Search results for: 3-amino-1-propanol

• Application of COSMO-RS-DARE as a Tool for Testing Consistency of Solubility Data: Case of Coumarin in Neat Alcohols

  Publication

  • P. Cysewski
  • T. Jeliński
  • M. Przybyłek

  - MOLECULES - Year 2022

  Coumarin is a naturally occurring lactone-type benzopyrone with various applications in the pharmaceutical, food, perfume, and cosmetics industries. This hydrophobic compound is poorly soluble in water but dissolves well in protic organic solvents such as alcohols. Despite the extensive use of coumarin, there are only a few reports documenting its solubility in organic solvents, and some reported data are incongruent, which...

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• Optimization of Chemical Functionalities of Indole-2-carboxamides To Improve Allosteric Parameters for the Cannabinoid Receptor 1 (CB1)

  Publication

  • L. Khurana
  • H. I. Ali
  • T. Olszewska
  • K. H. Ahn
  • A. Damaraju
  • D. A. Kendall
  • D. Lu

  - JOURNAL OF MEDICINAL CHEMISTRY - Year 2014

  5-Chloro-3-ethyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-carboxamide (1; ORG27569) is a prototypical allosteric modulator for the cannabinoid type 1 receptor (CB1). Here, we reveal key structural requirements of indole-2-carboxamides for allosteric modulation of CB1: a critical chain length at the C3-position, an electron withdrawing group at the C5-position, the length of the linker between the amide bond and the phenyl ring...

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• Studies on Aminoanthraquinone-Modified Glassy Carbon Electrode: Synthesis and Electrochemical Performance toward Oxygen Reduction

  Publication

  • Ł. Macewicz
  • G. Skowierzak
  • P. Niedziałkowski
  • J. Ryl
  • T. Ossowski
  • R. Bogdanowicz

  - RUSSIAN JOURNAL OF ELECTROCHEMISTRY - Year 2021

  In this paper, 9,10-anthraquinone (AQ) derivative-modified glassy carbon (GC) electrodes were studied towards the electrochemical reduction of oxygen in aqueous and non-aqueous solutions. The reaction of 1-chloro-9,10-anthraquinone with aliphatic diamines was applied for the synthesis of amino-9,10-anthraquinone derivatives. The obtained AQ derivatives were grafted onto the surface of glassy carbon electrodes by electropolymerisation...

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• Fluorescent analogs of trypsin inhibitor SFTI-1 isolated from sunflower seeds-synthesis and applications

  Publication

  • A. Lesner
  • N. Karna
  • M. Psurski
  • A. Łęgowska
  • M. Wysocka
  • K. Guzow
  • A. Sieradzan
  • M. Sieńczyk
  • P. Trzonkowski
  • P. Marek... and 7 others

  - BIOPOLYMERS - Year 2014

  This article describes the synthesis and enzymatic study of newly synthesized analogs of trypsin inhibitors SFTI-1 that were fluorescent labeled on their N-terminal amino groups. Two fluorescent derivatives of benzoxazole (3-[2-(4-diphenylaminophenyl) benzoxazol-5-yl]-L-alanine[(4NPh(2)) Ph] Box-Ala and 3-[2-(2', 4', 5'-trimethoxyphenyl) benzoxazol-5-yl]-l-alanine-[2,4,5-(OMe)3Ph] Box-Ala) were used as efficient fluorescent labels....

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• Studies on Aminoanthraquinone-Modified Glassy Carbon Electrode: Synthesis and Electrochemical Performance toward Oxygen Reduction

  Publication

  • Ł. Macewicz
  • G. Skowierzak
  • P. Niedziałkowski
  • J. Ryl
  • T. Ossowski
  • R. Bogdanowicz

  - RUSSIAN JOURNAL OF ELECTROCHEMISTRY - Year 2021

  In this paper, 9,10-anthraquinone (AQ) derivative-modified glassy carbon (GC) electrodes werestudied towards the electrochemical reduction of oxygen in aqueous and non-aqueous solutions. The reaction of 1-chloro-9,10-anthraquinone with aliphatic diamines was applied for the synthesis of amino-9,10-anthraquinone derivatives. The obtained AQ derivatives were grafted onto the surface of glassy carbon electrodes by electropolymerisation...

• Witold Zbirohowski-Kościa, WZiE, 3 i 4 semestralne studia niest. II st. 1 sem 22/23z

  e-Learning Courses

  • W. Zbirohowski-Kościa
  • U. Kamińska
  • I. Mokwa-Tarnowska
  • J. Wielgus
  • E. Wawoczna

• Język obcy Business English, WZiE, zarządzanie (studia w jęz. angielskim), 1 st, 3 sem, 20/21

  e-Learning Courses

  • I. Mokwa-Tarnowska
  • E. Rogala

• Total Ionization Cross Sections of Selected Amino Acids

  Open Research Data

  open access

  • P. Możejko

  The data set contains tabulated values ​​of cross-sections for a single electron-impact ionization of selected amino acids (glycine, alanine, phenylalanine, proline and tryptophan) calculated using binary-encouter-Bethe method. The data have been published in graphical form (figure 1) in the following paperA.M. Sheer, P. Mozejko, G.A. Gallup, P.D. Burrow...

• Zbigniew Łubniewski dr hab. inż.

  People

  Department of Geoinformatics

• Język obcy angielski, WZiE, zarządzanie (3 i 4 semestralne), II st, 1 (lub 2) sem, 22/23L

  e-Learning Courses

  • E. Rogala

• W. Zbirohowski-Kościa WZiE, 3 i 4 semestralne studia niest. II st., 1 sem, online, 23/24z

  e-Learning Courses

  • W. Zbirohowski-Kościa
  • U. Kamińska
  • I. Mokwa-Tarnowska
  • J. Wielgus
  • E. Wawoczna

• Synthesis of 3-Carbamoyl b-Lactams via Manganese(III)-Promoted Cyclization of N-Alkenylmalonamides

  Publication

  • P. Punda
  • Ł. Ponikiewski
  • S. Makowiec

  - HELVETICA CHIMICA ACTA - Year 2013

  Manganese(III)-promoted cyclization of N-alkenylmalonamides (¼N-alkenylpropanediamides) gave 3-(aryl/(alkylamino)carbonyl) b-lactams as well as 3-(aryl/(alkylamino)thiocarbonyl) b-lactams. The relative configuration of the obtained products was unambiguously determined by X-ray crystallography. The proposed method is very useful for the one-pot synthesis of a number of 3-(aryl/ (alkylamino)carbonyl) b-lactams, especially those...

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• Invasive breast carcinoma of no special type - Female, 68 - Tissue image [7100730013393011]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: VS200 Olympus slide scanner (20x magnification) and saved to DICOM format.

• Invasive breast carcinoma of no special type - Female, 68 - Tissue image [710073001339961]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: VS200 Olympus slide scanner (20x magnification) and saved to DICOM format.

• Invasive breast carcinoma of no special type - Female, 68 - Tissue image [7100730013391341]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: VS200 Olympus slide scanner (20x magnification) and saved to DICOM format.

• Invasive breast carcinoma of no special type - Female, 68 - Tissue image [7100730013393191]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: VS200 Olympus slide scanner (20x magnification) and saved to DICOM format.

• Invasive breast carcinoma of no special type - Female, 68 - Tissue image [7100730013391331]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: VS200 Olympus slide scanner (20x magnification) and saved to DICOM format.

• Invasive breast carcinoma of no special type - Female, 68 - Tissue image [7100730013397491]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: VS200 Olympus slide scanner (20x magnification) and saved to DICOM format.

• Pomiar ryzyka bankowego - propozycja typologii

  Publication

  • B. Kochański

  - Finanse, Rynki Finansowe, Ubezpieczenia - Year 2013

  W artykule zaproponowano typologię pomiaru ryzyk bankowych. Wyodrębnione kryteria podziału podejść do pomiaru ryzyka to: (1) pomiar bezpośredni/pośredni, (2) pomiar ex post/ex ante, (3) kryterium oparte o składnik ryzyka – częstotliwość, dotkliwość, ekspozycja, całościowa strata, (4) kryterium oparte o parametr rozkładu: pomiar wartości oczekiwanej/przeciętnej, pomiar rozproszenia, pomiar wartości skrajnych. Wśród motywów pomiaru...

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• Synthesis of 7-oxo-7h-naphto[1,2,3-de]quinoline derivatives as potential anticancer agents active on multidrug resistant cell lines

  Publication

  • M. Dzieduszycka
  • M. Bontemps-Gracz
  • B. Stefańska
  • S. Martelli
  • A. Piwkowska
  • M. Arciemiuk
  • E. Borowski

  - BIOORGANIC & MEDICINAL CHEMISTRY - Year 2006

  Opierając się na naszym wcześniejszym stwierdzeniu, że tetracykliczne analogi antrachinonów z wbudowanym pierścieniem pirydynowym wykazują aktywną cytotoksyczność względem komórek z indukowaną opornością, przeprowadzono syntezę pochodnych 7-oxo-7h-nafto[1,2,3-de]chinoliny (3, 6-8, 10-12, 14,15 i 18) posiadających jeden lub dwa zasadowe łańcuchy boczne i różne podstawniki w pierścieniu pirydynowym, związków o potencjalnym działaniu...

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• Anna Brillowska-Dąbrowska dr hab. inż.

  People

  Department of Biotechnology and Microbiology

  Anna Brillowska-Dąbrowska, born in 1971 in Gdańsk, Poland, graduated in 1996 in Biotechnology from the Faculty of Chemistry, Gdańsk University of Technology (GUT). In 2001 she got her PhD, in 2013 became a DSc (habilitation). She was employed in 2004 as a researcher in Statens Serum Institut in Denmark. Currently she is an Associate Professor (adiunkt) in the Department of Molecular Biotechnology and Microbiology and Vice-dean...

• The overexpression of CPR and P450 3A4 in pancreatic cancer cells changes the metabolic profile and increases the cytotoxicity and pro-apoptotic activity of acridine antitumor agent, C-1748

  Publication

  • B. Borowa-Mazgaj
  • A. Mróz
  • E. Augustin
  • E. Paluszkiewicz
  • Z. Mazerska

  - BIOCHEMICAL PHARMACOLOGY - Year 2017

  Drug resistance is one of the major cause of pancreatic cancer treatment failure. Thus, it is still imperative to develop new active compounds and novel approach to improve drug efficacy. Here we present 9-amino-1-nitroacridine antitumor agent, C-1748, developed in our laboratory, as a candidate for pancreatic cancer treatment. We examined (i) the cellular response of pancreatic cancer cell lines: Panc-1, MiaPaCa-2, BxPC-3 and...

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• General, Mild, and Metal-Free Functionalization of Indole and Its Derivatives Through Direct C3-Selenylation

  Publication

  • A. Hałuszczuk
  • N. Babul
  • Ł. Nierzwicki
  • W. Przychodzeń

  - EUROPEAN JOURNAL OF ORGANIC CHEMISTRY - Year 2019

  A very mild method for the introduction of functionalized alkylselenyl group at C-3 position of the indole ring was developed. The proposed procedure consists of an electrophilic substitution of indole and its derivatives with bis(O,O-diisopropoxyphosphorothioyl) diselenide and subsequent cleavage of the P–Se bond with tetrabutylammonium fluoride in the presence of various electrophilic reagents. This method can be successfully...

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• Lobular carcinoma, NOS - Female, 85 - Tissue image [6260730021899961]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Lobular carcinoma, NOS - Female, 85 - Tissue image [6260730021896621]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Determination of bromhexine and its metabolites in equine serum samples by liquid chromatography – Tandem mass spectrometry: Applicability to the elimination study after single oral dose

  Publication

  • E. Waraksa
  • K. Owczarek
  • P. Kubica
  • E. Kłodzińska
  • M. Ozimek
  • R. Wrzesień
  • B. Bobrowska-Korczak
  • J. Namieśnik

  - JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES - Year 2020

  Bromhexine (BH), expectorant used in the treatment of respiratory disorders associated with viscid or excessive mucus, is not permitted for use in the competing horse by many authorities in horseracing and Olympic disciplines. Metabolic studies are of the great importance in anti-doping field because they allow for updating the selection of the most appropriate markers for prohibited substances, such as metabolites present at higher...

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• Tomasz Zubowicz dr inż.

  People

  Department of Intelligent and Decision Support Systems

  Tomasz Zubowicz has received his M.Sc. Eng. degree in Control Engineering from the Faculty of Electrical and Control Engineering at the Gda{\'n}sk University of Technology (GUT) in $2008$. He received his Ph.D. Eng. (Hons.) in the field of Control Engineering from the same faculty in $2019$. In $2012$ he became a permanent staff member at the Department of Intelligent Control and Decision Support Systems at GUT and a member of...

• Język obcy angielski, WZiE, Zarządzanie (3 i 4 semestralne), II st, 1 (lub 2) sem, stacjonarne 23/24L

  e-Learning Courses

  • E. Rogala

• Invasive breast carcinoma of no special type - Female, 37 - Tissue image [6250730010627281]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Invasive breast carcinoma of no special type - Female, 37 - Tissue image [625073001062501]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Invasive breast carcinoma of no special type - Female, 37 - Tissue image [6250730010624871]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Invasive breast carcinoma of no special type - Female, 37 - Tissue image [6250730010628471]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Invasive breast carcinoma of no special type - Female, 37 - Tissue image [625073001062401]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Invasive breast carcinoma of no special type - Female, 37 - Tissue image [6250730010621281]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Invasive breast carcinoma of no special type - Female, 37 - Tissue image [6250730010621111]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Invasive breast carcinoma of no special type - Female, 37 - Tissue image [6250730010622881]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Invasive breast carcinoma of no special type - Female, 37 - Tissue image [6250730010624591]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Invasive breast carcinoma of no special type - Female, 37 - Tissue image [6250730010629801]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Invasive breast carcinoma of no special type - Female, 37 - Tissue image [6250730010625531]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Lobular carcinoma, NOS - Female, 85 - Tissue image [6260730021895521]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Invasive breast carcinoma of no special type - Female, 62 - Tissue image [6180730013798121]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Adenocarcinoma, NOS - Male, 68 - Tissue image [5160730021342231]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of PROSTATE GLAND tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• Adenocarcinoma, NOS - Male, 68 - Tissue image [5160730021343061]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of PROSTATE GLAND tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• IDENTIFICATION OF ODOR OF VOLATILE ORGANIC COMPOUNDS USING CLASSICAL SENSORY ANALYSIS AND ELECTRONIC NOSE TECHNIQUE

  Publication

  • J. Gębicki
  • T. Dymerski
  • S. Rutkowski

  - Environment Protection Engineering - Year 2014

  The paper compares two methods of analysis of odour of volatile organic compounds: classical sensory analysis and electronic nose technique. Eight volunteers participated in the classical sensory analysis investigations, which lasted two weeks. An instrumental odour analysis involved a prototype of 6-sensor electronic nose designed by the authors. The research performed with this device provided higher reproducibility and reliability...

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• One-Step Synthesis of b-Lactams with Retro-Amide Side Chain

  Publication

  • K. Janikowska
  • N. Pawelska
  • S. Makowiec

  - SYNTHESIS-STUTTGART - Year 2011

  Abstract: A one pot synthesis for preparation of 1,4-disubstituted-2-oxo-azetidine-3-carboxylic acid amides was developed. 5-(α-N-substituted-amino-α'-hydroxy)methylene Meldrum's acids act as a source of ketenes that react with aldimines in boiling toluene to give b-lactams with retro-amid side chain.

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• Strategie rozwoju byłych miast wojewódzkich w Polsce Wschodniej

  Publication

  • J. Sołtys

  - Studia Komitetu Przestrzennego Zagospodarowania Kraju PAN - Year 2018

  Przedmiotem opracowania są strategie rozwoju 9 miast należących do najsilniejszych ośrodków poza obecnymi miastami wojewódzkimi w najsłabiej rozwiniętych polskich regionach. Miasta te mogą dawać szansę aktywizacji swojego otoczenia. Przyczynić się do tego mogą dobre strategie zwiększające konkurencyjność miast i pobudzające rozwój. Celem badań było uzyskanie odpowiedzi na pytania, czy i w jakim stopniu badane strategie: (1) zgodne...

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• Acinar adenocarcinoma of prostate - Male, 72 - Tissue image [1160630015012061]

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  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of PROSTATE GLAND tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Acinar adenocarcinoma of prostate - Male, 72 - Tissue image [1160630015018631]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of PROSTATE GLAND tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Metaplastic carcinoma, NOS - Female, 77 - Tissue image [3140630024317041]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Metaplastic carcinoma, NOS - Female, 77 - Tissue image [3140630024317811]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.