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Search results for: bone regeneration
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Antibacterial Activity and Cytocompatibility of Bone Cement Enriched with Antibiotic, Nanosilver, and Nanocopper for Bone Regeneration
PublicationBacterial infections due to bone replacement surgeries require modifications of bone cement with antibacterial components. This study aimed to investigate whether the incorporation of gentamicin or nanometals into bone cement may reduce and to what extent bacterial growth without the loss of overall cytocompatibility and adverse effects in vitro. The bone cement Cemex was used as the base material, modified either with gentamicin...
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In vivo and in vitro study of a novel nanohydroxyapatite sonocoated scaffolds for enhanced bone regeneration
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Polyphenol-Enriched Composite Bone Regeneration Materials: A Systematic Review of In Vitro Studies
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Green engineered biomaterials for bone repair and regeneration: Printing technologies and fracture analysis
PublicationDespite the exceptional self-regeneration properties of bone, severe injuries often require additional surgical intervention such as using artificial bone constructs. These structures need to meet a number of criteria regarding their structure, performance, alongside the rate and the mechanism of erosion and fracture when implanted, for stimulating the regeneration of defected bone and, more critically providing support in the...
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Formulation and In Vitro Characterization of Bioactive Mesoporous Silica with Doxorubicin and Metronidazole Intended for Bone Treatment and Regeneration
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Silk Fibroin/Collagen/Chitosan Scaffolds Cross-Linked by a Glyoxal Solution as Biomaterials toward Bone Tissue Regeneration
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Cu-HKUST-1 and Hydroxyapatite–The Interface of Two Worlds toward the Design of Functional Materials Dedicated to Bone Tissue Regeneration
PublicationA novel composite based on biocompatible hydroxyapatite (HA) nanoparticles and Cu-HKUST-1 (Cu-HKUST-1@HA) has been prepared following a layer-by-layer strategy. Cu-HKUST-1 was carefully selected from a group of four Cu-based metal−organic frameworks as the material with the most promising antimicrobial activity. The formation of a colloidal Cu- HKUST-1 layer on HA nanoparticles was confirmed by various techniques, e.g., infrared...
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Biomaterials with Potential Use in Bone Tissue Regeneration—Collagen/Chitosan/Silk Fibroin Scaffolds Cross-Linked by EDC/NHS
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Comparative review of piezoelectric biomaterials approach for bone tissue engineering
PublicationBone as a minerals’ reservoir and rigid tissue of the body generating red and white blood cells supports various organs. Although the self-regeneration property of bone, it cannot regenerate spontaneously in severe damages and still remains as a challenging issue. Tissue engineering offers several techniques for regenerating damaged bones, where various biomaterials are examined to fabricate scaffolds for bone repair. Piezoelectric...
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Biomechanical properties of 3D-printed bone models
PublicationBone lesions resulting from large traumas or cancer resections can be successfully treated by directly using synthetic materials or in combination with tissue engineering methods (hybrid). Synthetic or hybrid materials combined with bone tissue’s natural ability for regeneration and biological adaptation to the directions of loading, allow for full recovery of its biological functions. Increasing interest in new production methods...
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Development of polyurethanes for bone repair
PublicationThe purpose of this paper is to review recent developments on polyurethanes aimed at the design, synthesis, modifications, and biological properties in the field of bone tissue engineering. Different polyurethane systems are presented and discussed in terms of biodegradation, biocompatibility and bioactivity. A comprehensive discussion is provided of the influence of hard to soft segments ratio, catalysts, stiffness and hydrophilicity...
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Marcin Wekwejt dr inż.
PeopleMarcin Wekwejt, absolwent studiów inżynierskich w inż. biomedycznej (2016; Politechnika Bydgoska im. J. i J. Śniadeckich & Collegium Medicum im. L. Rydygiera), studiów magisterskich w inż. mechaniczno-medycznej (2018; Politechnika Gdańska & Gdański Uniwersytet Medyczny) oraz studiów doktoranckich w dyscyplinie inż. materiałowej (2021, Politechnika Gdańska). Uzyskał z wyróżnieniem stopień naukowy doktora nauk inżynieryjno-technicznych...
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Degradable poly(ester-ether) urethanes of improved surface calcium deposition developed as novel biomaterials
PublicationBones, which are considered as hard tissues, work as scaffold for human body. They provide physical support for muscles and protect intestinal organs. Percentage of hard tissues in human body depends on age, weight, and gender. Human skeleton consists of 206 connected bones. Therefore, it is natural that the hard-tissue damage such as fractures, osteoporosis, and congenital lack of bone may appear. The innovative way of bone healing...
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Polyurethane Composite Scaffolds Modified with the Mixture of Gelatin and Hydroxyapatite Characterized by Improved Calcium Deposition
PublicationThe skeleton is a crucial element of the motion system in the human body, whose main function is to support and protect the soft tissues. Furthermore, the elements of the skeleton act as a storage place for minerals and participate in the production of red blood cells. The bone tissue includes the craniomaxillofacial bones, ribs, and spine. There are abundant reports in the literature indicating that the amount of treatments related...
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The Influence of Calcium Glycerophosphate (GPCa) Modifier on Physicochemical, Mechanical, and Biological Performance of Polyurethanes Applicable as Biomaterials for Bone Tissue Scaffolds Fabrication
PublicationIn this paper we describe the synthesis of poly(ester ether urethane)s (PEEURs) by using selected raw materials to reach a biocompatible polyurethane (PU) for biomedical applications. PEEURs were synthesized by using aliphatic 1,6-hexamethylene diisocyanate (HDI), poly(ethylene glycol) (PEG), α,ω-dihydroxy(ethylene-butylene adipate) (Polios), 1,4-butanediol (BDO) as a chain extender and calcium glycerolphosphate salt (GPCa) as...
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Myelodysplastic syndrome, NOS - Male, 65 - Tissue image [11290630017292921]
Open Research DataThis is the histopathological image of HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Titania Nanofiber Scaffolds with Enhanced Biointegration Activity—Preliminary In Vitro Studies
PublicationThe increasing need for novel bone replacement materials has been driving numerous studies on modifying their surface to stimulate osteogenic cells expansion and to accelerate bone tissue regeneration. The goal of the presented study was to optimize the production of titania-based bioactive materials with high porosity and defined nanostructure, which supports the cell viability and growth. We have chosen to our experiments TiO2...
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Polyurethanes Crosslinked with Poly(vinyl alcohol) as a Slowly-Degradable and Hydrophilic Materials of Potential Use in Regenerative Medicine
PublicationNovel, slowly-degradable and hydrophilic materials with proper mechanical properties and surface characteristics are in great demand within the biomedical field. In this paper, the design, synthesis, and characterization of polyurethanes (PUR) crosslinked with poly(vinyl alcohol) (PVA) as a new proposition for regenerative medicine is described. PVA-crosslinked PURs were synthesized by a two-step polymerization performed in a solvent...
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Biopolymer-based composites for tissue engineering applications: A basis for future opportunities
PublicationBiomimetic scaffolds supporting tissue regeneration are complex materials with multifunctional characteristics. The unique biocompatibility and biodegradability of biopolymers make them excellent candidates for tissue engineering and regenerative medicine. Biopolymers, which have a wide range of properties, can be obtained from different natural sources. Depending on the target tissue, biopolymers can be engineered to meet a series...
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Myelodysplastic syndrome, NOS - Male, 65 - Tissue image [11290630017295671]
Open Research DataThis is the histopathological image of HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Myelodysplastic syndrome, NOS - Male, 65 - Tissue image [11290630017293721]
Open Research DataThis is the histopathological image of HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Myelodysplastic syndrome, NOS - Male, 65 - Tissue image [11290630017298631]
Open Research DataThis is the histopathological image of HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Genome-wide DNA methylation profiling of the regenerative MRL/MpJ mouse and two normal strains
PublicationAims We aimed to identify the pivotal differences in the DNA methylation profiles between the regeneration capable MRL/MpJ mouse and reference mouse strains. Materials and Methods Global DNA methylation profiling was performed in ear pinnae, bone marrow, spleen, liver, heart from uninjured adult females of the MRL/MpJ and C57BL/6J and BALB/c. Results and conclusion A number of differentially methylated regions distinguishing between...
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Green Polymer Nanocomposites for Skin Tissue Engineering
PublicationFabrication of an appropriate skin scaffold needs to meet several standards related to the mechanical and biological properties. Fully natural/green scaffolds with acceptable biodegradability, biocompatibility, and physiological properties quite often suffer from poor mechanical properties. Therefore, for appropriate skin tissue engineering and to mimic the real functions, we need to use synthetic polymers and/or additives as complements...
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Effect of Nanohydroxyapatite on Silk Fibroin–Chitosan Interactions—Molecular Dynamics Study
PublicationFibroin–chitosan composites, especially those containing nanohydroxyapatite, show potential for bone tissue regeneration. The physicochemical properties of these biocomposites depend on the compatibility between their components. In this study, the intermolecular interactions of fibroin and chitosan were analyzed using a molecular dynamics approach. Two types of systems were investigated: one containing acetic acid and the other...
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Transcriptome profiling reveals distinctive traits of retinol metabolism and neonatal parallels in the MRL/MpJ mouse
PublicationBackground: The MRL/MpJ mouse is a laboratory inbred strain known for regenerative abilities which are manifested by scarless closure of ear pinna punch holes. Enhanced healing responses have been reported in other organs. A remarkable feature of the strain is that the adult MRL/MpJ mouse retains several embryonic biochemical characteristics, including increased expression of stem cell markers. Results: We explored the transcriptome...
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Forest habitat types in the State Forests in Polish provinces in years 2019- 2023
Open Research DataThe dataset contains data illustrating changes in forest habitat structure occurring between 2019 and 2023 in various provinces of Poland. It should be noted that this only concerns forests managed by the State Forests National Forest Holding. The term forest area refers to the area of forests excluding land related to forest management. The main source...
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Forest habitat types in the State Forests and their age structure in the years 2019-2023
Open Research DataThe dataset contains data illustrating the area occupied by various types in the State Forests and their age structure over the years 2019-2023. It should be noted that this only concerns forests managed by the State Forests National Forest Holding. The average age is determined as a weighted average, with the area in individual age classes and subclasses...
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Photomonitoring of activities carried out in the area of the "Mercato di Sant’Ambrogio" Sant'Ambrogio market and its direct neighbourhood, in the Florence, Italy, case study; stage from March 2023 year
Open Research DataThe data presents photomonitoring (visual documentation report in the form of photographs) of activities carried out in the area of the "Mercato di Sant’Ambrogio" Sant'Ambrogio market and its immediate vicinity, in the Florence, Italy, case study; stage from March 2023 year, during the one week of the monitoring. The monitoring is a part of follow-up...
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Monitoring of activities carried out as part of prototyping and implementation of the pilot project in the area of the "Polanki" market and its direct neighbourhood, in the Gdańsk-Oliwa district, step2; stage from June 2021 year.
Open Research DataThe data presents tabular monitoring lists (quantitative and qualitative documentation report in the form of tables) of activities carried out as part of prototyping and implementation of the pilot project in the area of the Polanki market and its immediate vicinity in the Gdańsk-Oliwa district in 2021 year - step 2, stage from June 2021.The monitoring...
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Monitoring of activities carried out as part of prototyping and implementation of the pilot project in the area of the "Polanki" market and its direct neighbourhood, in the Gdańsk-Oliwa district, step2; stage from September 2021 year.
Open Research DataThe data presents tabular monitoring lists (quantitative and qualitative documentation report in the form of tables) of activities carried out as part of prototyping and implementation of the pilot project in the area of the Polanki market and its immediate vicinity in the Gdańsk-Oliwa district in 2021 year - step 2, stage from September 2021.The monitoring...
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Monitoring of activities carried out as part of prototyping and implementation of the pilot project in the area of the "Polanki" market and its direct neighbourhood, in the Gdańsk-Oliwa district, step2; stage from October 2021 year.
Open Research DataThe data presents tabular monitoring lists (quantitative and qualitative documentation report in the form of tables) of activities carried out as part of prototyping and implementation of the pilot project in the area of the Polanki market and its immediate vicinity in the Gdańsk-Oliwa district in 2021 year - step 2, stage from October 2021.The monitoring...
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Monitoring of activities carried out as part of prototyping and implementation of the pilot project in the area of the "Polanki" market and its direct neighbourhood, in the Gdańsk-Oliwa district, step2; stage from July 2021 year.
Open Research DataThe data presents tabular monitoring lists (quantitative and qualitative documentation report in the form of tables) of activities carried out as part of prototyping and implementation of the pilot project in the area of the Polanki market and its immediate vicinity in the Gdańsk-Oliwa district in 2021 year - step 2, stage from July 2021.The monitoring...
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Monitoring of activities carried out as part of prototyping and implementation of the pilot project in the area of the "Polanki" market and its direct neighbourhood, in the Gdańsk-Oliwa district, step2; stage from May 2021 year.
Open Research DataThe data presents tabular monitoring lists (quantitative and qualitative documentation report in the form of tables) of activities carried out as part of prototyping and implementation of the pilot project in the area of the Polanki market and its immediate vicinity in the Gdańsk-Oliwa district in 2021 year - step 2, stage from May 2021.The monitoring...
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Monitoring of activities carried out as part of prototyping and implementation of the pilot project in the area of the "Polanki" market and its direct neighbourhood, in the Gdańsk-Oliwa district, step2; stage from August 2021 year.
Open Research DataThe data presents tabular monitoring lists (quantitative and qualitative documentation report in the form of tables) of activities carried out as part of prototyping and implementation of the pilot project in the area of the Polanki market and its immediate vicinity in the Gdańsk-Oliwa district in 2021 year - step 2, stage from August 2021.The monitoring...
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Influence of Ultrasound on the Characteristics of CaP Coatings Generated Via the Micro-arc Oxidation Process in Relation to Biomedical Engineering
PublicationOver the past decade, bone tissue engineering has been at the core of attention because of an increasing number of implant surgeries. The purpose of this study was to obtain coatings on titanium (Ti) implants with improved properties in terms of biomedical applications and to investigate the effect of ultrasound (US) on these properties during the micro-arc oxidation (MAO) process. The influence of various process parameters, such...
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Treatment of Odontogenic Maxillary Sinusitis with the Use of Growth Factors in Advanced Platelet-Rich Fibrin for Immediate Closure of Oro-Antral Communication: A Case Report
PublicationChronic odontogenic maxillary sinusitis (COMS), a prolonged inflammation of the maxillary sinus lasting over 12 weeks, is often a result of periapical lesions, marginal periodontitis, and complications like oro-antral communication (OAC) and fistula (OAF). OAC, commonly emerging post-teeth extraction in the lateral maxilla, lacks documented treatments using advanced platelet-rich fibrin (A-PRF). This study evaluates A-PRF’s efficacy...