki gen p53 oraz podlinii nie posiadającej tego genu. Wszystkie eksperymenty przeprowadzone zostały przy stężeniu hamującym proliferację komórek nowotworowych w 90%. Wykazano, że indukowana przez C-1748 autofagia w komórkach raka okrężnicy jest zależna...
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Red Kale (Brassica oleracea L. ssp. acephala L. var. sabellica) Induces Apoptosis in Human Colorectal Cancer Cells In Vitro
PublicationThis article presents the results of studies investigating the effect of red kale (Brassica oleracea L. ssp. acephala L. var. sabellica) extract on cancer cells (HT-29). The cytotoxicity of the red kale extract was assessed using MTT and LDH assays, while qRT-PCR was employed to analyze the expression of genes associated with the p53 signaling pathway to elucidate the effect of the extract on cancer cells. Furthermore, HPLC-ESI-QTOF-MS/MS...
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Reprezentatywne dla danego języka spektra odpowiedzi impulsowej kanału głosowego = English language specific spectrum generated in the human vocal tract
PublicationW pracy omówiono wybrane problemy ekstrakcji kodu informacji zawartego w dźwiękach mowy etnicznej. Autorzy, wykorzystując kompilację własnych i firmowych algorytmów, wydzielają w procesie wygładzania cepstralnego z cyfrowego zapisu dźwięków mowy naturalnej strukturę spektralną pobudzenia tonem krtaniowym i szumem oraz strukturę spektralną kanału głosowego modulującego to pobudzenie. W następnym kroku powstają -statystycznie reprezentatywne...
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Identification of safety hazards and their sources in tram transport
PublicationBoth in Poland and in most countries of the European Union, the tram infrastructure is extensively expanding. Contemporary low-floor trams are constructed according to different technical assumptions than typical railway vehicles or high floor trams. In Poland such vehicles rides often on lines designed according to standards developed to the classical vehicles. At the same time, the intensity of road traffic and the number of...
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Pro-apoptotic action of protein-carbohydrate fraction isolated from coelomic fluid of the earthworm Dendrobaena veneta against human colon adenocarcinoma cells
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Human Induced Pluripotent Stem Cell-Derived Microvesicles Transmit RNAs and Proteins to Recipient Mature Heart Cells Modulating Cell Fate and Behavior
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Highly Specific Substrates of Proteinase 3 Containing 3-(2-Benzoxazol-5-yl)-l-alanine and Their Application for Detection of This Enzyme in Human Serum
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Bardoxolone Methyl Displays Detrimental Effects on Endothelial Bioenergetics, Suppresses Endothelial ET-1 Release, and Increases Endothelial Permeability in Human Microvascular Endothelium
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Replicating DNA by cell factories: roles of central carbon metabolism and transcription in the control of DNA replication in microbes, and implications for understanding this process in human cells
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The effect of oxidized cholesterol on barrier functions and IL-10 mRNA expression in human intestinal epithelium co-cultured with dendritic cells in the transwell system
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The cellular response of human colon carcinoma HCT116 cells to 4-methyl-1-nitroacridine derivative C-1748 treatment depending on p53 status
PublicationWykazano, że pochodna C-1748 indukuje apoptozę w komórkach linii ludzkich raków jelita grubego HCT116 p53+/+ i p53-/- w sposób zależny od czasu inkubacji i stężenia związku. Wskazują na to: pojawienie się frakcji komórek sub-G1, charakterystyczne zmiany w morfologii jąder komórkowych, zmiany w strukturze błony plazmatycznej. Ponadto, pod wpływem badanego związku komórki HCT116 p53+/+ wykazują większą podatność do ulegania apoptozie...
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When Biobanks Meet Religion: Association Between Religiosity and Attitudes of Polish Medical Students Toward Biobanking of Human Biological Material for Research Purposes
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The photodynamic effect of far-red range phthalocyanines (AlPc and Pc green) supported by electropermeabilization in human gastric adenocarcinoma cells of sensitive and resistant type
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Antiproliferative activity of side-chain truncated vitamin D analogs (PRI-1203 and PRI-1204) against human malignant melanoma cell lines
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Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation
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Can cornelian cherry mask bitter taste of probiotic chocolate? Human TAS2R receptors and a sensory study with comprehensive characterisation of new functional product
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Modern approach for determination of lactulose, mannitol and sucrose in human urine using HPLC-MS/MS for the studies of intestinal and upper digestive tract permeability
PublicationA new analytical procedure was described for the simultaneous determination of lactulose, mannitol and sucrose in urine, in which HILIC chromatography and tandem mass spectrometry detection are used. Sugars are orally administered for the estimation of intestinal permeability in children digestive tract. Samples were purified by dispersive solid phase extraction (d-SPE) using Amberlite MB150 resin. Raffinose was selected as an...
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Monitoring of occupational exposure to volatile organohalogen solvents (VOXs) in human urine samples of dry-cleaner workers by TLHS-DAI-GC-ECD procedure
PublicationChlorinated hydrocarbon solvents are often used for dry-cleaning clothes in the laundry industry. The object of this study was to monitor the occupational exposure of dry-clean employees coming into contact with VOXs. 25 workers collected their urine samples before the work shift, after 4 hours of work and after the work shift. The analyses of urine samples and solvents used in dry-cleaning were performed using TLHS-DAI-GC-ECD....
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Imidazoacridinone derivative C-1311 (SymadexTM) induces apoptosis, mitotic catastrophe or senescence in human colon carcinoma HCT116 cells depending on p53 status
PublicationPrzeprowadziliśmy badania zmierzające do wyjaśnienia odpowiedzi komórek ludzkiego raka jelita grubego HCT116 traktowanych C-1311 w zależności od statusu białka p53. Wykazaliśmy, że pochodna imidazoakrydonu C-1311 w stężeniach biologicznie istotnych indukuje przejściowy blok w fazie G2M komórek HCT116 p53-/- oraz blok w fazie G1 i G2M komórek HCT116 p53+/+. W komórkach z niefunkcjonalnym białkiem p53 imidazoakrydon indukował katastrofę...
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Bio and slide biobearings, their lubrication by non-newtonian fluids and application in non-conventional systems. Vol. 2, The theory of human joint unsteady lubrication.
PublicationW monografii przedstawiono zasady niestacjonarnego smarowania stawów człowieka o odkształcalnych chrząstkach i powierzchniach kostnych w polach indukcji magnetycznej. W opisie stochastycznym uwzględnione zostały nienewtonowskie, lepkosprężyste właściwości cieczy synowialnych jako czynnika smarującego. Monografia prezentuje rozkłady wartości ciśnienia i nośności stawów człowieka w warunkach niestacjonarnego smarowania dla drgań...
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Application of analytical procedure based on accelerated solvent extraction and ion chromatography technique for determination of thiocyanate and other inorganic ions in human placenta samples
PublicationExposure of a pregnant woman during pregnancy is a special case of exposure to toxic substances. Samples of placenta collected for the studies had been prepared with the technique of accelerated solvent extraction and later analyzed for the presence of thiocyanate ion and other inorganic ions, with the use of the technique of ion chromatography. The concentration of thiocyanate ion in placenta samples collected from active smokers...
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The concept of anti-collision system of autonomous surface vehicle
PublicationThe use of unmanned vehicles in various fields of science and the economy is becoming more common. An extremely important aspect of creating this type of solution is to provide autonomous vehicle navigation, which does not require interference of the human factor or in which it is limited to a minimum. This article discusses the concept of autonomous anti-collision system of unmanned surface vehicle. It proposed a sensor system...
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Protective effect of Aronia melanocarpa polyphenols against cadmium-induced disorders in bone metabolism: A study in a rat model of lifetime human exposure to this heavy metal
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Drug affinity to human serum albumin prediction by retention of cetyltrimethylammonium bromide pseudostationary phase in micellar electrokinetic chromatography and chemically advanced template search descriptors
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Antitumor potential of new low molecular weight antioxidative preparations from the white rot fungus Cerrena unicolor against human colon cancer cells
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Induction of Secreted Human Immunodeficiency Virus Type 1 (HIV-1) Resistance Factors in CD4-Positive T Lymphocytes by Attenuated HIV-1 Infection
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Destabilization of β‐Hemocyanin from Helix pomatia in Presence of Choline Amino Acids Results in Improved Cell Specificity and Cytotoxicity against Human Breast Cancer
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Effect of silver/copper and copper oxide nanoparticle powder on growth of Gram-negative and Gram-positive bacteria and their toxicity against the normal human dermal fibroblasts
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Expression of genes involved in neurogenesis, and neuronal precursor cell proliferation and development: Novel pathways of human ovarian granulosa cell differentiation and transdifferentiation capability in�vitro
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Genes responsible for proliferation, differentiation, and junction adhesion are significantly up-regulated in human ovarian granulosa cells during a long-term primary in vitro culture
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Środowiskowy dym tytoniowy - skład, oddziaływanie na organizm, problemy analityczne = Environmental tobacco smoke - chemical constituents, impact on human health, analytical problems
PublicationPalenie tytoniu jest przyczyną znacznego zanieczyszczenia powietrza wewnętrznego różnego typu pomieszczeń. Wiele związków chemicznych wydzielających się wraz z głównym i bocznym strumieniem dymu papierosowego wykazuje charakter rakotwórczy, a także wywołuje skutki toksyczne odległe w czasie. Różny stopień narażenia na szkodliwe składniki środowiskowego dymu tytoniowego obserwuje się zarówno u aktywnych, jak i biernych palaczy....