Search results for: LINES
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Induction of G2/M phase arrest and apoptosis of human pancreatic cancer BxPC-3 cells by potenet antitumor 1-nitroacridine derivative C-1748
PublicationPancreatic ductal adenocarcinoma (PDA) is among the most lethal human cancers, in part because it is insensitive to many chemotherapeutic drugs. Gemcitabine still remains the best chemotherapeutic agent available for the treatment of advanced pancreatic cancer. However, gemcitabine treatment results in only a marginal survival advantage. Thus, there is a strong need for the continuous development of novel therapeutic agents...
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THE VIBRATION BASED DIAGNOSTICS OF SHIP PROPULSION SYSTEMS
PublicationThe article has been worked out on the basis of the report devoted to the conducted diagnostic investigations of the ship main propulsion unit’s mechanical system. Gdansk University of Technology has been ordered with such investigations by the repair Shipyard carrying out the ship’s overhaul. Diagnostic tests involved measurements and analyses of the vibration signals generated in selected constructional kinematic pairs of the...
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Safety issues referred to induced sheath voltages in high-voltage power cables – case study
PublicationLoad currents and short-circuit currents in high-voltage power cable lines are sources of the induced voltages in the power cables’ concentric metallic sheaths. When power cables operate with single-point bonding, which is the simplest bonding arrangement, these induced voltages may introduce an electric shock hazard or may lead to damage of the cables’ outer non-metallic sheaths at the unearthed end of the power cable line. To...
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Similarities and differences in d6 low-spin ruthenium, rhodium and iridium half-sandwich complexes: synthesis, structure, cytotoxicity and interaction with biological targets
PublicationIn this paper, we discussed the similarities and diferences in d6 low-spin half-sandwich ruthenium, rhodium and iridium complexes containing 2,2′-biimidazole (H2biim). Three new complexes, {[RuCl(H2biim)(η6 -p-cymene)]PF6}2·H2O (1), [(η5 - Cp)RhCl(H2biim)]PF6 (2), and [(η5 -Cp)IrCl(H2biim)]PF6 (3), were fully characterized by CHN, X-ray difraction analysis, UV–Vis, FTIR, and 1 H, 13C and 15N NMR spectroscopies. The complexes exhibit...
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Novel therapeutic compound acridine–retrotuftsin action on biological forms of melanoma and neuroblastoma
PublicationPURPOSE: As a continuation of our search for anticancer agents, we have synthesized a new acridine-retrotuftsin analog HClx9-[Arg(NO2)-Pro-Lys-Thr-OCH3]-1-nitroacridine (named ART) and have evaluated its activity against melanoma and neuroblastoma lines. Both tumors develop from cells (melanocytes, neurons) of neuroectodermal origin, and both are tumors with high heterogeneity and unsatisfactory susceptibility to chemotherapies....
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METODA WIELOKRYTERIALNEJ OCENY PRZEBUDOWY UKŁADÓW TOROWYCH NA SZLAKACH
PublicationRozprawa doktorska dotyczy zagadnienia projektowania układów geometrycznych toru kolejowego w procesie modernizacji linii kolejowych. Scharakteryzowano główne cechy dotyczące tej tematyki w oparciu o literaturę polską i zagraniczną, w tym przepisy branżowe. Przedstawiono czynniki wpływające na projektowanie modernizacji linii kolejowych. Określono wartości dopuszczalne parametrów kinematycznych i geometrycznych. Specyfika omawianego...
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The short-term flicker severity level measured in the industrial power system supplying the rolling mill motors
Open Research DataThe dataset presents a short-term flicker severity level measured on the bus bars of the main switchgear of the industrial power network for the supply of rolling mills. The data were obtained during an experiment whose purpose was to determine a level of short-term and long-term flicker caused by voltage fluctuations. In the virtual application of...
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Koncepcja zdalnego sterowania i monitoringu urządzeń trakcyjnych z wykorzystaniem technologii teleinformatycznych
PublicationAdvancement in wireless communication enables engineers to apply sophisticated and relatively inexpensive technologies in new fields of industry, which were previously designated solely to wire-based solutions. One of those fields is railway transportation system. In effect of a high reliability and safety demands, this area was resistive to new technologies. Nowadays, increased security and reliability of wireless sensor networks...
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Nowa metoda diagnostyki stanu technicznego nakładek stykowych
PublicationThe current collection system, which consists of the overhead contact line and a current collector, is particularly important in electric rail vehicles, where their reliability is concerned. Faultless current collection is conditioned not only by suitable construction of these elements but also by their proper maintenance. Retaining permanent electrical contact is essential in DC systems, where current demand is relatively high. In...
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An Overview of Bidirectional EV Chargers: Empowering Traction Grid-Powered Chargers
PublicationIn recent years, the number of electric vehicles has been at least doubling year after year. As a result, today electric vehicles already account for approximately 10% of the global automotive market, which positively affects environment in urbanized areas. However, to take full advantage of the EV integration it is necessary to use renewable sources for their charging; optimally place charging stations/terminals; optimally manage...
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Green porous benzamide-like nanomembranes for hazardous cations detection, separation, and concentration adjustment
PublicationGreen biomaterials play a crucial role in the diagnosis and treatment of diseases as well as health-related problem-solving. Typically, biocompatibility, biodegradability, and mechanical strength are requirements centered on biomaterial engineering. However, in-hospital therapeutics require an elaborated synthesis of hybrid and complex nanomaterials capable of mimicking cellular behavior. Accumulation of hazardous cations like...
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Electrochemical simulation of enzymatic transformations studied for the selected antitumor acridine derivatives
PublicationThe elucidation of the metabolic pathways and the biotransformation mechanisms of potential drugs is a crucial point in drug development. It allows to know the activation routes of the new biologically active compounds, especially in respect to their possible toxicity. Generally, in vivo or in vitro experiments with liver microsomes or hepatocytes are performed. However, these testing schemes are tedious, time consuming and of...
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Electrochemistry meets enzymes: Investigation of the biotransformation pathway of C-1311 based on electrochemical simulation in comparison to in vitro methods.
PublicationThe knowledge of the metabolic pathways and the biotransformation of new drugs is one of the major challenges in pharmaceutical research. It is crucial for elucidation of degradation routes of the new biologically active compounds, especially in the area of possible toxicity. Conventional in vitro drug metabolism studies are based on incubating drug candidate with e.g. hepatocytes or, most importantly, liver cell microsomes and...
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Development of biocompatible iron oxide-silicon oxide core-shell nanoparticles as subcellular delivery platform for glucosamine-6-phosphate synthase inhibitors
PublicationIn order to develop the preparation of iron oxide-silica coreshell nanoparticles (CSNPs), thesis deeply explores the cetyltrimethylammonium (CTA+) directed silica coating methods of the oleic-acid capped iron oxide nanoparticles (OA-IONPs) initialized under near-neutral pH conditions. It is demonstrated that the initial alkaline hydrolysis of ethyl acetate in the presence of CTA+ and OA-IONPs induces an unusual ligand exchange...
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Przegląd miar oceny oprogramowania
PublicationProblem oceny oprogramowania istnieje od momentu pojawienia się pierwszego programu komputerowego. Historycznie miary jakości oprogramowania miały zupełnie inne przeznaczenie, gdyż skupiały się na częstotliwości defektów lub błędów oprogramowania. Błędnie bazowało to na założeniu, że jakość oprogramowania to brak błędów. Stąd też używano prostej statystyki typu liczby błędów, wykrytych w określonym przedziale czasu (np. rocznym)...
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Wpływ przechyłki na zjawisko postępowania zużycia bocznego szyn kolejowych w łukach poziomych
PublicationDegradacja elementów nawierzchni kolejowej jest zagadnieniem bardzo złożonym, w które uwikłane jest wiele czynników związanych między innymi z układem geometrycznym toru kolejowego, właściwościami trybologicznymi poszczególnych elementów nawierzchni, jak również z parametrami podłoża gruntowego, a także z właściwościami samych pojazdów szynowych. W artykule omówiono jeden z powyższych problemów, tj. wpływ ukształtowania toru kolejowego...
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Antitumor 1-nitroacridine derivative C-1748 induces significant apoptosis in pancreatic cancer cells.
PublicationPancreatic cancer is the fifth leading cause of cancer death and has the lowest survival rate of any solid cancer in the industrial countries. The poor prognosis of pancreatic cancer results from its tendency for late presentation, aggressive invasion, early metastasis, and resistance to chemotherapy. Gemcitabine still remains the best chemotherapeutic agent available for the treatment of advanced pancreatic cancer. However, gemcitabine...
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Architektura i woda - przekraczanie granic
PublicationPublikacja daje wgląd w procesy kształtowania połączeń wody i form zbudowanych. W obserwowanych współcześnie eksperymentach struktury budynków przeplatają się z zarysami pól wodnych, powstają konstrukcje architektoniczne unoszące się na różnego rodzaju platformach pływających. Woda jest także coraz częściej włączana w projekty urbanistyczne. Linie styku pomiędzy lądem i wodą ulegają modyfikacjom, przywraca się dawne kanały i tworzy...
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Development of Biocompatible Fe3O4@SiO2 Nanoparticles as Subcellular Delivery Platform for Glucosamine-6-phosphate Synthase Inhibitors
PublicationNumerous inhibitors of glucoseamine-6-phophate synthase (GlcN-6-P), the enzyme responsible from catalysis of the first step of metabolic pathway leading to metabolism 5’-diphospho-N-acetyl-D- glucosamine, were reported as effective agents for inhibiting the growth of various fungal pathogens. Among the reported inhibitors,...
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Computer controlled systems - 2022/2023
e-Learning Coursesmateriały wspierające wykład na studiach II stopnia na kierunku ACR pod tytułem komputerowe systemy automatyki 1. Computer system – controlled plant interfacing technique; simple interfacing and with both side acknowledgement; ideas, algorithms, acknowledge passing. 2. Methods of acknowledgement passing: software checking and passing, using interrupt techniques, using readiness checking (ready – wait lines). The best solution...
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CCS-lecture-2023-2024
e-Learning Coursesmateriały wspierające wykład na studiach II stopnia na kierunku ACR pod tytułem komputerowe systemy automatyki 1. Computer system – controlled plant interfacing technique; simple interfacing and with both side acknowledgement; ideas, algorithms, acknowledge passing. 2. Methods of acknowledgement passing: software checking and passing, using interrupt techniques, using readiness checking (ready – wait lines). The best solution optimization...
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Architektura a dekonstrukcja. Przypadek Petera Eisenmana i Bernarda Tschumiego
PublicationArchitecture and Deconstruction Case of Peter Eisenman and Bernard Tschumi Introduction Towards deconstruction in architecture Intensive relations between philosophical deconstruction and architecture, which were present in the late 1980s and early 1990s, belong to the past and therefore may be described from a greater than...