Filters
total: 2514
filtered: 1090
displaying 1000 best results Help
Search results for: TARGETED CANCER THERAPY
-
Myotilin, a New Topotecan Resistant Protein in Ovarian Cancer Cell Lines
Publication -
Potentiation of the anti-tumour effects of Photofrin®-based photodynamic therapy by localized treatment with G-CSF
Publication -
Maintenance therapy with everolimus for subependymal giant cell astrocytoma in patients with tuberous sclerosis (the EMINENTS study)
Publication -
An inherited NBN mutation is associated with poor prognosis prostate cancer
Publication -
The presence of prostate cancer at biopsy is predicted by a number of genetic variants
Publication -
(CA)n Microsatellite polymorphism of ERBB-1 in breast cancer
Publication -
Understanding the early-stage release of volatile organic compounds from rapeseed oil during deep-frying of tubers by targeted and omics-inspired approaches using PTR-MS and gas chromatography
PublicationDuring deep-frying, a plethora of volatile products is emitted with the fumes. These compounds could act as oil quality indicators and change the indoor air composition leading to health risks for occupants. The presented experiments focus on deep-frying of different tubers in rapeseed oil at different frying temperatures. Here, two scenarios for real-time monitoring of volatile organic compounds (VOCs) using proton transfer reaction...
-
Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition
PublicationHeterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based...
-
Caffeine Inhibits Differentiation Of Lung Cancer Stem Cells By Modulating Their Respiratory Metabolism
PublicationIt is ell established that many tumor types contain a fraction of cells, with stem cell-like properties, called cancer stem cells (CSCs), that are resistant to apoptosis induced by therapeutic agents. The presence of CSCs may explain why a standard anticancer treatment, that eliminates only differentiated cancer cells, does not lead to cancer cure.We previously showed the existence of caffeine-sensitive mechanism that controls...
-
Towards Cancer Patients Classification Using Liquid Biopsy
PublicationLiquid biopsy is a useful, minimally invasive diagnostic and monitoring tool for cancer disease. Yet, developing accurate methods, given the potentially large number of input features, and usually small datasets size remains very challenging. Recently, a novel feature parameterization based on the RNA-sequenced platelet data which uses the biological knowledge from the Kyoto Encyclopedia of Genes and Genomes, combined with a classifier...
-
Use of Materials Based on Polymeric Silica as Bone-Targeted Drug Delivery Systems for Metronidazole
Publication -
Tracking Clonal Evolution of Multiple Myeloma Using Targeted Next-Generation DNA Sequencing
Publication -
Antihypertensive therapy in the obese hypertensive patient
Publication -
Photodynamic therapy – mechanisms, photosensitizers and combinations
Publication -
Rare extragenital endometriosis: pathogenesis and therapy
Publication -
Hyperbaric Oxygen Therapy (HBOT) in Pediatrics
Publication -
Optical properties of the chemotherapy drugs used in the central nervous system lymphoma therapy: monitoring drug delivery
PublicationOur aim is to optically monitor the delivery of the chemotherapy drugs for brain tumours, particularly used in the central nervous system (CNS) lymphoma therapy. In vivo monitoring would help to optimize the treatment and avoiding unnecessary medications. Moreover, it would be beneficial to be able to measure which of the multi-regimen drugs actually do penetrate and how well into the brain tissue. There exist several potential...
-
Role of size scale of ZnO nanoparticles and microparticles on toxicity toward bacteria and osteoblast cancer cells
PublicationThe specific role of size scale, surface capping, and aspect ratio of zinc oxide (ZnO) particles on toxicity toward prokaryotic and eukaryotic cells was investigated. ZnO nano and microparticles of controlled size and mor- phology were synthesized by wet chemical methods. Cytotoxicity toward mammalian cells was studied using a human osteoblast cancer cell line and antibacterial activity using Gram-negative bacteria (Escherichia...
-
Gene copy numbers of HER family in breast cancer
Publication -
MC1R common variants, CDKN2A and their association with melanoma and breast cancer risk
Publication -
Severe oxidatively damaged DNA after cisplatin treatment of cancer patients
Publication -
A deletion in CHEK2 of 5,395 bp predisposes to breast cancer in Poland
Publication -
XPD Common Variants and their Association with Melanoma and Breast Cancer Risk
Publication -
Cancer Familial Aggregation (CFA) and G446A polymorphism in ARLTS1 gene
Publication -
Comparison of 2D and 3D culture models in the studies of the biological response induced by unsymmetrical bisacridines in cancer cells
PublicationMulticellular tumor spheroids are a good tool for testing new anticancer drugs, including those that may target cancer stem cells (CSCs), responsible for cancer progression, metastasis, and recurrence. Therefore, following the initial evaluation of the impact of antitumor unsymmetrical bisacridines (UAs) on lung and colon cancer cells using traditional monolayer cultures, I extended my investigations and applied the spherical model....
-
Novel chalcone-derived pyrazoles as potential therapeutic agents for the treatment of non-small cell lung cancer
PublicationLung cancer is considered to account for approximately one-fifth of all malignant tumor-related deaths worldwide and is therefore one of the most lethal malignancies. Pyrazole scaffold possesses a wide range of biological and pharmacological activities, which play important roles in medicinal chemistry. The present study reports the synthesis and in vitro biological characterization of nine pyrazoles derived from chalcones as potential...
-
Improving platelet‐RNA‐based diagnostics: a comparative analysis of machine learning models for cancer detection and multiclass classification
PublicationLiquid biopsy demonstrates excellent potential in patient management by providing a minimally invasive and cost-effective approach to detecting and monitoring cancer, even at its early stages. Due to the complexity of liquid biopsy data, machine-learning techniques are increasingly gaining attention in sample analysis, especially for multidimensional data such as RNA expression profiles. Yet, there is no agreement in the community...
-
Serum lipid profile discriminates patients with early lung cancer from healthy controls
Publication -
A targeted metabolomic protocol for quantitative analysis of volatile organic compounds in urine of children with celiac disease
Publication -
PLS-Based and Regularization-Based Methods for the Selection of Relevant Variables in Non-targeted Metabolomics Data
Publication -
Cytochromes P450 and Skin Cancer: Role of Local Endocrine Pathways
Publication -
Role of miR-15b/16–2 cluster network in endometrial cancer: An in silico pathway and prognostic analysis
PublicationEndometrial cancer (EC) is the second most common cancer in women. A large number of human cancers exhibit dysregulation of microRNA expression including EC. MiR-15b/16–2 is one of the best-known miRNA clusters that is expressed in many types of cancer tissues. Herein, we analyzed the expression of individual miR-15b/16–2 cluster members, its paralogues, and their target network analysis, as well as their prognostic significance...
-
Plasma free amino acid profiling as metabolomic diagnostic and prognostic biomarker in paediatric cancer patients: a follow‑up study
PublicationAmino acids (AAs) play a crucial role in cancer cell metabolism. Levels of 22 plasma AAs at the time of diagnosis and after treatment were established among 39 pediatric cancer patients and 33 healthy children. Glutamic acid levels decreased and tryptophan levels increased during treatment. Cancer patients presented significantly lower levels of glutamine and leucine post-treatment while levels of 12 other AAs were higher comparing...
-
CDKN2A common variant and multi-organ cancer risk—a population-based study
Publication -
Germline mutations in theCHEK2 kinase gene are associated with an increased risk of bladder cancer
Publication -
A personalised approach to prostate cancer screening based on genotyping of risk founder alleles
Publication -
314 Osteopontin as a Potential Serum Marker in Early Breast Cancer-Preliminary Results
Publication -
The use of the Warnke Method in dyslexia therapy for children
Publication -
Complications associated with oncological therapy - how to minimize?
Publication -
Novel Baroreflex Activation Therapy in Resistant Hypertension
Publication -
A Comprehensive Review of Phytonutrients as a Dietary Therapy for Obesity
PublicationObesity is a complex medical condition mainly caused by eating habits, genetics, lifestyle, and medicine. The present study deals with traditional diets like the Mediterranean diet, Nordic diet, African Heritage diet, Asian diet, and DASH, as these are considered to be sustainable diets for curing obesity. However, the bioavailability of phytonutrients consumed in the diet may vary, depending on several factors such as digestion...
-
The Role of FLT3 Kinase as an AML Therapy Target
Publication...
-
Computer based system for strabismus and amblyopia therapy
PublicationW publikacji opisano system komputerowy do badania i treningu zeza i amblyopii.W przypadku zeza i amblyopii lub tak zwanego syndromu leniwego oka terapia polega na zasłanianiu oka dominującego przez kilka godzin dziennie lub rozmywanie obrazu w tym oku poprzez zastasowanie kropli do oczu lub silnych soczewek w okularach. Taki sposób terapii powoduje zaburzenie widzenia obuocznego. Proponowane rozwiązanie zachowuje widzenie obuoczne....
-
RAGE as a Novel Biomarker for Prostate Cancer: A Systematic Review and Meta-Analysis
PublicationThe receptor for advanced glycation end-products (RAGE) has been implicated in driving prostate cancer (PCa) growth, aggression, and metastasis through the fueling of chronic inflammation in the tumor microenvironment. This systematic review and meta-analysis summarizes and analyzes the current clinical and preclinical data to provide insight into the relationships among RAGE levels and PCa, cancer grade, and molecular effects....
-
The rs1447295 and DG8S737 markers on chromosome 8q24 and cancer risk in the Polish population
Publication -
Interpretable deep learning approach for classification of breast cancer - a comparative analysis of multiple instance learning models
PublicationBreast cancer is the most frequent female cancer. Its early diagnosis increases the chances of a complete cure for the patient. Suitably designed deep learning algorithms can be an excellent tool for quick screening analysis and support radiologists and oncologists in diagnosing breast cancer.The design of a deep learning-based system for automated breast cancer diagnosis is not easy due to the lack of annotated data, especially...
-
Metabolomics in urogenital cancer
Publication -
Increased Expression of Several Collagen Genes is Associated with Drug Resistance in Ovarian Cancer Cell Lines
Publication -
Molecular mechanism(s) of regulation(s) of c-MET/HGF signaling in head and neck cancer
Publication -
Effect of the Combined Therapy of the Muscle Energy Technique and Trigger Point Therapy on the Biophysical Parameters of the Trapezius Muscle: a Randomized Clinical Trial
Publication